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γ干扰素防治增殖性玻璃体视网膜病变的实验研究

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眼科研究 1993年第4期11卷 259-261页

作者：李锦文 leonard M Hjelmeland 南京铁道医学院附院眼科 210009 美国加州大学戴维斯校区眼科

在兔眼玻璃体内移植５０００００个同种异体皮肤纤维细胞后，玻璃体内一次性注射γ干扰素显著降低牵引性视网膜脱离的发生率。第一周，对照组为４０％（２０眼中８眼），治疗组仅１０％（２０眼中２眼）（Ｐ＜０．０５）。第四周，对照... 详细信息

在兔眼玻璃体内移植５０００００个同种异体皮肤纤维细胞后，玻璃体内一次性注射γ干扰素显著降低牵引性视网膜脱离的发生率。第一周，对照组为４０％（２０眼中８眼），治疗组仅１０％（２０眼中２眼）（Ｐ＜０．０５）。第四周，对照且１００％（２０眼中２０眼），治疗组降为６０％（２０眼中１２眼）（Ｐ＜０．０１）。实验表明γ干扰素对防治增殖性玻璃体视网膜病变有效，玻璃体内注射γ干扰素１０＾４单位对眼部无毒性作用。

关键词：成纤维细胞干扰素视网膜病变

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Stability of Mbuna Species populations in Lake Malawi

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Journal of Environmental Science and Engineering(B) 2012年第4期1卷 543-555页

作者： Lucious G. Kanyumba Wisdom J. Changadeya Aggrey J.D. Ambali leonard A. Kamwanja EmmanuelK.W. Kaunda Department of Biology University of Malawi Zomba 280 Malawi NEpAD planning and Coordinating Agency Pretoria 0184 South Africa University Office University of Malawi Zomba 278 Malawi Department of Aquaculture and Fisheries Science University of Malawi Lilongwe 219 Malawi

The first comprehensive study of abundance, richness and distribution of Mbuna in Lake Malawi was carried out in the 1980s. The present study examined changes of species richness and abundance of Mbuna with time. Most sites demarcated during the 1980s survey were explored in order to determine changes in abundance and composition of Mbuna over a period of more than 20 years Chi-square analysis revealed significant difference （p 〈 0.05） in abundance of Mbuna between 1983 and 2005 with the exception of Chinyankhwazi and Chinyamwezi where the difference was not significant （p 〉 0.05）. Cluster analysis showed changes in species composition between 1983 and 2005 in various sites. Generally, there were more species lost in a given area than new species observed in 2005. Decline in Mbuna species richness might have been caused by siltation, harvesting of Mbuna for food and ornamental fish trade while new species were mostly introduced through translocation from one part of the lake to another.

关键词： Mbuna species abundance species richness translocation.

Hemodialysis patients’ satisfaction and associated factors in National Teaching Hospital Hemodialysis Center, Cotonou (Benin)

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Open Journal of Nephrology 2019年第4期9卷 127-138页

作者： Séraphin Ahoui Jacques Vigan Bruno Léopold Agboton Evariste Eteka Francis Tchegnonsi Tognon A. Anselme Djidonou prosper Gandaho leonard Fourn Department of Nephrology Borgou Regional Teaching Hospital Parakou Benin Nephrology-Hemodialysis University Clinic (CUNH) Hubert Koutoukou Maga National Teaching Hospital Cotonou (CNHU-HKM) Benin Department of psychiatry Borgou Regional Teaching Hospital Parakou Benin Faculty of Health Sciences University of Abomey-Calavi Abomey-Calavi Benin

