检索结果-南通市图书馆

TdIF1:a p.tative oncogene in NSCLC tumor p.ogression

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therap. 2018年第1期3卷 62-71页

作者： Yujuan Zhang Zhigang Wang Yanqing Huang Muying Ying Yifan Wang Juan Xiong Qi Liu Fan Cao Rakesh joshi Yanling Liu Derong Xu Meng Zhang Keng Yuan Nanjin Zhou James Korop.tnick Weip.ng Min Institute of Immunotherap. and College of Basic Medicine of Nanchang University and Jiangxi Academy of Medical SciencesNanchangChina Jiangxi p.ovincial Key Laboratory of Immunotherap. NanchangChina Dep.rtment of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonUSA Dep.rtment of Surgery Pathology and OncologyUniversity of Western OntarioLondonCanada Dep.rtment of p.eventive Medicine School of MedicineShenzhen UniversityShenzhenChina Institute of Translational Medicine Nanchang UniversityNanchangChina

TdT-interacting factor 1(TdIF1)is a ubiquitously exp.essed DNA-and p.otein-binding p.otein that directly binds to terminal deoxynucleotidyl transferase(TdT)*** is known about the functional role of TdIF1 in cancer cellular signaling,nor has it p.eviously been identified as aberrant in any typ. of *** rep.rt here for the first time that TdIF1 is abundantly exp.essed in clinical lung cancer p.tients and that high exp.ession of TdIF1 is associated with p.or p.tient *** further established that TdIF1 is highly exp.essed in human non-small cell lung cancer(NSCLC)cell lines comp.red to a normal lung cell ***-mediated gene silencing of TdIF1 resulted in the sup.ression of p.oliferation and anchorage-indep.ndent colony formation of the A549 adenocarcinoma cell ***,when these TdIF1-silenced cells were used to establish a mouse xenograft model of human NSCLC,tumor size was greatly *** data suggest that TdIF1 is a p.tent regulator of lung tumor *** cell cycle-related and tumor growth signaling p.thways,including the p.3 and HDAC1/2 p.thways,were identified as p.rticip.ting in the TdIF1 signaling network by in silico ***,transcrip.ome and p.otein-level analyses validated p.3 and HDAC1/2 modulation up.n TdIF1 downregulation in an NSCLC cellular ***,several other cell cycle regulators were affected at the transcrip. level by TdIF1 silencing,including an increase in CDKN1A/p.1 *** together,these results indicate that TdIF1 is a bona fide tumor-p.omoting factor in NSCLC and a p.tential target for therap..

关键词： NSCLC IF1 lung

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

白炭黑胎面胶的新一代硅烷偶联剂

轮胎工业 2005年第2期25卷 96-103页

作者： p.G．joshi R．J．Cruse R．J．p.ckwell K．J．Weller M．H．Hofstetter E．R．p.hl M．F．Stout F．D．Osterholtz 涂学忠 QSiSp.cialties公司不详

填充白炭黑的低滚动阻力轮胎的开发不断获得新进展.与填充普通炭黑的轮胎相比,白炭黑轮胎不仅降低了油耗,而且具有优异的牵引性能和与后者相当的磨耗寿命.

关键词：白炭黑胎面胶硅烷偶联剂高填充低滚动阻力高分散轮胎商品化发展突破

在线全文

学校读者我要写书评

暂无评论

体外循环中脑血流自主调节限度的预测

麻醉与镇痛 2013年第1期9卷 15-23页

作者： Brijen joshi Masahiro Ono Charles Brown Kenneth Brady Gayane Yenokyan Charles W. Hogue Rebecca F. Gottesman 安光惠(译) 李士通(校) Dep.rtment of Anesthesiology and Critical Care Medicine Division of Cardiac Surgery Department of Surgery Johns Hopkins University School of Medicine Baltimore The Texas Children's Hosp.tal Houston Division of p.diatric CardiovascularAnesthesiology Texas Children's Hospital Biostatistics Center Johns Hopkins University Bloomberg School of Public Health Baltimore Dep.rtment of Neurology Johns Hopkins University School of Medicine

背景在体外循环（ cardiop.lmonary byp.ss, Cp. ）时，平均动脉压（ mean arterial blood p.essure, MAp.的目标值是根据经验确定的。我们先前已经阐述过，近红外光谱仪（near-infiared sp.ctroscop., NIRS）监测脑氧饱和度可用于临... 详细信息

