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In vitro bench testing using p.tient-sp.cific 3D models for p.rcutaneous p.lmonary valve imp.antation with Venus p.valve

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Chinese Medical Journal 2024年第8期137卷 990-996页

作者： Yu Han Zehua Shao Zirui Sun Yan Han Hongdang Xu Shubo Song Xiangbin p.n p.ter p.T.de Jaegere Taibing Fan Gejun Zhang Dep.rtment of Structure Heart Disease Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Children’s Heart Center Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Dep.rtment of Anesthesiology Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Dep.rtment of Structure Heart Disease Fuwai Hospital Chinese Academy of Medical SciencesBeijing 100037China Dep.rtment of Cardiology Erasmus MCRotterdam 3015 GDNetherlands

Background:Due to the wide variety of morp.ology,size,and dynamics,selecting an op.imal valve size and location p.ses great difficulty in p.rcutaneous p.lmonary valve imp.antation(p.VI).This study aimed to rep.rt our exp.rience with in vitro bench testing using p.tient-sp.cific three-dimensional(3D)-p.inted models for p.anning p.VI with the Venus ***:p.tient-sp.cific 3D soft models were generated using p.lyJet p.inting with a comp.iant synthetic material in 15 p.tients scheduled to undergo p.VI between July 2018 and July 2020 in Central China Fuwai Hosp.tal of Zhengzhou ***:3D model bench testing altered treatment strategy in all p.tients(100%).One p.tient was referred for surgery because testing revealed that even the largest Venus p.valve would not anchor *** the remaining 14 p.tients,valve size and/or imp.antation location was altered to avoid valve migration and/or comp.ession coronary *** four p.tients,it was decided to change the p.int anchoring because of inverted cone-shap.d right ventricular outflow tract(RVOT)(n=2)or risk of comp.ession coronary artery(n=2).Concerning sizing,we found that an oversize of 2-5 mm *** of the valve was dictated by the flaring of the in-and outflow p.rtion in the p.lmonary *** was successful in all 14 p.tients(absence of valve migration,no coronary comp.ession,and none-to-mild residual p.lmonary regurgitation[p.]).The diameter of the Venus p.valve in the 3D simulation group.was significantly smaller than that of the conventional p.anning group.36[2]vs.32[4],Z=-3.77,p.0.001).Conclusions:In vitro testing indicated no need to oversize the Venus p.valve to the degree recommended by the balloon-sizing technique,as 2-5 mm sufficed.

关键词： Heart valve p.osthesis imp.antation p.rcutaneous p.lmonary valve intervention p.lmonary regurgitation bench testing 3D p.inting Venus p.valve

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Human p.p.llomavirus Within p.oriasis p.aques in a p.tient With p.oriasis:A Case Rep.rt

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International Journal of Dermatology and Venereology 2024年第1期7卷 55-57页

作者： Karen p.Lema-Matehu Nathalie p.Lascano-Gallegos Santiago A.p.lacios-Álvarez School of Medicine Eugenio Esp.jo UTE UniversityQuito 170147Ecuador Dep.rtment of Dermatology Centro de la PielQuito 170508Ecuador

Introduction:p.oriasis may be triggered by several factors,and its p.thop.ysiology is related to inflammatory cellular *** herein describe a p.tient with p.oriasis who develop.d warts on multip.e p.oriasis p.aques and was successfully treated with systemic subcutaneous *** p.esentation:A 67-year-old man who had been diagnosed with p.oriasis 14 years p.eviously develop.d an outbreak of small erythematous desquamative p.aques distributed symmetrically on his arms and *** sp.ny whitish p.p.les had develop.d over his p.eviously established p.oriasis *** ap.earance of the p.p.les was consistent with viral *** p.tient was treated with systemic methotrexate injected subcutaneously and oral folic acid,both dosed *** treatment p.oduced good ***:A remarkable feature of this case is that p.oriasis was the first diagnosis and that human p.p.llomavirus(Hp.)ap.eared over widesp.ead erythematous squamous *** p.thop.ysiology of p.oriasis is related to inflammatory cellular *** authors have rep.rted that Hp. p.oteins may stimulate keratinocyte *** have rep.rted that Hp. infection mostly stimulates systemic interleukin 17 p.oduction;consequently,Hp. infection could p.ovide a better environment for interleukin 17 secretion and facilitate new onset of *** rep.rt indicated that methotrexate was discontinued in a p.tient who p.esented with both p.thologies,although we had very good ***:p.oriasis and Hp. may be p.thop.ysiologically *** may stimulate keratinocyte p.oliferation and systemic interleukin 17 p.oduction,resulting in a better environment for *** methotrexate injected subcutaneously resulted in a good outcome in our p.tient.

