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Treatment and Maintenance of Interstitial Cystitis/Bladder p.in Syndrome in Female p.tients with Cetirizine-Famotidine: A Case Series

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Case Rep.rts in Clinical Medicine 2023年第2期12卷 61-71页

作者： Reed B. Hogan II paul H. Moore III Doug paul Thomas p. Dooley GI Associates Flowood MS USA Division of Urogynecology Department of Obstetrics and Gynecology University of Mississippi Medical Center Jackson MS USA Dep.rtment of p.armacy Administration School of Pharmacy University of Mississippi Oxford MS USA Trends in p.arma Develop.ent LLC Pinson AL USA

p.rp.se: Interstitial cystitis/Bladder p.in syndrome is an inflammatory disorder of the bladder, for which histamine has been imp.icated in the p.thogenesis of the disease. The condition is often refractory to standard-of-care medical treatments, including the antihistamines hydroxyzine or cimetidine, and p.ocedures. Herein we rep.rt a p.ysician-sp.nsored p.oof-of-p.incip.e case series of four adult female p.tients with chronic p.inful bladder and frequent urination, who were treated once daily with a low dose H1 + H2 histamine recep.or antagonist combination. Materials and Methods: Four adult females with Interstitial cystitis/Bladder p.in syndrome were treated once daily with a comp.unded oral dosage form containing the H1 recep.or antagonist-cetirizine 8 mg in combination with the H2 recep.or antagonist-famotidine 22 mg. The case series consists of a retrosp.ctive review of the symp.om severity p.ior to versus following H1 + H2 treatment. Results and Conclusions: The once daily dual histamine recep.or antagonist therap. substantially reduced the p.in and urination frequency, and p.op.ylactically maintained all four p.tients long-term with substantially reduced disease severity. The reduction in symp.om severity was achieved at amounts that do not exceed the US FDA ap.roved and excep.ionally safe daily doses for the two over-the-counter monotherap.es. This case series p.ovides p.oof-of-p.incip.e evidence that a dual antihistamine combination of cetirizine p.us famotidine effectively treated and maintained female p.tients, who were p.eviously refractory to standard-of-care medications and/or p.ocedures.

关键词： Histamine Antihistamine Bladder Treatment p.op.ylaxis

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A gene exp.ession estimator of intramuscular fat p.rcentage for use in both cattle and sheep

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Journal of Animal Science and Biotechnology 2014年第4期5卷 379-390页

作者： Bing Guo Kritaya Kongsuwan paul L Greenwood Guanghong Zhou Wangang Zhang Brian p.Dalrymp.e Key Laboratory of Meat p.ocessing and Quality Control Synergetic Innovation Center of Food Safety and NutritionCollege of Food Science and TechnologyNanjing Agriculture University CSIRO Animal Food and Health SciencesSt.Lucia QLD 4067Australia National Institute of Animal Health 50/2 KasetklangLadyaoBangkok 10900Thailand CSIRO Animal Food and Health SciencesArmidale NSW 2350Australia NSW Dep.rtment of p.imary Industries Armidale NSW 2350Australia

Background：The exp.ession of genes encoding p.oteins involved in triacyglyceride and fatty acid synthesis and storage in cattle muscle are correlated with intramuscular fat（IMF）%.Are the same genes also correlated with IMF%in sheep.muscle,and can the same set of genes be used to estimate IMF%in both sp.cies？Results：The correlation between gene exp.ession（microarray） and IMF%in the longissimus muscle（LM） of twenty sheep.was *** integrated analysis of this dataset with an equivalent cattle correlation dataset and a cattle differential exp.ession dataset was undertaken.A total of 30 genes were identified to be strongly correlated with IMF%in both cattle and *** overlap.of genes was highly significant,8 of the 13 genes in the TAG gene set and 8 of the 13 genes in the FA gene set were in the top.100 and 500 genes resp.rtively most correlated with IMF%in sheep.p.value = *** the 30 genes,CIDEA,THRSp.ACSM1,DGAT2 and FABp. had the highest average rank in both *** the data from two small group. of Brahman cattle（control and Hormone growth p.omotant-treated[known to decrease IMF%in muscle]） and 22 animals in total,the utility of a direct measure and different estimators of IMF%（ultrasound and gene exp.ession） to differentiate between the two group. were *** measured IMF%and IMF%estimated from ultrasound scanning could not discriminate between the two ***,using gene exp.ession to estimate IMF%discriminated between the two *** the number of genes used to estimate IMF%from one to five significantly increased the discrimination p.wer;but increasing the number of genes to 15 resulted in little further ***：We have demonstrated the utility of a comp.rative ap.roach to identify robust estimators of IMF%in the LM in cattle and *** have also demonstrated a number of ap.roaches（p.tentially ap.licable to much smaller group. of animals than conventional methods） to using gene exp.ession to rank animal

关键词： Cattle Gene exp.ession p.enotyp. IMF% Sheep

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Distinct exp.ession p.ofiles of transcrip.ional coactivators for thyroid hormone recep.ors during Xenop.s laevis metamorp.osis

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Cell Research 2003年第6期13卷 459-464页

作者： BINDU D paul National Institutes of Health Laboratory of Gene Regulation and Develop.ent National Institute of Child Health and Human Develop.ent Bldg. USA.

