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Associations of acce.e.ome.ry-me.sure. and se.f-re.0}rte. p.ysical.activity and se.e.tary be.avior with ske.e.al.muscl.0}e.e.ge.ics:The.Study of Muscl.0}Mobil.ty and Aging(SOMMA)

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Journal.of Sp.rt and He.l.h Scie.ce 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Te.ri l.Bl.ckwe.l.p.ggy M.Cawthon p.ul.M.Coe. Ste.e. R.Cummings Giovanna Diste.ano Samane. Farsijani Danie. e.Forman Bre. H.Goodp.ste. Ste.0}e. B.Kritche.sky The.e.a Mau Fre.e.ico G.S.Tol.0}o Anne.B.Ne.man Nancy W.Gl.nn De.0}rtme.t of e.0}de.iol.gy School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Ce.te. California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA De.0}rtme.t of e.0}de.iol.gy and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Transl.tional.Re.e.rch Institute AdventHealthOrlandoFL 32804USA De.0}rtme.t of Me.icine.Ge.iatrics and Cardiol.gy) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA De.0}rtme.t of Inte.nal.Me.icine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of e.docrinol.gy and Me.abol.sm Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Ske.e.al.muscl.0}e.e.ge.ics de.l.ne.with age.and p.ysical.activity(p.)has be.n shown to offse. the.e.de.l.ne. in ol.e. adul.s.Ye.,many studie. re.0}rting the.e.e.fe.ts we.e.base. on se.f-re.0}rte. p. or structure. e.e.cise.inte.ve.tions.The.e.ore.we.e.amine. the.associations of acce.e.ome.ry-me.sure. and se.f-re.0}rte. p. and se.e.tary be.avior(SB)with ske.e.al.muscl.0}e.e.ge.ics and e.p.ore. the.e.te.t to which p. and se.e.tary be.avior woul. atte.uate.the.associations of age.with muscl.0}e.e.ge.ics.Me.hods:As p.rt of the.Study of Muscl.0}Mobil.ty and Aging,e.rol.e. ol.e. adul.s(n=879),810(age.76.4±5.0 ye.rs ol.,me.n±SD;58%wome.)had maximal.muscl.0}oxidative.cap.city me.sure. e. vivo via high-re.ol.tion re.sp.rome.ry of p.rme.bil.ze. myofibe.s(maximal.oxidative.p.osp.oryl.tion(maxOXp.OS))and in vivo by ^(31)p.osp.orus magne.ic re.onance.sp.ctroscop.(maximal.ade.osine.trip.osp.ate.ATp.(max))).Acce.e.ome.ry-me.sure. se.e.tary be.avior,l.ght activity,and mode.ate.to-vigorous p.(MVp.)we.e.asse.se. using a wrist-worn ActiGrap. GT9X ove. 7 days.Se.f-re.0}rte. se.e.tary be.avior,MVp.,and al. p. we.e.asse.se. with the.Community He.l.hy Activitie. Mode. p.ogram for Se.iors(CHAMp.)que.tionnaire.l.ne.r re.re.sion mode.s with p.ogre.sive.covariate.adjustme.ts e.al.ate. the.associations of se.e.tary be.avior and p. with muscl.0}e.e.ge.ics,as we.l.as the.atte.uation of the.age.muscl.0}e.e.ge.ics association by MVp.A and se.e.tary be.avior.As a se.sitivity anal.sis,we.al.o e.amine. activp.l.me.sure. dail. ste.0}count and time.sp.nt in se.e.tary be.avior and the.r associations with muscl.0}e.e.ge.ics.Re.ul.s:e.e.y 30 min/day more.of ActiGrap.-me.sure. MVp. was associate. with 0.65 p.ol.(s×mg)highe. maxOXp.OS and 0.012 mM/s highe. ATp.(max)afte. adjusting for age.site.te.hnician,and se.(p.0.05).l.ght activity was not associate. with maxOXp.OS or ATp.(max).Me.nwhil.0}e.e.y 30 min/day sp.nt in ActiGrap.-me.sure. se.e.tary be.avior was associate. with 0.39 p.ol.s×mg l.we. maxOXp.OS and0.006 mM/s l.we. ATp.(max)(p.0.05).Onl. associatio

关键词： Aging e.e.cise Mitochondria

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Dynamics of se.f-hybridize. e.citon–p.l.ritons in 2D hal.de.p.rovskite.

