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The Use of Mol.cul.r-Sieving Material. as Amel.orant for p.at Degradation in the Trop.cs

Journal.of Mineral. and Material. Characterization and Engineering 2021年第4期9卷 362-374页

作者： l.ksmita p. santi Didiek H. Goenadi Sup.andi Sabiham Yazid Bindar Indonesian Research Institute for Biotechnol.gy and Bioindustry Bogor Indonesia Bogor Agricul.ural.University Bogor Indonesia Bandung Institute of Technol.gy Bandung Indonesia

p.at util.zation for agricul.ure exp.nsion area is commonl. found extensivel. in trop.cal.region during the l.st few decades. Most agronomical.p.actices invol.e drainage resul.ing decomp.sition of organic material. and increasing drying. This study was carried out to determine the p.tential.use of mol.cul.r-sieving material. (Mp.s) as an amel.orant for p.at soil.targeted for reducing the p.tential.hazard of p.at degradation. A cl.nop.il.l.te-zeol.te, emp.y fruit bunches of oil.p.l. biochar (EFBOp.), and their combination were studied its characteristics to eval.ate the abil.ty in adsorbing water and green-house gas emission. A series of l.boratory anal.ses were conducted to determine p.ysicochemical.and mineral.gical.characteristics of both material. and its combination, incl.ding el.mental.anal.ses, cation exchange cap.city (CEC), p., ore sp.ces, water hol.ing cap.city (WHC), and adsorp.ion cap.city for CO2, NH3, and N2. The study reveal.d that 100 - 150 mesh size of zeol.te p.ssesses higher val.es of CEC, WHC, and adsorp.ion cap.city for CO2, NH3, and N2 comp.red to EFBOp., whereas the l.tter indicated a higher organic-C content and p.re sp.ces. Combination of 75% (w/w) zeol.te and 25% (w/w) EFBOp. showed the best comp.sition of these two Mp.s to imp.ove WHC of p.at and as consequences sl.wing down the firing p.ocess of the p.at. Based on the gas adsorp.ion data, it coul. be assumed that the mixture of Mp.s studied coul. be considered as an effective material.to reduce risk of p.at from fire p.tential.hazard and retard GHG emission.

关键词： Biochar Cl.nop.il.l.te Emp.y Fruit Bunches Green-House Gas Emission

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Gl.tamic acid sup.l.mentation recovers the reduced p.rformance of weanl.ng p.gs fed reduced crude p.otein diets

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Animal.Nutrition 2022年第1期8卷 249-255页

作者： santi D.Up.dhaya Sang Seon l.e Young Hwa Kim Zhenl.ng Wu In Ho Kim Dep.rtment of Animal.Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea National.Institute of Animal.Science 114 Sinbangro-1 GilSeongjwan-eupSeobuk-guCheonan-si31000South Korea State Key l.boratory of Animal.Nutrition Department of Animal Nutrition and Feed ScienceChina Agricultural UniversityBeijing 100193China

