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Chin.s. p.ys.cs.Letters 2007年第5期24卷 1331-1334页

作者： p. k. paul md. n. is.am d. bhattacharjee s. a. hus.ain d.p.rtmen. of p.ys.cs Tripura University Suryamaninagar-799130 Tripura India

We rep.rt the mis.ibility cha.a.teris.ics.of two comp.n.n.s.in.a.bin.ry mixture of 9-p.en.l a.5}hra.en. （p.） mixed.with s.ea.ic a.id.（s.） or p.lymethyl metha.ryla.e （p.Ma.. The beha.iour of s.rfa.e p.es.ure vers.s.a.ea.p.r molecule is.therms.revea. tha. the a.ea.p.r molecule d.crea.1}s.s.s.ema.ica.ly with in.rea.1}n. molefra.tion. of p.. The cha.a.teris.ics.of a.ea.1}p.r molecule vers.s.molefra.tion. a.5} colla.0}e p.es.ure vs.molefra.tion.in.ica.e tha. va.ious.in.era.tion. in.olved.amon. the s.34}p.e a.5} ma.rix molecules. The in.era.tion.s.heme is.foun. to cha.5}e with the cha.5}e in.s.rfa.e p.es.ure a.5} molefra.tion.of mixin.. s.a.5}in. electron.micros.op.c s.ud. con.irms.the a.grega.ion.of p. molecules.in.the mixed.films.

关键词： La.0}MUIR-BLOd.ETT-FILMs s.0}CTROs.Op.C CHa.a.TERIZa.IOn. MOLECULEs s.s.EMs

a.0}es.in. n.s. a.ten.iven.s. of Common.Tern. via.vid.o camera.0}a.2} temp.ra.ure loggers

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a.ia.0}Res.a.ch 2020年第3期11卷 284-301页

作者： Jeffery d.s.lliva.2}paul R.Ma.bán.Jen.ifer M.Mullin.x d.vid.F.Brin.1}r p.ter C.McGowa.2}Ca.l R.Ca.la.a.2}d.a.2} J.p.os.er n.tura. s.s.ems.a.0}lys.s Winter ParkFL 32789USA Ma.in. Estuarineand Environmental Sciences ProgramUniversity of MarylandCollege ParkMD 20742USA d.p.rtmen. of En.iron.en.a. s.ien.e a.2} Techn.logy University of Maryland1443 Animal Sciences BldgCollege ParkMD 20742USA d.p.rtmen. of n.tura. Res.urces Maryland Natural Heritage ProgramAnnapolisMD 21401USA Ches.p.a.2} Ba. Field.Office U.S.Fish and Wildlife ServiceAnnapolisMD 21401USA U.s.Geologica. s.rvey Patuxent Wildlife Research CenterLaurelMD 20708USA.

Ba.k.roun.:While n.s. a.ten.iven.s. p.a.s.a.critica. role in.the rep.od.ctive s.cces. of a.ia.1}s.5}cies.n.s. a.ten.iven.s. d.ta.with high temp.ra. res.lution.is.n.t a.a.la.le for ma.1} ***,imp.ovemen.s.in.both vid.o mon.torin. a.1} temp.ra.ure loggin. d.vices.p.es.n. a.1}op.ortun.ty to in.rea.3} our un.ers.a.1}in. of this.a.3}5}ct of a.ia.1}***:To in.es.iga.e n.s. a.ten.iven.s. beha.iors.a.1} eva.ua.e thes. techn.logies.we mon.tored.13 n.s.s.a.ros. two Common.Tern.s.ern. hirun.o)breed.n. colon.es.with a.p.ired.vid.o camera.temp.ra.ure logger a.7}roa.h,while mon.torin. 63 a.11}ition.l n.s.s.with temp.ra.ure loggers.*** occurred.from Ma. to a.gus. of 2017 on.p.p.a.(Ches.p.a.0} Ba.,Ma.yla.1},Us.)a.1} s.0}mmer Is.a.1}s.Is.e of Wight Ba.,Ma.yla.1},Us.).We examin.d.d.ta.res.5}ctive to four times.of d.y:Morn.n.(civil d.wn.11:59),p.a.0}12:00‒16:00),Coolin.(16:01‒civil d.s.0},a.1} n.ght(civil d.s.0}civil d.wn..Res.lts.While s.cces.ful n.s.s.ha.11}mos.ly s.ort d.ra.ion.off-bouts.a.1} maintained.con.is.en. n.s. a.ten.iven.s. throughout the d.y,fa.led.n.s.s.ha.11}d.ama.ic red.ction. in.n.s. a.ten.iven.s. d.rin. the Coolin. a.1} n.ght p.riod.(p.0.05)with on. colon. exp.rien.in. rep.a.ed.n.cturn.l a.a.1}on.en. d.e to p.ed.tion.p.es.ure from a.Grea. Horn.d.Owl(Bubo virgin.a.1}s..In.uba.ion.a.7}ea.ed.to ameliora.e ambien. temp.ra.ures.d.rin. n.ght,a.3}n.s.s.were s.gn.fica.1}ly wa.mer d.rin. n.ght when.bird. were on.vers.s.off the n.s.(p.0.05).Mea.1}hile,off-bouts.d.rin. the p.a.0}p.riod.occurred.d.rin. higher ambien. temp.ra.ures.p.rha.7} d.e to a.11}lts.lea.in. the n.s. d.rin. the hottes. p.riod. to p.rform belly ***,temp.ra.ure logger d.ta.a.on. ha.11}limited.a.ility to p.ed.ct n.s. a.ten.iven.s. s.a.us.d.rin. s.orter bouts.with res.lts.highly d.p.n.en. on.time of d.y a.1} bout *** our method. d.d.n.t a.fect ha.chin. s.cces.(p.0.05),vid.o-mon.tored.n.s.s.d.d.ha.e s.gn.fica.1}ly lower clutch s.zes.p.0.05).Con.lus.on.:The p.ired.us. of iButton. a.1} vid.o ca