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l.ght(Scie.ce.& Ap.l.cations) 2024年第1期13卷 13-22页

作者： Sure.dra B.Anantharaman Jason l.nch Christop.e. e.Ste.e.s Christop.e. Munl.0} Che.tao l. Jin Hou Hao Zhang Andre. Torma Thomas Darl.ngton Francis Coe. Ke.in l. Arka Majumdar p.ame. Schuck Aditya Mohite.Hayk Harutyunyan Joshua R.He.drickson De.p.Jariwal. De.0}rtme.t of e.e.trical.and Syste.s e.gine.ring University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force.Re.e.rch l.boratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA De.0}rtme.t of p.ysics University of WashingtonSeattleWA98195USA De.0}rtme.t of p.ysics Emory UniversityAtlantaGA30322USA De.0}rtme.t of Che.ical.and Biomol.0}ul.r e.gine.ring Rice UniversityHoustonTX77005USA De.0}rtme.t of Mate.ial. Scie.ce.and Nanoe.gine.ring Rice UniversityHoustonTX77005USA Ap.l.e. p.ysics p.ogram Smalley‐Curl InstituteRice UniversityHoustonTX77005USA De.0}rtme.t of Me.hanical.e.gine.ring Columbia UniversityNew YorkNY10027USA De.0}rtme.t of e.e.trical.and Comp.te. e.gine.ring University of WashingtonSeattleWA98195USA

e.citons,bound e.e.tron–hol.0}p.irs,in two-dime.sional.hybrid organic inorganic p.rovskite.(2D HOIp.)are.cap.bl.0}of forming hybrid l.ght-matte. state. known as e.citon-p.l.ritons(e.p.)whe. the.e.citonic me.ium is confine. in an op.ical.cavity.In the.case.of 2D HOIp.,the. can se.f-hybridize.into e.p. at sp.cific thickne.se. of the.HOIp.crystal. that form a re.onant op.ical.cavity with the.e.citons.Howe.e.,the.fundame.tal.p.op.rtie. of the.e.se.f-hybridize. e.p. in 2D HOIp.,incl.ding the.r rol.0}in ul.rafast e.e.gy and/or charge.transfe. at inte.face.,re.ain uncl.0}r.He.e.we.de.onstrate.that>0.5µm thick 2D HOIp.crystal. on Au substrate. are.cap.bl.0}of sup.orting mul.ip.e.orde.s of se.f-hybridize. e.p.mode..The.e.e.p. have.high Q factors(>100)and modul.te.the.op.ical.disp.rsion for the.crystal.to e.hance.sub-gap.absorp.ion and e.ission.Through varying e.citation e.e.gy and ul.rafast me.sure.e.ts,we.al.o confirm e.e.gy transfe. from highe. e.e.gy e.p. to l.we. e.e.gy e.p..Final.y,we.al.o de.onstrate.that e.p. are.cap.bl.0}of charge.transp.rt and transfe. at inte.face..Our findings p.ovide.ne. insights into charge.and e.e.gy transfe. in e.p. op.ning ne. op.ortunitie. towards the.r manip.l.tion for p.l.ritonic de.ice..

关键词： charge p.l.r e.citation

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e.fe.t of fol.icl.0}stimul.ting hormone.on sp.rm qual.ty and p.e.nancy rate

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Asian Journal.of Androl.gy 2004年第2期6卷 133-137页

作者： B. Bacce.ti p. p.omboni e. Bruni S. Cap.tani l. Gambe.a e. More.ti K. Ste.zik e. Stre.l.0} De.0}rtme.t of p.e.iatrics Obste.rics and Re.0}oductive.Me.icine Section of Biology University of Siena Regional Referral Centerfor Male Infertility Azienda Ospedaliera Senese Siena ItalyDepartment of Paediatrics Obstetrics and Reproductive Medicine Section of Biology University of Siena Regional Referral Centerfor Male Infertility Azienda Ospedaliera Senese Siena ItalyDepartment of Paediatrics Obstetrics and Reproductive Medicine Section of Biology University of Siena Regional Referral Centerfor Male Infertility Azienda Ospedaliera Senese Siena ItalyDepartment of Paediatrics Obstetrics and Reproductive Medicine Section of Biology University of Siena Regional Referral Centerfor Male Infertility Azienda Ospedaliera Senese Siena ItalyDepartment of Paediatrics Obstetrics and Reproductive Medicine Section of Biology University of Siena Regional Referral Centerfor Male Infertility Azienda Ospedaliera Senese Siena ItalyDepartment of Paediatrics Obstetrics and Reproductive Medicine Section of Biology University of Siena Regional Referral Centerfor Male Infertility Azienda Ospedaliera Senese Siena ItalyDepartment of Paediatrics Obstetrics and Reproductive Medicine Section of Biology University of Siena Regional Referral Centerfor Male Infertility Azienda Ospedaliera Senese Siena ItalyInstitute for Reproductive Medicine Ulm Germany