Background: patients’ satisfaction is a relevant component in assessing healthcare services. The objective of this study was to study the level of satisfaction of chronic hemodialysis patients and the associated factors in Cotonou CNHU-HKM dialysis center. patients and Methods: It was a cross-sectional, descriptive and analytical study conducted by administering a questionnaire on days off dialysis. It was carried out from 1st November 2015 to 1st January 2016 in CNHU-HKM Nephrology University Clinic of Cotonou. Hemodialysis patients aged 18 years and above having given their informed consent were included in the study. patients’ recruitment was comprehensive. Likert scale was used in assessing the level of satisfaction with 4 as “very satisfied” and 1 for “very dissatisfied”. Satisfaction was evaluated on the basis of Ware dimensions. The threshold for satisfaction was 50. Outcomes: Overall, 377 patients were included in the study. Respondents’ mean age was 51.5 ± 13.3 years with 1.37 as sex ratio. Arteriovenous fistula was used for 80.1% of hemodialysis patients. 77.7% of the patients underwent dialysis twice a week while 45.9% were administered a four-hour dialysis. The overall average proportion of “satisfied” was 76.5%. The level of satisfaction was 52% for healthcare environment, 61% for service delivery, 73.9% for healthcare accessibility, 76.1% for healthcare structure, 77.5% for healthcare management, 90.3% for quality of healthcare, 88.3% for interpersonal relationship and 93.2% for efficiency and continuum of healthcare. Factors associated with satisfaction included age (p = 0.02), vascular access (p = 0.04) and urea reduction ratio (p = 0.01). In addition, the degree of satisfaction of hemodialysis patients was not statistically associated with sex, marital status, educational level, history of the disease, age of dialysis, number of sessions per week, and duration per session. Conclusion: The overall level of hemodialysis patients’ satisfaction is above

关键词： Satisfaction Chronic Hemodialysis Cotonou

Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon:impact of more than 13 years of ivermectin

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Infectious Diseases of poverty 2018年第1期7卷 1191-1201页

作者： Joseph Nelson Siewe Fodjo Godwin Tatah Earnest Njih Tabah leonard Ngarka leonard Njamnshi Nfor Samuel Eric Chokote Michel KMengnjo Fidele Dema Aurelien Tele Sitouok Grace Nkoro Felicien ENtone Anne-Cecile Zoung-Kanyi Bissek Cedric BChesnais Michel Boussinesq Robert Colebunders Alfred K.Njamnshi Global Health Institute University of AntwerpAntwerpBelgium Neurology Department YaoundeCentral HospitalYaoundeCameroon Neurology Department CH Saint-NazaireSaint-NazaireFrance Neuroscience Laboratory FMBSThe University of YaoundeIYaoundeCameroon Ministry of public Health YaoundeCameroon Neurology Department CHU BrugmanBrusselsBelgium Yoko District Hospital YaoundeCameroon UMI 233 Institut de Recherche pour le Developpement(IRD)MontpellierFrance UniversiteMontpellier MontpellierFrance INSERM Unite1175 MontpellierFrance Brain Research Africa Initiative(BRAIN) YaoundeCameroon.

Background:A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon,including Bilomo and *** sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ivermectin(CDTI).Methods:Door-to-door surveys were performed on the entire resident population in the villages in August 2017 and January *** was diagnosed using a 2-step approach:administration of a standardized 5-item questionnaire followed by confirmation by a *** published diagnostic criteria for onchocerciasis-associated epilepsy(OAE)were ***16 serology was done for children aged 7-10 years to assess onchocerciasis *** were compared with previous data from these two ***:A total of 1525 individuals(1321 in Bilomo and 204 in Kelleng)in 233 households were surveyed in both *** crude prevalence of epilepsy was 4.6%in Bilomo(2017)and 7.8%in Kelleng(2018),including 12(15.6%of cases)persons with epilepsy(pWE)with nodding *** age and sex-standardized prevalence in Kelleng decreased from 13.5%in 2004 to 9.3%in 2018(ppWE shifted from 17(IQR:12-22)years to 24(IQR:20-30)years in Bilomo(pp=0.112).Furthermore,47.6%of all tested children between 7 and 10 years had Ov16 ***:There is a decrease in epilepsy prevalence after 13 years and more of CDTI in both *** age-shift observed in pWE suggests that ivermectin may prevent OAE in younger ***16 seropositivity in children indicates ongoing onchocerciasis transmission possibly due to suboptimal control *** findings support the existence of OAE in Cameroon and highlight the need to strengthen onchocerciasis elimination programs.