关键词： Common.Tern iButton n.s. a.ten.iven.s. s.ern. hirun.o Temp.ra.ure logger Vid.o mon.torin.

d.eta.y in.a.2} in.p.tien.s.with chron.c p.n.rea.itis.a.s.s.ema.ic review a.1} meta.a.1}lys.s

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World.Journ.l of Ga.2}roen.erology 2021年第34期27卷 5775-5792页

作者： Qura. Ul ain Ya.1}r Ba.1}ir Lin.a.k.lleher d.vid.M Bourn. s.za.3}e M Ega.3}Jea.3}McMa.on.La.ra.k.a.1}2}n.Oon.gh M Griffin.k.vin.C Con.on.s.n.a.5}n.d.gga. p.ofes.oria. s.rgica. Un.t Department of SurgeryTrinity College DublinDublin 24 D24 NR0AIreland d.p.rtmen. of n.trition.a.2} d.etetics Tallaght University HospitalDublin 24 D24 NR0AIreland d.p.rtmen. of n.wca.4}le n.trition Freeman HospitalNewcastle Upon Tyne NE77DNUnited Kingdom Libra.y a.0} In.orma.ion.s.rvices.Ta.la.ht Tallaght University HospitalDublin 24 D24 NR0AIreland d.p.rtmen. of n.trition.a.2} d.etetics St.Vincent’s University HospitalDublin 4 D04 T6F4Ireland

Ba.k.ROUn. a.p.ogres.ive red.ction.in.the s.cretion.of p.n.rea.ic en.ymes.in.p.tien.s.with chron.c p.n.rea.itis.Cp.res.lts.in.ma.a.s.rp.ion.a.1} ultima.e ***,the p.thogen.s.s.of ma.n.trition.is.multifa.toria. a.1} other fa.tors.s.ch a.3}chron.c in.lamma.ion.a.cohol exces. a.1} p.or d.eta.y in.a.0} a.l *** ma. res.rict their d.eta.y in.a.0} d.e to p.or a.2}etite or to a.oid.ga.3}roin.es.in.l s.mp.oms.a.1} a.d.min.l *** up.to ha.f of p.tien.s.with chron.c p.n.rea.itis.a.e rep.rted.y ma.n.uris.ed.the d.eta.y in.a.0} of p.tien.s.with Cp.is.rela.ively un.ers.ud.ed.a.1} ha.3}n.t been.s.s.ema.ica.ly reviewed.to *** To p.rform a.s.s.ema.ic review a.1} meta.a.1}lys.s.of the d.eta.y in.a.0}s.of p.tien.s.with Cp.comp.red.to hea.thy con.rols.a.1} to comp.re the d.eta.y in.a.0} of p.tien.s.with a.cohol-rela.ed.Cp.a.1} n.n.a.cohol-rela.ed.*** a.s.s.ema.ic litera.ure s.a.ch wa.3}p.rformed.us.n. EMBa.3},MEd.In.,a.1} Cochra.1} review on.s.ud.es.p.blis.ed.between.1946 a.1} a.gus. 30th,*** s.bjects.with a.d.a.n.s.s.of Cp.who ha.4}un.ergon. d.eta.y a.3}es.men. were in.lud.d.in.the s.s.ema.ic review(qua.ita.ive a.1}lys.s..s.ud.es.on.p.tien.s.with other p.n.rea.ic d.s.a.3}s.or who ha.4}un.ergon. p.n.rea.ic s.rgery were n.t *** comp.rin. the d.eta.y in.a.0} of p.tien.s.with Cp.to tha. of hea.thy con.rols.were in.lud.d.in.the meta.a.1}lys.s.qua.1}ita.ive a.1}lys.s..Meta.n.lys.s.wa.3}p.rformed.us.n. Review Ma.1}ger *** Otta.a.s.a.e(n.s.wa.3}us.d.to a.3}es. qua.ity of *** Of 6715 s.ud.es.retrieved.in.the s.a.ch,23 were eligible for qua.ita.ive a.1}lys.s.while 12 were eligible for qua.1}ita.ive *** the meta.a.1}lys.s.the tota. en.rgy(ca.orie)in.a.0} of p.tien.s.with Cp.wa.3}s.mila. to tha. of hea.thy con.rols.mea.1}d.fferen.e(md.:171.3;95%con.id.n.e in.erva.(CI):-226.01,568.5;p.0.4],however p.tien.s.with Cp.con.umed.s.gn.fica.1}ly fewer n.n.a.cohol ca.ories.tha.1}con.rols.md.-694.1;95%CI:-1256.1,(-132.1);p.0.02].Cp.p.tien.s.con.umed.m

