检索结果-南通市图书馆

西南民族大学学报（自然科学版） 2003年第6期29卷 674-675页

作者：舒元梯乐山师范学院环境与生命科学系乐山614000

基于元素的p.uling电负性、原子成σ键的电子数，原子直接键连的氢原子数目和原子未参与形成离域π键的孤时电子对对数，建立了一种分子拓扑指教(^4x)，它与21种取代酚酸性p.α线性方程为：11．5258-20．4052^4x=p.α。结果表明，^4x具... 详细信息

基于元素的p.uling电负性、原子成σ键的电子数，原子直接键连的氢原子数目和原子未参与形成离域π键的孤时电子对对数，建立了一种分子拓扑指教(^4x)，它与21种取代酚酸性p.α线性方程为：11．5258-20．4052^4x=p.α。结果表明，^4x具有良好的结构选择性和性质相关性，可用于预测其它取代酚酸性p.α值。

关键词：取代酚分子拓扑指数 p.uling电负性 p.a值计算化学分子结构

Role of AXL in invas.on and drug res.s.anc. of c.lon and breas. c.nc.r c.lls.and its.as.oc.ation with p.3 alterations

在线全文

学校读者我要写书评

暂无评论

World Journal of Gas.roenterology 2017年第19期23卷 3440-3448页

作者： Wael M Abdel-Rahman Noura A Al-khayyal Vidhya A Nair s.R Aravind Maha s.ber-Ayad Dep.rtment of Medic.l Laboratory s.1}enc.s College of Health Sciences and Sharjah Institute for Medical ResearchUniversity of Sharjah c.llege of Medic.ne and s.arjah Ins.itute for Medic.l Res.arc. University of Sharjah Environment and c.nc.r Res.arc. Group Sharjah Institute for Medical ResearchUniversity of Sharjah Dep.rtment of Bas.c.Medic.l s.1}enc.s College of Medicineand Sharjah Institute for medical ResearchUniversity of SharjahSharjah c.iro Univers.ty

To c.arac.erize AXL rec.p.or tyros.ne kinas. (AXL) exp.es.ion in relations.ip.to tumor p.otein p.3 (Tp.3 gene, p.3 p.otein) and its.role in tumor invas.on and res.3}ns. to *** us.d 14 c.ll lines. inc.uding 3 is.genic.p.irs.c.rrying mutant/knoc.out p.3, to gain ins.ght into the relations.ip.between AXL and Tp.3. Thes. inc.uded Hc.116, Hc.116.p.3 mutant, RKO, and RKO.p.3s.p.-/-s.p. lines.(all from c.lon c.nc.rs. as.well as.breas. c.nc.r c.ll lines.Mc.7 and 1001 (Mc.7-p.3 mutant c.one). HeLa c.ll line was.us.d as.a p.s.tive c.ntrol for ep.thelial to mes.nc.ymal trans.tion (EMT). AXL exp.es.ion was.determined by Wes.ern blotting us.ng rabbit monoc.onal antibody c.one c.9E7. AXL s.RNA s.lenc.ng was.p.rformed and followed by c.llagen invas.on as.ay. c.ll viability analys.s.us.ng the s.lforhodamine B as.ay and the invas.on as.ay were p.rformed after exp.s.re to c.emotherap.utic.agents.(doxorubic.n for breas. c.nc.r c.lls. 5FU or irinotec.n for c.lon c.nc.r c.lls..REs.LTs.e s.owed that the introduc.ion of p.3 mutations.or knoc.out inc.eas.d exp.es.ion levels.of AXL in is.genic.c.lls.c.mp.red to the matc.ing p.3 wild-typ. p.rental c.lls. Overall, we found a trend for c.rrelation between the p.tential EMT c.ndidate AXL, p.3 alterations. and EMT markers.in c.lorec.al and breas. c.nc.rs. The exp.es.ion of AXL in RKO c.lls. a rare c.lon c.nc.r c.ll line with inac.ive Wnt s.gnaling, s.gges.s.that the AXL onc.gene might p.ovide an alternative genetic.p.thway for c.lorec.al c.rc.nogenes.s.in the abs.nc. of Wnt s.gnaling ac.ivation and Tp.3 mutation. AXL s.lenc.ng in the Tp.3 mutant is.genic.c.ll lines.1001, Hc.116.p.3 mutant and RKO.p.3s.p.-/-s.p. was.> 95% effic.ent and the s.lenc.d c.lls.were les. invas.ve c.mp.red to the p.rental Tp.3 wild-typ. c.lls. AXL s.lenc.ng s.owed a s.btle trend to res.ore c.lon c.nc.r c.ll s.ns.tivity to 5FU or irinotec.n. Imp.rtantly, AXL exp.es.ing c.lls.develop.d more invas.ve p.tential after exp.s.re to c.emotherap. c.mp.red to th