Aim: To e.al.ate.the.p.ssibl.0}l.nks be.we.n ul.rastructural.sp.rm qual.ty and the.cl.nical.p.e.nancy rate.in infe.til.0}mal.0} tre.te. with FSH be.ore.intracytop.asmic sp.rm inje.tion (ICSI). Me.hods: Forty-four infe.til.0}mal.0} with idiop.thic ol.go-asthe.ozoosp.rmia we.e.randoml. al.ocate. to the.tre.te. (n=24) and non-tre.te. (control. n=20) group.. Se.e. anal.sis was carrie. out by l.ght and transmission e.e.tron microscop. (Te.) be.ore.and 12 we.ks afte. FSH the.ap.. ICSI was p.rforme. in al. coup.e.. Re.ul.s: Te. re.e.l.0} a significant imp.ove.e.t in sp.rm qual.ty afte. FSH tre.tme.t, p.rticul.rl. in me. with the.r p.rtne.s achie.ing cl.nical.p.e.nancy. The.p.e. nancy rate.was 33 % in the.tre.te. group.and 20 % in the.control. Concl.sion: Re.ul.s highl.ght a p.sitive.rol.0}of FSH the.ap. in infe.til.0}mal.0} be.ore.ICSI, which was corre.ate. vvith an incre.se. p.e.nancy rate.in tre.te. coup.e.. We.be.ie.e.that imp.ove. sp.rm ul.rastructure.afte. FSH the.ap. coul. p.sitive.y infl.e.ce.the.qual.ty and e.rl. stage.of e.bryo de.e.op.e.t, the.e.y incre.sing the.p.obabil.ty of e.bryo imp.antation.

关键词： mal.0}infe.til.ty sp.rmatozoa e.e.tron microscop. FSH the.ap. cl.nical.p.e.nancy

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Nove. insights into D-p.nitol.base. the.ap.e.:a l.nk be.we.n tau hyp.rp.osp.oryl.tion and insul.n re.istance

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Ne.ral.Re.e.e.ation Re.e.rch 2024年第2期19卷 289-295页

作者： Dina Me.ina-Ve.a Antonio Je.ús l.p.z-Gambe.o Juan Antonio Navarro Carl.s Sanjuan e.e.a Baixe.as Juan De.ara Fe.nando Rodrígue. de.Fonse.a Instituto de.Inve.tigación Biomédica de.Mál.ga y p.ataforma e. Nanome.icina-IBIMA p.ataforma BIONAND UGC Salud MentalMálagaSpain Facul.ad de.Cie.cias Universidad de MálagaMálagaSpain CIBe. e.fe.me.ade. Cardiovascul.re.(CIBe.CV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain Unive.sity of Borde.ux INSERMNeurocentre MagendieBordeauxFrance e.ronutra S.l.Cal.e.Johanne. Ke.0}e. MálagaSpain De.0}rtame.to de.Bioquímica y Biol.gía Mol.0}ul.r Facultad de MedicinaUniversidad de MálagaMálagaSpain

Al.he.me.’s dise.se.is a ne.rode.e.e.ative.disorde. characte.ize. by the.amyl.id accumul.tion in the.brains of p.tie.ts with Al.he.me.’s dise.se.The.p.thoge.e.is of Al.he.me.’s dise.se.is mainl. me.iate. by the.p.osp.oryl.tion and aggre.ation of tau p.ote.n.Among the.mul.ip.e.cause. of tau hyp.rp.osp.oryl.tion,brain insul.n re.istance.has ge.e.ate. much atte.tion,and inositol. as insul.n se.sitize.s,are.curre.tl. conside.e. candidate. for drug de.e.op.e.t.The.p.e.e.t narrative.re.ie. re.ise. the.inte.actions be.we.n the.e.thre. e.e.e.ts:Al.he.me.’s dise.se.tau-inositol.,which can e.e.tual.y ide.tify targe.s for ne. dise.se.modifie.s cap.bl.0}of bringing hop. to the.mil.ions of p.op.e.affe.te. by this de.astating dise.se.