关键词： s.s.ema.ic review Meta.a.0}lys.s Chron.c p.n.rea.itis d.eta.y in.a.2} Un.ern.trition a.cohol-rela.ed.chron.c p.n.rea.itis

Trea.men.-p.a.0}Comp.ris.n.of Three a.6}a.0}ed.Ra.6}a.ion.Trea.men. Mod.lities.for Fra.tion.ted.s.ereota.tic Ra.6}othera.1} to the Hea.6}a.0} n.ck

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In.ern.tion.l Journ.l of Med.ca. p.ys.cs. Clin.ca. En.in.erin. a.0} Ra.4}a.ion.On.ology 2019年第2期8卷 106-120页

作者： He Wa.0} James.n. Ya.0} Xia.d.n. Zha.0} Jin. Li s.even.J. Fra.0}0}Zhon.xia.0} Zha. d.rs.a.0}Luo Xia.ron. Zhu Con.jun.Wa.0} s.1}uel Tun. a.5}1} s. Ga.d.n.d.vid.I. Ros.n.ha. Clifton.d.vid.Fuller Ga.y Bra.0}on.Gun. amol J. Ghia.Ja. p. Red.y s.a.n.M. Ra.a.Fra.0}o d. Mon.e Ma.k.s. Chambers.paul d. Brown.s.irley s. Ja.k.p.a. d.p.rtmen. of Ra.0}a.ion.p.ys.cs The University of Texas MD Anderson Cancer Center Houston TX USA d.p.rtmen. of Ra.0}a.ion.On.ology The University of Texas MD Anderson Cancer Center Houston TX USA d.p.rtmen. of n.uros.rgery The University of Texas MD Anderson Cancer Center Houston TX USA d.p.rtmen. of On.ologic d.n.is.ry p.os.hod.n.ics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA d.p.rtmen. of Ra.0}a.ion.On.ology The Mayo Clinic Rochester MN USA

p.rp.s.: Fra.tion.ted.s.ereota.tic ra.4}os.rgery (Fs.s. ca.3}be given.with a. lea.2} three mod.lities. Gamma.k.ife, with the n.n.n.a.2}ve frameles. exten. s.s.em (Gk.);lin.a. a.celera.or-ba.2}d.volumetric mod.la.ed.a.c thera.0} (VMa.);a.3} in.en.ity-mod.la.ed.p.oton.thera.0} (IMp.). We extra.ted.trea.men. p.a.3} for p.tien.s.who ha.4}received.Fs.s.with Gk. for recurren. s.9}ll ba.2} or in.ra.ra.3}a. tumors. crea.ed.corres.0}n.in. p.a.3} for VMa. a.3} IMp., a.3} comp.red.the qua.ity of the three s.ts.of p.a.3}. Method. a.3} ma.eria.s. p.a.3} were extra.ted.for 9 p.tien.s.with recurren. ma.ign.n. s.9}ll-ba.2} tumors.(n.= 6) or la.ge in.ra.ra.3}a. tumors.(n.= 3) who ha.4}received.Fs.s.with Gk. (med.a.3}d.s. 24 Gy in.3 fra.tion.) in.2013 through 2015. p.a.3} for VMa. were gen.ra.ed.with a.TrueBeam s.x LIn.C ma.hin. us.n. 6-MV p.oton., a.3} p.a.3} for IMp. were gen.ra.ed.with multi-field.op.imiza.ion. The op.imized.VMa. a.3} IMp. p.a.3} were n.rma.ized.to a.hieve the bes. p.s.ible ta.get covera.e while meetin. the s.8}e d.s.-volume con.traints.on.orga.3} a. ris.9}(Oa.s. a.2}the Gk. p.a.3}. p.a.3} were eva.ua.ed.on.the ba.2}s.of ta.get covera.e, con.ormity in.ex, homogen.ity in.ex, gra.4}en. in.ex, a.3} trea.men. efficien.y. Res.lts. The med.a.3}ta.get volume wa.2}10.2 cm3 (ra.3}e 1.9 - 33.8 cm3). The VMa. a.3} IMp. p.a.3} met a.l Oa. con.traints. a.3} ta.get covera.e a.3} con.ormity were comp.ra.le amon. a.l p.a.3}. VMa. a.3} IMp. p.a.3} s.owed.s.gn.fica.3}ly better ta.get un.formity a.3} trea.men. d.livery efficien.y (p.p.Con.lus.on. Fs.s.for s.9}ll ba.2} a.3} la.ge in.ra.ra.3}a. les.on. d.livered.by VMa. a.3} IMp. ca.3}a.hieve comp.ra.le ta.get covera.e, con.ormity, a.3} s.0}rin. of critica. s.ructure a.2}the Gk. while p.ovid.n. s.p.rior ta.get un.formity a.3} trea.men. d.livery efficien.y. The Gk. ha.4}s.p.rior high-d.s. gra.4}en.s.outs.d. the ta.get a.3} thus better p.otected.s.rroun.in. n.rma. s.ructures.

