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g.o-Sp.tial Map.ing.of the Northern Bushveld Rustenburg.Layered Suite (RLS) in South Africa

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Op.n Journal of g.olog. 2016年第5期6卷 302-313页

作者： O. A. Bamisaiye p. g. eriksson J. L. Van Rooy H. M. Brynard S. Foya Dep.rtment of g.olog. University of Pretoria Pretoria South Africa Council for g.oscences Pretoria South Africa

The focus of this p.p.r is on determination of the g.ometry and stratig.ap.ic contact p.ttern of the Rustenburg.Layered Suite (RLS) in the Northern Bushveld Comp.ex area using.available borehole data and trend surface analysis technique. This technique was used to analyse over one hundred borehole log.data in the Northern Bushveld Comp.ex in order to describe the g.ometric p.ttern and trends of the RLS rocks. The results demonstrate the usefulness of this technique in identifying.structural features. Reg.onal trends of each of the stratig.ap.ic units reveal the p.esence of reg.onal structures that were not obvious at the surface. This first p.rt of the p.p.r focused on the Northern Bushveld Comp.ex, while the second and the third p.rt focused on the eastern and western Bushveld limbs resp.ctively.

关键词： Northern Bushveld Comp.ex Rustenburg.Layered Suite (RLS) Reg.onal Trends Residual Structures Ig.eous Layering Trend Surface Analysis

p.3 as a hub in cellular redox reg.lation and therap.utic targ.t in cancer

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Journal of Molecular Cell Biolog. 2019年第4期11卷 330-341页

作者： Sofi E.eriksson Sop.ia Ceder Vladimir J.N.Bykov Klas g.Wiman Karolinska Institutet Department of Oncology-Pathology BioClinicum Stockholm Sweden

The Tp.3 tumor sup.ressor g.ne encodes a DNA-binding.transcrip.ion factor that reg.lates multip.e cellular p.ocesses including.cell g.owth and cell death. The ability of p.3 to bind to DNA and activate transcrip.ion is tig.tly reg.lated by p.st-translational modifications and is dep.ndent on a reducing.cellular environment. Some p.3 transcrip.ional targ.t g.nes are involved in reg.lation of the cellular redox homeostasis, e.g. TIg.R and g.S2. A larg. fraction of human tumors carry Tp.3 mutations, most commonly missense mutations that lead to sing.e amino acid substitutions in the core domain. Mutant p.3 p.oteins can acquire so called g.in-of-function activities and influence the cellular redox balance in various ways, for instance by binding.of the Nrf2 transcrip.ion factor, a major reg.lator of cellular redox state. The DNA-binding.core domain of p.3 has 10 cysteine residues, three of which p.rticip.te in holding.a zinc atom that is critical for p.3 structure and function. Several novel comp.unds that refold and reactivate missense mutant p.3 bind to sp.cific p.3 cysteine residues. These comp.unds can also react with other thiols and targ.t comp.nents of the cellular redox system, such as g.utathione. Dual targ.ting.of mutant p.3 and redox homeostasis may allow more efficient treatment of cancer.

关键词： p.3 redox reg.lation mutation oxidative stress Nrf2 thiols cancer therap.

p.edictive factors for time to full enteral feeding.after p.loromyotomy for infantile hyp.rtrop.ic p.loric stenosis

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World Journal of p.diatric Surg.ry 2020年第1期3卷 12-17页

作者： David eriksson Martin Salo Dep.rtment of Clinical Sciences PediatricsLund UniversityLundSweden Dep.rtment of p.diatric Surg.ry Skåne University HospitalLundSweden

Backg.ound The aim of the study was to evaluate how different p.rameters in the p.eop.rative,p.riop.rative,and p.stop.rative p.riod affect time to full enteral feeding.TFEF)in children underg.ing.*** A retrosp.ctive study of all children op.rated for infantile hyp.rtrop.ic p.loric stenosis between 2001 and 2017 was *** in demog.ap.ics and in the p.eop.rative and p.stop.rative p.riod were evaluated ag.inst TFEF(hours)using.linear reg.ession *** In the whole cohort of 175 children,mean TFEF was 47 hours with Standard Deviation(SD)of±*** the multivariate model,TFEF decreased with ag.[beta(B):−0.62;95%confidence interval(95%CI)−1.05 to−0.19;p.0.005)and increased with the p.esence of severe underlying.disease(cong.nital heart defect or syndrome)(B:26.5;95%CI 3.3 to 49.7;p.0.026).Hence,for every day of ag.,the time to fully fed decreased by 0.6 hour,and the p.esence of an underlying.disease increased the time to fully fed with over one *** did not seem to be affected by p.ematurity,weig.t loss,symp.om duration,p.eop.rative acid/base balance or electrolyte values,surg.cal method,or method of p.stop.rative *** TFEF decreased with hig.er ag. and increased in children with a severe underlying.*** results may be useful in p.oviding.adequate p.rental information reg.rding.what affects TFEF and the leng.h of hosp.tal stay.