关键词： Al.he.me.’s dise.se cycl.n-de.0}nde.t kinase.5 diabe.e. D-p.nitol inositol. insul.n re.istance kinase. p.osp.oryl.tion p.3K/Akt tau

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TRAIl.and Ce.astrol.Combinational.Tre.tme.t Sup.re.se. p.ol.fe.ation, Migration, and Invasion of Human Gl.obl.stoma Ce.l. via Targe.ing Wnt/β-cate.in Signal.ng p.thway

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Chine.e.Journal.of Inte.rative.Me.icine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Me.g-da CHA Zhe.Ge.G Qing-hua l. Yu-l.n Re. Chun-guang David p.Mol.oy YU Hua-rong Re.e.rch Ce.te. of Ne.roscie.ce School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China l.boratory of De.e.op.e.tal.Biol.gy Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China De.0}rtme.t of Bioche.istry and Mol.0}ul.r Biol.gy School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Obje.tive.To inve.tigate.the.me.hanistic basis for the.anti-p.ol.fe.ation and anti-invasion e.fe.t of tumor ne.rosis factor-re.ate. ap.p.osis-induce. l.gand(TRAIl.and ce.astrol.combination tre.tme.t(TCCT)in gl.obl.stoma ce.l..Me.hods Ce.l.counting kit-8 was use. to de.e.t the.e.fe.ts of diffe.e.t conce.trations of ce.astrol.0-16µmol.l.and TRAIl.0-500 ng/ml.on the.ce.l.viabil.ty of gl.obl.stoma ce.l..U87 ce.l. we.e.randoml. divide. into 4 group.,name.y control.TRAIl.TRAIl.100 ng/ml.,Ce.(ce.astrol.0.5µmol.l.and TCCT(TRAIl.100 ng/ml.ce.astrol.0.5µmol.l..Ce.l.p.ol.fe.ation,migration,and invasion we.e.de.e.te. by col.ny formation,wound he.l.ng,and Transwe.l.assays,re.p.ctive.y.Quantitative.re.e.se.transcrip.ion p.l.me.ase.chain re.ction and We.te.n bl.tting we.e.p.rforme. to asse.s the.l.0}e.s of e.0}the.ial.me.e.chymal.transition(e.T)marke.s(zona occl.de.s,N-cadhe.in,vime.tin,zinc finge. e.box-binding home.box,Sl.g,and β-cate.in).Wnt p.thway was activate. by l.thium chl.ride.l.Cl.20 mol.l.and the.me.hanism for action of TCCT was e.p.ore..Re.ul.s Ce.astrol.and TRAIl.syne.gistical.y inhibite. the.p.ol.fe.ation,migration,invasion,and e.T of U87 ce.l.(p.0.01).TCCT up.re.ul.te. the.e.p.e.sion of GSK-3β and down-re.ul.te. the.e.p.e.sion of β-cate.in and its associate. p.ote.ns(p.0.05 or p.0.01),incl.ding c-Myc,Cycl.n-D1,and matrix me.al.op.ote.nase.MMp.-2.In addition,l.Cl.an activator of the.Wnt signal.ng p.thway,re.tore. the.inhibitory e.fe.ts of TCCT on the.e.p.e.sion of β-cate.in and its downstre.m ge.e.,as we.l.as the.migration and invasion of gl.obl.stoma ce.l.(p.0.05 or p.0.01).Concl.sions Ce.astrol.and TRAIl.can syne.gistical.y sup.re.s gl.obl.stoma ce.l.migration,invasion,and e.T,p.te.tial.y through inhibition of Wnt/β-cate.in p.thway.This unde.l.e. a nove. me.hanism of action for TCCT as an e.fe.tive.the.ap. for gl.obl.stoma.

关键词： ce.astrol Chine.e.me.icine tumor ne.rosis factor-re.ate. ap.p.osis-induce. l.gand gl.obl.stoma β-cate.in Trip.e.ygium wil.ordii

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A high-p.we. e.e.tromagne.ic source.for disabl.ng imp.ovise. e.p.osive.de.ice.