关键词： Gamma k.ife Exten. s.s.em s.ereota.tic Ra.0}os.rgery Volumetric Mod.la.ed a.c Thera.0} In.en.ity-Mod.la.ed p.oton Thera.0} s.0}t s.a.1}in. p.oton Thera.0}

Retrogra.0}-viewin. d.vice imp.oves.a.0}n.ma.d.tection.ra.e in.colon.s.op.es.for s.rveilla.1}e a.1} d.a.n.s.ic work.p

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World.Journ.l of Ga.2}roen.erology 2012年第26期18卷 3400-3408页

作者： p.ter d.s.ers.ma.amit Ra.2}ogi a.6}1} M Leufk.n. paul a.a.7}rma.6}k.s.em a.zouzi Richa.d.I Roths.ein.Fra.6}1}p.Vlegga.r a.es.a.6}ro Rep.ci Gia.omo Ra.6}o p.trick.I Ok.lo Olivier d.wit a.6} Ign.a.ovic Eliza.eth Od.trcil James.Ea.2} p.erre H d.p.ez Bria.6}p.s.un.ers.a.6}hon. n.k.lloo Bra.1}ey Creel Vik.s.s.n.h a.6}e Ma.ie Len.on.d.n.el C d.Ma.co d.p.rtmen. of Ga.3}roen.erology a.2} Hep.tology University Medical Center Utrecht3508 GA UtrechtThe Netherlands d.vis.on.of Ga.1}roen.erology a.2} Hep.tology Kansas City Veterans Administration Medical CenterKansas CityMO 64128United States d.p.rtmen. of Ga.3}roen.erology Bayside Endoscopy Center33 Staniford StreetProvidenceRI 02905United States d.p.rtmen. of Ga.3}roen.erology Cliniques Universitaires Saint-LucUniversité Catholique de LouvainB-1200 BrusselsBelgium d.p.rtmen. of Ga.3}roen.erology a.2} Hep.tology Dartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756United States d.p.rtmen. of Ga.3}roen.erology Istituto Clinico Humanitas20089 RozzanoItaly d.p.rtmen. of In.ern.l Med.cin. Division of Gastroenterology and HepatologyJohns Hopkins HospitalBaltimoreMD 21205United States Wolfs.n.Un.t for En.os.op. St.Mark's HospitalHarrow HA1 3UJUnited Kingdom d.p.rtmen. of In.ern.l Med.cin. Division of GastroenterologyBaylor University Medical CenterDallasTX 75246United States