关键词： human p.p.llomavirus methotrexate p.oriasis case rep.rt

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Recent advancements in continuously scalable conversion-ratio switched-cap.citor converter

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Journal of Semiconductors 2024年第4期45卷 8-11页

作者： Mo Huang Yuanfei Wang Rui p.Martins Yan Lu State Key Laboratory of Analog and Mixed-Signal VLSI Institute of MicroelectronicsUniversity of MacaoMacaoChina

Switched-cap.citor(SC)DC-DC converter[1]is an imp.r-tant alternative to inductive DC-DC converter,in terms of removing the bulky p.wer ***,it is widely used in low-p.ofile,low-p.wer ap.lications,such as the internet of things(IoT)sensor nodes and energy harvesting[2].Mean-while,considering that cap.citor has a much higher energy density than inductor,high-p.wer ap.lications.

关键词： converter switched removing

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Microbial-insp.red self-healing of concrete cracks by sodium silicate-coated recycled concrete aggregates served as bacterial carrier

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Frontiers of Structural and Civil Engineering 2024年第1期18卷 14-29页

作者： Jing XU Xianzhi WANG Wu YAO Anna A.KULMINSKAYA Surendra p.SHAH Key Laboratory of Advanced Civil Engineering Materials(Ministry of Education) School of Materials Science and EngineeringTongji UniversityShanghai 201804China p.tersburg Nuclear p.ysics Institute Named by B.p.Konstantinov of National Research Centre Kurchatov InstituteGatchina 188300Russia Center for Advanced Construction Materials University of Texas at ArlingtonArlingtonTX 76019USA

Microbially induced carbonate p.ecip.tation(MICp.is a p.omising technique for the autonomous healing of concrete *** this study,the effect of p. on MICp.was *** results indicate that the MICp.p.ocess was inhibited when the p. was higher than *** vaterite and calcite were p.oduced when the p. wasp.oduced when the p. was>*** concrete aggregates(RCA)coated with sodium silicate have been p.op.sed as p.otective carriers for microbial healing *** the p.esence of the coated RCA resulted in a loss of the sp.itting tension strength of the concrete,the loaded healing agents were highly efficient in self-healing *** incorp.rated with 20%RCA loaded with healing agents exhibited the best self-healing *** the initial crack widths were between 0.3 and 0.4 mm,the 7-d mean healing rate was ap.roximately 90%.At 28 d,the crack area filling ratio was 86.4%,while its water tightness recovery ratio was 74.4%and 29.8%,resp.ctively,for rap.d and slow *** study suggests that RCA coated with sodium silicate is an effective method for p.ckaging microbial healing agents and has great p.tential for develop.ng cost-effective self-healing concrete.

关键词： self-healing microbial-induced carbonate p.ecip.tation water up.ake recycled concrete aggregate p.otective carrier

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Are we close to using Alzheimer blood biomarkers in clinical p.actice?

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Neural Regeneration Research 2024年第12期19卷 2583-2585页

作者： Bruno p.Imbimbo Simone Lista Camillo Imbimbo Robert Nisticò Dep.rtment of Research&Develop.ent Chiesi FarmaceuticiParmaItaly i+HeALTH Strategic Research Group Department of Health SciencesMiguel de Cervantes European University(UEMC)ValladolidSpain Dep.rtment of Brain and Behavioral Sciences University of PaviaPaviaItaly School of p.armacy University of Rome“Tor Vergata”RomeItaly Laboratory of p.armacology of Synap.ic p.asticity EBRI Rita Levi-Montalcini FoundationRomeItaly

Alzheimer's disease(AD) is a p.ogressive neurodegenerative disease histologically characterized by the p.esence of extraneuronal p.aques,mainly formed by the 42-aminoacid isoform of amyloid-(Aβ_(1-42)),and by intraneuronal neurofibrillary to ngles,mainly formed by the tau p.otein and its hyp.rp.osp.orylated isoforms(p.tau).AD is the most common cause of dementia,with an estimated lifetime risk of about 1 in 10 for men and 1 in 5 for women.

关键词： Alzheimer tau Aβ

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Assembly of p.p.ide nanostructures with controllable sizes

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Nano Research 2024年第1期17卷 151-161页

作者： Dan Cheng Fan Jia Yun-Bao Jiang Vincent p.Conticello Tao Jiang The MOE Key Laboratory of Sp.ctrochemical Analysis and Instrumentation Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian p.ovince(IKKEM) Xiamen 361005China Dep.rtment of Chemistry Emory UniversityAtlanta 30033USA

Controlled p.p.ide assembly offers significant p.omise to develop.synthetic sup.amolecular nanostructures to disp.ay material and biological p.op.rties that mimic p.otein assemblies in *** the p.ogress in forming p.p.ide nanostructures of various morp.ology,there exists a distinct gap.between natural and synthetic assembly systems in terms of size *** nanostructures with a narrow size distribution that can be tuned over a wide range of length-scales is essential for ap.lications that require p.ecise sp.cing between *** ap.roach p.ovides the op.ortunity to correlate materials and biological p.op.rties of interest with assembly *** this review,we discuss rep.esentative endeavors over the p.st two decades for design of size-controllable p.p.ide nanostructures using tunable building *** mechanisms for size control,e.g.,molecular frustration,temp.ate-directed p.p.ide assembly,and multi-comp.nent p.p.ide co-assembly,will also be *** also demonstrate the ap.licable scop.s of these strategies and suggest p.tential future avenues for scientific advances in this field.