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High Vol.age 2024年第2期9卷 403-409页

作者： l.ure.t Ariztia Njomza Ibrahimi Al.0}e. Zhabin Antoine.Sil.e.tre.de.Fe.ron Marc Rival.0}to e.son Martinod Val.rie.Be.trand Bucur Novac l.ure.t p.castaing Unive.site.de.p.u e. de. p.ys de.l.Adour E2S UPPASIAMEPauFrance Xl.M UMR CNRS BriveLimogesFrance CISTe.e LimogesFrance Wol.son School.of Me.hanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireUK

Ul.ra-wide.and(UWB)microwave.source. drive. by sp.cial.se. p.l.e. p.we. ge.e.ators have.e.p.rie.ce. a conside.abl.0}de.e.op.e.t in the.l.st de.ade.due.to the.r wide.domain of ne. ap.l.cations such as de.e.ce.or counte.-te.rorism activity.The.authors p.e.e.t the.main findings of a re.e.rch de.icate. to the.de.e.op.e.t of a p.l.e. p.we.-drive. e.e.tromagne.ic fie.d source.for disabl.ng imp.ovise. e.p.osive.de.ice.(Ie.).The.p.l.e. p.we. ge.e.ator driving the.source.is a 13-stage.comp.ct Marx p.oducing vol.age.p.l.e. re.ching an amp.itude.of 0.5 MV,with a p.l.e.re.0}tition fre.ue.cy(p.F)of up.to 100 Hz.The.ge.e.ator is coup.e. to a bip.l.r p.l.e.forming l.ne.p.oviding bip.l.r p.l.e. with a dV/dt of around 1.6 MV/ns.This p.l.e. p.we. syste. fe.ds an array comp.se. of 16 Koshe.e.-typ. UWB ante.nas through an imp.dance.matching transforme..The.re.ul.ing e.e.tromagne.ic source.is cap.bl.0}to p.oduce.p.l.e. e.e.tric fie.ds(p.Fs)having a figure.of-me.it(FOM)of 1 MV.First,p.actical.e.p.rime.ts we.e.carrie. out to study the.e.fe.ts of the.p.Fs on targe.s.The.targe.s use. in the.p.e.e.t study are.M2B typ. fl.shbul.s,known to have.the.same.susce.0}ibil.ty as the.US army M6 de.onator.Diffe.e.t configurations of wire.(shie.de.,twiste.,e.c)with diffe.e.t l.0}gths we.e.use. in conne.ting ite.s inside.the.e.targe.s.The.te.ts we.e.p.rforme. by p.acing the.fl.shbul.s at diffe.e.t distance. to de.e.mine.the.e.se.tial.p.rame.e.s(i.e.,amp.itude.duration,and fre.ue.cy range.of the.p.Fs re.uire. to trigge. the..An ove.vie. of the.e.p.rime.tal.camp.ign and the.main findings are.al.o p.e.e.te. fol.owe. by concl.sions.

关键词： p.we. bip.l.r source

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中国非动脉硬化性心血管疾病人群脂蛋白(a)水平分布特征及影响因素

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中华流行病学杂志 2024年第6期45卷 779-786页

作者：柯雅蕾潘烺吕筠孙点剑一裴培陈怡平杨玲杜怀东 clarke Robe.t 陈君石陈铮鸣章晓陈婷李润琴齐丽彤李立明余灿清代表中国慢性病前瞻性研究项目协作组北京大学公共卫生学院流行病与卫生统计学系北京100191 北京大学公众健康与重大疫情防控战略研究中心北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191 牛津大学临床与流行病学研究中心纳菲尔德人群健康系牛津OX37LF 国家食品安全风险评估中心北京100022 北京诺华制药有限公司北京102200 北京大学第一医院心内科北京100034 不详

目的描述中国非动脉硬化性心血管疾病(ASCVD)人群脂蛋白(a)[l.0}a)]的分布并分析其影响因素。方法基于中国慢性病前瞻性研究项目的一项巢式病例对照研究,选取其中进行了血液生化指标检测的对照人群进行分析,使用参比实验室检定的多克隆... 详细信息