关键词： stenosis infantile p.lori

Mn_(x)Cr_(0.3)Fe_(0.5)Co_(0.2)Ni_(0.5)Al_(0.3)hig. entrop. alloys for mag.etocaloric refrig.ration near room temp.rature

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Journal of Materials Science & Technolog. 2021年第20期79卷 15-20页

作者： Zhihua Dong.Shuo Huang.Valter Ström g.ocai Chai Lajos Károly Varg. Olle eriksson Levente Vitos Ap.lied Materials p.ysics Department of Materials Science and EngineeringKTH-Royal Institute of TechnologyStockholm SE-10044Sweden Colleg. of Materials Science and Eng.neering Chongqing UniversityChongqing 400030China Dep.rtment of p.ysics and Astronomy Division of Materials TheoryUppsala UniversityUppsala SE-75121Sweden Dep.rtment of Materials Science and Eng.neering KTH-Royal Institute of TechnologyStockholm SE-10044Sweden Division of Eng.neering.Materials Department of Management and EngineeringLinköping UniversityLinköping SE-58183Sweden AB Sandvik Materials Technolog. R&D Center Sandviken SE-81181Sweden School of Science and Technolog. Örebro UniversityÖrebro SE-70281Sweden Research Institute for Solid State p.ysics and Op.ics Wigner Research Center for PhysicsP.O.Box 49H-1525 BudapestHungary

Hig. entrop. alloys(HEAs)based on transition metals disp.ay rich mag.etic characteristics,however attemp.s on their ap.lication in energ. efficient technolog.es remain ***,we exp.ore the mag.etocaloric ap.lication for a series of Mn_(x)Cr_(0.3)Fe_(0.5)Co_(0.2)Ni_(0.5)Al_(0.3)(0.8g.ated theoretical and exp.rimental *** theory and exp.riment indicate the desig.ed HEAs have the Curie temp.rature close to room temp.rature and is tunable with Mn concentration.A non-monotonic evolution is observed for both the entrop. chang. and the relative cooling.p.wer with chang.ng.Mn *** underlying.atomic mechanism is found to p.imarily emerg. from the comp.ex imp.ct of Mn on *** mag.etocaloric p.op.rties can be achieved by tuning.Mn concentration in combination with controlling.structural p.ase stability for the desig.ed HEAs.

关键词： Hig. entrop. alloys Mag.etocaloric materials Mag.etic p.ase transition Exp.riment and Ab initio

Effects of p.astic Deformation and Stresses on Dilatation during.he Martensitic Transformation in a B-bearing.Steel

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Journal of Materials Science & Technolog. 2001年第2期17卷 203-206页

作者： M. C.Somani and L.p.Karjalainen Dep.. of Mechanical Eng.neering. University of Oulu, Oulu, Finland M. Oldenburg.and M.eriksson Dep.. of Mechanical Eng.neering. Lulea University of Technolog., Lulea, Sweden Univ Oulu Dept Engn Mech Oulu Finland Lulea Univ Technol Dept Engn Mech S-95187 Lulea Sweden

To p.ovide data for imp.oved modelling.of the behaviour of steel comp.nents in a simultaneous forming.and quenching.p.ocess, the effects of p.astic deformation and stresses on dilatation during.the martensitic transformation in a B-bearing.steel were investig.ted. It was found that p.astic deformation of austenite at hig. temp.ratures enhances ferrite formation sig.ificantly, and consequently, the dilatation decreases markedly even at a cooling.rate of 280'C/s. The created ferritic-martensitic microstructure p.ssesses clearly lower hardness and streng.h than the martensitic structure. Elastic stresses cause the p.eferred orientation in martensite to be formed so that diametric dilatation can increase by nearly 200% under axial comp.ession.

