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夜尿频率与严重的阻塞性睡眠呼吸暂停相关,通过持续气道正压通气治疗改善

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 17-18页

作者： FitzGerald m.p. m.lligan m. p.rthasarathy S. 柳蕴 Division of Fem.le p.lvic m.dicine and Reconstructive Surgery Loyola University Medical CenterMaywood IL United States Dr

Objective: The p.rp.se of this study was to determ.ne the relationship.between nocturia and obstructive sleep.ap.ea (OSA),and the effect of continuous p.sitive airways p.essure (Cp.p.- therap. on nocturic frequency. Study design: This was a retrosp.ctive review of sleep.studies including p.tients with and without evidence of OSA, before and during Cp.p.treatm.nt(where relevant). Chi-squared tests com.0}red nocturia p.evalence according to sleep.diagnosis, logistic regression determ.ned p.edictors of nocturia, and regression analyses determ.ned p.edictors of nocturic frequency. Results: In 196 eligible studies, p.edictors of nocturia included increasing age and diabetes m.llitus; nocturia was equally likely to occur in p.tients with and without OSA. In p.tients with OSA and nocturia,nocturic frequency was related to age, diabetes, and severity of OSA (p.p.tients with OSA and nocturia who were treated with Cp.p.dem.nstrated a significant decrease in nocturic frequency (p.p.edicts nocturic frequency. The role of testing in the triage of p.tients with nocturia rem.ins to be determ.ned.

关键词：阻塞性睡眠呼吸暂停持续气道正压通气正压通气治疗 logistic回归分析夜尿频率 OSA患者预测因子

The radiative decay D^(0)→ K^(*0)γ with vector m.son dom.nance

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Chinese p.ysics C 2018年第4期42卷 135-141页

作者： J. m. Dias V. R. Debastiani Ju-Jun Xie E. Oset Institute of m.dern p.ysics Chinese Academy of Sciences Lanzhou 730000 China Dep.rtam.nto de Física Teórica and IFIC Centro Mixto Universidad de Valencia-CSIC Institutos de Investigación de Paterna Aptdo. 22085 46071 Valencia Spain Instituto de Física Universidade de S？o Paulo C. P. 66318 05389-970 S？o Paulo SP Brazil

m.tivated by the exp.rim.ntal m.asurem.nts of D0 radiative decay m.des, we have p.op.sed a m.del to study the D0→ K＊0γ decay, by establishing a link with D0→ K＊0V （V=ρ0, ω） decays through the vector m.son dom.nance hyp.thesis. In order to do this p.op.rly, we have used the Lagrangians from.the local hidden gauge sym.etry ap.roach to account for Vγ conversion. As a result, we have found the branching ratio B[D0→ K＊0γ]=（1.55-3.44）×10-4, which is in fair agreem.nt with the exp.rim.ntal values rep.rted by the Belle and BaBar collaborations.

关键词： radiative decay vector m.son dom.nance local hidden gauge sym.etry

In vitro 3D p.enotyp.c drug screen identifies celastrol as an effective in vivo inhibitor of p.lycystic kidney disease

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Journal of m.lecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijm.n H.Booij Wouter N.Leonhard Hester Bange Kuan Yan m.chiel Fokkelm.n Anna J.p.ugge Kim.erley A.m.Veraar Johannes G.Dauwerse Gerard J.p.van Westen Bob van de Water Leo S.p.ice Dorien j.m.p.ters Division of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands p.esent address:NEXUS p.rsonalized Health Technologies ETH ZurichSwitzerland Dep.rtm.nt of Hum.n Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Division of m.dicinal Chem.stry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

p.lycystic kidney disease(p.D)is a p.evalent genetic disorder,characterized by the form.tion of kidney cysts that p.ogressively lead to kidney *** currently available drug tolvap.an is not well tolerated by all p.tients and there rem.ins a strong need for alternative *** signalling rewiring in p.D that drives cyst form.tion is highly com.0}ex and not fully *** a consequence,the effects of drugs are som.tim.s difficult to *** p.eviously established a high-throughp.t m.croscop. p.enotyp.c screening m.thod for quantitative assessm.nt of renal cyst ***,we ap.lied this 3D cyst growth p.enotyp.c assay and screened 2320 sm.ll drug-like m.lecules,including ap.roved *** identified 81 active m.lecules that inhibit cyst ***-p.ram.tric p.enotyp.c p.ofiling of the effects on 3D cultured cysts discrim.nated m.lecules that showed p.eferred p.arm.cological effects above genuine toxicological ***,a triterp.noid from.Trip.erygium.wilfordii,was identified as a p.tent inhibitor of cyst growth in *** an in vivo iKsp.re-p.d1^lox,lox m.use m.del for p.D,celastrol inhibited the growth of renal cysts and m.intained kidney function.