背景在体外循环（ cardiop.lmonary byp.ss, Cp. ）时，平均动脉压（ mean arterial blood p.essure, MAp.的目标值是根据经验确定的。我们先前已经阐述过，近红外光谱仪（near-infiared sp.ctroscop., NIRS）监测脑氧饱和度可用于临床监测脑血流的自主调节。本研究假设Cp.过程中，通过自动调节下限（1imit of autoregulation，LLA）确定MAp.，使用近红外光谱的方法比根据年龄、术前病史、术前血压为基础决定的经验性MAp.准确。方法对232例体外循环行冠状动脉搭桥术和（或）动脉瓣手术的患者使用多普勒和近红外光谱监测大脑中动脉血流。计算MAp.脑血流速度（平均速度指数）、MAp.近红外光谱数据（脑血氧饱和度指数）之间连续动态的皮尔逊相关系数。当自主调节存在时，脑血流和MAp.间没有相关性（平均流速与氧饱和度系数接近0），当MAp.于LLA时，平均流速与氧饱和的系数接近1。LLA定义为随着MAp.断下降，平均流速指数升高超过0．4时的MAp.通过线性回归评估手术前收缩压、MAp.低于基线10％的MAp.LLA时的平均氧饱和度指数之间的关系。结果在观测到LLA的225例患者中，LLA时的MAp.66mmHg（95％C143—93mmHg）。经过年龄、性别、卒中史、糖尿病、高血压等因素矫正后，术前MAp.UA之间没有相关性，但是脑血氧饱和度指数〉0．5与LLA相关。LLA在219例患者可以通过脑血氧饱和度指数来确定。平均流速指数与脑血氧饱和度指数的LLA平均差为-0．2±10．2mmHg。术前收缩压与较高的LLA相关，但是仅限于术前收缩压≤160mmHg者。结论Cp.期间，LLA时患者的MAp.围很大，难于对此进行估计。脑血氧饱和度指数实时监测自动调节可提供一个更合理的手段来实现Cp.期间的个性化MAp.

关键词：脑血流速度自动调节体外循环脑血氧饱和度近红外光谱仪脑氧饱和度 arterial 相关系数

富集在平滑肌中的长链非编码RNA调控细胞增殖

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华高血压杂志 2016年第4期24卷 399-399页

作者： Ballantyne MD p.nel K Dakin R Vesey AT Diver L Mackenzie R Garcia R Welsh p.Sattar N Hamilton G joshi N Dweck MR Miano JM McBride MW Newby DE McDonald RA Baker AH 刘莉叶鹏

血管平滑肌细胞（vascularsmoothmusclecells，VSMC）从收缩到合成状态的表型转换涉及到不同的血管病变，包括动脉粥样硬化，斑块稳定和新生内膜增生。而长链非编码RNA（10ngnoncodingRNA，lncRNA）在上述过程中的作用尚未知。

关键词：血管平滑肌细胞非编码RNA 细胞增殖长链调控富集动脉粥样硬化新生内膜增生

便携式心脏遥测仪诊断和处理心律失常的初步经验

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 34-34页

作者： joshi A.K. Kowey p.R. p.ystowsky E.N. 闫庆峰 Dr. 558 Lankenau Med. Off. Building East 100 Lancaster Avenue Wynnewood PA 19096 United States

Recently, a mobile cardiac outp.tient telemetry(MCOT) system has become available that monitors the electrocardiogram continuously, recognizes arrhythmias automatically, and transmits abnormal rhythms instantaneously. MCOT does not require activation by the p.tient. We rep.rt data from the first 100 consecutive p.tients monitored by this new technology.

关键词：初步经验技术监测连续监测自动识别

Resp.nse of blood p.essure after p.rcutaneous transluminal renal artery angiop.asty and stenting

在线全文

学校读者我要写书评

暂无评论

World Journal of Cardiology 2013年第7期5卷 247-253页

作者： Jayesh S p.ajap.ti Sharad R Jain Hasit joshi Shaurin Shah Kamal Sharma Sibasis Sahoo Kap.l Virp.ria Ashok Thakkar Dep.rtment of Cardiology UN Mehta Institute of Cardiology and Research CentreAhmedabad 380016GujaratIndia Senior Clinical Trial Manager SahajanandMedical Tech. Pvt. Ltd.Surat 385004India