The biological effects of thyroid hormone (T3) are mediated by the thyroid hormone recep.or (TR). Amp.ibian metamorp.osis is one of the most dramatic p.ocesses that are dep.ndent on T3. T3 regulates a series of orchestrated develop.ental changes, which ultimately result in the conversion of an aquatic herbivorous tadp.le to a terrestrial carnivorous frog. T3 is p.esumed to bind to TRs, which in turn recruit coactivators, leading to gene activation. The best-studied coactivators belong to the p.60 or SRC family. Members of this family include SRC1/ NCoA-1, SRC2/TIF2/GRIp., and SRC3/p.Ip.ACTR/AIB-l/RAC-3/TRAM-1. These SRCs interact directly with liganded TR and function as adap.er molecules to recruit other coactivators such as p.00/CBp. Here, we studied the exp.ession p.tterns of these coactivators during various stages of develop.ent. Amongst the coactivators cloned in Xenop.s laevis, SRC3 was found to be dramatically up.egulated during natural and T3-induced metamorp.osis, and SRC2 and p.00 are exp.ess

关键词： transcrip.ion coactivators thyroid hormone recep.or Xenop.s laevis metamorp.osis histone acetylation.

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水平地面变方向行走步态研究

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中国生物医学工程学报 1998年第4期17卷 350-354页

作者：陈小安 paul,J.p 重庆大学

本文用ＶＩＣＯＮ运动分析系统研究日常活动中单侧负重条件下，常人水平地面变方向行走的步态，重点分析了步态循环周期中各步相的特征以及地面对足的三维反作用力规律，并且与有关文献的结果进行了比较。

关键词：步态变方向行走反作用力

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Use of models in large-area forest surveys： comp.ring model-assisted, model-based and hybrid estimation

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Forest Ecosystems 2016年第2期3卷 153-163页

作者： Goran Stahl Svetlana Saarela Sebastian Schnell Soren Holm Johannes Breidenbach Sean p. Healey paul L. p.tterson Steen Magnussen Erik Naesset Ronald E. McRoberts Timothy G. Gregoire Dep.rtment of Forest Resource Management Swedish University of Agricultural Sciences UmeA Sweden. Norwegian Institute for Bioeconomy Research As Norway. USDA Forest Service Washington D.C. USA. Canadian Forest Service Pacific Forestry Centre British Columbia Canada Norwegian University of Life Sciences As Norway. School of Forestry and Fnvirnnmental Studies. Yale Universitv New Haven CT USA.

This p.p.r focuses on the use of models for increasing the p.ecision of estimators in large-area forest surveys. It is motivated by the increasing availability of remotely sensed data, which facilitates the develop.ent of models p.edicting the variables of interest in forest surveys. We p.esent, review and comp.re three different estimation frameworks where models p.ay a core role： model-assisted, model-based, and hybrid estimation. The first two are well known, whereas the third has only recently been introduced in forest surveys. Hybrid inference mixes design- based and model-based inference, since it relies on a p.obability samp.e of auxiliary data and a model p.edicting the target variable from the auxiliary *** review studies on large-area forest surveys based on model-assisted, model- based, and hybrid estimation, and discuss advantages and disadvantages of the ap.roaches. We conclude that no general recommendations can be made about whether model-assisted, model-based, or hybrid estimation should be p.eferred. The choice dep.nds on the objective of the survey and the p.ssibilities to acquire ap.rop.iate field and remotely sensed data. We also conclude that modelling ap.roaches can only be successfully ap.lied for estimating target variables such as growing stock volume or biomass, which are adequately related to commonly available remotely sensed data, and thus p.rely field based surveys remain imp.rtant for several imp.rtant forest p.rameters.

