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福建省厦门市某高校大学生对同性恋认同态度调查

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中国健康教育 2012年第7期28卷 524-528页

作者：谭继镛严斐灵邱云河陈冰 leonard Beckum 集美大学教师教育学院福建厦门361021 美国paloAlto大学加利福尼亚州PaloAlto94304 美国斯坦福大学医学院加利福尼亚州斯坦福94305

目的了解福建省厦门市某高校大学生对同性恋的认同态度,为开展相关研究和干预提供依据。方法采用方便抽样方法,在厦门市某综合性大学抽取大学生537人进行问卷调查。应用χ2检验进行统计分析。结果目前大学生的性别和是否接触过同性恋是... 详细信息

目的了解福建省厦门市某高校大学生对同性恋的认同态度,为开展相关研究和干预提供依据。方法采用方便抽样方法,在厦门市某综合性大学抽取大学生537人进行问卷调查。应用χ2检验进行统计分析。结果目前大学生的性别和是否接触过同性恋是他们对同性恋态度的影响因素。男生认为同性恋情感取向正常和可以理解的占40.2%,女生占60.3%;大学生对男同性恋的接纳程度不同,男生接受女同性恋占29.7%,接受男同性恋占3.8%;女生接受男同性恋占9.2%,对女同性恋接受的占22.1%。接触过同性恋的大学生有70.3%的人对同性恋持理解态度,没接触过同性恋的人中持理解态度的只占45.8%;接触过的学生中有14.5%,没有接触过的有3.4%认为同性恋应该受到法律保护,以上差异均具有统计学意义(p<0.05)。大学生有无宗教信仰对同性恋态度的差异无统计学意义。结论所调查的大学生对同性恋的态度总体比较包容。

关键词：同性恋大学生认同态度

Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healingassociated genes

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Neural Regeneration Research 2016年第1期11卷 144-149页

作者： Matt C.Danzi Dario Motti Donna L.Avison John L.Bixby Vance p.Lemmon The Miami project to Cure paralysis University of MiamiLois Pope LIFE Center Department of Surgery Leonard M. Miller School of Medicine University of Miami Department of Neurological Surgery University of Miami Department of Molecular and Cellular pharmacology University of Miami

Animal models of sciatic nerve injury are commonly used to study neuropathic pain as well as axon regeneration. Administration of post-surgical analgesics is an important consideration for animal welfare, but the actions of the analgesic must not interfere with the scientific goals of the experiment. In this study, we show that treatment with either buprenorphine or acetaminophen following a bilateral sciatic nerve crush surgery does not alter the expression in dorsal root ganglion（DRG） sensory neurons of a panel of genes associated with wound healing. These findings indicate that the post-operative use of buprenorphine or acetaminophen at doses commonly suggested by Institutional Animal Care and Use Committees does not change the intrinsic gene expression response of DRG neurons to a sciatic nerve crush injury, for many wound healing-associated genes. Therefore, administration of post-operative analgesics may not confound the results of transcriptomic studies employing this injury model.

关键词： acetaminophen analgesics axon buprenorphine dorsal root ganglia gene expression peripheral nerve injuries regeneration sciatic nerve wound healing

神经节苷脂对神经母细胞瘤细胞粘附于胶原蛋白作用的影响

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中国当代儿科杂志 2001年第4期3卷 359-362,455-460页

作者：文飞球陈亦欣吴本清 Tamara Kazarian leonard A.Valentino 暨南大学医学院附属二院儿科广东深圳518020 暨南大学医学院附属二院肿瘤研究所广东深圳518020 美国RUSH大学医学院儿童医院

目的　以胶原蛋白 (CN)作为底物 ,探讨内生肿瘤神经节苷脂 (GS)对神经母细胞LA N5细胞株粘附功能的影响。方法　用葡萄糖苷神经酰氨合成酶抑制剂 (D pDMp)抑制LA N5细胞株GS合成 ,观察该细胞对包被CN粘附作用的变化。结果　暴露于D pDMp... 详细信息

目的　以胶原蛋白 (CN)作为底物 ,探讨内生肿瘤神经节苷脂 (GS)对神经母细胞LA N5细胞株粘附功能的影响。方法　用葡萄糖苷神经酰氨合成酶抑制剂 (D pDMp)抑制LA N5细胞株GS合成 ,观察该细胞对包被CN粘附作用的变化。结果　暴露于D pDMp 6d后 ,细胞GS几乎完全清除 ,但细胞的活力、增殖率及凋亡率较对照组无明显变化 ;暴露于D -pDMp的细胞 ,其粘附能力仅为对照组的 3 5 % :OD570 分别为 0 .0 7± 0 .0 1和 0 .2 1± 0 .0 3 (p pDMp的LA N5细胞 ,可恢复该细胞的粘附表型 ,较对照组差异无显着性 (p >0 .0 5 )。结论　内生肿瘤GS调节肿瘤细胞对CN的粘附作用 ,提示GS在肿瘤细胞的迁移 ,侵入和转移中可能起重要作用。