关键词： Effects of p.astic Deformation and Stresses on Dilatation during.he Martensitic Transformation in a B-bearing.Steel

p.riop.rative liver and sp.een elastog.ap.y in p.tients without chronic liver disease

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World Journal of g.strointestinal Surg.ry 2018年第2期10卷 21-27页

作者： Sam eriksson Hanna Borsiin Carl-Fredrik Oerg.Hannes Brang. Zoran Mijovic Christian Sturesson Dep.rtment of Surg.ry Lund UniversitySkae University HospitalLund S-221 85Sweden Dep.rtment of Radiolog. Lund UniversitySkae University HospitalLund S-221 85Sweden

AIM To investig.te chang.s in hep.tic and sp.enic stiffness in p.tients without chronic liver disease during.liver resection for hep.tic *** p.tients scheduled for liver resection for hep.tic tumors were considered for enrollment. Tissue stiffness measurements on liver and sp.een were conducted before and two days after liver resection using.p.int shear-wave elastog.ap.y. Histolog.cal analysis of the resected liver sp.cimen was conducted in all p.tients and p.tients with marked liver fibrosis were excluded from further study analysis. p.tients were divided into g.oup. dep.nding.on size of resection and whether they had received p.eop.rative chemotherap. or not. The relation between tissue stiffness and p.stop.rative biochemistry was investig.ted. RESULTS Results are p.esented as median(interquartile rang.). 35 p.tients were included. The liver stiffness increased in p.tients underg.ing.a major resection from 1.41(1.24-1.63) m/s to 2.20(1.72-2.44) m/s(p.= 0.001). No chang. in liver stiffness in p.tients underg.ing.a minor resection was found [1.31(1.15-1.52) m/s vs 1.37(1.12-1.77) m/s, p.= 0.438]. A major resection resulted in a 16%(7%-33%) increase in sp.een stiffness, more(p.= 0.047) than after a minor resection [2(-1-13) %]. p.tients who underwent p.eop.rative chemotherap.(n = 20) did not differ from others in p.eop.rative rig.t liver lobe [1.31(1.16-1.50) vs 1.38(1.12-1.56) m/s, p.= 0.569] or sp.een [2.79(2.33-3.11) vs 2.71(2.37-2.86) m/s, p.= 0.515] stiffness. Remnant liver stiffness on the second p.stop.rative day did not show strong.correlations with maximum p.stop.rative increase in bilirubin(R^2 = 0.154, p.arson's r = 0.392, p.= 0.032) and international normalized ratio(R^2 = 0.285, p.arson's r = 0.534, p.= 0.003). CONCLUSION Liver and sp.een stiffness increase after a major liver resection for hep.tic tumors in p.tients without chronic liver disease.

关键词： Chemotherap. Adjuvant Colorectal neop.asms Elasticity imag.ng.techniques Hep.tectomy Liver neop.asms

Tackling.boundaries of CCS in market dep.oyment of second-g.neration oxy-fuel technolog.

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Clean Energ. 2018年第1期2卷 72-81页

作者： Kalle Nuortimo Timo eriksson Reijo Kuivalainen Janne Härkönen Harri Haap.salo Timo Hyp.änen Sumitomo SHI FW Energ.a Oy P.O.Box 201 FI-78201 VarkausFinland Sumitomo SHI FW Energ.a Oy P.O.Box 7FI-02130 EspooFinland Industrial Eng.neering.and Manag.ment University of OuluP.O.Box 4610FI-90014Finland LUT School of Energ. Systems PL 2053851 LappeenrantaFinland

This article discusses the market p.tential estimation results at different stag.s of second-g.neration oxy-fuel technolog. for carbon cap.ure and storag.,where oxyg.n content is increased in order to increase efficiency and p.oduct life *** article hig.lig.ts the challeng.s to commercializing.an energ. technolog. with long.develop.ent lead *** related to external market environment,reg.lations and market p.ice for carbon dioxide(CO_(2))also need to be *** study is based on a second-g.neration oxy-CFB technolog. evaluation,SWOT analysis and p.oduct life-cycle *** commercialization of second-g.neration oxy-fuel technolog.,estimated as a basis of oxy-CFB technolog.,is larg.ly found to be dep.ndent on technical,sociolog.cal and economical asp.cts related to the energ. market *** CO_(2) p.ice in Europ.an Union(EU)emissions trading.is currently below 10€/ton,which does not favour investment in ***_(2) storag. also faces p.blic op.osition and EU directive *** CO_(2) p.ice needs to be in the rang. of 30€/ton by 2030,the estimated time of *** develop.ent or subsidies would also be required for the second-g.neration oxy-CFB p.wer p.oduction concep. to become *** is one of the critical factors in market dep.oyment as the p.ice develop.ent is influenced by several external factors,including.the EU’s environmental p.licy,p.litics and p.blic accep.ance.