关键词： AXL Breas. c.nc.r c.emotherap. c.lon c.nc.r Invas.on

Extreme brightnes. las.r-bas.d neutron p.ls.s.as.a p.thway for inves.igating nuc.eos.nthes.s.in the laboratory

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2019年第5期4卷 7-16页

作者： s.N.c.en F.Negoita K.s.1}hr E.d’Humieres.I.p.merantz J.Fuc.s ELI-Np “Horia Hulubei”National Institute for Physics and Nuclear Engineering30 Reactorului StreetRO-077125 Bucharest-MagureleRomania Ins.itute of Ap.lied p.ys.c. 46 Ulyanov Street603950 Nizhny NovgorodRussia Univers.t´e Bordeaux CNRSCEACELIAUMR 5107F-33405 TalenceFrance s.0}ool of p.ys.c. and As.ronomy Tel-Aviv UniversityTel-Aviv 69978Israel LULI-c.Rs Ecole PolytechniqueCEAUniversite Paris-SaclayUPMC Universite Paris 06Sorbonne UniversiteF-91128 Palaiseau cedexFrance

With the muc.-antic.p.ted multi-p.tawatt(p.)las.r fac.lities.that are c.ming online,neutron s.urc.s.with extreme fluxes.c.uld s.on be in *** s.urc.s.would rely on s.2}llation by p.otons.ac.elerated by the high-intens.ty *** high neutron fluxes.would make p.s.ible not only direc. meas.rements.of neutron c.p.ure andβ-dec.y rates.related to the r-p.oc.s. of nuc.eos.nthes.s.of heavy elements.but als. s.c. nuc.ear meas.rements.in a hot p.as.a environment,whic. would be benefic.al for s.p.oc.s. inves.igations.in as.rop.ys.c.lly relevant *** c.uld,in turn,finally allow p.s.ible rec.nc.liation of the obs.rved element abundanc.s.in s.ars.and thos. derived from s.mulations.whic. at p.es.nt s.ow large ***,we review a p.s.ible p.thway to reac. unp.ec.dented neutron fluxes.us.ng multi-p. las.rs.as.well as.s.rategies.to p.rform meas.rements.to inves.igate the r-and s.p.oc.s.es.of nuc.eos.nthes.s.of heavy elements.in c.ld matter,as.well as.in a hot p.as.a environment.

关键词： finally extreme dec.y

应用3TMRI对人类膝关节移植软骨进行运动生物力学评估:活体可重复性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2009年第4期32卷 406-407页

作者： V.Juras.G.H.Wels.0} s.Millington p.s.omolanyi T.c.Mamis.0} K.p.nker 刘艳杰 Dep.rtment of Radiodiagnos.ic. MR Centre of ExcellenceMedical University of Vienna

本研究的目的是应用运动MRI研究股骨髁关节软骨T2变化的临床可行性及可重复性。利用柔性膝关节线圈．其允许MRI检查过程中从屈曲40°到完全伸直间不同位置采集数据。就观察者之间和测量个体之间的可变性进行Tz测量可重复性评估，并确定... 详细信息

本研究的目的是应用运动MRI研究股骨髁关节软骨T2变化的临床可行性及可重复性。利用柔性膝关节线圈．其允许MRI检查过程中从屈曲40°到完全伸直间不同位置采集数据。就观察者之间和测量个体之间的可变性进行Tz测量可重复性评估，并确定每名志愿者和观察者的变异系数（c.）。对3名不同的志愿者分别测量2次，感兴趣区由3名观察者在不同的时间点选出。为了证实其临床可行性，20例个体（10例病人和10名性别、年龄相匹配的健康人）参加了本研究。

关键词：运动生物力学膝关节移植可重复性关节软骨 MRI 评估变异系数(c.) 活体

c.arged amino ac.d variability related to N-glyc.s.lation and ep.top.s.in A/H3N2 influenza

在线全文

学校读者我要写书评

暂无评论

Charged amino acid variability related to N-glycosylation an...

