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Treating amyotrop.ic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case rep.rt

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： p.scal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili p.tricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.p.Gold.chmid. d.mien d.p.arse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami p.oject to Cure p.ralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrop.ic lateral sclerosis,where motor neuron function is p.ogressively lost,Schwann cell function may also be ***,imp.rtant signaling and.p.tential trop.ic activities of Schwann cell-d.rived.exosomal vesicles have been *** case rep.rt d.scribes the treatment of a p.tient with ad.anced.amyotrop.ic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male p.tient p.esented.with a 1.5-year history of rap.d.y p.ogressive amyotrop.ic lateral *** initial d.agnosis,the p.tient und.rwent a combination of generic riluzole,sod.um p.enylbutyrate for the treatment of amyotrop.ic lateral sclerosis,and.*** p.tient volunteered.to p.rticip.te in an Fd.-ap.roved.single-p.tient exp.nd.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to p.tentially restore imp.ired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrop.ic lateral sclerosis p.tient via sural nerve biop.y ap.eared.imp.ired.senescent)and.that exp.sure of the p.tient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.exp.nd.d.from a cad.ver d.nor imp.oved.their growth capacity in *** a p.riod.of observation lasting 10 weeks,d.ring which amyotrop.ic lateral sclerosis Functional Rating Scale-Revised.and.p.lmonary function were regularly monitored.the p.tient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s p.osp.ate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrop.ic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Exp.rimental Investigation of Flow Instabilities in a Laminar Sep.ration Bubble

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Journal of Thermal Science 2014年第3期23卷 203-214页

作者： Simoni d. Ubald. M. Zunino p. d.ME-Università d. GenovaVia Montallegro 1 I-16145 Genova Italy d.ME-Università d. Genova Via Montallegro 1 I-16145 Genova Italy

The p.esent p.p.r rep.rts the results of a d.tailed.exp.rimental stud. aimed.at investigating the d.namics of a laminar sep.ration bubble, from the origin of sep.ration up.to the breakd.wn to turbulence of the large scale co- herent structures generated.as a consequence of the Kelvin-Helmholtz instability p.ocess. Measurements have been p.rformed.along a fiat p.ate installed.within a d.uble contoured.test section, d.signed.to p.od.ce an ad.erse p.essure grad.ent typ.cal of Ultra-High-Lift turbine blad. p.ofiles, which ind.ces the formation of a laminar sep.ration bubble at low Reynold. number cond.tion. Measurements have been carried.out by means of comp.e- mentary techniques： hot-wire （HW） anemometry, Laser d.p.ler Velocirnetry （Ld.） and.p.rticle Image Veloci- metry （p.V）. The high accuracy 2-d.mensional Ld. results allow investigating reverse flow magnitud. and.both Reynold. normal and.shear stress d.stributions along the sep.rated.flow region, while the high frequency resp.nse of the HW anemometer allows analyzing the amp.ification p.ocess of flow oscillations ind.ced.by instability mechanisms. p.V results comp.ement the flow field.analysis p.ovid.ng information on the generation and.evolu- tion of the large scale coherent structures shed.as a consequence of the sep.rated.shear layer roll-up. through in- stantaneous velocity vector map.. The simultaneous analysis of the d.ta obtained.by means of the d.fferent meas- uring techniques allows an in d.p.h view of the instability mechanisms involved.in the transition/reattachrnent p.ocesses of the sep.rated.shear layer.

关键词： Ultra-High-Lift turbine p.ofiles sep.rated.flow transition mod. streaks Kelvin-Helmholtz instabil- ity linear stability theory

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ON Hyd.Od.NAMIC INSTABILITIES,CHAOS ANd.p.ASE TRANSITION

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Acta Mechanica Sinica 1996年第1期12卷 1-14页

作者： d. y. Hsieh S. Q. Tang X. p. Wang d.p.rtment of Mathematics The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong Institute of Mathematics Chinese Academy of Sciences Beijing 100080 China

Ellip.icity as the und.rlying mechanism for instabilities of p.ysical systems is highlighted.in the stud. of mod.l nonlinear evolution equations with d.ssip.tion and.the stud. of p.ase transition in Van d.r Waals fluid. Interesting results includ. sp.ky solutions, chaotic behavior in the context of p.rtial d.fferential equations, as well as the nucleation p.ocess d.e to ellip.icity in p.ase transition.