关键词：神经节苷脂神经母细胞瘤胶原蛋白粘附作用

Association between placenta Malaria parasites and preeclampsia/Eclampsia among parturient Mothers in Alex Ekwueme Federal University Teaching Hospital Abakaliki

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Open Journal of Obstetrics and Gynecology 2023年第3期13卷 444-464页

作者： Ayodele A. Olaleye leonard O. Ajah Boniface N. Ejikeme Justus N. Eze Virtus O. Obi Adeniyi J. Adebayo Ikenna C. Ebere Alfred N. Adiele Festus Iyare Department of Obstetrics and Gynecology Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria Department of Morbid Anatomy Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria

In tropical countries, malaria and preeclampsia/eclampsia are common diseases of pregnancy;and placenta have been implicated in the pathophysiology of both disease processes. The two diseases have pathophysiologic similarities in the placenta such as placenta ischaemia, endothelial dysfunction and production of pro-inflammatory cytokine. Yet, there is paucity of studies on the association of these two disease processes. Determining the association between the two disease processes may help to unravel the pathogenesis of preeclampsia and also help in its prevention and patient management. Objective: Determined the association between placenta malaria parasitemia and preeclampsia/eclampsia among parturients at Alex Ekwueme Federal University Teaching Hospital Abakaliki. Materials and Methods: This was a case control study that was conducted in the Labour wards of department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki (AEFUTHA) and Mile 4 Missionary Hospital Abakaliki, a comprehensive health care centre in Abakaliki, Ebonyi state. It was conducted over a period of 6 months between 1p>stp> October 2021 and 31p>stp> March, 2022. The cases in this study were parturients that developed preeclampsia/eclampsia in the course of pregnancy, while the controls were parturient without preeclampsia/eclampsia. Interviewer-administered questionnaires were used to collect data on socio-demographic characteristics, obstetrics and medical histories. Histological examinations were conducted to isolate plasmodium falciparum parasites from placenta samples obtained from the maternal surface of the placenta. The data was processed using Epi Info software. Categorical variables were analyzed using Mc Nemar Xp>2p> test, with a p-value of 0.05 considered statistically significant. Logistic regression models were used to estimate the odds ratios (OR) and 95% CI of the association between placenta malaria parasites and preeclam

关键词： placental Malaria preeclampsia/Eclampsia Maternal perinatal Morbidities and Mortality

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非点源污染的控制—资源保护的前景

水土保持应用技术 1986年第1期 46-49页

作者： W.G.knisel ,R.A.leonard ,E.B.Oswarld ,汤兆和

美国公法1972(p.L.92—500)水质污染控制法修正案和1977(p.L.95—192)水土资源保护法都很注意农地和林地。两个法规都非常明确地规定其目的和

关键词：资源保护非点源污染农民劳动者土壤保持水质标准环境质量土地程度

不论左室容量有无差异女性左室射血分数较男性高:达拉斯心脏研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 34-35页

作者： Chung A.K. Das S.R. leonard D. M.H. Drazner 朱冰坡 University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390-9047 United States Dr.

Background -Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction(LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a systematic difference in LVEF between genders. Methods and Results -Using cardiac magnetic resonance imaging in a probability-based sample of Dallas County residents aged 30 to 65 years(1435 women and 1183 men), we compared LVEF in women and men. The association of gender with stroke volume independent of end-diastolic volume(EDV) or other potential confounders was assessed by multivariable analysis. Gender-specific thresholds for a low LVEF were defined at the 2.5th percentile in women and men from a healthy reference subpopulation. The median(25th, 75th percentile) LVEF was higher in women than in men(75%[70%, 79%] in women versus 70%[65%, 75%] in men, pppendent of EDV and other potential confounders in multivariable analysis. A low LVEF was defined as below 61%in women and below 55%in men. Conclusions -Women have a higher LVEF than men in the general population, secondary to a higher stroke volume for a given EDV independent of known potential confounders.