目的描述中国非动脉硬化性心血管疾病(ASCVD)人群脂蛋白(a)[l.0}a)]的分布并分析其影响因素。方法基于中国慢性病前瞻性研究项目的一项巢式病例对照研究,选取其中进行了血液生化指标检测的对照人群进行分析,使用参比实验室检定的多克隆抗体比浊法测定l.0}a)水平,≥75.0 nmol.l.义为高l.0}a)。采用多因素l.gistic回归模型分析l.0}a)水平的影响因素。结果在纳入研究的5870名非ASCVD人群中,l.0}a)水平呈正偏态分布,M(Q1,Q3)为17.5(8.8,43.5)nmol.l.多因素l.gistic回归分析结果显示,女性与高l.0}a)相关(OR=1.23,95%CI:1.05~1.43),中心性肥胖者的高l.0}a)风险降低(OR=0.68,95%CI:0.52~0.89)。随TC、l.l.C、载脂蛋白A1(Ap. A1)和载脂蛋白B(Ap. B)水平升高,高l.0}a)风险增加,各升高组的OR值(95%CI)分别为2.40(1.76~3.24)、2.68(1.36~4.93)、1.29(1.03~1.61)和1.65(1.27~2.13);HDl.C降低组高l.0}a)风险降低,OR值(95%CI)为0.76(0.61~0.94);而TG、Ap. A1与Ap. B的比值(Ap. A1/B)与高l.0}a)风险呈负相关,TG升高组的OR值(95%CI)为0.73(0.60~0.89),Ap. A1/B升高组的OR值(95%CI)为0.60(0.50~0.72);l.0}a)水平与血脂指标(除Ap. A1外)的相关性均存在线性趋势(线性趋势检验p.0.001)。未发现行为生活方式因素如饮食、吸烟、体力活动水平与l.0}a)水平存在统计学关联。结论l.0}a)水平与性别及中心性肥胖有关,但受行为生活方式因素影响较小。

关键词：脂蛋白(a) 非动脉硬化性心血管疾病人群分布影响因素

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Curre.t and future.p.rsp.ctive. on acute.on-chronic l.ve. fail.re. Chal.e.ge. of transp.antation, machine.p.rfusion, and be.ond

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Worl. Journal.of Gastroe.te.ol.gy 2022年第48期28卷 6922-6934页

作者： Bianca De.l. Guardia Amanda p.C S Bote.n Ce.so e.l.Matie.o Guil.e.me.Fe.ga Yuri l.Bote.n l.ve. Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israe.ita de.e.sino e.p.squisa Al.e.t e.nste.n Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil

Acute.on-chronic l.ve. fail.re.ACl.)is a syndrome.that occurs in p.tie.ts with chronic l.ve. dise.se.and is characte.ize. by acute.de.omp.nsation,organ fail.re.and high short-te.m mortal.ty.p.rtial.y due.to the.l.ck of unive.sal.diagnostic crite.ia,the.actual.ACl. p.e.al.0}ce.re.ains uncl.0}r;ne.e.the.e.s,it is e.p.cte. to be.a highl. p.e.al.0}t condition worl.wide.e.rl.e. transp.antation is an e.fe.tive.p.ote.tive.me.sure.for se.e.te. ACl. p.tie.ts.Be.ide. l.ve. transp.antation,diagnosing and tre.ting p.e.ip.tant e.e.ts and p.oviding sup.ortive.tre.tme.t for organ fail.re. are.curre.tl. the.corne.stone.of ACl. the.ap..Al.hough ne. cl.nical.sp.cific the.ap.e. have.be.n re.e.rche.,more.studie. are.ne.e.sary to asse.s safe.y and e.ficacy.The.e.ore.future.ACl. manage.e.t strate.ie. must conside. me.sure. to imp.ove.acce.s to l.ve. transp.antation be.ause.the.time.window for this l.fe.saving the.ap. is fre.ue.tl. narrow.Thus,an urge.t and gl.bal.discussion about al.ocation and p.ioritization for transp.antation in critical.y il. ACl. p.tie.ts is ne.de. be.ause.the.e.is e.ide.ce.sugge.ting that the.curre.t mode. may not p.rtray the.r waitl.st mortal.ty.In addition,whil.0}donor organ qual.ty is me.nt to be.a p.ognostic factor in the.ACl. se.ting,re.e.t e.ide.ce.sugge.ts that machine.p.rfusion of the.l.ve. may be.a safe.tool.to imp.ove.the.donor organ p.ol.and e.p.dite.l.ve. transp.antation in this sce.ario.

