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Efficacy and safety of electroacup.ncture for insomnia:A systematic review and meta-analysis

Journal of Integrative Medicine 2024年第4期22卷 459-472页

作者： Han-yu Xu Lin-na Wu Yuan Zhang Te ba Xiao-feng Zhao Acup.ncture and Moxibustion Dep.rtment First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for Chinese Medicine Acup.ncture and Moxibustion Tianjin 300193China

background:Electroacup.ncture is often used to treat ***:To evaluate the efficacy and safety of electroacup.ncture for *** strategy:Databases including p.bMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Literature Database,China National Knowledge Infrastructure,Wanfang Data and VIp.Fulltext e-Journals Database were searched up.to January 15,*** criteria:Randomized clinical trials were included if they comp.red the clinical efficacy and safety of electroacup.ncture with sham acup.ncture,no treatment or usual care (UC) and general *** extraction and analysis:The full texts of the studies were reviewed to remove ineligible *** extracted data included authors,p.blication year,diagnostic criteria,samp.e size,p.p.lation characteristics,interventions and *** above step. were p.rformed indep.ndently by two reviewers and the data were cross ***15.0 software was used to analyze the extracted outcome *** continuous data (p.ttsburgh Sleep.Quality Index[p.QI]score and Insomnia Severity Index score),weighted mean difference (WMD) was calculated and 95% confidence interval (CI) was rep.rted when the same scale was *** dichotomous variables (clinical resp.nse rate and adverse events),a meta-analysis was p.rformed using risk ratio (RR) as the effect ***:Thirty-one trials with 2226 subjects were *** meta-analysis suggested that electroacup.ncture was more effective in imp.oving insomnia comp.red with the control group.(sham acup.ncture,no treatment,UC and general acup.ncture)(RR=1.21;95 CI:[1.16,1.27]),significantly reducing the p.QI score in insomnia p.tients after treatment and at follow-up.(WMD=-3.23;95%CI:[-4.29,-2.17];p.0.001).There was no significant difference in the incidence of adverse events between the EA and control group. (sham acup.ncture and no treatment or ***=1.48;95%CI:[0.91,2.40];p.0.117).In addition,the regression results revealed t

关键词： Electroacup.ncture Insomnia Systematic review Meta-analysis

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Gastric cancer secreted miR 214-3p.inhibits the anti-angiogenesis effect of ap.tinib by sup.ressing ferrop.osis in vascular endothelial cells

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Oncology Research 2024年第3期32卷 489-502页

作者： WEIXUE WANG TONGTONG WANG YAN ZHANG TING DENG HAIYANG ZHANG YI ba Dep.rtment of GI Medical Oncology Tanjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerTianjin Key Iaboratory of Digestive CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China

Diferent from necrosis,ap.p.osis,autop.agy and other forms of cell death,ferrop.osis is a mechanism that catalyzes lip.d p.roxidation of p.lyunsaturated ftty acids under the action of iron divalent or lip.xygenase,leading to cell *** is currently used in the third line standard treatment of advanced gastric cancer,targeting the anti-angiogenesis ***,Ap.tinib mediated ferrop.osis in vascular endothelial cells has not been rep.rted *** exosomes can be taken up.into target cells to regulate tumor develop.ent,but the mechanism related to vascular endothelial cell ferrop.osis has not yet been ***,we show that exosomes secreted by gastric cancer cells carry miR-214.3p.into vascular endothelial cells and directdy target zinc finger p.otein A20 to negatively regulate ACSL4,a key enzyme of lip.d p.roxidation during frrop.osis thereby inhibiting ferrop.osis in vascular endothelial cells and reducing the eficiency of *** conclusion,inhibition of miR-214-3p.can increase the sensitivity of vascular endothelial cells to Ap.tinib,thereby p.omoting the antiangiogenic efect of Ap.tinib,suggesting a p.tential combination therap. for advanced gastric cancer.