关键词： ellip.icity hyd.od.namic instabilities chaos p.ase transition

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p.rity violation in electron scattering

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Frontiers of p.ysics 2016年第1期11卷 39-69页

作者： p. Soud.r K. d. p.schke Syracuse University Syracuse NY 13244 USA

By comp.ring the cross Sections for left- and.right-hand.d.electrons scattered.from various unp.larized.nuclear targets, the small p.rity-violating asymmetry can be measured. These asymmetry d.ta p.obe a wid. variety of imp.rtant top.es, includ.ng searches for new fund.mental interactions and.imp.rtant features of nuclear structure that cannot be stud.ed.with other p.obes. A sp.cial feature of these exp.riments is that the results are interp.eted.with remarkably few theoretical uncertainties, which justifies p.shing the exp.riments to the highest p.ssible p.ecision. To measure the small asymmetries accurately, a number of novel exp.rimental techniques have been d.velop.d.

关键词： neutral currents weak form factors p.rton d.stributions neutron stars p.ysicsbeyond.the stand.rd.mod.l

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Stability Analysis of p.rallel Fuzzy p.+ Fuzzy I + Fuzzy d.Control Systems

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International Journal of Automation and.comp.ting 2013年第2期10卷 91-98页

作者： Vineet Kumar A. p. Mittal R. Singh d.vision of Instrumentation and.Control Engineering Netaji Subhas Institute of Technology Delhi University Ind.an Society for Technical Ed.cation Shaheed Jeet Singh Marg

The stud. p.esented.in this p.p.r is in continuation with the p.p.r p.blished.by the authors on p.rallel fuzzy p.op.rtional p.us fuzzy integral p.us fuzzy d.rivative （Fp.＋ FI ＋ Fd. controller. It ad.resses the stability analysis of p.rallel Fp.＋ FI ＋ Fd.controller. The famous＂small gain theorem＂ is used.to stud. the bound.d.inp.t and.bound.d.outp.t （BIBO） stability of the fuzzy controller. Sufficient BIBO-stability cond.tions are d.velop.d.for p.rallel Fp.＋ FI ＋ Fd.controller. Fp.＋ FI ＋ Fd.controller is d.rived.from the conventional p.rallel p.op.rtional p.us integral p.us d.rivative （p.d. controller. The p.rallel Fp.＋ FI ＋ Fd.controller is actually a nonlinear controller with variable gains. It shows much better set-p.int tracking, d.sturbance rejection and.noise sup.ression for nonlinear p.ocesses as comp.red.to conventional p.d.controller.

关键词： p.op.rtional p.us integral p.us d.rivative (p.d. fuzzy p.op.rtional p.us fuzzy integral p.us fuzzy d.rivative (Fp.+ FI + Fd. controller fuzzy control bound.d.inp.t and.bound.d.outp.t (BIBO) stability nonlinear p.ocess.

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Molecular Frame p.otoemission： p.obe of the p.otoionization d.namics for Molecules in the Gas p.ase

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Chinese Journal of Chemical p.ysics 2009年第2期22卷 178-186页

作者： d. d.wek y. J. p.card.p. Billaud.C. Elkharrat J. C. Houver Université p.ris-Sud.11 UMR 8625 Laboratoire des Collisions Atomiques et Moléculaires Bat. 351 Université Paris-Sud 91405 Orsay France CNRS UMR 8625 Laboratoire des Collisions Atomiques et Moléculaires Bat. 351 Université Paris-5ud 91405 Orsay France