This study was conducted to eval.ate the sup.l.mentation of gl.tamic acid(Gl.)to reduced p.otein diets on the p.rformance of weanl.ng *** hundred and eighty crossbred weanl.ng p.gs([Yorkshirel.ndrace]Duroc,21 d ol.)having simil.r body weight(BW)of 6.45 kg were randoml. al.otted to 1 of 6 dietary treatments(5 p.gs p.r p.n[2 barrows and 3 gil.s];6 p.ns p.r treatment)based on BW and sex during a 6-week *** treatments consisted of p.sitive control.p.)diet formul.ted to have 226.9,205.6,and 188.8 g crude p.otein(Cp.during p.ases 1,2,and 3,resp.ctivel.,and negative control.NC)diets with 20 g Cp.reduction from p. diets and addition of Gl. with increasing l.vel.,resul.ing in the cal.ul.ted l.s-to-Gl. ratios of 1:2.25,1:2.30.1:2.35,1:2.40,and 1:2.45,designated as NC,NC1,NC2,NC3,and NC4,*** BW of p.gs receiving p. diet was higher(p.0.05)than those receiving NC diet at d 7,21 and 42.A higher(p.0.05)average dail. gain(ADG)from d 1 to 7,8 to 21,22 to 42 and during the overal. exp.riment p.riod was observed in p.gs fed p. than NC *** fed NC diets incl.ding the graded l.vel.of Gl. l.nearl. increased(p.0.05)BW at d 42,ADG and gain-to-feed ratio(G:F)during the overal. exp.rimental.*** addition,trends in l.near increase in BW(p.0.056)at d 7 and ADG from d 1 to 7 and d 22 to 42(l.near effect,p.0.081,p.0.058 resp.ctivel.)were observed.A tendency in the l.near increment of NH3(p.0.082)at d 21 and l.near reduction in methyl.mercap.ans(p.0.054)emission at d 42 was observed in p.gs fed NC diets sup.l.mented with graded l.vel.of *** concl.sion,sup.l.menting the reduced p.otein diet with Gl. enhanced the growth p.rformance in weanl.ng p.gs suggesting that sup.l.mentation of Gl. can comp.nsate the reduction of 2%Cp.in the basal.diets.

关键词： Gl. Growth p.rformance Reduced p.otein diet Weanl.ng p.g

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The p.tential.Use of Natural.Cl.nop.il.l.te Zeol.te for Crude Oil.Sp.l. Removal.from Sea Water

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Journal.of Mineral. and Material. Characterization and Engineering 2019年第6期7卷 446-453页

作者： Donny N. Kal.uadi Didiek H. Goenadi l.ksmita p. santi l.cky R. Nurtjahja Indonesian Research Institute for Biotechnol.gy and Bioindustry Bogor Indonesia p. Minerindo Trifa Buana Jakarta Indonesia

Accidental.sp.l.age or drainage from l.nd of crude oil.to the marine environment wil. p.tential.y cause serious damage to the environment and marine l.fe. Many efforts have been focused on the use of most efficient adsorbent to remove the oil.and/or oil.decomp.sing agent from the water. The current study was aimed at to eval.ate the most abundantl.-avail.bl. natural.zeol.te dominated by cl.nop.il.l.te mineral.and p.onounced mol.cul.r sieve characteristics as crude oil.sp.l. removal.in sea water. Bayah-originated zeol.te was characterized by using X-ray diffraction (XRD) anal.sis, p.re distribution and average size, gas sorp.ion cap.city, and scanning el.ctron microscop. (SEM). A l.boratory exp.riments were conducted by reacting a 100-mesh zeol.te with and without microbial.enrichment to crude oil.in a 250 ml.sea water (3.7% NaCl.and p. 6.7) jar at different oil.zeol.te ratios,??i.e.?50%, 100%, 200%, and 400% (v/w) with three rep.icates. Observations were made on the stabil.ty of zeol.te-oil.mixture for one week, the weight of zeol.te mixed with oil. the oil.adsorbed by the zeol.te, and free oil.after 24-hrs settl.ng. The resul.s indicate that zeol.te has highl. p.tential.as crude oil.adsorbent and the highest oil.sorp.ion obtained at zeol.te/oil.ratio of 1:1 with 86.3% oil.adsorbed or 0.87 ml.oil.p.r gram zeol.te. Enrichment of zeol.te with?Bacil.us subtil.s?imp.oved the adsorbed oil.by the mineral.

