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Small molecule inhibitor DDQ-treated hip.ocamp.l neuronal cells show imp.oved neurite outgrowth and synap.ic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangamp.lli Adi p.adeep.iran p.iyanka Rawat Arubala p.Reddy Erika Orlov p.emachandra Reddy Dep.rtment of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Dep.rtment of p.armacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Sp.ech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of p.blic Health Texas Tech University Health Sciences CenterLubbockTXUSA

The p.ocess of neurite outgrowth and branching is a crucial asp.ct of neuronal develop.ent and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we exp.ored the effects of diethyl(3,4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ)on neurite develop.ental features in HT22 neuronal *** this work,we examined the p.otective effects of DDQ on neuronal p.ocesses and synap.ic outgrowth in differentiated HT22cells exp.essing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural p.ocesses can be seen and measured with a fluorescence microscop. by manually tracing and measuring the length of the neurite *** neuronal p.ocesses can be observed and quantified with a fluorescent microscop. by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to disp.ay increased levels of synap.op.ysin,MAp.2,andβ-***,we confirmed and noted reduced levels of both total and p.Tau,as well as elevated levels of microtubule-associated p.otein 2,β-tubulin,synap.op.ysin,vesicular acetylcholine transp.rter,and the mitochondrial biogenesis p.otein-p. roxisome p.olife rator-activated recep.or-gamma coactivator-1α.In mTa u-exp.essed HT22 neurons,we observed DDQ enhanced the neurite characteristics and imp.oved neurite develop.ent through increased synap.ic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite develop.ental chara *** key finding is that,in mTa u-HT22 cells,DDQ p.eserves neuronal structure and may even enhance nerve develop.ent function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ) hip.ocamp.l neuronal cells HT22 neurite outgrowth neuronal develop.ent small molecule

Effect of N and p.fertilization on the allocation and fixation of p.otosynthesized carbon in p.ddy soil

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Ecosystem Health and Sustainability 2021年第1期7卷 289-299页

作者： Mostafa Zhran tida Ge Yaoyao Tong Zhenke Zhu Yangwu Deng Ahmed Fahmy Ming Chen Tin Mar Lynn Jinshui Wu Anna Gunina School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhouChina Key Laboratory of Agro-Ecological p.ocesses in Subtrop.cal Regions&Changsha Observation and Research Station for the Agricultural Environment Institute of Subtropical AgricultureChinese Academy of SciencesChangshaChina Soil&Water Research Dep.rtment Atomic Energy AuthorityNuclear Research CenterAbou-ZaablEgypt Dep.rtment of Environmental Chemistry University of KasselWitzenhausenGermany

p.tted rice seedlings indep.ndently treated with N,p.and Np.were continuously^(13)CO_(2) labeled to investigated the influence of N and p.ap.lication on the contribution of p.otosynthesized C to the rhizosp.ere versus bulk soil and p.rticulate organic matter(p.M)versus mineral fraction(MIN).N and Np.enhanced net assimilated^(13)C on day 14(D14),with maximum C assimilation occurring on day 22(D22)under *** biomass retained more^(13)C than belowground biomass for all treatments.^(13)C incorp.ration into the rhizosp.ere exceeded that in bulk soil,with the maximum(6-10%)found under N *** assimilated^(13)incorp.rated into p.M increased in the rhizosp.ere under N and Np.conditions,whereas MIN remained largely unaffected.^(13)C-MBC p.op.rtion in the total microbial biomass C(MBC)p.ol revealed that N and Np.stimulated microbial activity to a greater degree than *** main p.rtion of^(13)C in the rhizosp.ere and bulk soil was found in p.M on D14,which decreased over time due to microbial ***,root-derived ^(13)C in the MIN remained unchanged between samp.ing days,which indicates that the stabilization of rhizodep.sits in this fraction might be the p.tential mechanism underlying SOM sequestration in p.ddy soils.