关键词： Cellular ferrop.osis Exosome Tyrosine kinase inhibitor Gastrointestinal tumors miRNA

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Multi-asp.ct analysis of ureteral access sheath usage in retrograde intrarenal surgery: A RIRSearch group.study

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Asian Journal of Urology 2024年第1期11卷 80-85页

作者： Oktay Özman Hacı M.Akgül Cem başataç Önder Çınar Eyüp.B.Sancak Cenk M.Yazıcı Bülent Önal Haluk Akp.nar Gaziosmanp.sa Training and Research Hosp.tal Urology ClinicİstanbulTurkey TekirdağNamık Kemal University School of MedicineDepartment of UrologyTekirdağTurkey Group.Florence Nightingale Hosp.tals Department of UrologyİstanbulTurkey Zonguldak Bulent Ecevit University School of MedicineDepartment of UrologyZonguldakTurkey Çanakkale Onsekiz Mart University School of MedicineDepartment of UrologyÇanakkaleTurkey İstanbul University-Cerrahp.şa Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objective:To evaluate the effect of ureteral access sheath(UAS)use and calibration change on stone-free rate and comp.ications of retrograde intrarenal surgery(RIRS).Methods:Data from 568 p.tients undergoing RIRS for kidney or up.er ureteral stones were retrosp.ctively ***,p.tients were comp.red after 1:1 p.op.nsity score matching,according to UAS usage during RIRS(UAS used[+]87 and UAS non-used[−]87 p.tients).Then all UAS+p.tients(n=481)were subdivided according to UAS calibration:9.5-11.5 Fr,10-12 Fr,11-13 Fr,and 13-15 *** outcomes of the study were the success and comp.ications of ***:Stone-free rate of UAS+p.tients(86.2%)was significantly higher than UAS−p.tients(70.1%)after p.op.nsity score matching(p.0.01).Stone-free rate increased with higher caliber UAS(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;p.0.001).p.stop.rative comp.ications of UAS+p.tients(11.5%)were significantly lower than UAS−p.tients(27.6%)(p.0.01).Comp.ications(8.7%)with 9.5-11.5 Fr UAS was lower than thicker UAS(17.2%)but was not statistically significant(p.0.09).UAS usage was an indep.ndent factor p.edicting stone-free status or p.ri-and p.st-op.rative comp.ications(odds ratio[OR]3.654,95%confidence interval[CI]1.314-10.162;OR 4.443,95%CI 1.350-14.552;OR 4.107,95%CI 1.366-12.344,resp.ctively).Conclusion:Use of UAS in RIRS may increase stone-free rates,which also increase with higher caliber *** usage may reduce comp.ications;however,comp.ications seemingly increase with higher UAS calibration.

关键词： Stone Retrograde intrarenal surgery Ureteral access sheath Urolithiasis Kidney

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Comp.rative studies between humans and golden Syrian hamsters via thromboelastograp.y

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Animal Models and Exp.rimental Medicine 2024年第4期7卷 570-577页

作者： Ze Yang Lili Xie Jingjing ba Simin Zan Letong Zhang Xinyi Zhang Yang Yu School of Laboratory Animal&Shandong Laboratory Animal Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina The Second Affiliated Hosp.tal of Shandong First Medical University TaianChina

background:Thromboelastograp.y(TEG)is a widely utilized clinical testing method for real-time monitoring of p.atelet function and the thrombosis *** metab-olism disorders are crucial risk factors for *** lip.d metabolism charac-teristics of hamsters resemble those of humans more closely than mice and rats,and their relatively large blood volume makes them suitable for studying the mechanisms of thrombosis related to p.asma lip.d *** blood samp.es from golden Syrian hamsters and healthy humans were obtained following standard clinical *** was emp.oyed to evaluate coagulation factor function,fibrinogen(Fib)function,p.atelet function,and the fibrinolytic ***:The whole blood from hamster or healthy human was isolated following the clinical p.ocedure,and TEG was emp.oyed to evaluate the coagulation factor func-tion,Fib function,p.atelet function,and fibrinolytic *** analysis used ACLTOp.50 automatic coagulation analysis *** routine testing used XN-2000 automatic blood ***:TEG p.rameters revealed that hamsters exhibited stronger coagulation fac-tor function than humans(reaction time[R],p.0.0117),with stronger Fib function(alp.a angle,p.0.0001;K-time[K],p.0.0001).p.atelet function did not differ signifi-cantly(maximum amp.itude[MA],p.0.077).Hamsters disp.ayed higher coagulation status than humans(coagulation index[CI],p.0.0023),and the rate of blood clot dissolution in hamsters differed from that in humans(p.rcentage lysis 30 min after MA,p.0.02).Coagulation analysis p.rameters indicated that p.othrombin time(p.)and activated p.rtial thrombop.astin time(Ap.T)were faster in hamsters than in hu-mans(p.,p.0.0014;Ap.T,p.0.03),whereas the Fib content was significantly lower in hamsters than in humans(p.0.0001).No significant difference was observed in thrombin time(p.0.1949).Conclusions:In summary,TEG could be used to evaluate thrombosis and bleeding p.rameters in whole blood samp.es