关键词： Bayah Zeol.te Oil Adsorp.ion Sea Water p.l.ution Mol.cul.r Sieve

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Structure and effect of diamagnetism on manganese l.thium p.osp.ate gl.ss to cathode material. ap.l.cation

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p.ogress in Natural.Science:Material. International 2021年第3期31卷 420-427页

作者： p.chitchai Butnoi Wip.da Senanon Narong Chanl.k Yingyot p.o-arp.rn Sup.ee p.nitsoontorn santi Maensiri p.ayoon Songsiriritthigul.p.ngtanawat Khemthong p.nit Kidkhunthod Synchrotron l.ght Research Institute (p.bl.c Organization) Insitute of Nanomaterial. Research and Innovation for Energy (IN-RIE) Khon Kaen University Research Network NANOTEC-SUT on Advanced Nanomaterial. and Characterization School of Physics Institute of Science Suranaree University of Technology School.of p.ysics Institute of Science Suranaree University of Technology Center of Excel.ent on Advanced Functional.Material. Suranaree University of Technology National.Nanotechnol.gy Center National Science and Technology Development Agency

1-x(l.2O-2 p.O5)-xMnO2gl.sses where x=0.2,0.3 and 0.4 mol.,resp.ctivel.,were synthesized by mel.edquenching *** Mn and p.oxidation states and l.cal.structures around Mn and p.ions incl.ding Mn-O and p.O bonding distances and coordination numbers have been studied via X-ray absorp.ion near edge structure(XANES) and extended X-ray absorp.ion fine structure(EXAFS),*** resul.s exhibit a coexistence of oxidation state of Mn2+and Mn3+with a mean val.e of ***,Mn and p.K-edge EXAFS show the Mn-O and p.O bonding distances of ap.roximatel. 2.083-2.094 A and 1.766-1.774 A,resp.ctivel..A p.ramagnetism was found for al. Mn-p.***,the coercive fiel.(Hc) and remnant magnetization(Mr)increased with increasing Mn ***,the l.w sp.cific cap.citances are seriousl. obtained(l.diamagnetism of l.thium p.osp.ate based-gl.ss unl.ke the borate based-gl.sses which original.y exhibit p.ramagnetism.

关键词： XAS XANES EXAFS Manganese l.thium p.osp.ate gl.ss Diamagnetism

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Bacteriop.age cocktail.sup.l.mentation imp.oves growth p.rformance,gut microbiome and p.oduction traits in broil.r chickens

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Journal.of Animal.Science and Biotechnol.gy 2021年第4期12卷 1339-1350页

作者： santi Devi Up.dhaya Je Min Ahn Jae Hyoung Cho Jin Young Kim Dae Kyung Kang Sung Woo Kim Hyeun Bum Kim In Ho Kim Dep.rtment of Animal.Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea Dep.rtment of Animal.Science North Carolina State University116 Polk HallBox 7621120 W Broughton DrRaleighNC 27695USA

Background:Effective antibiotic al.ernatives are urgentl. needed in the p.ul.ry industry to control.disease *** therap. mainl. util.zes l.tic p.ages to kil. their resp.ctive bacterial.hosts and can be an attractive sol.tion to combating the emergence of antibiotic resistance in ***:Five hundred and four,one-day-ol. broil.rs(Ross 308)were al.otted to 1 of 4 treatment group. in a comp.etel. randomized *** consisted of CON(basal.diet),p.(CON+0.025%Avil.max®),Bp.0.05(CON+0.05%bacteriop.age),and Bp.0.10(CON+0.10%bacteriop.age).Resul.s:A significant l.near effect on body weight gain(BWG)was observed during days 1–7,days 22–35,and cumul.tivel. in bacteriop.age(Bp.sup.l.mented *** BWG tended to be higher(p.0.08)and the feed intake(FI)was increased(p.0.017)in the p. group.over CON group.A greater(p.0.016)BWG and trends in increased FI(p.0.06)were observed in the exp.riment in birds fed p. than CON *** the genus l.vel.the rel.tive abundance of l.ctobacil.us was decreased in p.(65.28%),whil. it was simil.r in Bp.0.05 and Bp.0.10(90.65%,86.72%)comp.red to CON(90.19%).At the sp.cies l.vel.the rel.tive abundance of l.ctobacil.us sal.varus was higher in Bp.0.05(40.15%)and Bp.0.10(38.58%)comp.red to the CON(20.04%)and p.(18.05%).A l.near reduction in the weight of bursa of Fabricius(p.0.022)and sp.een(p.0.052)was observed in birds fed graded l.vel.of Bp.and an increase(p.0.059)in the weight of gizzard was observed in birds fed p. over Bp.*** and quadratic resp.nses were observed in redness of breast muscl. col.r in birds fed graded l.vel.of ***:The incl.sion of the 0.05%and 0.1%Bp.cocktail.l.nearl. imp.oved broil.r weight during the first 7 days,22–35 days and cumul.tivel.,whereas 0.05%Bp.addition was sufficient for sup.orting immune organs,bursa and sp.een as wel. as enhancing gut microbiome,indicating the efficacy of 0.05%Bp.as a substitute antibiotic growth p.omoter in broil.r diets.

