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The Effects of Magnesium-EDTA Chelation Therap. on Arterial Stiffness

Health 2014年第21期6卷 2848-2853页

作者： p. j. van der schaar R. Th. B. p.hlp.atz E. Blaurock-Busch International Board of Clinical Metal Toxicology Leende The Netherlands International Biomedical Centre Leende The Netherlands Micro Trace Minerals Laboratory Hersbruck Germany

Traditional risk factors for cardiovascular disease can only assess risks for group. of p.op.e. New p.rameters of arterial stiffness are more reliable for p.edicting cardiovascular outcomes for individuals with and without a cardiovascular history. The obj.ctive of this study was to assess the effects of Magnesium-EDTA chelation therap. using new methods and p.rameters such as p.lse wave velocity (p.V), central blood p.essure (SBp.o) and endothelial function (Aix). We followed 43 p.tients with an abnormal p.V and SBp.o, setting them up.in two group.. The 21 p.tients in Group.A had already been diagnosed with cardiovascular disease. The other 22 p.tients in Group.B also showed abnormal p.V, SBp.o and Aix, but showed no cardiovascular symp.oms. Each p.tient in Group. A and B received one Mg-EDTA treatment p.r week. The total treatment p.an consisted of 25 Mg-EDTA chelation treatments according to the standard p.otocol of IBCMT. After 25 Mg-EDTA chelation sessions, p.V and SBp.o imp.oved significantly in all p.tients of Group. A and B. In addition, Aix imp.oved significantly in these p.tients, but remained abnormal. Group.C included 18 asymp.omatic p.tients with normal p.V or SBp.o. Aix was abnormal in this group. but to a much lesser extent than Group. A and B. The 18 asymp.omatic p.tients of Group.C did not receive Mg-EDTA treatment. Observation showed no significant changes in all three p.rameters of arterial stiffness. The results of this study indicate that a course of treatment with Magnesium-EDTA chelation therap. significantly lowers cardiovascular risks. We conclude that Mg-EDTA chelation therap. imp.oves p.V as an indicator of arterial stiffness, SBp.o (central blood p.essure) as an indicator of aortic elasticity and Aix (augmented aortic index) as an indicator of endothelial functioning. These imp.ovements in p.V, SBp.o and Aix demonstrate that atherosclerosis is a dynamic and (p.rtially) reversible p.ocess.

关键词： Arterial Stiffness p.lse Wave Velocity Central Blood p.essure Augmented Aortic Index Magnesium-EDTA Chelation Therap. Cardiovascular Risks

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CD4^(+)T cells p.oduce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij.j.p.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia j.Santegoets Timo Oosenbrug Annemarthe van der Veen j.ris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz j.cobs Sj.erd H.van der Burg j.nnie Borst Yanling Xiao Dep.rtment of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Dep.rtment of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Dep.rtment of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Dep.rtment of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Dep.rtment of p.thology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help.or"license" conventional typ. 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymp.ocyte(CTL)anticancer resp.nses,as p.oven in mouse *** recently identified cDC1s with a transcrip.omic imp.int of CD4^(+)T-cell help.sp.cifically in T-cell-infiltrated human cancers,and these cells were associated with a good p.ognosis and resp.nse to p.-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells p.oduce IFNβvia the STING p.thway,which p.omotes MHC-I antigen(cross-)p.esentation by cDC1s and thereby imp.oves their ability to induce CTL anticancer *** coop.ration with CD40 ligand(L),IFNβalso op.imizes the costimulatory and other functions of cDC1s required for CTL resp.nse ***-I-p.oducing CD4^(+)T cells are p.esent in diverse T-cell-infiltrated cancers and likely deliver“help.signals to CTLs locally,according to their transcrip.omic p.ofile and colocalization with“help.d/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the p.esence of IFN-I-p.oducing CD4^(+)T cells in the TME is associated with overall survival and the resp.nse to p.-1 checkp.int blockade in cancer p.tients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)p.esentation CTL p.iming Tumor control

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Late Quaternary sinistral slip.rate along the Altyn Tagh fault and its structural transformation model

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Science China Earth Sciences 2005年第3期48卷 384-397页

作者： p. Tap.onnier j. van der Woerd F. j. Ryerson A.S. Meriaux Laboratoire de Tectonique Institut de Physique du Globe de Paris FranceLaboratoire de Tectonique Institut de Physique du Globe de Paris FranceIGPP Lawrence Livermore Laboratory Livermore CA 94550 USALaboratoire de Tectonique Institut de Physique du Globe de Paris France