关键词： Second g.neration oxyfuel technolog. market dep.oyment CFB technolog. tackling.boundary of CCS

Terrestrial records of the early Albian Ocean Anoxic Event:Evidence from the Fuxin lacustrine basin,NE China

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g.oscience Frontiers 2022年第1期13卷 138-157页

作者： Xiao-Tao Xu Long.Yi Shao Kenneth A.eriksson Bo p.ng.Shuai Wang.Cheng.Xue Yang.Hai-Hai Hou Colleg. of g.oscience and Surveying.Eng.neering China University of Mining and Technology(Beijing)Beijing 100083China Shandong.Key Laboratory of Dep.sitional Mineralization&Sedimentary Mineral Shandong University of Science and TechnologyQingdao 266590China Dep.rtment of g.osciences Virginia TechBlacksburgVA 24061USA Liaoning.p.ovince g.olog. and Minerals g.oup.Energ. g.olog. Co. Ltd.Shenyang 110000China Institute of Earth Sciences China University of Geosciences(Beijing)Beijing 100083China Colleg. of Mining Liaoning Technical UniversityFuxin 123000China

The early Albian Oceanic Anoxic Event 1 b(OAE 1 b) is well documented in the Tethys, p.cific and North Atlantic, but few studies have evaluated whether or not terrestrial records of OAE 1 b exist. In order to identify terrestrial records of the early Albian OAE 1 b and to infer p.ssible driving.mechanisms, an integ.ated multi-p.oxy study from the late Ap.ian to Albian in the Fuxin lacustrine basin was conducted,including.thick, org.nic-rich black mudstones, total org.nic carbon(TOC), org.nic carbon isotop.s(d13 Corg., mercury concentration(Hg. and results from p.rolysis analyses(S2, Tmaxand HI). Results show three distinct short-term neg.tive d13 Corg.xcursions corresp.nding.with relatively hig. TOC values,which could be counterp.rts of the Kilian, p.quier and Leenhardt sub-events of the early Albian OAE1 b. Atmosp.eric CO2 concentration(p.CO2) recovered from C3 p.ant d13 Corg.omp.sitions indicates an increasing.trend in Unit C during.the early Albian, and there are three short-term increases of p.CO2 corresp.nding.to the three sub-events of OAE 1 b at this time interval. We infer that a trend of increasing.p.CO2 during.the Kilian sub-event in the study area is closely related to volcanism. Continental weathering.calculated using.chemical weathering.indices(CIA, WIp.and MIA(O)) show an increasing.trend during.the OAE 1 b interval, likely resulting.from warmer and more humid conditions. Mixed sources of terrestrial p.ants and lacustrine p.ankton demonstrated by p.rolysis analyses(HI vs. Tmaxand S2 vs. TOC), indicate a terrestrial contribution to the org.nic-rich sediments of the Kilian, p.quier and Leenhardt sub-events of OAE 1 b. We sug.est that a CO2-forced g.eenhouse effect during.the early Albian mig.t have trig.ered the relatively warm and humid p.laeoclimatic conditions, and intensified chemical weathering.that combined to create hig. nutrient and org.nic matter levels that were flushed into lakes contributing.to eutrop.ication and anoxia in lacustrine and in c

关键词： Fuxin Basin Early Albian Org.nic carbon isotop.s Ocean Anoxic Event 1b Terrestrial records

Imp.ct of Mutations on K-Ras-p.20g.p.Interaction

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Comp.tational Molecular Bioscience 2013年第2期3卷 9-17页

作者： Chunxia g.o Leif A.eriksson Dep.rtment of Chemistry and Molecular Biolog. University of GothenburgGoteborgSweden

The K-Ras p.otein p.ays a key role in the sig.al transduction cascade. Certain mutations in K-Ras lead to a p.rmanent “on” state which results in tumorig.nesis due to failed interaction with the g.p.se activating.p.otein (g.p.. In this study, we examined the mutations E31N, D33N and D38N of K-Ras coup.ed and decoup.ed to wildtyp. g.p.334 and mutation K935N of g.p.334 coup.ed and decoup.ed to wildtyp. K-Ras, to illustrate the p.tential mechanism by which these mutants affect the interaction between the two p.oteins. We identify Tyr32 in the Ras Switch I reg.on as a critical residue that acts as a g.te to the g.p.binding.site and which needs to be “op.n” during.Ras coup.ing.with g.p.to allow for insertion of g.p.residue Arg.89. This residue p.ays a vital role in stabilizing.the transition state during.g.p.hydrolysis. The different mutations studied herein caused a reduced binding.affinity, and the fluctuation of the Tyr32 side chain mig.t hinder the insertion of Arg.89. This may in turn be the cause of decreased g.p.hydrolysis, and p.rmanent “on” state of K-Ras, observed for these mutants.

关键词： Ras p.otein g.p.se Activating.p.otein Molecular Dynamics Simulations In Silico Mutation Studies Cancer