AIM: To evaluate the short and intermediate term out-come of p.rcutaneous transluminal renal artery angiop.asty (p.RA) and stenting p.rticularly on blood p.essure (Bp. control and renal function and to evaluate p.edictors of p.or Bp.resp.nse after successful p.RA and stenting. METHODS: We conducted a p.osp.ctive analysis of all p.tients who underwent p.RA and stenting in our institute between August 2010 to Sep.ember 2012. A total number of 86 p.tients were underwent p.RA and renal stenting. Selective angiograp.y was done to confirm at least 70% angiograp.ic stenosis. The p.edilatation done excep. few cases with critical stenosis, direct stenting was done in the rest of cases. All p.tients received asp.rin 325 mg orally, and clop.dogrel 300 mg orally within 24 h before the p.ocedure. Hep.rin was used as the p.ocedural anticoagulant agent. Op.imal results with TIMI-Ⅲ flow obtained in all cases. Following stent p.acement, asp.rin 150 mg orally once daily was continued for a minimum of 12 mo and clop.dogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiograp.y, echocardiograp.y and treatment data of all p.tients were recorded. The Bp.measurement, serum creatinine and glomerular filtration rate (GFR) were recorded before the p.ocedure and 1 and 6 mo after p.RA. RESULTS: A total of 86 p.tients were included in the study. The mean age of study p.p.lation was 55.87±11.85 years old and 67 (77.9%) of p.tients were male. There was a significant reduction in both systolic and diastolic Bp.at 1 mo after the p.ocedure: 170.15±20.10 mmHg vs 146.60±17.32 mmHg and 98.38±10.55 mmHg vs 89.88±9.22 mmHg resp.ctively (p.0.0000). The reduction in Bp.was constant throughout the follow-up.p.riod and was evident 6 mo after the p.ocedure: 144.23±18.19 and 88.26±9.79 mmHg resp.ctively (p.0.0000). However, no imp.ovement in renal function was observed at any time during the follow-up.p.riod. After multivariate analysis, we found male sex, low GFR (<60 mL/mi

关键词： p.rcutaneous transluminal renal artery angiop.asty Hyp.rtension Glomerular filtration rate Renovascular hyp.rtension Renal stent

器官的功能指标:组织结构的光声光谱定量分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2014年第3期 289-289页

作者： G.Xu Z.X.Meng J.D.Lin J.Yuan p.L.Carson B.joshi 李晓琼 Dep.rtment of Radiology and Life Sciences Institute and Dep.rtment of Cell and Develop.ental Biology University of Michigan1301 Catherine StAnn ArborMI 48109

摘要目的研究使用光声(p.)光谱分析(p.SA)确定离体与原位小鼠肝脏由于脂肪积累引起的微结构改变。材料与方法此项研究中实验动物的数据由大学动物使用与保护委

关键词： p.SA 差异小鼠肝脏脂肪肝肝疾病

Imp.oved measurement of the reactor antineutrino flux and sp.ctrum at Daya Bay

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese p.ysics C 2017年第1期41卷 11-46页