Based on technical p.ocessing of high-resolution Sp.T images and aerop.otos, detailed map.ing of offset landforms in combination with field examination and disp.acement measurement, and dating of offset geomorp.ic surfaces by using carbon fourteen (14C), cos- mogenic nuclides (10Be+26Al) and thermoluminescence (TL) methods, the Holocene sinistral slip.rates on different segments of the Altyn Tagh Fault (ATF) are obtained. The slip.rates reach 17.5 ±2 mm/a on the central and western segments west of Aksay Town, 11±3.5 mm/a on the Subei-Shibaocheng segment, 4.8±1.0 mm/a on the Sulehe segment and only 2.2±0.2 mm/a on the Kuantanshan segment, an easternmost segment of the ATF. The sudden change p.ints for loss of sinistral slip.rates are located at the Subei, Shibaocheng and Shulehe trip.e j.nctions where NW-trending active thrust faults sp.ay from the ATF and p.op.gate southeastward. Slip.vector analyses indicate that the loss of the sinistral slip.rates from west to east across a trip.e j.nction has structurally transformed into local crustal shortening p.rp.ndicular to the active thrust faults and strong up.ifting of the thrust sheets to form the NW-trending Danghe Nanshan, Daxueshan and Qilianshan Ranges. Therefore, the eastward extrusion of the northern Qing- hai-Tibetan p.ateau is limited and this is in accord with “the imbricated thrusting transforma- tion-limited extrusion model”.

关键词： Altyn Tagh Fault, sinistral strike-slip rate, structural transformation, extrusion tectonics.

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Towards efficient strain engineering of 2D materials:A four-p.ints bending ap.roach for comp.essive strain

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Nano Research 2024年第6期17卷 5317-5325页

作者： Hao Li Félix Carrascoso Ana Borrás Gloria p.Moreno Francisco j.Ap.ricio Ángel Barranco Andrés Castellanos Gómez Camp.s de Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on Surfaces and p.asma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Dep.rtamento de Física Ap.icada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

Strain engineering,as a p.werful strategy to tune the op.ical and electrical p.op.rties of two-dimensional(2D)materials by deforming their crystal lattice,has attracted significant interest in recent years.2D materials can sustain ultra-high strains,even up.to 10%,due to the lack of dangling bonds on their surface,making them ideal brittle *** remarkable mechanical resilience,together with a strong strain-tunable band structure,endows 2D materials with a broad op.ical and electrical resp.nse up.n ***,strain engineering based on 2D materials is restricted by their nanoscale and strain quantification *** this study,we have modified a homebuilt three-p.ints bending ap.aratus to transform it into a four-p.ints bending ap.aratus that allows for the ap.lication of both comp.essive and tensile strains on 2D *** ap.roach allows for the efficient and rep.oducible construction of a strain system and minimizes the buckling effect caused by the van der Waals interaction by adamantane encap.ulation *** results demonstrate the feasibility of introducing comp.essive strain on 2D materials and the p.tential for tuning their op.ical and p.ysical p.op.rties through this ap.roach.

关键词： uniaxial comp.essive strain p.lymer encap.ulation differential reflectance sp.ctroscop. exciton tunability

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p.ysical Simulation of Thermally Induced Martensite Formation from Retained Austenite in TRIp.Steels

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j.urnal of Materials Science & Technology 2003年第z1期19卷 105-108页

作者： Lie ZHAO Fred j. VERMOLEN j.lt SIETSMA Sybrand van der ZWAAG Netherlands Institute for Metals Research P.O.Box 5008 2600 GA Delft The Netherlands Dep.rtment of Materials Science Delft University of Technology R otterdamseweg 137 2628 AL Delft The Netherlands Department of Applied Mathematics Delft University of Technology Mekelweg 4 2628 CD Delft The Netherlands Department of Materials ScienceDelft University of TechnologyRotterdamseweg 1372628 AL DelftThe Netherlands Netherlands Institute for Metals Research P.O.Box 5008 2600 GA Delft The Netherlands Faculty of Aerosp.ce Engineering Delft University of Technology Kluyverweg 1 2629 HS Delft The Netherlands

The p.esent work analyses the total free energy of the material during the martensitic transformation. A general exp.ession for the martensite fraction as a function of temp.rature is derived, assuming that the nonchemical free energyis p.op.rtional to the volume of martensite. This exp.ession indicates that the temp.rature-dep.ndent martensitefraction can be p.edicted once the characteristic transformation temp.ratures and the relation between the chemicalfree energy and temp.rature of the martensite and austenite are known. An advantage of this develop.ent is thatthe p.op.sed equation is valid for all typ.s of relations between the chemical free energy and temp.rature. Thissimulation is successfully ap.lied to the martensitic transformation up.n further cooling of retained austenite in alow-alloyed TRIp.steel, in which the relation between chemical free energy and temp.rature is quadratic and thefraction is determined from a thermo-magnetic measurement.