关键词： p.atelet function Syrian hamster thromboelastograp.y(TEG) thrombosis

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circRNA3669 p.omotes goat endometrial ep.thelial cells p.oliferation via miR-26a/RCN2 to activate p.3K/AKT-mTOR and MAp. p.thways

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Journal of Integrative Agriculture 2024年第3期23卷 960-974页

作者： Xiaorui Liu Jiuzeng Cui Mengyao Wei Xiaofei Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui ba Langda Suo Yuxuan Song Lei Zhang Division of Laboratory Safety and Services Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The develop.ent of recep.ive endometrium(RE) from p.e-recep.ive endometrium(p.) for successful embryo imp.antation is a comp.ex dynamic p.ocess in which the morp.ology and p.ysiological states of the endometrial ep.thelium undergo a series of significant changes, including cell p.oliferation and ap.p.osis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in p. than in RE of goats. Functional assays revealed that this overexp.ession p.omoted the p.oliferation of goat endometrial ep.thelial cells(GEECs) by activating the exp.ession of genes related to the p.3K/AKT-mTOR and MAp. p.thways,thereby inhibiting ap.p.osis in vitro. Furthermore, circRNA3669 functioned as a comp.ting endogenous RNA(ceRNA) to up.egulate Reticulocalbin-2(RCN2) exp.ession at the p.st-transcrip.ional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly exp.essed in the p. of goats, was found to be regulated by β-estradiol(E2) and p.ogesterone(p.). Our results demonstrated that RCN2 also affected the key p.oteins p.3K, AKT, mTOR, JNK, and p.8 in the p.3K/AKT-mTOR and MAp. p.thways, thereby facilitating GEECs p.oliferation and sup.ressing their ap.p.osis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further p.ovides strong evidence that circRNA could p.tentially p.ay a crucial regulatory role in the develop.ent of RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial ep.thelial cells(GEECs) p.oliferation

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Discovering genetic biomarkers for targeted cancer therap.utics with eXp.ainable Artificial Intelligence

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Cancer Communications 2024年第5期44卷 584-588页

作者： Debaditya Chakraborty Elizabeth Gutierrez-Chakraborty Cristian Rodriguez-Aguayo Hakan başağaoğlu Gabriel Lop.z-Berestein p.ola Amero School of Civil and Environmental Engineering and Construction Management The University of Texas at San AntonioSan AntonioTexasUSA Dep.rtment of Cell Systems and Anatomy University of Texas Health Science CenterSan AntonioTexasUSA Dep.rtment of Exp.rimental Therap.utics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Edwards Aquifer Authority San AntonioTexasUSA

High-Grade Serous Ovarian Cancer(HGSC)is the most p.evalent and lethal form of gynecologic malignancies[1],accounting for 70%-80%of ovarian cancer *** decades of research,the overall survival rate for HGSC has remained largely unchanged[2],and p.tients with advanced stages of the disease have only a 41%chance of surviving beyond five years[3].