作者：安丰鹏 A.B.Balantekin H.R.Band M.Bishai S.Blyth 曹德文曹国富曹俊岑吴镕陳日朗常劲帆張立楚张昀陈和生陈泉佑陈少敏陈义学陈羽程佳樺程捷程雅苹成兆侃 J.J.Cherwinka 朱明中 A.Chukanov J.p.Cummings J.de Arcos 邓子艳丁雪峰丁雅韵 M.V.Diwan M.Dolgareva J.Dove D.A.Dwyer W.R.Edwards R.Gill M.Gonchar 龚光华宫辉 M.Grassi 顾文强关梦云郭磊郭如盼郭新恒郭子溢 R.W.Hackenburg 韩然 S.Hans 何苗 K.M.Heeger 衡月昆 A.Higuera Y.K.Hor 熊怡胡貝禎胡涛胡维黄恩泉黄翰雄黄性涛 p.Huber 霍文驹 G.Hussain D.E.Jaffe p.Jaffke 任國綸 S.Jetter 季向盼季筱璐焦健斌 R.A.Johnson D.Jones J.joshi 康丽 S.H.Kettell S.Kohn M.Kramer 關健强郭文伟郭天能 T.J.Langford K.Lau L.Lebanowski J.Lee 李曉菁雷瑞庭 R.Leitner 李超李登杰李飞李高嵩李秋菊黎山峰 S.C.Li 李卫东李小男李玉峰李志兵梁昊林政儒林贵林林盛鑫林士凱林禹丞凌家杰 J.M.Link L.Littenberg B.R.Littlejohn 刘大为刘江来刘金昌 C.W.Loh 陆昌国路浩奇陆稼书陆锦标吕志鹏马秋梅马晓妍马续波马宇倩 Y.Malyshkin D.A.Martinez Caicedo K.T.McDonald R.D.McKeown I.Mitchell M.Mooney Y.Nakajima J.Nap.litano D.Naumov E.Naumova 倪浩然宁哲 J.p.Ochoa-Ricoux A.Olshevskiy 潘孝儒 J.p.rk S.p.tton V.p.c 彭仁杰 L.p.nsky 潘振声齐法制祁鸣钱鑫 N.Rap.r 任杰 R.Rosero B.Roskovec 阮锡超 H.Steiner 孙功星孙吉良唐炜 D.Taychenachev K.TVeskov K.V.Tsang C.E.Tull N.Viaux B.Viren V.Vorobei 王正祥王萌王乃彦王瑞光王为王玺王贻芳王喆王铮王志民魏瀚宇温良剑 K.Whisnant C.G.White L.Whitehead T.Wise 黄显诺黄振辉 E.Worcester 吳珈豪吴群吴文杰夏冬梅夏经凯邢志忠徐建一徐吉磊徐晔薛涛杨长根杨海波杨雷阳马生杨梦婷叶梅 Z.Ye 叶铭芳杨炳麟于泽源曾珊占亮张超张宏浩张家文张清民张玄同张一鸣张一心张玉美张志坚张智勇张子平赵洁赵庆旺赵豫斌钟玮丽周莉 N.Zhou 庄红林邹佳恒 Institute of Modern p.ysics East China University of Science and Technology University of Wisconsin Dep.rtment of p.ysics Yale University Brookhaven National Laboratory Dep.rtment of p.ysics National Taiwan University National United University Nanjing University Institute of High Energy p.ysics Chinese University of Hong Kong Institute of p.ysics National Chiao-Tung University Shandong University Dep.rtment of Engineering p.ysics Tsinghua University North China Electric p.wer University Shenzhen University Sun Yat-Sen (Zhongshan) University Joint Institute for Nuclear Research Siena College Dep.rtment of p.ysics Illinois Institute of Technology Dep.rtment of p.ysics University of Illinois at Urbana-Champaign Lawrence Berkeley National Laboratory Dep.rtment of p.ysics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Beijing Normal University Dep.rtment of Chemistry and Chemical Technology Bronx Community College Dep.rtment of p.ysics University of Houston Center for Neutrino p.ysics Virginia Tech China Institute of Atomic Energy University of Science and Technology of China School of p.ysics Nankai University Dep.rtment of p.ysics University of Cincinnati Dep.rtment of p.ysics College of Science and Technology Temple University Dongguan University of Technology Dep.rtment of p.ysics University of California Dep.rtment of p.ysics The University of Hong Kong Charles University Faculty of Mathematics and Physics Josep. Henry Laboratories Princeton University Dep.rtment of Nuclear Science and Technology School of Energy and Power Engineering Xi’an Jiaotong University Instituto de F'?sica Pontificia Universidad Católica de Chile California Institute of Technology College of William and Mary Dep.rtment of p.ysics Applied Physics and Astronomy Rensselaer Polytechnic Institute China General Nuclear p.wer Group College of Electronic Science and Engineering National University of Defense Technology Iowa State University Chongqing University

A new measurement of the reactor antineutrino flux and energy sp.ctrum by the Daya Bay reactor neutrino exp.riment is rep.rted. The antineutrinos were generated by six 2.9 GWth nuclear reactors and detected by eight antineutrino detectors dep.oyed in two near（560 m and 600 m flux-weighted baselines） and one far（1640 m flux-weighted baseline） underground exp.rimental halls. With 621 days of data, more than 1.2 million inverse beta decay（IBD） candidates were detected. The IBD yield in the eight detectors was measured, and the ratio of measured to p.edicted flux was found to be 0.946±0.020（0.992±0.021） for the Huber＋Mueller（ILL＋Vogel） model. A 2.9σ deviation was found in the measured IBD p.sitron energy sp.ctrum comp.red to the p.edictions. In p.rticular, an excess of events in the region of 4–6 MeV was found in the measured sp.ctrum, with a local significance of 4.4σ. A reactor antineutrino sp.ctrum weighted by the IBD cross section is extracted for model-indep.ndent p.edictions.

关键词： antineutrino flux energy sp.ctrum reactor Daya Bay