关键词： Thermodynamics, Martensitic transformation, Retained austenite, TRIp steels.

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A Sp.ce-Time Interior p.nalty Discontinuous Galerkin Method for the Wave Equation

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Communications on Ap.lied Mathematics and Comp.tation 2022年第3期4卷 904-944页

作者： p.orvi Shukla j.j.W.van der Vegt Dep.rtment of Ap.lied Mathematics University of TwenteP.O.Box 2177500 AE EnschedeThe Netherlands

A new higher-order accurate sp.ce-time discontinuous Galerkin(DG)method using the interior p.nalty flux and discontinuous basis functions,both in sp.ce and in time,is p.e-sented and fully analyzed for the second-order scalar wave *** attention is given to the definition of the numerical fluxes since they are crucial for the stability and accuracy of the sp.ce-time DG *** theoretical analysis shows that the DG discre-tization is stable and converges in a DG-norm on general unstructured and locally refined meshes,including local refinement in *** sp.ce-time interior p.nalty DG discre-tization does not have a CFL-typ. restriction for *** order of accuracy is obtained in the DG-norm if the mesh size h and the time step.t satisfy h≅CΔt,with C a p.sitive *** op.imal order of accuracy of the sp.ce-time DG discretization in the DG-norm is confirmed by calculations on several model *** calculations also show that for p.h-order tensor p.oduct basis functions the convergence rate in the L∞and L2-norms is order p.1 for p.lynomial orders p.1 and p.3 and order p.for p.lynomial order p.2.

关键词： Wave equation Sp.ce-time methods Discontinuous Galerkin methods Interior p.nalty method A p.iori error analysis

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The imp.ct of p.ehosp.tal blood samp.ing on the emergency dep.rtment p.ocess of p.tients with chest p.in:a p.agmatic non-randomized controlled trial

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World j.urnal of Emergency Medicine 2023年第4期14卷 257-264页

作者： j.han L.van Nieuwkerk M.Christien van der Linden Rolf j.Verheul Merel van Loon-van Gaalen Marij. j.nmaat Naomi van der Linden Emergency Dep.rtment Haaglanden Medical Centre&Emergency Medical Services Haaglandenthe Hague 2501 CBthe Netherlands Research and Develop.ent Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Laboratory Services Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Emergency Dep.rtment Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Faculty of Health University of Applied Sciences LeidenLeiden 2300 AJthe Netherlands Faculty of Technology Policy and ManagementDelft University of TechnologyDelft 2628 BXthe Netherlands

BACKGROUND:In p.tients with chest p.in who arrive at the emergency dep.rtment(ED)by ambulance,venous access is frequently established p.ehosp.tal,and could be utilized to samp.e *** blood samp.ing may save time in the diagnostic *** this study,the association of p.ehosp.tal blood draw with blood samp.e arrival times,trop.nin turnaround times,and ED length of stay(LOS),number of blood samp.e mix-up. and blood samp.e quality were ***:The study was conducted from October 1,2019 to February 29,*** p.tients who were transp.rted to the ED with acute chest p.in with low susp.cion for acute coronary syndrome(ACS),outcomes were comp.red between cases,in whom p.ehosp.tal blood draw was p.rformed,and controls,in whom blood was drawn at the *** analyses were used to assess the association of p.ehosp.tal blood draw with the time ***:p.ehosp.tal blood draw was p.rformed in 100 *** 406 p.tients,blood draw was p.rformed at the *** blood draw was indep.ndently associated with shorter blood samp.e arrival times,shorter trop.nin turnaround times and decreased LOS(p.0.001).No differences in the number of blood samp.e mix-up. and quality were observed(p.0.05).CONCLUSION:For p.tients with acute chest p.in with low susp.cion for ACS,p.ehosp.tal blood samp.ing is associated with shorter time intervals,while there were no significant differences between the two group. in the validity of the blood samp.es.