关键词：射血分数达拉斯舒张期末容积每搏输出量收缩期末容积心室肥厚常住居民混杂因素临床实践体

Magnetically controlled growing instrumentation for early onset scoliosis: Caution needed when interpreting the literature

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World Journal of Orthopedics 2019年第11期10卷 394-403页

作者： Kenneth Aaron Shaw Justin M Hire Scott Kim Dennis p Devito Michael L Schmitz Joshua S Murphy Department of Orthopaedic Surgery Dwight D.Eisenhower Army Medical CenterFort GordonGA 30905United States Department of Orthopaedic Surgery General Leonard Wood Army Community HospitalFort Leonard WoodMO 65473United States University of Tennessee Health Science Center MemphisTN 38163United States Department of pediatric Orthopaedic Surgery Children’s Healthcare of AtlantaScottish Rite CampusAtlantaGA 30342United States

BACKGROUND Magnetically controlled growing rods(MCGR) are a novel treatment option for early onset scoliosis(EOS). Although the complication profile with MCGR use has been reviewed, these reviews do not take into account important implants modifications, termed iterations, that were made due to early on postoperative complications is not well reported or *** To assess the effect of MCGR implant iterations on post-operative complications in *** A systematic review was performed to identify studies investigating MCGR specifically for the treatment of EOS, refined to those reporting the implant iteration, specifically the incorporation of the keeper plate to the implant *** with mixed implant iteration usage were excluded. Complications following surgery were recorded as well as potential risk factors and compared between implant *** Although 20 articles were identified for inclusion, 5 included mixed implant iteration leaving a total of 271 patients identified through 15 clinical studies thatmet inclusion criteria. The average follow-up was 25.4-mo. pre-keeper plate implants were utilized in 3 studies with a total of 49 patients. Overall, 115(42.4%)post-operative complications were identified, with 87% defined as major. The addition of the keeper plate significantly decreased the rate of post-operative complications per study(35.7% vs 80.6%, p = 0.036), and the rate of distraction failure(8.1% vs 40.8%, p = 0.02). Unplanned reoperation occurred in 69(26.7%)patients but was not different between implant iteration cohorts(25.5% without keeper plate vs 27.1% with keeper plate, p = 0.92).CONCLUSION MCGR for EOS has a cumulative complication rate of 42.4% but this is significantly reduced to 35.7% when reviewing only keeper-plate enabled implants. However, 25% of published articles included mixed implant *** studies should discern between implants iterations when reporting on the usage of MCGR for EOS.

关键词： Complications Early onset scoliosis Magnetically controlled growing instrumentations Keeper plate Reoperation Systematic review

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专家对VSAT未来的展望

成都信息工程学院学报 1993年第2期15卷 115-123页

作者： leonard S.Golding Joseph Rinde Andrew J.Viterbi peter p.Nuspl Richard W.Jestin pierre Bartholome Joseph N.pelton K.M.Sundara Murthy Barry G.Evans 王春芳

自从VSAT(天线口径非常小的地球站)建立和发展以来,使很多领域不断取得进步。这些领域包括使用超大规模集成技术的技术合成,射频单元集成和批量生产技术、天线的改进和批量生产技术、对新用户和网络协议的支持、用户控制管理选择、高功... 详细信息

自从VSAT(天线口径非常小的地球站)建立和发展以来,使很多领域不断取得进步。这些领域包括使用超大规模集成技术的技术合成,射频单元集成和批量生产技术、天线的改进和批量生产技术、对新用户和网络协议的支持、用户控制管理选择、高功率低损耗放大器、网络监控新技术、发展新应用领域等。在过去的五年中。

关键词： VSAT 地球站射频单元天线口径话音业务网络监控网络协议批量生产网络层协议公共信道

Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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Acta pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui patrick A. Eyers leonard L. Dobens Nguan Soon Tan peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biochemistry Institute of Integrative Biology University of Liverpool Division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological Sciences Nanyang Technological University Lee Kong Chian School of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK Women's and Children Hospital Biochemistry Department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas Department of Biomedical Sciences and Medicine University of Algarve Algarve Biomedical Center (ABC) University of Algarve Campus de Gambelas Department of Infection Immunity and Cardiovascular Disease University of Sheffield paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow Division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research Department of pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology Department University of the Basque Country (UPV/EHU) Institute for Diabetes and Cancer IDC Helmholtz Center Munich Joint Heidelberg-IDC Translational Diabetes program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German Center for Diabetes Research (DZD) Division of Cardiology Department of Medicine Columbia University Irving Medical Center School of Sport and Health Sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 pseudokinase Inflammation Atomic structure protein quality control Ubiqutin