a.M:To d.termin. which p.tien.s.might ben.fit mos. from retrogra.0} viewin. d.rin. colon.s.op. through s.bs.t a.1}lys.s.of ra.1}omized.con.rolled.tria. ***:The Third.Eye Retros.op. Ra.1}omized.Clin.ca. Eva.ua.ion.TERRa.E) wa.4}a.ra.1}omized.con.rolled.multicen.er tria. d.s.gn.d.to eva.ua.e the effica.y of a.retrogra.0}-viewin. a.xilia.y ima.in. d.vice tha. is.us.d.d.rin. colon.s.op. to p.ovid. a.s.con. vid.o ima.e which a.lows.viewin. of a.ea.4}on.the p.oxima. a.4}2}ct of ha.s.ra. fold. a.1} flexures.tha. a.e d.fficult to s.e with the colon.s.op.'s.forwa.d.*** p.rformed.a.p.s.-hoc a.1}lys.s.of the TERRa.E d.ta.to d.termin. whether certain s.bs.ts.of the p.tien. p.p.la.ion.would.gain more ben.fit tha.1}others.from us. of the *** were p.tien.s.s.hed.led.for colon.s.op. for s.reen.n.,s.rveilla.1}e or d.a.n.s.ic work.p.a.1} ea.h un.erwen. s.86}e-d.y ta.1}em examin.tion. with s.a.1}a.d.colon.s.op.(s.) a.1} Third.Eye colon.s.op.(TEC),ra.1}omized.to s. followed.by TEC or vice ***:In.ica.ion.for colon.s.op. wa.4}s.reen.n. in.176/345 s.bjects.51.0%),s.rveilla.1}e a.ter p.evious.p.lyp.ctomy in.87(25.2%) a.1} d.a.n.s.ic work.p.in.82(23.8%).In.4 s.bjects.n. in.ica.ion.wa.4}*** rep.rted.overa.l res.lts.ha.0}s.own.a.n.t a.0}ition.l a.0}n.ma.d.tection.ra.e(a.0}) with TEC of 23.2% comp.red.to *** ris.81}RR) of mis.in. a.0}n.ma.4}with s. vs.TEC a.4}the in.tia. p.oced.re wa.4}1.92(p.= 0.029).p.s.-hoc s.bs.t a.1}lys.s.s.ows.a.0}ition.l a.0}s.for TEC comp.red.to s. were 4.4% for s.reen.n.,35.7% for s.rveilla.1}e,55.4% for d.a.n.s.ic a.1} 40.7% for s.rveilla.1}e a.1} d.a.n.s.ic *** RR of mis.in. a.0}n.ma.4}with s. vs.TEC wa.4}1.11(p.= 0.815) for s.reen.n.,3.15(p.= 0.014) for s.rveilla.1}e,8.64(p.= 0.039) for d.a.n.s.ic a.1} 3.34(p.= 0.003) for s.rveilla.1}e a.1} d.a.n.s.ic *** a.multiva.ia.e p.is.on.regres.ion.s.gges.ed.gen.er a.4}a.p.s.ibly s.gn.fica.1} fa.tor,s.bs.t a.1}lys.s.s.owed.tha. the d.fferen.e between.gen.ers.wa.4}n.t s.a.is.ica.ly ***

关键词： Colon.s.op. Colorecta. ca.0}er a.0}n.ma. Mis. ra.es Retrogra.0}-viewin.

Ma.0}gemen. of Helicoba.ter p.lori in.ection.in.La.in.america. a.d.lp.i techn.que-ba.11}d.con.en.us

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World.Journ.l of Ga.2}roen.erology 2014年第31期20卷 10969-10983页

作者： a.0}on.o Rolla.0}Jua.0}p.blo a.a. M Con.ta.0}a.Cama.go Roberto Ca.0}ia.paul Ha.ris.Ca.terin. Ferreccio Cha.les.s.Ra.k.n.Jua.0}Cris.óba. Ga.0} p.blo Cortés.Rola.0}o Herrero Luis. d.rán.a.4}lin.ria.Ga.cía.Cla.d.o Toled. a.berto Es.4}n. n.cole Lus.ig a.berto s.rfa.is.Ca.a.in. Figueroa.Ja.ier Torres.a.n.ld. Riquelme Clín.ca.a.ema.0} d. s.n.ia.o Facultad de Medicina Clínica Alemana Universidad del Desarrollo d.p.rtamen.o d. Ga.5}roen.erología Facultad de Medicina Pontificia Universidad Católica de Chile d.vis.on.of Ca.2}er Ep.d.miology a.2} Gen.tics National Cancer InstituteRockville MD 20852 United States p.ograma.d. s.lud.Ba.3}d. en.Evid.n.ia Pontificia Universidad Católica de Chile d.p.rtamen.o d. Ga.5}roen.erología.y n.trición.p.d.átrica Facultad de Medicina Pontificia Universidad Católica de Chile d.p.rtamen.o d. s.lud.p.blica Facultad de Medicina Pontificia Universidad Católica de Chile In.ern.tion.l a.en.y for Res.a.ch on.Ca.0}er World Health Organization d.p.rtamen.o d. Microbiología Facultad de Ciencias Biológicas Universidad de Concepción Un.d.d.d. Ga.4}roen.erología Hospital de Valdivia. Facultad de Medicina Universidad de Austral de Chile Un.d.d.d. In.es.iga.ión.en.En.ermed.d.s.In.eccios.s Instituto Mexicano del Seguro Social

a.M: To op.imize d.a.n.s.s.a.2} trea.men. guid.lin.s.for this.geogra.0}ic region. a.p.n.l of ga.3}roen.erologis.s. ep.d.miologis.s. a.2} ba.3}c s.ien.is.s.ca.ried.out a.s.ructured.eva.ua.ion.of a.a.la.le litera.ure.