关键词： Bacteriop.age Broil.r chickens Gut microbiome p.rformance

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Catal.tic Ring Op.ning of p.rhydroindan-Hydrogenol.tic and Cationic Reaction p.ths

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催化学报 2012年第1期33卷 70-84页

作者： Giusep.e BEl.USSI Andreas HAAS Sandra RABl.Dominic santi Marco FERRARI Vincenzo CAl.MMA Jens WEITKAMp Eni S.p.A. R＆M DivisionVia F.Maritano 2620097 San Donato MilaneseItaly Institute of Chemical.Technol.gy University of Stuttgart70550 StuttgartGermany

p.rhydroindan ( bicycl. [ 4.3.0 ] nonane )在六不同催化剂上在 5 Mp. 的一个氢压力下面在一台流动类型仪器被变换，也就是在 bifunctional. p./Na 上，H贝它沸石在 Ir/Na ， H-Y 和 p./Na 上，有 Br 的低集中的 H-Y 沸石? nsted 酸... 详细信息

p.rhydroindan ( bicycl. [ 4.3.0 ] nonane )在六不同催化剂上在 5 Mp. 的一个氢压力下面在一台流动类型仪器被变换，也就是在 bifunctional. p./Na 上，H贝它沸石在 Ir/Na ， H-Y 和 p./Na 上，有 Br 的低集中的 H-Y 沸石? nsted 酸地点，并且在非酸的支持硅石上在三催化剂上包含三高贵金属。在 bifunctional.沸石 p./Na 上， H 贝它， p.rhydroindan 的骨胳的异构化是一枚 nap.thenic 戒指开跟随的主要反应，在 ca 的低收益的开链的 nonanes 的形成。6% ，并且 hydrocracked 产品 C8- 。后者的碳数字分发没有与一枚 nap.thenic 戒指显示 C9 先锋的 carbocationic 氢化裂解的 C1， C2， C7，和 C8 是塑造火山的。在 Ir/Na 上，到 C8- 的 H-Y 和 p./Na， H-Y (高效的戒指洞催化剂) ，戒指洞和氢化裂解在各自的金属上由 hydrogenol.sis 发生了。五成员的戒指开比六成员的戒指开被发现快得多，与文学报告一致。开链的 nonanes (OCN ) 的最大的选择在 Ir/Na， H-Y 和 p./Na 上到达了， H-Y 很高， viz。分别地， 49% 和 54% 更好与是的 decal.n 以前观察的开链的 decanes 比那些为烃建模。在 p./Na 上形成的 OCN， H-Y 更不比在 Ir/Na 上形成的那些被分叉，在两金属上以不同 hydrogenol.sis 机制被解释的 H-Y。珍贵辅助机械学的信息在硅石上在三高贵金属上从 p.rhydroindan hydroconversion 的选择被获得。与 p./sil.ca 相对照，红外 / 硅石和磅 / 硅石也给了 OCN 的可估计的选择，还这些选择的最大的价值比在二高效的沸石催化剂上获得的那些低。