关键词： Design-based inference Model-assisted estimation Model-based inference Hybrid inference Nationalforest inventory Remote sensing Samp.ing

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The structure of colloidal p.lyethylenimine-silica nanocomp.site microp.rticles

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p.rticuology 2023年第5期76卷 86-100页

作者： Alexandra Semenova Luke W.Giles Mark Louis p.Vidallon Bart Follink paul L.Brown Rico F.Tabor School of Chemistry Monash University19 Rainforest Walk.Clayton3800Australia Rio Tinto Bundoora Technical Development Centre1 Research AvenueBundoora3083Australia

Dep.sition of silica from an organosilane tetraethoxysilane(TEOS)onto p.rent p.lyethylenimine(p.I)microgel p.rticles p.oduces a novel p.I-silica nanocomp.site,which p.ssesses greater adsorp.ion ca-p.city for cop.er ions than either p.rent *** study exp.ores factors governing interactions of silica with the p.I matrix,along with structural features of resulting p.I-silica comp.site p.rticles,to exp.ain their p.op.rties and determine their ap.lication *** influence of initial TEOS/p.I mass ratio and the duration of silica dep.sition on the final silica content and distribution in the comp.site are studied.A comp.rative analysis of the structural architecture of chemically etched silica remnants,original p.I-silica comp.site p.rticles and the p.rent p.I-microgel is carried out using X-ray p.oto-electron sp.ctroscop.,small-angle X-ray scattering,and electron microscop. *** is found that silica sol nanop.rticles are evenly distributed throughout the p.I-microgel framework and interlinked with it via electrostatic interactions,enabling a structural model of the p.I-silica nanocomp.site to be *** chemical stability of resulting nanocomp.site p.rticles in p.rallel with the p.rent p.I-microgel is tested and shown to be robust for more than 100 days of storage in aqueous disp.rsions across a range of p. conditions,highlighting the ap.lication p.tential for these p.rticles in cop.er cap.ure.

关键词： p.lyethylenimine Silica Organic-inorganic comp.site Nano-scale morp.ology Small angle X-ray scattering

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Vegetable p.oduction After Flooded Rice Imp.oves Soil p.op.rties in the Red River Delta, Vietnam

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p.dosp.ere 2015年第1期25卷 130-139页

作者： Arij p.EVERAARTS Jacques J.NEETESON p.am T.T.HUONG paul C.STRUIK Ap.lied p.ant Research Wageningen University and Research Centre p.ant Research International Wageningen University and Research Centre Field Crop.Research Institute Hai Duong and Hanoi University of Agriculture Centre for Crop.Systems Analysis Wageningen University

Vegetable p.oduction in South East Asia often is in rotation with flooded rice. The p.ddling of the soil with flooded rice p.oduction may result in unfavourable soil conditions for the subsequent p.oduction of dry land crop.. To establish whether p.rmanent vegetable p.oduction results in favourable soil conditions for vegetables, the effects of five different p.rmanent vegetable p.oduction systems and a system of vegetable p.oduction in rotation with flooded rice on soil p.op.rties after flooded rice were studied in a 2-year field exp.riment. Bulk density at 0.05–0.10 m dep.h layer decreased with p.rmanent vegetable p.oduction and vegetable p.oduction in rotation with flooded rice. The decrease in bulk density was influenced by the ap.lication of organic manure and rice husks, and esp.cially by the number of crop. cultivated, suggesting that frequency of soil tillage had a major effect on bulk density. p.oughing with buffalo traction after flooded rice, in combination with construction of raised beds, could reduce or totally eliminate negative effects of p.ddling on soil structure. Bulk density at 0.15–0.20 m soil dep.h was not influenced. Soil acidity decreased significantly in all systems. Soil organic carbon increased in all systems, but significant increase was only found in two p.rmanent vegetable p.oduction systems. Available p.osp.orus(p. significantly increased in two p.rmanent vegetable p.oduction systems, with a p.sitively correlation to the amount of p.ap.lied. The significant decrease in bulk density and increase in p.H(H2O), after only 2 years, showed that soil conditions after flooded rice could be imp.oved in a short time under intensive vegetable p.oduction.

关键词： available p.osp.orus bulk density organic carbon p.ddling soil fertility soil imp.ovement

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关于《〈垄断资本〉一些理论含义》的最后通信

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政治经济学季刊 2024年第1期3卷 117-133页

作者：保罗·巴兰保罗·斯威齐张雪琴当代著名马克思主义中共中央党校(国家行政学院)马克思主义学院

“最后通信”系保罗·巴兰和保罗·斯威齐于1964年2月底至3月初的往来通信,其内容主要同垄断资本缺失的理论章《一些理论含义》有关。这一章由巴兰于1962年起草,那时他们正在从事《垄断资本》的出版修订工作。关于《一些理论含义》的讨... 详细信息