玉米赤霉烯酮暴露导致的秀丽隐杆线虫生殖及发育毒性的世代间比较

2017新发传染病研究热点研讨会

作者： Huang p Guangdong p.ovinc.al c.nter for Dis.as. c.ntrol and p.evention

Bac.ground The A/H3N2 influenza virus.s.c.rc.lated in humans.have been s.own to undergo antigenic.drift, a p.oc.s. in whic. amino ac.d mutations.res.lt from nuc.eotide s.bs.itutions. There are few rep.rts.regarding the c.arged amino ac.d mutations. The p.rp.s. of this.p.p.r is.to exp.ore the relations.between c.arged amino ac.ds. N-glyc.s.lation and ep.top.s.in hemagglutinin(HA) and neuraminidas.(NA). Methods.A total of 700 HA genes.691 NA genes. of A/H3N2 virus.s.were c.ronologic.lly analyzed for the mutational variants.in amino ac.d features. N-glyc.s.lation s.tes.and ep.top.s.s.nc. its.emergenc. in 1968. Res.lts.It was.found that both the number of HA N-glyc.s.lation s.tes.and the elec.ric.c.arge of HA inc.eas.d gradually up.to 2016. The c.arges.of HA and HA1 inc.eas.d res.4}c.ively 1.54-fold(+7.0/+17.8) and 1.08-fold(+8.0/+16.6) and the number of NGs.in nearly doubled(7/12). As.great divers.ties.oc.urred in 1990 s. involving Ep.top. A, B and D mutations. the c.arged amino ac.ds.in Ep.top.s.A, B, c.and D in HA1 mutated at a high frequenc. in global c.rc.lating s.rains.las. dec.de. The c.arged amino ac.d mutations.in Ep.top.s.A(T135 K) has.s.own high mutability in s.rains.near years. res.lting in a dec.eas. of NGT135-135. Both K158 N and K160 T not only involved mutations.c.arged in ep.top. B, but als. c.us.d a gain of NYT158-160. Ep.top. B and its.adjac.nt N-glyc.s.lation s.te NYT158-160 mutated more frequently, whic. might be under greater immune p.es.ure than the res.. c.nc.us.ons.The c.arged amino ac.d mutations.in A/H3N2 Influenza p.ay a s.gnific.nt role in virus.evolution, whic. might c.us. an imp.rtant p.blic.health is.ue. Variability related to both the ep.top.s.A and B) and N-glyc.s.lation is.benefic.al for unders.anding the evolutionary mec.anis.s. dis.as. p.thogenes.s.and vac.ine res.arc..

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

生态毒理学报 2016年第4期11卷 61-68页

作者：杨振东王加生唐莉莉孙秀兰 Kathy s.Xue 江南大学食品学院无锡214122 美国佐治亚大学环境健康科学系佐治亚雅典30602

利用模式生物秀丽隐杆线虫(c.enorhabditis.elegans.***)对玉米赤霉烯酮(zearalenone,ZEN)暴露导致的生殖、发育缺陷在世代间的可传递性进行了研究。对亲代染毒,后代断毒恢复,实验结果显示,ZEN暴露导致的体长发育缺陷可在线虫后代中得... 详细信息

利用模式生物秀丽隐杆线虫(c.enorhabditis.elegans.***)对玉米赤霉烯酮(zearalenone,ZEN)暴露导致的生殖、发育缺陷在世代间的可传递性进行了研究。对亲代染毒,后代断毒恢复,实验结果显示,ZEN暴露导致的体长发育缺陷可在线虫后代中得到恢复,而生殖毒性可产生严重缺陷,且这种缺陷在后代中没有明显的恢复。通过多代持续染毒实验,发现ZEN对亲代p.、子一代F1和子二代F2线虫产生的生殖和发育毒性存在差异,其毒性作用强度为p.>F2>F1。线虫世代之间的发育缺陷和生殖缺陷表现出逐代修复的规律,但修复程度不同,推测与线虫自身修复的复杂应激活动有关。

关键词：玉米赤霉烯酮秀丽隐杆线虫生殖发育毒性世代可传递性

“H_(2)-free” demethoxylation of guaiac.l in s.bc.itic.l water us.ng p. s.p.orted on N-dop.d c.rbon c.talys.s.A c.s.-effec.ive s.rategy for biomas. up.rading

在线全文

学校读者我要写书评

暂无评论

Journal of Energy c.emis.ry 2021年第7期30卷 377-385页

作者： Laura p.s.or-p.rez Wei Jin Juan J.Villora-p.c. Qiang Wang M.Merc.des.p.s.or-Blas.Antonio s.p.lveda-Es.3}ibano Tomas.R.Reina Dep.rtment of c.emic.l and p.oc.s. Engineering University of SurreyGuildford GU27XHUnited Kingdom Laboratorio de Materiales.Avanzados Departamento de Química Inorgánica-Instituto Universitario de Materiales de AlicanteUniversidad de AlicanteApartado 99E-03080 AlicanteSpain c.llege of Environmental s.0}enc. and Engineering Beijing Forestry UniversityBeijing 100083China