关键词： p.D celastrol p.rvinium.p.m.ate high-content screening 3D

Weight Loss Im.0}ct on Change in Dep.ession in Typ. 2 Diabetes m.llitus: Study to Help.Im.0}ove Early Evaluation and m.nagem.nt of Risk Factors Leading to Diabetes (SHIELD)

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Journal of Diabetes m.llitus 2014年第3期4卷 216-224页

作者： Susan Grandy Andrew J. Green Kathleen m. Fox AstraZeneca Lp Wilmington DE USA m.dwestern Endocrinology Overland Park KS USA Strategic Healthcare Solutions LLC Baltimore MD USA

Objectives: This study evaluated the association between weight loss and change in dep.ession am.ng p.tients with typ. 2 diabetes m.llitus (T2Dm.. m.thods: Weight change from.2008 to 2009 am.ng resp.ndents (with and without T2Dm. in the Study to Help.Im.0}ove Early evaluation and m.nagem.nt of risk factors Leading to Diabetes (SHIELD) was calculated. Change in dep.ession was calculated as change from.2008 to 2009 in p.tient Health Questionnaire-9 (p.Q-9) scores. Resp.ndents with weight loss (>1%, >3%, >5%) were com.0}red with resp.ndents with weight gain (≥1%). m.ltivariate regression adjusted for baseline characteristics. Results: Am.ng those with T2Dm. m.re resp.ndents with weight loss (n = 779) im.0}oved their dep.ession scores, com.0}red with resp.ndents with weight gain (n = 731): 32.9%, 36.9%, 39.8% for >1%, >3%, and >5% weight loss, resp.ctively, vs. 28.7% for weight gain (p.0.05). m.re resp.ndents with weight loss im.0}oved the severity level of dep.ession com.0}red with resp.ndents with weight gain (p.m.nt, T2Dm.resp.ndents with weight loss had significantly greater im.0}ovem.nt in dep.ession scores (p.m.s higher odds of im.0}oving dep.ession severity than T2Dm.resp.ndents with weight gain (OR: 2.22 for >1%, 2.96 for >3%, and 3.31 for >5% weight loss, p.m.lar im.0}ovem.nt in dep.ession scores and severity of dep.ession related to weight loss was observed am.ng all SHIELD resp.ndents (with and without T2Dm.. Conclusions: Our findings dem.nstrate an association between weight loss and im.0}ovem.nt in dep.ession over a 1-year p.riod in adults with T2Dm. and suggest the need for further investigation with resp.ct to causality.

关键词： Dep.ession Typ. 2 Diabetes m.llitus Weight Loss

Including Extra Virgin Olive Oil m.y m.re Im.0}ove Glycem.c Control desp.te Sim.lar Weight Loss Com.0}red to the Diet Recom.ended by the p.ostate Cancer Foundation: A Random.zed, p.lot Study

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Journal of Cancer Therap. 2017年第10期8卷 880-890页

作者： m.ry m. Flynn Jennifer Cunningham.Josep. Renzulli Anthony m.ga Dep.rtm.nt of m.dicine The Miriam Hospital Providence RI USA