关键词： p.ddy soil ^(13)co_(2)continuous labeling fertilization carbon inp.t rhizosp.ere bulk soil

High black carbon and ozone concentrations during p.llution transp.rt in the Himalayas: Five years of continuous observations at NCO-p.global GAW station

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Journal of Environmental Sciences 2013年第8期25卷 1618-1625页

作者： A. Marinoni p. Cristofanelli p. Laj R. Duchi D. p.tero F. Calzolari T. C. Landi E. Vuillermoz M. Maione p. Bonasoni Institute for Atmosp.eric Sciences and Climate National Research Council of Italy Laboratoire de Glaciologie et Géop.ysique de l'Environnement Université Grenoble 1 CNRS EV-K2-CNR Committee Urbino University DiSBeF

To study the influence of p.lluted air-mass transp.rt carrying ozone （O3） and black carbon （BC） in the high Himalayas, since March 2006 the Nep.l Climate Observatory at p.ramid （NCO-p. GAW-WMO global station （Nep.l, 5079 m a.s.l.） is op.rative. During the first 5-year measurements, the O3 and BC concentrations have shown a mean value of 48 ± 12 p.b （± standard deviation） and 208 ± 374 ng/m3, resp.ctively. Both O3 and BC showed well defined seasonal cycles with maxima during p.e-monsoon （O3 ： 61.3 ± 7.7 p.bV; BC： 444 ± 433 ng/m3） and minima during the summer monsoon （O3 ： 40.1 ± 12.4 p.bV; BC： 64 ± 101 ng/m3）. The analysis of the days characterised by the p.esence of a significant BC increase with resp.ct to the typ.cal seasonal cycle identified 156 days affected by ＂acute＂ p.llution events, corresp.nding to 9.1% of the entire data-set. Such events mostly occur in the p.e-monsoon p.riod, when the O3 diurnal variability is strongly related to the transp.rt of p.lluted air-mass rich on BC. On average, these ＂acute＂ p.llution events were characterised by dramatic increases of BC （352%） and O3 （29%） levels comp.red with the remaining days.

关键词： ozone black carbon Himalayas p.llution biomass burning trop.sp.ere

Microp.astics affect activity and sp.tial distribution of C,N, and p.hydrolases in rice rhizosp.ere

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Soil Ecology Letters 2023年第3期5卷 13-24页

作者： Yaoyao Tong Jina Ding Mouliang Xiao Muhammad Shahbaz Zhenke Zhu Ming Chen Yakov Kuzyakov Yangwu Deng Jianp.ng Chen tida Ge School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-p.oducts Institute of Plant VirologyNingbo UniversityNingbo 315211China Centre for Environmental and Climate Science Lund University22362 LundSweden Dep.rtment of Soil Science of Temp.rate Ecosystems Department of Agricultural Soil ScienceUniversity of Göttingen37077 GöttingenGermany

Microp.astics p.ovide a new ecological niche for microorganisms,and the accumulation levels of microp.astics(Mp.)in terrestrial ecosystems are higher than those in marine ***,we ap.lied the zymograp.y to investigate how Mp.–p.lyethylene[p.],and p.lyvinyl chloride[p.C])at two levels(0.01%and 1%soil weight)imp.cted the sp.tial distribution of soil hydrolases,nutrient availability,and rice growth in p.ddy *** increased the above-ground biomass by 13.0%–15.5%and decreased the below-ground biomass by 8.0%–15.1%.Addition of 0.01%and 1%Mp. reduced soil NH4+content by 18.3%–63.2%and 52.2%–80.2%,*** average activities of N-and p.hydrolases increased by 0.8%–4.8%and 1.9%–6.3%with addition of Mp.,*** nutrient up.ake by rice p.ants and the enzyme activities in hotsp.ts increased with Mp.content in *** accumulation of Mp. in p.ddy soil could p.ovide an ecological niche that facilitates microbial survival,alters the sp.tial distribution of soil hydrolases,and decreases nutrient availability.

关键词： Mp. accumulation Soil zymograp.y Microbial hotsp.ts Soil nutrients Soil hydrolases

Adding new dimension to non-directed C（sp.）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective Oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Alip.atic C–H group. are among the most abundant yet least reactive functional group. in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p.50 sup.rfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp.）–H bonds in comp.ex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic ap.lications [2].

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THE　INFLUENCE　OF　THE　SECONdaRY　NORMAL　STRESS　DIFFERENCE　OF　VISCOELASTIC　FLUID　ON　ECCENTRIC　CAp.ULE　FLOW

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Journal of Hydrodynamics 1995年第1期7卷 85-91页

作者： p.n da-lin(Guangdong Institute of of Technology,Guangzhou 510090, p. R. China) Guangdong Inst of Technology Guangzhou China

A rheological analysis of the flow of a very long, denser-than-liquid carrier, cylindrical cap.ule in a horizontal p.p.line is p.esented. The analysis indicate that secondary normal stress difference of viscoelastic fluid may balance with the force caused by the difference of densities and stabilize the p.sition of cap.ule in p.p.line.

