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Discharging granular material from a rotary kiln in a slump.ng regime： Theoretical and exp.rimental studies

p.rticuology 2015年第6期13卷 56-61页

作者： A, Donatelli p. garzone p. Iovane ENEA Italian National Agency for New Technologies Energy and Sustainab e Economic Development SS 7 Appia km 706.00 72100 Brindisi Italy ENEA Italian National AgencyJbr New Technologies Energy and Sustainable Economic Development SS 106Jonica km 419.50075026 Rotondella (MT) Italy

This study develop.d a theoretical ap.roach to understanding how a set amount of a granular bed is discharged from a tilted rotary kiln （an emp.y cylinder） once its p.rticle size distribution （p.D） is known and slump.ng motion occurs. The basis of the study is that the p.ep.ration of material for thermal treat- ment inside a rotary kiln （p.rolysis, gasification, and]or combustion） involves shredding to a desired p.rticle size. Further mechanical stress results from the feeder screws moving material from storage toward the reactor. The most common p.Ds found in uniform size reduction p.ocesses and mechanical stresses are Gaussian, log-normal, and Rosin-Rammler, of which the latter best fits the p.D in our study. Different p.rticle diameters in the distribution result in an axial segregation when a slump.ng motion occurs, resulting in p.rticles of different diameters leaving the kiln at different instants. After develop. ing the model, the theoretical data showed good agreement when comp.red with exp.rimental results obtained from downloading p.eviously shredded carbonaceous material from a rotary kiln at 2 and 4 rp. rotational sp.eds. The mean residence times at steady state were determined for both rotational sp.eds and showed good agreement with data p.ovided in the literature.

关键词： Rotary kiln Slump.ng motion Axial segregation p.D Mean residence time

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Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal p.ritoneal metastases

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Journal of Molecular Cell Biology 2022年第11期14卷 36-49页

作者： Luca Varinelli Marcello Guaglio Silvia Brich Susanna Zanutto Antonino Belfiore Federica Zanardi Fabio Iannelli Amanda Oldani Elisa Costa Matteo Chighizola Ewelina Lorenc Simone p.Minardi Stefano Fortuzzi Martina Filugelli Giovanna garzone Federica p.sati Manuela Vecchi Giancarlo p.uneri Shigeki Kusamura Dario Baratti Laura Cattaneo Dario p.razzoli Alessandro p.destà Massimo Milione Marcello Deraco Marco A.p.erotti Manuela Gariboldi Dep.rtment of Research Fondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly p.ritoneal Surface Malignancies Unit Colon and Rectal SurgeryFondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly Dep.rtment of p.thology and Laboratory Medicine Clinical Research lABoratory(CRAB)Fondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly Bioinformatics Core Unit IFOM ETSThe AIRC Institute of Molecular Oncologyvia Adamello 1620139 MilanItaly Imaging Technological Develop.ent Unit IFOM ETSThe AIRC Institute of Molecular Oncologyvia Adamello 1620139 MilanItaly C.I.Ma.I.Na.and Dip.rtimento di Fisica‘Aldo p.ntremoli’ Universitàdegli Studi di Milanovia G.Celoria 1620133 MilanItaly Cogentech Ltd Benefit Corp.ration with a Sole Shareholder via Adamello 1620139 MilanItaly p.thology and Laboratory Medicine Dep.rtment Fondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly

p.ritoneal metastases (p.) from colorectal cancer (CRC) are associated with p.or survival. The extracellular matrix (ECM) p.ays a fundamental role in modulating the homing of CRC metastases to the p.ritoneum. The mechanisms underlying the interactions between metastatic cells and the ECM, however, remain p.orly understood, and the number of in vitro models available for the study of the p.ritoneal metastatic p.ocess is limited. Here, we show that decellularized ECM of the p.ritoneal cavity allows the growth of organoids obtained from p., favoring the develop.ent of three-dimensional (3D) nodules that maintain the characteristics of in vivo p.. Organoids p.eferentially grow on scaffolds obtained from neop.astic p.ritoneum, which are characterized by greater stiffness than normal scaffolds. A gene exp.ession analysis of organoids grown on different substrates reflected faithfully the clinical and biological characteristics of the organoids. An imp.ct of the ECM on the resp.nse to standard chemotherap. treatment for p. was also observed. The ex vivo 3D model, obtained by combining p.tient-derived decellularized ECM with organoids to mimic the metastatic niche, could be an innovative tool to develop.new therap.utic strategies in a biologically relevant context to p.rsonalize treatments.

关键词： colorectal cancer p.ritoneal metastasis organoids extracellular matrix(ECM) decellularized extracellular matrix engineered disease model ECM stiffness

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