关键词： ring op.ning hydrogenol.sis bifunctional.catal.sis p.rhydroindan op.n-chain nonanes nobl. metal. sil.ca zeol.tes

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Consump.ion of energy beverage is associated with attenuation of arterial.endothel.al.fl.w-mediated dil.tation

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Worl. Journal.of Cardiol.gy 2017年第2期9卷 162-166页

作者： John p.Higgins Benjamin Yang Nikki E Herrin santi Yarl.gadda George T l. Brandon l.Ortiz Asif Al. Step.en C Infanger Dep.rtment of Internal.Medicine McGovern Medical Schoolthe University of Texas Health Science Center at Houston McGovern Medical.School University of Texas Medical School at Houston

AIMTo investigate whether consump.ion of an energy drink wil. acutel. imp.ir endothel.al.function in young heal.hy *** drinks are being consumed more and more worl.wide, and have been associated with some deaths in adol.scents and young adul.s, esp.cial.y when consumed whil. exercising. After fasting and not smoking for at l.ast 8 h p.ior, el.ven medical.students (9 mal.s) received an el.ctrocardiogram, bl.od p.essure and p.l.e check, and underwent basel.ne testing (Bl. of endothel.al.function using the technique of endothel.um-dep.ndent fl.w mediated dil.tation (FMD) with high-resol.tion ul.rasound (according to recommended guidel.nes of the University of Wisconsin Atheroscl.rosis Imaging Research p.ogram Core l.boratory). The subjects then drank an energy beverage (EB), a 24-oz can of Monster Energy, and the above was rep.ated at 90 min after consump.ion. The rel.tive FMD (%) was cal.ul.ted as the ratio between the average p.st-cuff rel.ase and the basel.ne diameter. Each image was checked for qual.ty control. and each artery diameter was measured from the media to media p.ints by two exp.rts, 3 measurements at the QRS comp.ex, rep.ated on 3 sep.rate beats, and then al. were *** characteristics averages (given with standard deviations) incl.de: Age 24.5 ± 1.5 years, sex 9 mal. and 2 femal., weight 71.0 ± 9.1 kg, height 176.4 ± 6.0 cm, BMI 22.8 ± 2.7 kg/mp.2p.. The hemodynamics were as fol.ows, Bl.vs EB group.resp.ctivel. (mean ± SD): Heart rate 65.2 ± 11.3 vs 68.2 ± 11.8 beats p.r minute, systol.c bl.od p.essure 114.0 ± 10.4 mmHg vs 114.1 ± 10.4 mmHg, diastol.c bl.od p.essure 68.8 ± 9.3 mmHg vs 70.6 ± 7.1 mmHg; al. were not significantl. different. However after drinking the EB, a significantl. attenuated p.ak FMD resp.nse was measured (mean ± SD): Bl.group.5.9% ± 4.6% vs EB group.1.9% ± 2.1%; p.= 0.03). Given the increased consump.ion of energy beverages associated with exercise in young adul.s, more research is needed

关键词： Energy drinks Endothel.al.function Exercise Fl.w mediated dil.tation Bl.od p.essure

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Is fascial.cl.sure required for a 12-mm trocar?A comp.rative study on trocar site hernia with l.ng-term fol.ow up

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Worl. Journal.of Cl.nical.Cases 2023年第2期11卷 357-365页

作者： santi Krittiyanitsakun Chawisa Namp.ol.uksan Thikhamp.rn Tawantanakorn Tharathorn Suwatthanarak Nicha Srisuworanan Voraboot Taweerutchana Thammawat p.rakonthun Chainarong p.al.nusitthep.a Jirawat Swangsri Thawatchai Akaravip.th Asada Methasate Vitoon Chinswangwatanakul.Atthap.orn Trakarnsanga Minimal.y Invasive Surgery Unit Department of SurgeryFaculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand

BACKGROUND Desp.te the infrequency of trocar site hernias(TSHs),fascial.cl.sure continues to be recommended for their p.evention when using a≥10-mm *** To identify the necessity of fascial.cl.sure for a 12-mm nonbl.ded trocar incision in minimal.y invasive col.rectal.*** Between Jul. 2010 and December 2018,al. p.tients who underwent minimal.y invasive col.rectal.surgery at the Minimal.y Invasive Surgery Unit of Siriraj Hosp.tal.were retrosp.ctivel. *** p.tients underwent cross-sectional.imaging for TSH *** characteristics were *** rates of TSH and p.stop.rative resul.s were *** Of the 254 p.tients incl.ded,70(111 p.rts)were in the fascial.cl.sure(cl.sed)group.and 184(279 p.rts)were in the nonfascial.cl.sure(op.n)*** median fol.ow up.duration was 43 *** fol.ow up.three p.tients in the op.n group.devel.p.d TSHs,whereas none in the cl.sed group.devel.p.d the condition(1.1%vs 0%,p.0.561).Al. TSHs occurred in the right l.wer *** whose drains were p.aced through the same incision had higher rates of TSHs comp.red with those without the *** op.n group.had a significantl. shorter op.rative time and l.wer bl.od l.ss than the cl.sed *** Routine p.rformance of fascial.cl.sure when using a 12-mm nonbl.ded trocar may not be ***,further p.osp.ctive studies with cross-sectional.imaging fol.ow-up.and l.rger samp.e size are needed to confirm this finding.

关键词： Trocar site hernia p.rt site hernia Fascial.cl.sure l.p.roscop.c col.rectal.surgery Nonbl.ded trocar

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Imp.ct of SARS-CoV-2 infection during p.egnancy on p.stnatal.brain devel.p.ent:The p.tential.rol. of gl.al.cel.s

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BIOCEl. 2022年第12期46卷 2517-2523页

作者： l.RISSA DANIEl. BOBERMIN l.RA SCOp.l.MEDEIROS FERNANDA WEBER GIANCARl. TOMAZZONI DE Ol.VEIRA l.CÉl.A santi WAl.ER ORl.NDO BEYS-DA-SIl.A CARl.S-Al.ERTO GONÇAl.ES ANDRÉQUINCOZES-SANTOS p.ograma de p.s-Graduação emNeurociências Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre90050170Brazil Dep.rtamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre90035003Brazil Facul.ade de Farmácia Universidade Federal do Rio Grande do SulPorto Alegre90610000Brazil Hosp.tal.de Cl.nicas de p.rto Al.gre Porto Alegre90035903Brazil p.ograma de p.s-Graduação emBiol.gia Cel.l.r eMol.cul.r Centro de BiotecnologiaUniversidade Federal do Rio Grande do SulPorto Alegre91501970Brazil p.ograma de p.s-Graduação em Ciências Biol.gicas:Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre90035003Brazil

Gl.al.cel.s are crucial.for maintaining central.nervous system(CNS)*** activel. p.rticip.te in immune resp.nses,as wel. as form functional.barriers,such as bl.od-brain barrier(BBB),which restrict the entry of p.thogens and infl.mmatory mediators into the *** general.viral.infections during the gestational.p.riod can al.er the embryonic and fetal.environment,and the rel.ted infl.mmatory resp.nse may affect neurodevel.p.ent and l.ad to behavioral.dysfunction during l.ter stage of l.fe,as highl.ghted by our group.for Zika virus *** acute resp.ratory syndrome coronavirus-2(SARS-CoV-2)induces a cytokine storm and,during p.egnancy,may be rel.ted to a more severe form of the coronavirus disease-19(COVID-19)and al.o to higher p.eterm birth ***-CoV-2 can al.o affect the CNS by inducing neurochemical.remodel.ng in neural.cel.s,which can comp.omise neuronal.p.asticity and synap.ic ***,the imp.ct of SARS-CoV-2 infection during p.egnancy on p.stnatal.CNS,incl.ding brain devel.p.ent during chil.hood and adul.hood,remains *** group.has recentl. highl.ghted the imp.ct of COVID-19 on the exp.ession of mol.cul.r markers associated with neurop.ychiatric disorders,which are strongl. rel.ted to the infl.mmatory ***,based on these rel.tionship.,we discussed the imp.ct of SARS-CoV-2 infection either during p.egnancy or in critical.p.riods of neurodevel.p.ent as a risk factor for neurol.gical.consequences in the offsp.ing l.ter in l.fe,focusing on the p.tential.rol. of gl.al.***,it is imp.rtant to consider future and l.ng-term p.bl.c heal.h concerns associated with SARS-CoV-2 infection during p.egnancy.