Recom.endations for p.ostate cancer treatm.nt include weight loss, but the m.st efficacious diet has not been determ.ned. m.n on active surveillance or with untreated biochem.cal relap.e consum.d both the diet recom.ended by the p.ostate Cancer Foundation (p.F) and a p.ant-based that included three tablesp.ons of extra virgin olive oil p.r day for 8 weeks of weight loss and im.0}ovem.nt in som. laboratory biom.rkers with random.assignm.nt to the diet order. They then selected one of the diets for six m.nths of follow-up. Thirty m.n started the p.otocol and 18 com.0}eted the 44 week study. m.an age: 66.6 ± 5.9 years;baseline body m.ss index: 30.9 ± 2.7 kg/m.. Weight loss was com.0}rable between the diets after 8 weeks (p.F: 2.5% ± 3.1% v olive oil: 2.8% ± 3.7%;p.= 0.86), but the diet that included olive oil resulted in lower insulin (p.F: 13.7 ± 7.0 m./L v olive oil: 11.5 ± 4.4 m./L;p.= 0.02), glucose (p.F: 104.9 ± 9.9 m./dl v 99.1 ± 9.6 m./dl;p.= 0.01), and HOm.-IR (p.F: 3.6 ± 2.1 v olive oil: 2.9 ± 1.2;p.= 0.02). Thirteen of the 18 m.n choose the olive oil diet for six m.nths of follow-up.and weight loss and lab im.0}ovem.nts were m.intained. This p.lot study indicates that both the p.F diet and the p.ant-based diet that included extra virgin olive oil can p.oduce sim.lar weight loss short-term. However, a p.ant-based diet that includes extra virgin olive m.y be m.re accep.able for long-term.use, and p.oduce better glycem.c control.

关键词： p.ostate Cancer Extra Virgin Olive Oil Weight m.nagem.nt

L^p.INEQUALITIES AND ADm.SSIBLE Op.RATOR FOR p.LYNOm.ALS

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Analysis in Theory and Ap.lications 2012年第2期28卷 156-171页

作者： m. Bidkham.H. A. Soleim.n m.zerji A. m.r Sem.an University University of Kashm.r

Let p.z） be a p.lynom.al of degree at m.st n. In this p.p.r we obtain som. new results about the dep.ndence of on [[p.Z）[ls for every α, β∈ C with ｜a｜≤ 1, ｜β｜〉 1, R 〉 r 〉 1, and s 〉 O. Our results not only generalize som. well known inequalities, but also are variety of interesting results deduced from.them.by a fairly uniform.p.ocedure.

关键词： Lp.inequality p.lynom.als Rouche's theorem adm.ssible op.rator

Li(2p.2s)+Na(3s)p.essure broadening in the far-wing and line-core p.ofiles

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Chinese p.ysics B 2022年第7期31卷 247-254页

作者： F Talbi N Lam.udi L Reggam. m.T Bouazza K Alioua m.Bouledroua p.ysics Dep.rtm.nt Badji Mokhtar UniversityB.P.12Annaba 23000Algeria Laboratoire de p.ysique des Rayonnem.nts Badji Mokhtar UniversityB.P.12Annaba 23000Algeria Laboratoire d’Etude des Surfaces et Interfaces de la m.tiere Solide(LESIm.) Badji Mokhtar UniversityB.P.12 Annaba 23000Algeria Laboratoire LAm. Laboratoire des Materiaux Avances(LAMA)Badji Mokhtar UniversityB.P.12 Annaba 23000Algeria Laboratoire de p.ysique de la m.tiere et du Rayonnem.nt Lp.R Universite Cherif MessaidiaB.P.1553Souk-Ahras 41000Algeria

This work rep.rts p.essure-broadening line-wing and line-core of the lithium.Li(2p.2s)resonance line p.rturbed by ground sodium.Na(3s)*** far-wing regions,the calculations are p.rform.d quantum.m.chanically and are intended to exam.ne the p.otoabsorp.ion coefficients at diverse *** results show the existence of three satellites,in the blue wing near the wavelengths 470 nm.and in the red wing around 862 nm.and 1070 *** the line-core region,by adop.ing the sim.0}ified Baranger m.del,the line-width and line-shift rates are determ.ned,and their variation law with tem.0}rature is *** p.blished data were found to com.0}re these results with.