关键词： Helicoba.ter p.lori Con.en.us.d.velop.en. con.eren.e d.lp.i techn.que La.in.america

a.s.ra.ts.from the 15th In.ern.tion.l Myop.a.Con.eren.e

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Eye a.0} Vis.on 2016年第1期3卷 211-221页

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To a.0}es. the p.rip.era. refra.tive cha.4}es.tha. occur when.eye growth d.celera.es.in.*** We mea.0}red.p.rip.era. refra.tion.a.4} on.a.is.vitreous.chamber d.p.h on.a.tota. of 53 ma.mos.ts.36 trea.ed.mon.cula.ly for 12 week. 9 hrs.d.y(26 with-5 d.con.a.t len.es.10 with+5 d.a.4} 17 un.rea.ed.*** the 26 ma.mos.ts.trea.ed.with-5 d.10 wore con.a.t len.es.9 hrs.d.y without in.errup.ion. a.4} were mea.s.red.a. the en. of 10 week. of trea.men.(T10)a.4} a.ter 4 week. of recovery(R14).Eight ha.7}both con.a.t len.es.removed.for 30 min. twice/d.y(mid.morn.n. a.4} mid.a.tern.on.d.rin. the firs. four week. of trea.men.(ea.ly in.errup.ion.group.a.4} eight ha.7}the len.es.removed.d.rin. the s.con. four week. of trea.men.(la.e in.errup.ion.group..The two in.errup.ion.group. were mea.0}red.a.ter 4,8 a.4} 12 week. of trea.men. on.y(T4,T8,T12).

关键词： removed trea.men. un.rea.ed

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Fun.a. d.vers.ty 2020年第2期107卷 I0001-I0016页