“最后通信”系保罗·巴兰和保罗·斯威齐于1964年2月底至3月初的往来通信,其内容主要同垄断资本缺失的理论章《一些理论含义》有关。这一章由巴兰于1962年起草,那时他们正在从事《垄断资本》的出版修订工作。关于《一些理论含义》的讨论因巴兰于1964年3月26日溘然长逝而被迫中断。这些通信由约翰·贝拉米·福斯特编辑注释并首次公开发表~((1))。

关键词：理论含义垄断资本巴兰修订工作通信

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Long‑term outcomes of two first‑generation trabecular micro‑byp.ss stents(iStent)with p.acoemulsification in p.imary op.n‑angle glaucoma:eight‑year results

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Eye and Vision 2021年第4期8卷 431-442页

作者： Ali Salimi Harrison Watt paul Harasymowycz Dep.rtment of Op.thalmology Faculty of MedicineMcGill UniversityMontrealQCCanada Montreal Glaucoma Institute MontrealQCCanada Faculty of Medicine McGill UniversityMontrealQCCanada Dep.rtment of Op.thalmology University of Montreal4135 de RouenMontrealQC H1V1G5Canada

Background:The short-and medium-term outcomes of iStent have been extensively studied;however,only few studies have investigated its long-term ***,we assessed the long-term efficacy and safety of two iStents with concomitant cataract surgery in glaucomatous eyes while also evaluating measures of disease stability using visual field and op.ical coherence tomograp.y(OCT)of the op.ic nerve and the macula throughout 8 years of ***:This longitudinal,single-center consecutive case series included glaucomatous eyes that underwent imp.antation of two first-generation trabecular micro-byp.ss stents(iStent)with concomitant cataract ***-year efficacy outcomes included mean intraocular p.essure(IOp.and medications,as well as surgical ***-year safety outcomes included best-corrected visual acuity(BCVA),visual field mean deviation(VF-MD),cup.todisc ratio(CDR),retinal nerve fiber layer(RNFL)thickness,ganglion cell-inner p.exiform layer(GC-Ip.)thickness,and adverse ***:A total of 62 eyes with p.imary op.n-angle glaucoma(p.AG)were *** 8 years p.stop.rative,IOp.reduced by 26%from 19.2±3.9 mmHg p.eop.ratively to 14.2±2.4 mmHg(p.0.001),91.1%of eyes achieved IOp.18 mmHg(vs.51.6%p.eop.ratively),69.6%of eyes achieved IOp.15 mmHg(vs.14.5%p.eop.ratively),and 25%of eyes achieved IOp.12 mmHg(vs.1.6%p.eop.ratively).Medication use decreased by 17.9%from 2.8±1.1 p.eop.ratively to 2.3±1.2(p.0.018).Surgical success was 90%,as six eyes underwent subsequent glaucoma *** measures of BCVA,CDR,RNFL thickness and GC-Ip. thickness remained stable through 8 years ***-MD remained stable until p.stop.rative year 5 and subsequently p.ogressed according to the natural history of glaucomatous ***:Imp.antation of two iStents with concomitant cataract surgery is an effective and safe treatment op.ion for surgery-naïve p.AG eyes,evidenced by significant IOp.and medication reductions,reasonable surgical success

关键词： Minimally invasive glaucoma surgery MIGS Trabecular micro-byp.ss stent iStent Glaucoma Cataract surgery Long-term outcomes

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CR Geometry in 3-D(Dedicated to p.ofessor Haim Brezis with admiration)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 695-710页

作者： paul C.YANG dep.rtment of mathematics princeton universityFine HallW ashington RoadPrinceton NJ 08544 USA.

CR geometry studies the boundary of p.eudo-convex manifolds. By concentrating on a choice of a contact form, the local geometry bears strong resemblence to conformal geometry. This p.p.r deals with the role conformally invariant op.rators such as the p.neitz op.rator p.ays in the CR geometry in dimension three. While the sign of this op.rator is imp.rtant in the embedding p.oblem, the kernel of this op.rator is also closely connected with the stability of CR structures. The p.sitivity of the CR-mass under the natural sign conditions of the p.neitz op.rator and the CR Yamabe op.rator is discussed. The CR p.sitive mass theorem has a consequence for the existence of minimizer of the CR Yamabe p.oblem. The p.eudo-Einstein condition studied by Lee has a natural analogue in this dimension, and it is closely connected with the p.uriharmonic *** author discusses the introduction of new conformally covariant op.rator p.p.ime and its associated Q-p.ime curvature and gives another natural way to find a canonical contact form among the class of p.eudo-Einstein contact forms. Finally, an isop.rimetric constant determined by the Q-p.ime curvature integral is discussed.

关键词： p.neitz op.rator, Embedding p.oblem, Yamabe equation, Mass,p.p.ime, Q-p.ime curvature

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