关键词： Blood sp.cimen collection Crowding Emergency medical services Trop.nin

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CT影像组学模型在结直肠癌肝转移中的独立验证：预测肿瘤消融后局部进展

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国际医学放射学杂志 2024年第4期 500-501页

作者： D.j.van der Reij. C.Guerendel F.C.R.Staal M.p.Busard M.de Oliveira Taveira E.G.Klomp.nhouwer 刘晓彤

摘要目的对3种既往报道的基于CT预测结直肠癌肝转移（CRLM）病变热消融后局部肿瘤进展（LTp.的影像组学模型进行独立内部及外部验证。方法从2个机构收集接受

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Diffusion weighted imaging in the liver

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World j.urnal of Gastroenterology 2010年第13期16卷 1567-1576页

作者： p.tra G Kele Eric j.van der j.gt Dep.rtment of Radiology University Medical Center Groningen University of Groningen

Diffusion weighted magnetic resonance imaging (DWI) is an imaging technique which p.ovides tissue contrast by the measurement of diffusion p.op.rties of water molecules within tissues. Diffusion is exp.essed in an ap.arent diffusion coefficient (ADC), which reflects the diffusion p.op.rties unique to each typ. of tissue. DWI has been originally used in neuroradiology. More recently, DWI has increasingly been used in addition to conventional unenhanced and enhanced magnetic resonance imaging (MRI) in other p.rts of the body. The reason for this delay was a number of technical p.oblems inherent to the technique, making DWI very sensitive to artifacts, which had to be overcome. With assessment of ADC values, DWI p.oved to be help.ul in characterization of focal liver lesions. However, DWI should always be used in conj.nction to conventional MRI since there is considerable overlap.between ADC values of benign and malignant lesions. DWI is useful in the detection of hep.tocellular carcinoma in the cirrhotic liver and detection of liver metastases in oncological p.tients. In addition, DWI is a p.omising tool in the p.ediction of tumor resp.nsiveness to chemotherap. and the follow-up.of oncological p.tients after treatment, as DWI may be cap.ble of detecting recurrent disease earlier than conventional *** review focuses on the most common ap.lications of DWI in the liver.

关键词： Diffusion Magnetic resonance imaging Diffusion weighted imaging Benign neop.asms Liver neop.asms

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Differences in sensitivity of native and exotic fish sp.cies to changes in river temp.rature

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Current Zoology 2011年第6期57卷 852-862页

作者： R.S.E.W. LEUVEN A.j. HENDRIKS M.A.j. HUIj.REGTS H.j.R. LENderS j. MATTHEWS van der VELDE Radboud University Nij.egen Institute for Water and Wetland Research Department of Environmental Science Heyendaal- seweg 135 NL-6525 AJ Nijmegen The Netherlands Radboud University Nij.egen Institute for Water and Wetland Research Department of Animal Ecology and Ecophysiology Heyendaalseweg 135 NL-6525 AJ Nijmegen The Netherlands Netherlands Centre for Biodiversity Naturalis P.O. Box 9517 NL-2300 RA Leiden The Netherlands

This p.p.r describes the effects that temp.rature changes in the Rhine river distributaries have on native and exotic fish diversity. Site-sp.cific p.tentially affected fractions （p.Fs） of the regional fish sp.cies p.ol were derived using sp.cies sensitivity distributions （SSDs） for water temp.rature. The number of fish sp.cies in the river distributaries has changed remarkably over the last century. The number of native rheop.ilous sp.cies declined up.until 1980 due to anthrop.genic disturbances such as commercial fishing, fiver regulation, migration barriers, habitat deterioration and water p.llution. In sp.te of p.ogress in river re- habilitation, the native rheop.ilous fish fauna has only p.rtially recovered thus far. The total number of sp.cies has strongly in- creased due to the ap.earance of more exotic sp.cies. After the op.ning of the Rhine-Main-Danube waterway in 1992, many fish sp.cies originating from the p.nto-Casp.an area colonized the Rhine basin. The yearly minimum and maximum river temp.ra- tures at Lobith have increased by circa 4 ~C over the p.riod 1908-2010. Exotic sp.cies show lower p.Fs than native sp.cies at both ends of the temp.rature range. The intersp.cific variation in the temp.rature tolerance of exotic fish sp.cies was found to be large. Using temp.ral trends in river temp.rature allowed p.st p.edictions of p.Fs to demonstrate that the increase in maximum river temp.rature negatively affected a higher p.rcentage of native fish sp.cies than exotic sp.cies. Our results sup.ort the hy- p.thesis that alterations of the river Rhine＇s temp.rature regime caused by thermal p.llution and global wanning limit the full recovery of native fish fauna and facilitate the establishment of exotic sp.cies which thereby increases comp.tition between native and exotic sp.cies. Thermal refuges are imp.rtant for the survival of native fish sp.cies under extreme summer or winter temp.rature conditions

关键词： Aquatic invaders Global warming Heat discharges Lethal temp.rature River Rhine Thermal heterogeneity

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