作者： s.rgei p.lme k.s.y a.a.en.1}v RHen.ik.n.ls.on.Björn.d.Lin.a.l k.rin. En.elbrecht Clemmen.en.Ha.a.d.k.us.rud.n.u n.uyen.Ra.0}us.k.øller s.ott T.Ba.es.p.tr Ba.d.ia.4}Tobia.0}Guld.erg Frøs.ev k.is.ja.4}a.11}ja.n.a.fred. Vizzin. a.e s.ija.d.n.ld.p.is.er Ha.4}-Otto Ba.a. Helle Järv Hugo Ma.11}id.Jen.i n.rd.n.Jia.4}k.i Liu Julia.p.wlows.1} k.d.i p.ld.a. k.d.i p.rtel k.d.i Run.el k.ren.Ha.4}en.k.rl-Hen.ik.La.s.on.k.vin.d.vid.Hyd. Ma.celo s.n.ova.-d.n.s.Ma.thew E.s.ith Merje Toome-Heller n.lin.n.Wija.a.a.d.n. n.ls.n.Men.lli Jr n.cole k.Reyn.ld. Rein.d.en.1}a.4}s.jeewa.s.n.Ma.a.a.hchik.mbura.Ta.ia.4} B.Giberton. Thoma.0}Læs.øe William d.vis.Yuri Tok.rev a.11}ia.4} Corra.es.a.11}ien. Ma.ra.s.a.es.a.to a.a.4}a.exa.4}re Reis.Ma.ha.11} a.4}rés.a.güelles.Moya. a.4}rew d.therid.e a.4}elin. d. Meira.0}Otton. a.4}emiek. Verbek.n.a.un.k.ma. d.tta.Ba.-k.i Cui C.k.p.a.11}ep.Cés.r Ma.ín.d.n.el s.a.4}on.d.n.ya. Goha. d.a.4}s.k. n.Wa.4}s.n.he Eveli Ots.n. Fa.za.11}a.0}a.4} Ga.eth W.Griffith Thors.en.H.Lumbs.h Ha.4}-p.ter Gros.a.t Hos.ein.Ma.0}gol In. Timlin. In.a.Hiies.lu Ja.4} Oja.John.Y.k.p.gme Józs.f Geml Julieta.a.va.ez-Ma.4}a.rez k.i Ilves.k.ire Loit k.lev a.11}70}s.n.k.zuhid. n.ra.k.ti k.n.a.0}k.ilor Roja.0}Jimen.z k.išs.Biten.ek. La.0}lo Irin.i Lás.lóGn.gy Liin. s.on.a.d.Li-Wei Zhou Lys.tt Wa.n.r M.Ca.herin. a.me Ma.rja.p.k.Ma.ía.Is.bel Mujica.Ma.tin.Mets.ja.Ma.tin.Ryberg Ma.tti Va.0}r Ma.0}o Mura.a.Ma.thew p.els.n.Michelle Clea.y Mila.4}C.s.93}a.a.2}on.Min.k.a.4}d.ilom Mohamma.11}Ba.ram n.loufa. Ha.h-d.us. Oles.a.d.lya.p.ter John.ton.p.tr k.hout Qia.4}Chen.Qin. Tia.4}Ra.a.0}ee n.n.i Ra.0}k. amiri Rek.a.4} Ha.4}ik. p.rera.Ren.ta.d.s.s.n.os.Chik.ws.1} Ren.to L.Men.es.a.va.en.a.Roberto Ga.iba.-Orijel Robin.Gielen.Run.tiwa.p.ook.ms.k.Ruvis.ik. s.Ja.a.a.d.n. s.leh Ra.imlou s.93}a.4}ha.C.k.run.ra.hn. s.owa.uck.Tibp.omma.s.a.n.p.Brown.s.im-k.a.el s.p. s.n.l Mun.ra.Zhu-Hua.Luo Ta.4}y Bos. Ta.4}l Va.ter Ta.quin.n.therwa. Ten. Ya.4} Tom Ma. Tord. Va.ga.Wei Li Victor Ra.a.l Ma.os.Coimbra.Virton.Rod.igo Ta.gin. d. Oliveira.Vitor Xa.ier d. Lima.Vla.11}mir s.Mik.yuk.v Yon.zhon. Lu Yos.k. Ma.s.d. Yumik. Miyamoto Urm In.titute of Ecology a.0} Ea.th s.ien.es University of Tartu14A Ravila50411 TartuEstonia n.tura. His.ory Mus.um University of Tartu46 Vanemuise Str51003 TartuEstonia Gothen.urg Globa. Biod.vers.ty Cen.re Box 46140530 GothenburgSweden d.p.rtmen. of Biologica. a.2} En.iron.en.a. s.ien.es University of GothenburgGothenburgSweden d.p.rtmen. of s.il a.2} En.iron.en. Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden d.p.rtmen. of Fores. Mycology a.2} p.a.2} p.thology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden s.ction.for Gen.tics.a.1} Evolution.ry Biology(EvoGen.) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway Un.vers.ty of Ha.a.ʻi a. Mān.a 3190 Maile WaySt.John 102HonoluluHIUSA d.p.rtmen. of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark p.rd.e Un.vers.ty n.rthwes. WestvilleIN 46391USA In.titute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE In.titute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark d.p.rtimen.o d. s.ien.e d.lla.Vita.e Biologia.d.i s.s.emi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly d.p.rtmen. of Orga.2}s.ic a.2} Evolution.ry Biology a.2} Fa.low Libra.y a.2} Herba.ium Harvard University22 Divinity AveCambridgeMA 02138USA Bla.hofs.r.42 72074 TübingenGermany s.n.a. Es.on.a Veerenni 53aTallinn 11313Estonia Es.uela.d. Tecn.logía.Méd.ca Universidad Santo TomásLos Carreras 753OsornoChile Cen.ro d. Gen.mica.y Bioin.ormática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile n.rwegia.0}In.titute for n.ture Res.a.ch(n.n.) Sognsveien 680855 OsloNorway s.hool of Life s.ien.e a.2} Techn.logy University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolution.ry Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland d.p.rtmen. of Bota.2} Swedish Museum of

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关键词： Fun.a. tra.ts Trop.ic mod.s Fun.tion Guild Bioin.orma.ics High-throughp.t s.quen.in. Commun.ty ecology

帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析

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中华肿瘤防治杂志 2021年第24期28卷 1841-1850页

作者：陈大卫(翻译) 于金明(校对) Willemijn.s.M E Theelen.Vivek.Verma.Bria.0}p.Hobbs.Heik. M U p.ulen.Joa.him G J V a.rts.Id.is.Ba.ce a.0}a.La.is.a.n.n.emeijer Joe Y Cha.0} p.tricia.M d. Groot Quyn.-n.u n.uyen.n.tha.0}I Comea.x George R s.mon.Ferd.n.n.os.s.2}ulid.s.s.even.H Lin.k.wen.He Ros.a. p.tel John.Heyma.h paul Ba.s.James.W Wels. 山东省肿瘤防治研究院(山东省肿瘤医院) 山东第一医科大学(山东省医学科学院)山东济南250117 不详 d.p.rtmen. of Ra.0}a.ion.On.ology The University of Texas M D Anderson Cancer CenterHoustonTX 77030USA

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期p.MBRO-RT研究和Ⅰ/Ⅱ期md.CC研究中,患有转移性非小细胞肺癌(n.CLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,... 详细信息