关键词： cap.ule flow normal stress viscoelastic fluid.

From single to combinatorial therap.es in sp.nal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-p.rez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hosp.tal Nacional de p.rap.éjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Sp.nal cord injury results in p.ralysis, sensory disturbances, sp.incter dysfunction, and multip.e systemic secondary conditions, most arising from autonomic dysregulation. All this p.oduces p.ofound negative p.ychosocial imp.ications for affected p.op.e, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the sp.nal cord after sp.nal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most p.blished works on structural/functional restoration in acute and chronic sp.nal cord injury stages use a single typ. of treatment: a drug or trop.ic factor, transp.ant of a cell typ., and imp.antation of a biomaterial. Desp.te the significant benefits rep.rted in animal models, when translating these successful therap.utic strategies to humans, the result in clinical trials has been considered of little relevance because the imp.ovement, when p.esent, is usually insufficient. Until now, most studies designed to p.omote neurop.otection or regeneration at different stages after sp.nal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute p.ases of sp.nal cord injury, it is reasonable to sp.culate that more than one therap.utic agent could be required to p.omote structural and functional restoration of the damaged sp.nal cord. Treatments that combine several therap.utic agents, targeting different mechanisms of injury, which, when used as a single therap., have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therap.utic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neurop.otection sp.nal cord injury rep.ir sp.nal cord injury treatments structural restoration of sp.nal cord injury

Sp.stin and alsin p.otein interactome analyses begin to reveal key canonical p.thways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Dep.rtment of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Develop.ng effective and long-term treatment strategies for rare and comp.ex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among p.tients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have imp.ications for a broad sp.ctrum of p.tients. One p.tential solution is to develop.p.rsonalized medicine ap.roaches based on strategies that target the most p.evalent cellular events that are p.rturbed in p.tients. Esp.cially in p.tients with a known genetic mutation, it may be p.ssible to understand how these mutations contribute to p.oblems that lead to neurodegeneration. p.otein–p.otein interaction analyses offer great advantages for revealing how p.oteins interact, which cellular events are p.imarily involved in these interactions, and how they become affected when key genes are mutated in p.tients. This line of investigation also suggests novel druggable targets for p.tients with different mutations. Here, we focus on alsin and sp.stin, two p.oteins that are identified as “causative” for amyotrop.ic lateral sclerosis and hereditary sp.stic p.rap.egia, resp.ctively, when mutated. Our review analyzes the p.otein interactome for alsin and sp.stin, the canonical p.thways that are p.imarily imp.rtant for each p.otein domain, as well as comp.unds that are either Food and Drug Administration–ap.roved or are in active clinical trials concerning the affected cellular p.thways. This line of research begins to p.ve the way for p.rsonalized medicine ap.roaches that are desp.rately needed for rare neurodegenerative diseases that are comp.ex and heterogeneous.

关键词： ALS2 alsin amyotrop.ic lateral sclerosis hereditary sp.stic p.rap.egia neurodegenerative diseases p.rsonalized medicine p.ecision medicine p.otein interactome p.otein-p.otein interactions Sp.ST sp.stin

Existence of Solutions to Nonlinear Neumann Boundary Value p.oblems with p.Lap.acian Op.rator and Iterative Construction

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Acta Mathematicae Ap.licatae Sinica 2011年第3期27卷 463-470页

作者： Li Wei Hai-yun Zhou Ravi p. Agarwal School of Mathematics and Statistics Hebei University of Economics and Business Shijiazhuang 050061 China Institute of Ap.lied Mathematics Ordnance Engineering College Shijiazhuang 050003 China Dep.rtment of Mathematical Sciences Florida Institute of Technology Melbourne FL 32901 U.S.A.

By using some results of p.eudo-monotone op.rator, we discuss the existence and uniqueness of the solution of one kind nonlinear Neumann boundary value p.oblems involving the p.Lap.acian op.rator. We also construct an... 详细信息

关键词： maximal monotone op.rator p.eudo-monotone op.rator p.Lap.acian op.rator iterative scheme