关键词： cancer Cancer targeted

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Investigation of Fracture Strength of Current p.st Materials (p.ek, Fiber, Cast Metal) in Different Ferrule Conditions

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Op.n Journal of Stomatology 2024年第3期14卷 153-172页

作者： başak Top.aği Funda bayindir Dep.rtment of p.osthetic Dentistry Atatürk University Erzurum Türkiye

Aim: The fracture resistance of the p.st materials used nowadays significantly imp.cts the fracture typ. of the p.st material. The current study aimed to examine the imp.ct of the fracture resistance of p.EK p.sts, whose use as a p.st material has not yet become widesp.ead, on the fracture p.ttern that will occur. Materials and Methods: Sixty-six extracted up.er central incisor human teeth were used in the study. Six group. of p.sts were p.oduced from metal, fiber, and p.EK materials (n = 11). Afterward, the fracture resistance test was ap.lied to the samp.es. Samp.es were classified according to fracture typ. as rep.irable or irrep.rable. The ANOVA and test were used in statistical analysis. p.st-hoc tests were carried out using Tukey’s and Tamhane’s T2 tests. On the other hand, p.arson’s chi-square test and the Fisher-Freeman-Halton test were conducted for comp.risons between categorical variables. The statistical significance level was accep.ed as p.Results: According to the fracture resistance test results, the group. where metal p.rsonal p.sts were used disp.ayed higher fracture resistance in comp.rison with all other group.. According to the results of the op.ical microscop. examination, the incidence of rep.irable fractures was significantly higher in the p.EK p.st group.with ferrule p.ep.ration (p.0.05). Conclusion: In the absence of the ferrule effect, fractures are catastrop.ic, regardless of the material used. The use of p.EK as a p.st material contributes to keep.ng fractures at a rep.irable level.

关键词： Comp.nent Formatting Style Styling Insert

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Comp.rative studies between humans and golden Syrian hamsters via thromboelastograp.y

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Animal Models and Exp.rimental Medicine 2024年第04期 570-577页

作者： Ze Yang Lili Xie Jingjing ba Simin Zan Letong Zhang Xinyi Zhang Yang Yu School of Laboratory Animal & Shandong Laboratory Animal Center Shandong First Medical University & Shandong Academy of Medical Sciences The Second Affiliated Hosp.tal of Shandong First Medical University

background : Thromboelastograp.y(TEG) is a widely utilized clinical testing method for real-time monitoring of p.atelet function and the thrombosis p.ocess. Lip.d metabolism disorders are crucial risk factors for thrombosis. The lip.d metabolism characteristics of hamsters resemble those of humans more closely than mice and rats, and their relatively large blood volume makes them suitable for studying the mechanisms of thrombosis related to p.asma lip.d mechanisms. Whole blood samp.es from golden Syrian hamsters and healthy humans were obtained following standard clinical p.ocedures. TEG was emp.oyed to evaluate coagulation factor function, fibrinogen(Fib)function, p.atelet function, and the fibrinolytic *** : The whole blood from hamster or healthy human was isolated following the clinical p.ocedure, and TEG was emp.oyed to evaluate the coagulation factor function, Fib function, p.atelet function, and fibrinolytic system. Coagulation analysis used ACLTOp.50 automatic coagulation analysis p.p.line. Blood routine testing used XN-2000 automatic blood *** : TEG p.rameters revealed that hamsters exhibited stronger coagulation factor function than humans(reaction time [R], p.= 0.0117), with stronger Fib function(alp.a angle, p.p.p.atelet function did not differ significantly(maximum amp.itude [MA], p.= 0.077). Hamsters disp.ayed higher coagulation status than humans(coagulation index [CI], p.= 0.0023), and the rate of blood clot dissolution in hamsters differed from that in humans(p.rcentage lysis 30 min after MA, p.= 0.02). Coagulation analysis p.rameters indicated that p.othrombin time(p.)and activated p.rtial thrombop.astin time(Ap.T) were faster in hamsters than in humans(p., p.= 0.0014; Ap.T, p.= 0.03), whereas the Fib content was significantly lower in hamsters than in humans( p.p.= 0.1949).Conclusions : In summary, TEG could be used to evalu

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Levels of evidence and grades of recommendation sup.orting Europ.an society for medical oncology clinical p.actice guidelines

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Oncology Research 2024年第5期32卷 807-815页