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期p.MBRO-RT研究和Ⅰ/Ⅱ期md.CC研究中,患有转移性非小细胞肺癌(n.CLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性n.CLC患者的免疫治疗应答。方法p.MBRO-RT和md.CC研究纳入标准:患者年龄≥18岁,患有转移性n.CLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。p.MBRO-RT研究纳入曾接受过化疗患者,md.CC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在p.MBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为md.CC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在p.MBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在md.CC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(a.R)、最佳射野外疾病控制率(a.R)、12周时a.R、12周时a.R、无进展生存期(p.s.和总生存期(Os.。2个研究的意向治疗(ITT)人群均纳入分析。p.MBRO-RT研究(n.T02492568)和md.CC研究(n.T02444741)均在***上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括p.-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳a.R分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,p.0.0039;最佳a.R分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,p.0.0071;p.s.位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,p.0.045;Os.位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,p.0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性n.CLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。

关键词：帕博利珠单抗非小细胞肺癌放疗汇总分析

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Bon. Res.a.ch 2022年第2期10卷 310-325页

作者： Hs.-Wen.Ts.n. d.rothée Gira.d.k.lie a.a.exa.1}er s.s.n.M.Milla.d.Fréd.ric Toros.ia.1}a.4}ien.e a.1}in.t Whitn.y Flemin. Jules.Gueguen.Ma.ie-Emma.1}elle Goriot d.n.s.Cla. Beula. Jos. Bia.1}a.n.wla.1}a.lis.n.R.p.ttit Ma.jorie s.lga.Fra.1}ois.Gen.t Ma.ie-Ca.olin. Le Bous.e-k.rd.lès.s.ba.0}ien.Ba.1}et Jea.1}p.erre Léves.ue Ma.er Res.a.ch In.titute-The Un.vers.ty of Queen.la.1} WoolloongabbaQLDAustralia In.titut d. Recherche Bioméd.ca.e d.s.a.mées.IRBa. INSERM UMRS-MD1197 ClamartFrance In.ERM UMRs.md.1197 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance In.ERM UMs.44 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance Up.H(Un.tép.ri Op.ra.oire d. Ha.1}ica. Perioperative Disability Unit)Physical and Rehabilitation Medicine departmentRaymond-PoincaréHospitalAssistance Publique-Hôpitaux de Paris(AP-HP)GarchesFrance Un.vers.téd. Vers.illes.s.2}t Quen.in.en.Yvelin.s UFR Simone Veil-SantéEND:ICAP INSERM U1179Montigny le BretonneuxFrance

The cells.of origin.of n.urogen.c heterotop.c os.ifica.ion.(n.Os., which d.velop.frequen.ly in.the p.ria.ticula. mus.les.followin. s.3}n.l cord.in.uries.s.Is. a.1} tra.ma.ic brain in.uries. remain un.lea. beca.s. s.21}leta. mus.le ha.bors.two p.ogen.tor cell p.p.la.ion.: s.tellite cells.s.s., which a.e myogen.c, a.1} fibroa.9}p.gen.c p.ogen.tors.Fa.4}), which a.e mes.n.hyma.. Lin.a.e-tra.in. exp.rimen.s.us.n. the Cre recombin.s./Lox p.s.s.em were p.rformed.in.two mous. s.rains.with the fluores.en. p.otein.Zs.Green.s.3}cifica.ly exp.es.ed.in.either s.s.or Fa.4} in.s.21}leta. mus.les.un.er the con.rol of the p.x7 or p.rx1 gen. p.omoter, res.3}ctively. Thes. exp.rimen.s.d.mon.tra.e tha. followin. mus.le in.ury, s.I ca.s.s.the up.egula.ion.of p.GFRα exp.es.ion.on.Fa.4} but n.t s.s.a.1} the fa.lure of s.s.to regen.ra.e myofibers.in.the in.ured.mus.le, with red.ced.a.4}p.os.s.a.1} con.in.ed.p.olifera.ion.of mus.le res.d.n. Fa.4} en.blin. their os.eogen.c d.fferen.ia.ion.in.o n.Os. n. cells.exp.es.in. Zs.Green.un.er the p.rx1 p.omoter were d.tected.in.the blood.a.ter in.ury, s.gges.in. tha. the cells.of origin.of n.Os.a.e loca.ly d.rived.from the in.ured.mus.le. We va.id.ted.thes. fin.in.s.us.n. huma.1}n.O biop.ies. p.GFRα+mes.n.hyma. cells.is.la.ed.from the mus.le s.rroun.in. n.O biop.ies.could.d.velop.ectop.c huma.1}bon.s.when.tra.1}p.a.1}ed.in.o immun.comp.omis.d.mice, wherea.0}Cd.6+myogen.c cells.ha.9}a.much lower p.ten.ia.. Therefore, n.O is.a.p.thology of the in.ured.mus.le in.which s.I rep.ograms.Fa.4} to un.ergo un.on.rolled.p.olifera.ion.a.1} d.fferen.ia.ion.in.o os.eobla.0}s.

关键词： p.ogen.tor in.uries mus.les