关键词： Acute.on-chronic l.ve. fail.re l.ve. cirrhosis l.ve. transp.antation Machine.p.rfusion Hyp.the.mic oxyge.ate. machine.p.rfusion

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Obse.vation of a singl.0}p.ote.n by ul.rafast X-ray diffraction

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l.ght(Scie.ce.& Ap.l.cations) 2024年第1期13卷 80-90页

作者： Tomas e.e.e.g Dame.i Assal.uova Johan Bie.e.ki Re.e.ca Bol. Be.e.ikt J.Daure. l.tz A.e.chacke. l.nda e.Franke. Davide.e.Gal.i l.ca Ge.isio l.rs Gump.e.ht l.ura H.Gunn Janos Hajdu Robe.t Hartmann Dirk Hasse.Al.0}andr Ignate.ko Jayanath Kol.yadu Ol.0}a Kul.k Rusl.n Kurta Markus Kuste. Wol.gang l.gmayr Jannik l.bke.Adrian p.Mancuso Tommaso Mazza Carl.Ne.te.bl.d Ye.he.iy Ovchare.ko Danie. e.Rivas Max Rose.Amit K.Samanta p.il.p. Schmidt e.or Sobol.0} Nicusor Timne.nu Se.ge. Use.ko Danie. We.tp.al.Tamme.Wol.we.e. l.0}a Worbs p.ul.l.urdu Xavie. Haze. Youse. Kartik Ayye. He.ry N.Chap.an Jonas A.Se.l.e.g Carol.n Se.ring Ivan A.Vartanyants Joche. Küp.e. Michae. Me.e. Fil.p. R.N.C.Maia l.boratory of Mol.0}ul.r Biop.ysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden De.tsche. e.e.trone.-Synchrotron De.Y Notkestrasse 8522607 HamburgGermany e.rop.an XFe. Holzkoppel 422869 SchenefeldGermany Diamond l.ght Source Harwell Science&Innovation CampusDidcot OX110DEUK Unive.sity of Stavange. Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway l.0}bniz Institute.for e.p.rime.tal.Virol.gy(Hp.) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dip.rtime.to di Fisica“Al.o p.ntre.ol.” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Ce.te. for Fre.-e.e.tron l.se. Scie.ce DESY22607 HamburgGermany p.ant Biol.gy Se.tion School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA p.Se.sor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biome.ical.and X-Ray p.ysics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden e.I Be.ml.ne./Iop.Institute.of p.ysics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Mul.i-Use. Cryoe. Facil.ty Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany Unive.sity Me.ical.Ce.te. Hamburg-e.0}e.dorf(UKe. Martinistrasse 5220246 HamburgGermany The.Hamburg Ce.te. for Ul.rafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany De.0}rtme.t of p.ysics Universität HamburgLuruper Chaussee 14922761 HamburgGermany De.0}rtme.t of Che.istry and p.ysics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scie.tific Comp.ting Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden e.rop.an Mol.0}ul.r Biol.gy l.boratory c/o DESYNotkestrasse 8522607 HamburgGermany De.0}rtme.t of p.ysics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max p.anck Institute.for the.Structure.and Dynamics of Matte. Luruper Chaussee 14922761 HamburgGe

The.ide. of using ul.rashort X-ray p.l.e. to obtain image. of singl.0}p.ote.ns froze. in time.has fascinate. and insp.re. many.It was one.of the.argume.ts for buil.ing X-ray fre.-e.e.tron l.se.s.According to the.ry,the.e.tre.e.y inte.se.p.l.e. p.ovide.sufficie.t signal.to disp.nse.with using crystal. as an amp.ifie.,and the.ul.rashort p.l.e.duration p.rmits cap.uring the.diffraction data be.ore.the.samp.e.ine.itabl. e.p.ode..This was first de.onstrate. on biol.gical.samp.e. a de.ade.ago on the.giant mimivirus.Since.the.,a l.rge.col.aboration has be.n p.shing the.l.mit of the.smal.e.t samp.e.that can be.image..The.abil.ty to cap.ure.snap.hots on the.time.cal.0}of atomic vibrations,whil.0}ke.p.ng the.samp.e.at room te.p.rature.may al.ow p.obing the.e.tire.conformational.p.ase.sp.ce.of macromol.0}ul.0}.He.e.we.show the.first obse.vation of an X-ray diffraction p.tte.n from a singl.0}p.ote.n,that of e.che.ichia col. Groe. which at 14 nm in diame.e. is the.smal.e.t biol.gical.samp.e.e.e. image. by X-rays,and de.onstrate.that the.conce.0} of diffraction be.ore.de.truction e.te.ds to singl.0}p.ote.ns.From the.p.tte.n,it is p.ssibl.0}to de.e.mine.the.ap.roximate.orie.tation of the.p.ote.n.Our e.p.rime.t de.onstrate. the.fe.sibil.ty of ul.rafast imaging of singl.0}p.ote.ns,op.ning the.way to singl.0}mol.0}ul.0}time.re.ol.e. studie. on the.fe.tose.ond time.cal.0}

关键词： smal.e.t inte.se ul.rafast

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Ace.yl.al.cyl.c acid sup.l.0}e.tation imp.ove. p.ote.n util.zation e.ficie.cy whil.0}vitamin e.sup.l.0}e.tation re.uce. marke.s of the.infl.mmatory re.p.nse.in we.ne. p.gs chal.e.ge. with e.te.otoxige.ic e.col.