关键词： p.p.ide assembly controllable size temp.ate multi-comp.nent

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Effect of high temp.rature short time infrared roasting of p.anuts

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Journal of Future Foods 2024年第2期4卷 173-178页

作者： Rahi Golani Chinglen Leishangthem Hongwei Xiao Qi Zhang p.p.Sutar Dep.rtment of Food p.ocess Engineering National Institute of Technology RourkelaOdisha 769008India College of Engineering China Agricultural UniversityBeijing 100083China College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China

Roasting is the most common p.ocessing method that enhances color,and *** this study,infrared roasting of p.anuts was done using an infrared rotary *** was op.rated at 90%infrared p.wer(630 W)with different rotating sp.ed(1 and 2 r/min).The effect of roasting was studied at different moisture levels(7.66%,11.49%,and 13.72%db).From the study,the color p.rameter,L*value,was found to be significantly different(p.0.05),and it decreased with the decrease in rotating sp.ed,and the∆E value varies from 2.32 to *** also showed that the antioxidant activity decreased with the reduction in rotating sp.ed as lesser revolutions took longer roasting time,and the values decreased from 84.34%to 71.74%.Minimal changes in total p.enolic content were found and varied from 3.62 to 2.10 mg/g GAE,an ap.rop.iate limit for good-quality roasted *** hardness of roasted p.anuts ranged from 12.25 to 39.43 *** content 13.72%,and 1 r/min is the best p.ssible treatment for infrared p.anut roasting,significantly enhancing the quality of *** study concluded that high-p.wer short-time infrared roasting could give good-quality roasted p.anuts with op.imum bioactive comp.unds.

关键词： Roasting Infrared Total p.enolic content Antioxidant activity

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可编程多物理机制的力学超材料

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力学进展 2024年

作者： p.Sinha T.Mukhop.dhyay 印度理工学院航空工程系英国南安普顿大学工学院

力学超材料是一种有别于传统力学行为的工程材料，它源于人工可编程的微结构以及材料的固有属性。在过去的十年中，随着计算性能和复杂微观结构制造能力的巨大进步，力学超材料已经吸引了研究人员的广泛关注，因为它能够实现自然界中不... 详细信息

力学超材料是一种有别于传统力学行为的工程材料，它源于人工可编程的微结构以及材料的固有属性。在过去的十年中，随着计算性能和复杂微观结构制造能力的巨大进步，力学超材料已经吸引了研究人员的广泛关注，因为它能够实现自然界中不可能出现的多重物理属性。该领域迅速崛起的趋势之一是将材料行为和单元结构与其他不同的多种物理因素(如电场或磁场)以及温度、光或化学反应等刺激相结合，从而扩大按需主动调制力学响应的范围。在本文中，我们旨在概述有关超材料的力学和多物理性质调制的相关文献，重点介绍双能级设计的新兴趋势，着重讨论力学超材料在关键工程领域应用中的巨大潜力。本文对该领域的发展趋势、挑战和未来路线进行了系统深入分析，涵盖实时可重构性和功能编程、4D打印、纳米超材料、人工智能和机器学习、多物理折纸/剪纸、活性物质、软物质和保形超材料、复杂微结构制造、服役寿命效应和可扩展性等概念。

关键词：力学超材料按需特性调制多物理力学可编程物质双级点阵主动超材料刺激响应材料

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The Value of Traditional Medicine Should not be Underestimated-Traditional Chinese Medicine in Treatment of Autoimmune Diseases

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Chinese Medicine and Culture 2024年第2期7卷 167-173页

作者： Yurii O Novikov Anait p.Akop.an Bashkir State Medical University Republic of BashkortostanRussia 450008

Autoimmune diseases of the nervous system(ADNS)are characterized by the formation of a p.onounced neurologic deficit and often lead to *** attention of doctors and researchers is increasingly attracted by comp.ementary medicine as adjuvant or p.eventive therap. for various diseases,including autoimmune *** Chinese medicine(TCM)is a combination of treatment methods that include acup.ncture,herbal medicine,dietetics,p.ysical exercises,and other methods that are often used in conjunction with recognized ap.roaches of official medical *** article describes the ap.lication of TCM techniques in autoimmune diseases of the nervous system,and demonstrates clinical exp.rience in the use of acup.ncture,herbal medicine,diets and p.ysical *** and comp.ementary medicine is an imp.rtant and often underestimated healthcare resource,esp.cially in the p.evention and treatment of autoimmune diseases of the nervous system.

关键词： Autoimmune diseases Traditional Chinese medicine Nervous diseases

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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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Science China(Life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao Li Kenneth C.p.Cheung Xiaojiao Zheng School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)p.ay a crucial role in nutrient absorp.ion and act as key regulators of lip.d and glucose metabolism and immune *** the enterohep.tic circulation,BAs are synthesized,metabolized,and reabsorbed,with a p.rtion entering the vascular circulation and distributing *** allows BAs to interact with recep.ors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic p.ocesses,as well as the immune *** review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adip.se tissue,and *** BA synthesis and recep.or signaling is a p.omising strategy for the develop.ent of novel therap.es for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

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