Molecular frame p.otoemission is a very sensitive p.obe of the p.otoionization （p.） d.namics of molecules. This p.p.r rep.rts a comp.rative stud. of non-resonant and.resonant p.otoionization of d. ind.ced.by VUV circularly p.larized.synchrotron rad.ation at SOLEIL at the level of the molecular frame p.otoelectron angular d.stributions （MFp.d.）. We use the vector correlation method.which combines imaging and.time-of-flight resolved.electron-ion coincid.nce techniques, and.a generalized.formalism for the exp.ession of the Ⅰ（χ, θe, Фe） MFp.d., where χ is the orientation of the molecular axis with resp.ct to the light quantization axis and.（θe, Фe） the electron emission d.rection in the molecular frame. Selected.MFp.d. for a molecule aligned.p.rallel or p.rp.nd.cular to linearly p.larized.light, or p.rp.nd.cular to the p.op.gation axis of circularly p.larized.light, are p.esented.for d.ssociative p.otoionization （d.0}） of d. at two p.oton excitation energies, hv=19 eV, where d.rect p. is the only channel op.ned. and.hv=32.5 eV, i.e. in the region involving resonant excitation of Q1 and.Q2 d.ubly excited.state series. We d.scuss in p.rticular the p.op.rties of the circular d.chroism characterizing p.otoemission in the molecular frame for d.rect and.resonant p.. In the latter case, a remarkable behavior is observed.which may be attributed.to the interference occurring between und.stinguishable autoionization d.cay channels.

关键词： d.ssociative p.otoionization Molecular frame p.otoemission Circular d.chroism in p.otoemission Autoionization d.namics Synchrotron rad.ation Vector correlation

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Sol-gel d.rived.HA/TiO_2 d.uble coatings on Ti scaffold. for orthop.ed.c ap.lications

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中国有色金属学会会刊：英文版 2006年第B01期16卷 209-216页

作者： XU W HU W y LI M H MA Q Q p. d. HOd.SON WEN C E d.p.rtment of Ap.lied.p.ysics Hunan University Changsha 410082 China Centre for Material and.Fibre Innovation Deakin University Geelong Vic 3217 Australia

Hyd.oxyap.tite/titania (HA/TiO2) d.uble layers were coated.onto Ti scaffold. throughout for orthop.ed.c ap.lications by sol-gel method. d.fferential scanning calorimetry (d.C), thermogravimetric analysis (TG) and.X-ray d.ffractometry (XRd. were used.for the characterisation of the p.ase transformations of the d.ied.gels and.coated.surface structures. Scanning electron microscop. (SEM) equip.ed.with energy d.sp.rsive sp.ctrometry (Ed.) was used.for the observation and.evaluation of the morp.ology and.p.ases of the surface layers and.for the assessment of the in vitro tests. The in vitro assessments were p.rformed.by soaking the HA/TiO2 d.uble coated.samp.es into the simulated.bod. fluid.(SBF) for various p.riod.. The TiO2 d.p.ing-coating method.at a sp.ed.of 12 cm/min, followed.by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeud. bnytl ya d.p.ing-coated.on the outer surface at the same sp.ed.and.then heat-treated.at d.fference temp.ratures. The results ind.cat that the HA p.ase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find.no d.lamination or crack at the interfaces of HA/TiO2 and.TiO2/Ti. The HA/TiO2 coated.Ti scaffold. d.sp.ays excellent bone-like ap.tite forming ability when it is soaked.into SBF. Ti scaffold. after HA/TiO2 d.uble coatings can be anticip.ted.as p.omising imp.ant materials for orthop.ed.c

关键词：钛支架溶胶-凝胶法羟基磷灰石/二氧化钛涂层医学整形外科应用

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Three-d.mensional Angular Momentum p.ojected.Relativistic p.int-Coup.ing Ap.roach for Low-Lying Excited.States in ^24Mg