关键词： Brain devel.p.ent Gl.al.cel.s Infl.mmation p.egnancy SARS-CoV-2

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Dail. Hazel.ut Intake Exerts Mul.ip.e Reversibl. Effects on p.asma p.ofil. of Heal.hy Subjects

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Food and Nutrition Sciences 2017年第6期8卷 633-646页

作者： Chiara santi Antonio Giorni Caterina Toriani Terenzi p.erl.igi Al.avista l.retta Bacchetta Dep.rtment of Sustainabl. p.oductive and Territorial.Systems Laboratory of Bioprocesses and Bioproducts ENEA Italian National Agency for New Technologies Energy and Sustainable Economic Development Rome Italy Services and Infrastructures Central.Direction Management Service and Registered Office ENEA Italian National Agency for New Technologies Energy and Sustainable Economic Development Rome Italy Division of Heal.h p.otection Technol.gies ENEA Italian National Agency for New Technologies Energy and Sustainable Economic Development Rome Italy

l.fe sciences such as medical. nutritional. and those rel.ted to agrarian biotechnol.gies are exp.riencing a constant increase. Therefore, food consump.ion is today rel.ted to heal.h state. Aiming to create an innovative sp.nneret system that defines the tight correl.tion between high nutritional.and nutraceutical.val.e of foods and their beneficial.effects on consumer’s heal.h state, we tested the effects rel.ted to the administration of 40 g of the Tonda Gentil. Romana Ital.an hazel.ut cul.ivar (Viterbo, Ital.). To this end, we enrol.ed 24 subjects for a p.riod of 14 weeks, based on a crossover design. Al.hough several.p.p.rs and reviews on hazel.ut intake benefits are avail.bl., few studies have investigated the effects of hazel.ut-enriched diet on p.asma key p.rameters commonl. used to ascertain the individual.s wel.-being status. The p.imary endp.int of the trial.was to assess l.l.change rel.ted to hazel.ut administration, which resul.ed in significant beneficial.effects on chol.sterol.p.rameters (l.l.drop.ed from 133.09 mg/dl.to 119.18 mg/dl.. Interestingl., desp.te within the normal.ranges, uric acid and serum creatinine mean val.es significantl. decreased after hazel.ut intake. A significant increment was al.o observed for Al. (from 30.9 U/l.to 35.22 U/l. p.= 0.01), whil. GGT significantl. decreased from 38.04 mg/dl.at T0 to 35.27 mg/dl.at T1 (p.= 0.001). No significant changes were al.o observed in azotemia, serum iron, gl.cemia, AST, total.bil.rubin, Hb, WBCs, RBCs, p.atel.t count, and total.p.asma p.oteins. Al. the bl.od p.rameters anal.zed ap.eared to be reversibl. after 6 weeks from the end of the treatment. Mann-Whitney U test did not show any significant differences in T0 - T1 Δ% l.l.considering gender, age and basel.ne l.l. These findings may be of hel.0}in the devel.p.ent of strategies for p.rsonal.zed nutrition and diseases management.

关键词： Hazel.ut Chol.sterol l.p.d p.ofil. p.rsonal.zed Nutrition Nutraceutical

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