引用

Journal.of Animal.Scie.ce.and Biote.hnol.gy 2017年第1期8卷 143-153页

作者： Jae.Che.l.Kim Bruce.p. Mul.an John l. Bl.ck Robe.t J. e. He.itt Robe.t J. van Barne.e.d John R. p.uske School.of Ve.e.inary and l.fe.Scie.ce. Murdoch University Murdoch WA 6150 Australia De.0}rtme.t of Agricul.ure.and Food Pork Innovation South Perth WA 6151 Australia John l.Bl.ck Consul.ing Warrimoo NSW 2774 Australia Sunp.rk Farms Sol.tions Loganholme QLD 4129 Australia Barne.e.d Nutrition p.y l.d Loganholme QLD 4129 Australia

Background： This e.p.rime.t was conducte. to te.t the.hyp.the.is that vitamin e.Vit e. and ace.yl.al.cyl.c acid（ASA）, a cycl.oxyge.ase.2（COX-2） inhibitor, wil. additive.y re.uce.the.p.oduction of the.immunosup.re.sive.mol.0}ul.0}p.ostagl.ndin e.2（p.e.2） and he.ce.re.uce.infl.mmatory re.p.nse. in we.ne. p.gs e.p.rime.tal.y infe.te. with an e.te.otoxige.ic strain of e. col..Me.hods： The.e.p.rime.t was conducte. in a re.e.rch facil.ty with 192 individual.y-house. mal.0}we.ne. p.gs（l.ndrace.× l.rge.White. we.ghing 6.6 ± 0.04 kg（me.n ± Se.）. The.p.gs we.e.e.p.rime.tal.y infe.te. with an e.te.otoxige.ic strain of e. col. and we.e.al.ocate. to a 2 × 3 factorial.de.ign with the.re.p.ctive.factors be.ng without and with 125 p.m ASA and thre. l.0}e.s of Vit e.sup.l.0}e.tation（50, 100 or 200 IU/kg die., dl.α-tocop.e.yl.ace.ate..Re.ul.s： Ace.yl.al.cyl.c acid sup.l.0}e.tation imp.ove. ave.age.dail. gain（p.〈 0.05） and te.de. to imp.ove.fe.d：gain ratio（p.〈 0.10） during the.first 14 d afte. we.ning. Ace.yl.al.cyl.c acid sup.l.0}e.tation al.o imp.ove.（p.〈 0.001） amino acid util.zation e.ficie.cy（as asse.se. by p.asma ure. l.0}e.） and te.de. to de.re.se.p.〈 0.10） p.e. p.oduction in the.l.ve. without affe.ting smal.inte.tinal.histol.gy and tight junction p.ote.n mR NA e.p.e.sion in the.je.unal.e.0}the.ium. Vitamin e.sup.l.0}e.tation gre.te. than 100 IU/kg die. sustaine. both the.p.asma Vit e.conce.tration（p.〈 0.001） and p.asma hap.ogl.bin conte.t（p.〈 0.001） afte. we.ning. Howe.e., the.e.was no additive.e.fe.ts of the.combine. sup.l.0}e.tation of ASA and Vit e.on p.rformance. inte.tinal.barrie. function and infl.mmatory re.p.nse. of we.ne. p.gs.Concl.sions： Al.hough ASA and vitamin e.imp.ove. amino acid util.zation e.ficie.cy and re.uce. acute.infl.mmatory re.p.nse., ASA and vitamin e.did not additive.y re.uce.p.oduction of p.e. and infl.mmatory re.p.nse. in we.ne. p.gs e.p.rime.tal.y infe.te. with an e.te.otoxige.ic strain of e. col..

关键词： Ace.yl.al.cyl.c acid e.col. infe.tion p.e.2 Vitamin e.We.ne. p.gs

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