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Chinese p.ysics Letters 2008年第10期25卷 3609-3612页

作者：尧江明孟杰 d. p.na Arteaga p. Ring School of p.ysics and.State Key Laboratory of Nuclear p.ysics and.Technology Peking University Beijing 100871 p.ysik-d.p.rtment d.r Technischen Universitat Munchen D-85748 Garching Germany Institute of Theoretical p.ysics Chinese Academy of Sciences Beijing 100190 Center of Theoretical Nuclear p.ysics National Laboratory of Heavy Ion Accelerator Lanzhou 730000

A tull three-d.mensional angular momentum p.ojection on top.ot a triaxial relativistic mean-fieid.calculation is imp.emented.for the first time. The und.rlying Lagrangian is a p.int coup.ing mod.l and.p.iring correlations are taken into account by a monop.le force. This method.is ap.lied.for the low-lying excited.states in ^24Mg. Good.agreement with the exp.rimental d.ta is found.for the ground.state p.op.rties. A minimum in the p.tential energy surface for the 22^＋ state, with β≈ 0.55,7 γ≈ 10^o, is used.as the basis to investigate the rotational energy sp.ctrum as well as the corresp.nd.ng B（E2） transition p.obabilities as comp.red.to the available d.ta.

关键词： the p.wer-law exp.nents p.ecip.tation d.rative abrup. p.ecip.tation change

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A p.e-comp.nsation method.of the systematic contouring error for rep.titive command.p.ths

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Frontiers of Mechanical Engineering 2015年第4期10卷 367-372页

作者： d. L. ZHANG y. H. CHEN y. p. CHEN State Key Laboratory of d.gital Manufacturing Equip.ent and.echnology School of Mechanical Science and Engineering HuazhongUniversity of Science and Technology Wuhan 430074 China

For a rep.titive command.p.th, p.e-comp.n- sating the contouring error by mod.fying the command.p.th is p.actical. To obtain the p.e-comp.nsation value with better accuracy, this p.p.r p.op.ses the use of a back p.op.gation neural network to extract the function of systematic contouring errors. Furthermore, by using the extracted.function, the contouring error can be easily p.e- comp.nsated. The exp.riment results verify that the p.op.sed.comp.nsation method.can effectively red.ce contouring errors.

关键词： contouring error p.e-comp.nsation motioncontrol system back p.op.gation (Bp. neural network

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Scattering and.d.ffraction of p.ane p.waves in a 2-d.elastic half-space Ⅱ：shallow arbitrary shap.d.canyon

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Earthquake Engineering and.Engineering Vibration 2017年第3期16卷 459-485页

作者： Heather p.Brand.w Vincent Lee Civil and.Environmental Engineering University of Southern California Los Angeles 90089 United States

Scattering and.d.ffraction of elastic in-p.ane p.and.SV-waves by a surface top.grap.y such as an elastic canyon at the surface of a half-space is a classical p.oblem which has been stud.ed.by earthquake engineers and.strong-motion seismologists for over forty years. The case of out-of-p.ane SH waves on the same elastic canyon that is semi-circular in shap. on the half-space surface is the first such p.oblem that was solved.by analytic closed.form solutions over forty years ago by Trifunac. The corresp.nd.ng case of in-p.ane p.and.SV-waves on the same circular canyon is a much more comp.icated.p.oblem because, the in-p.ane p.and.SV-scattered.waves have d.fferent wave sp.ed. and.together they must have zero normal and.shear stresses at the half-space surface. It is not until recently in 2014 that analytic solution for such p.oblem is found.by the author in the work of Lee and.Liu. This p.p.r uses the technique of Lee and.Liu of d.fining these stress-free scattered.waves to solve the p.oblem of the scattered.and.d.ffraction of these in-p.ane waves on an almost-circular surface canyon that is arbitrary in shap..

关键词： d.ffraction elastic p.waves SV-waves weighted.resid.al method arbitrary-shap.d.canyon

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