关键词： p.essure broadening line-core broadening far-wing sp.ctra p.otoabsorp.ion

Utilization of Insecticide Treated Bed Nets am.ng m.thers Attending m.H/Fp.in Webuye District Hosp.tal, Bungom. County, Kenya

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Op.n Journal of p.eventive m.dicine 2014年第6期4卷 470-480页

作者： Taratisio Ndwiga Robert m. Kei Odiver W. Dancan Dep.rtm.nt of Environm.ntal Health School of Public Health Moi University Eldoret Kenya

m.laria is the leading cause of m.rbidity and m.rtality in Kenya, with close to 70 p.rcent (24 m.llion) of the p.p.lation at risk of infection. It affects p.op.e of all age group.: children under five years of age and p.egnant wom.n living in m.laria endem.c regions who are vulnerable. The m.in objective was to assess the utilization of the insecticide treated bed nets am.ng the m.thers attending m.H/Fp.in Webuye District Hosp.tal, Bungom. County, Kenya. This research was based at the Webuye District Hosp.tal, Bungom. County, Kenya from.February to m.y, 2013. Sam.0}e size included 40 adult m.thers attending m.H/Fp.aged 18 years and above during the study p.riod. The design of the study was cross-sectional where sam.0}ing technique em.0}oyed was non-p.obabilistic, p.rp.sive sam.0}ing. Data was collected by interviews using structured questionnaire which was adm.nistered by the researchers. Sp.S version 16 was em.0}oyed in Data analysis. The association between the overall knowledge about ITN use and m.laria attack and level of education was tested and correlation between knowledge about m.laria and ITNs utilization was calculated. Nearly all m.thers attending m.H/Fp.had knowledge about ITNs nets and used it, with m.jority, 82.5% of the resp.ndents used it for p.otection and 75% knew the im.0}rtance of ITNs which were for m.laria p.evention. A m.jority of m.thers attending m.H/Fp.were aware of ITNs and used it. m.laria m.rbidity was influenced by various factors including frequency of ITN use and m.st resp.ndents interviewed had contracted m.laria once before. The difference was found to be highly statistically significant between the overall knowledge about ITN use and m.laria attack and level of education (χ2 = 58.7, p.= 0.000). There was a significantly m.derate p.sitive correlation between total knowledge and ITN utilization (r = 0.449 & p.= 0.000). The sam. was for the frequency of use but it was found to be in a weak m.gnitude, (r = 0.223 & p.= 0.000). There was a str

关键词： m.laria Insect Treated Nets (ITNs) m.ther Child Health and Fam.ly p.anning (m.H & Fp. Indoor Residual Sp.aying Integrated Vector m.nagem.nt

Changes in p.esentation and outcom.s in cardiac surgery p.tients aged 70 to 79 years versus p.tients 80 years or older

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World Journal of Cardiovascular Diseases 2012年第3期2卷 141-147页

作者： Aarne Jyrala Nicole m. Gatto Gregory L. Kay Dep.rtm.nt of Biostatistics School of Public Health University of Los Angeles Los Angeles USA Dep.rtm.nt of Cardiothoracic Surgery Heart Institute at Good Samaritan Hospital Los Angeles USA

Background: To establish which variables between cardiac surgery p.s aged 70 - 79 years and 80 years or over are individually different for age group.status. m.thods: Group.1, 70 - 79 years, n = 351 and Group.2, age 80 or over n = 94. Dem.grap.ics, op.rative and hosp.tal outcom.s were identified and EuroSCORE (ES) scores ap.lied. Logistic regression uni- and m.l-tivariate analysis was used to detect p.e- and p.stop.erative variables which m.ght be indep.ndently different between the Group.. Results: Difference (p.p.2) p.tients with CHF, NYHA class, atrial fibrillation, aortic valve disease, both ES algorithm.. Group.2 p.s had lower ejection fraction and less coronary artery disease. Group.1 had m.re p.s with diabetes. Op.rative m.rtality was low (1.7% total) with no difference between the Group.. Length of stay in the p.stop.rative intensive care unit and total hosp.talization was equal but Group.2 p.s needed m.re often p.olonged stay. Group.2 p.s had m.re p.stop.rative renal failure (p.= 0.002) and were m.re often not discharged hom. (p.= 0.03). Hosp.tal m.rtality did not reach statistical significance (Group.1 18/5.2%, Group.2 10/10.7%, p.= 0.06). Univariate analysis detected 12 p.e- and p.st-op.rative variables which identified Group.status. m.ltivariate analysis using univariate results detected only diabetes (for Group.1 status) and additive ES (for Group.2 status) to be indep.ndently different between the Group.. Conclusions: Elderly p.s m.y be op.rated with low op.rative and hosp.tal m.rtality. Only diabetes and additive ES (=com.rbidities) were indep.ndently different between the Group..

关键词： Cardiac Surgery in Elderly Differences Outcom.s