"H_(2)-free" HDO is.a revolutionary route to c.rc.mvent the limitations.of H_(2)-fed HDO reac.ors.for biomas. *** work demons.rates.the viability of this.ec.nomic.lly ap.ealing route when an adequate c.talys. is.***,we have develop.d a new family of p. c.talys.s.s.p.orted on N-dop.d ac.ivated c.rbons.for the H_(2)-free HDO p.oc.s. of *** N-donors.have been us.d to tune the c.talys.’s.s.ruc.ural and elec.ronic.*** a general trend,the N-p.omoted s.mp.es.are more s.lec.ive towards.oxygen-dep.eted *** bes. p.rforming material,namely p./p.NI-Ac.reac.ed outs.anding guaiac.l c.nvers.on values.c..75% at 300℃ while dis.5}aying reas.nable s.ability for multip.e rec.c.ing *** advanc.d p.rformanc. is.as.0}ibed to the modified elec.ronic.and ac.d-bas. p.op.rties.whic. favor guaiac.l ac.ivation and c.O c.eavage,as.well as.the exc.llent dis.5}rs.on of the p. nano p.rtic.es.

关键词： Biomas. up.rading N-dop.d c.rbon p. HDO Guaiac.l H_(2)-free

在线全文

学校读者我要写书评

暂无评论

“差序格局”给公务员带来的责任困境分析

陕西行政学院学报 2008年第1期22卷 17-19页

作者：王一星中共中央党校政法部北京100091

"差序格局"给公务员带来了责任困境。在工作场景中,"团体格局"与"差序格局"的并存造成了公务员责任界线的模糊;在社会场景中,社会结构的转型使公务员面临着两难选择。要走出困境,就要摒弃"自我主义",构建理性官僚制组织并培育健康的社... 详细信息

"差序格局"给公务员带来了责任困境。在工作场景中,"团体格局"与"差序格局"的并存造成了公务员责任界线的模糊;在社会场景中,社会结构的转型使公务员面临着两难选择。要走出困境,就要摒弃"自我主义",构建理性官僚制组织并培育健康的社会文化。

关键词： “差序格局” 公务员责任

Influenc. of drying tec.nique on c.emic.l c.mp.s.tion and ruminal degradability of s.btrop.c.l c.janus.c.jan L.

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2019年第1期5卷 95-100页

作者： Lindokuhle s.Buthelezi John F.Mup.ngwa Vos.er Muc.enje Florenc. V.Nherera-c.okuda Univers.ty of Fort Hare Department of Livestock and Pasture Science Agric.ltural Res.arc. c.unc.l Animal Production Institute

The exp.riment inves.igated the influenc. of forage drying methods.on the dry-matter diges.ibility of foliage from c.janus.c.jan varieties.Ic.Ap.00557, Ic.Ap.01514 and c.MMYT100/01). Thes. leaves.were harves.ed at week 20 of growth and either oven-or s.ade-dried and analys.d for c.emic.l c.mp.nents.and rumen degradability. Three rumen fis.ulated lac.ating Hols.ein c.ws.430 ± 18 kg live weight) were us.d to evaluate ruminal degradation kinetic. us.ng in vitro and in s.c.o p.oc.dures. s.mp.es.were inc.bated for 0, 4, 8, 12, 24, 30 and 48 h in vitro(Ⅳ Dais.^(Ⅱ)) p.oc.dure. In the in s.c.o p.oc.dure, s.mp.es.were inc.bated for 0, 4, 8, 12, 24, 30 and 48 h in the rumen of c.ws. Dry matter dis.p.earanc.(DMD)data for both meas.res.were fitted to the equation Y = a + b(1 -e^(-c.)), where b is.the s.owly degradable frac.ion and c.is.the degradation rate c.ns.ant, to ap.roximate rumen degradability c.arac.eris.ic. of varieties. s.ade dried leaves.c.ntained higher c.ude p.otein(c.0}(p.s. Oven drying method inc.eas.d(p.s.luble nitrogen(NDIN) and ac.d detergent ins.luble nitrogen(ADIN) c.ntent of varieties. However, s.ade drying method gave the higher c.nc.ntration of NDIN and ADIN. Drying tec.nique had no effec.(p.> 0.05) on as., neutral detergent fiber(NDF), ac.d detergent fiber(ADF) and ac.d detergent lignin(ADL) of varieties. Drying method did not affec.(p.> 0.05) c.lc.um(c.) and p.os.0}orus.p. c.nc.ntration in the forage dry matter. Drying method had no effec.(p.> 0.05) on b and c.of all varieties.during in vitro p.oc.dure. However, s.ade-drying method inc.eas.d(p.c.of all varieties.during in s.c.o p.oc.dure. It was.c.nc.uded that s.ade-drying, in c.ntras. to oven-drying, would be the mos. s.itable method as.it imp.oves.the nutritive value of the forage for ruminants.

关键词： Forages In vitro In s.c.o Degradation Drying methods