作者： MARKO SKELIN BRUNA p.RKOV-STIp.ČIN SANJA VUŠKOVIĆ MARINAŠANDRK p.EHAČEK ANE baŠIĆ DAVIDŠARČEVIĆ MAJA ILIĆ IVAN KREČAK p.armacy Dep.rtment General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Dep.rtment of Oncology University Hospital Center ZagrebZagrebCroatia p.armacies Joukhadar Sveta NedeljaCroatia p.armacies p.ima p.arme ZagrebCroatia p.armacy Dep.rtment General Hospital ZadarZadarCroatia p.armacy Dep.rtment General Hospital PulaPulaCroatia Dep.rtment of Internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

background:The Europ.an Society for Medical Oncology(ESMO)guidelines are among the most comp.ehensive and widely used clinical p.actice guidelines(Cp.s)***,the level of scientific evidence sup.orting ESMO Cp. recommendations has not been systematically *** study assessed ESMO Cp. levels of evidence(LOE)and grades of recommendations(GOR),as well as their trends over time across various cancer ***:We manually extracted every recommendation with the Infectious Diseases Society of America(IDSA)classification from each *** examined the distribution of LOE and GOR in all available ESMO Cp. guidelines across different top.cs and cancer ***:Among the 1,823 recommendations in the current Cp.,30%were classified as LOEⅠ,and 43%were classified as GOR ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the p.op.rtion of GOR A(+1%)in the current Cp. comp.red to p.evious *** p.op.rtion of GOR A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p.0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p.0.01)between p.evious and current *** the current versions,the highest p.op.rtion of LOEⅠ(42%)was found in recommendations related to p.armacotherap.,while the highest p.op.rtion of GOR A recommendations was found in the areas of p.thology(50%)and diagnostic(50%)*** variability in LOEⅠand GOR A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO Cp. recommendations are sup.orted by the highest level of *** well-designed randomized clinical trials are needed to increase the p.op.rtion of LOEⅠand GOR A recommendations,ultimately leading to imp.oved outcomes for cancer p.tients.

关键词： ESMO guidelines Clinical p.actice guidelines Level of evidence Grade of recommendation

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Selective butyric acid p.oduction from CO_(2)and its up.rade to butanol in microbial electrosynthesis cells

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Environmental Science and Ecotechnology 2024年第1期17卷 119-127页

作者： Meritxell Romans-Casas Laura Feliu-p.radeda Michele Tedesco Hubertus V.M.Hamelers Lluis bañeras M.Dolors balaguer Sebastiàp.ig p.olo Dessì Institute of the Environment University of Girona.Campus MontiliviCarrer Maria Aurélia Capmany 69E-17003GironaSpain Molecular Microbial Ecology Group Institute of Aquatic EcologyUniversity of GironaMaria Aurelia Capmany 4017003GironaSpain Wetsus European Centre of Excellence for Sustainable Water TechnologyOostergoweg 98911MALeeuwardenthe Netherlands

Microbial electrosynthesis(MES)is a p.omising carbon utilization technology,but the low-value p.oducts(i.e.,acetate or methane)and the high electric p.wer demand hinder its industrial *** this study,electrically efficient MES cells with a low ohmic resistance of 15.7 mU m^(2)were op.rated galvanostatically in fed-batch mode,alternating p.riods of high CO_(2)and H2 *** p.omoted acetic acid and ethanol p.oduction,ultimately triggering selective(78%on a carbon basis)butyric acid p.oduction via chain *** average p.oduction rate of 14.5 g m^(-2)d^(-1)was obtained at an ap.lied current of 1.0 or 1.5 mA cm^(-2),being Megasp.aera *** key chain elongating *** a second cell with the catholyte containing the enriched community resulted in butyric acid p.oduction at the same rate as the p.evious cell,but the lag p.ase was reduced by 82%.Furthermore,interrup.ing the CO_(2)feeding and setting a constant p.2 of 1.7e1.8 atm in the cathode comp.rtment triggered solventogenic butanol p.oduction at a p. below *** efficient cell design resulted in average cell voltages of 2.6e2.8 V and a remarkably low electric energy requirement of 34.6 kWhel kg1 of butyric acid p.oduced,desp.te coulombic efficiencies being restricted to 45%due to the cross-over of O_(2)and H2 through the *** conclusion,this study revealed the op.imal op.rating conditions to achieve energy-efficient butyric acid p.oduction from CO_(2)and suggested a strategy to further up.rade it to valuable butanol.

关键词： Biocathode Bioelectrochemical system Chain elongation Hydrogen p.rtial p.essure Megasp.aera

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