关键词： Onchocerciasis Epilepsy Nodding syndrome Ov16 rapid diagnostic test Ivermectin Cameroon

The Skin Microbiome of <i>Gambusia affinis</i>Is Defined and Selective

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Advances in Microbiology 2014年第7期4卷 335-343页

作者： Annie B. leonard Jeanette M. Carlson Dayna E. Bishoff Sarah I. Sendelbach Sonja B. Yung Sonya Ramzanali Ananda B. W. Manage Embriette R. Hyde Joseph F. petrosino Todd p. primm Alkek Center for Metagenomics and Microbiome Research Department of Molecular Virology and Microbiology Baylor College of Medicine Houston USA Department of Biological Sciences Sam Houston State University Huntsville USA Department of Mathematics and Statistics Sam Houston State University Huntsville USA

Metagenomics and bacterial culture were used to determine the normal skin microbiome of the Western mosquitofish (Gambusia affinis). This is the first study of G. affinis, and the most in-depth study of any fish skin, utilizing a combination of 16S profile pyrosequencing and culture analysis. Over 1800 sequences obtained from three individuals reveal that over half of all sequences come from five invariant genera, Acinetobacter, Sphingomonas, Acidovorax, Enhydrobacter, and Aquabacterium. The microbiome is diverse but has low equitability, with a total of 81 genera detected. Challenge studies suggest that non-native bacteria cannot colonize the skin. This definition of the normal skin microbiome lays the foundation for future studies with this model system.

关键词： Fish Microbiome Acinetobacter Sphingomonas Metagenomics Mucosal

功能性电刺激改善急性脑卒中患者肢体功能的随机对照研究

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中华医学杂志 2006年第37期86卷 2627-2631页

作者：燕铁斌许云影李常威 510120广州香港理工大学康复科学系香港大学东华医院神经科(李常威)

目的研究功能性电刺激(FES)对急性脑卒中偏瘫患者下肢运动和步行能力的影响。方法 46例初发脑卒中患者,年龄71岁±8岁,发病后9d±4 d,随机分为 FES 组(13例)、安慰电刺激组(15例),对照组(13例)。3组常规治疗相同,FES 组给予功能性电刺... 详细信息

目的研究功能性电刺激(FES)对急性脑卒中偏瘫患者下肢运动和步行能力的影响。方法 46例初发脑卒中患者,年龄71岁±8岁,发病后9d±4 d,随机分为 FES 组(13例)、安慰电刺激组(15例),对照组(13例)。3组常规治疗相同,FES 组给予功能性电刺激治疗,每天1次,每次30 min,共3周(15次);安慰组给予没有电流输出的电刺激,对照组不给电刺激。用综合痉挛量表(CSS)评定踝跖屈肌群肌张力,用表面肌电图评定踝背伸和跖屈肌群最大等长收缩(MIVC)时的力矩、积分肌电图和肌肉的协同收缩率,以及患者在住院期间独自行走的能力。结果 3组患者一般资料及治疗前各项评定结果的差异无统计学意义。治疗3周后,FES 组踝跖屈肌群痉挛增加程度最低,CSS 增加率3组分别为30%±35%、50%±88%、65%±65%。踝背伸时胫前肌 MIVC 明显增加(9 Nm±5 Nm、5 Nm±3 Nm、4 Nm±5 Nm),踝背伸时的协同收缩率明显降低(8%±5%、27%±26%、28%±19%)。治疗3周内,FES 组恢复行走能力的时间较其他2组平均早2～3 d(18 d±8 d,20 d±7 d,21d±8 d)。结论 FES 能明显改善初发脑卒中急性期偏瘫患者下肢的运动功能和步行能力。

关键词：经皮神经电刺激脑血管意外随机对照试验

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Effect of Gangliosides on the Adhesion of Neuroblastom Cells to Collagen

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中国当代儿科杂志 2001年第4期 455-460页

作者： WEN Fei-Qiu, CHEN Yi-Xin, WU Ben-Qing, Tamara Kazarian, leonard A ValentinoDepartment of pediatrics, Second Affiliated Hospital, Jinan Medical College, Shenzhen 518020, China

Objective To study the effect of endogeneous ganglioside (GS) on the adhesion of LA-N5 neuroblastoma cells to collagen. Methods LA-N5 cells were cultured in the presence of D-threo-1-phenyl-2-decanolamino-3-morphinoline-1-propanol (D-pDMp), an inhibitor of glucosylceramide synthase. The adhesion of the LA-N5 cells to immobilized collagen was tested. Results After 6 days, endogenous GS was reduced by 98%. No change in the cell morphology, viability, proliferation rate or percentage of apoptotic cells was observed. The adhesion to collagen of cells exposed to D-pDMp was reduced by 65% compared to the control LA-N5 cells: OD 570 0.07± 0.01 vs 0.21± 0.030(ppleted cells were pre-incubated in a conditioned medium collected from the control cells, the adhesion to collagen was restored and was comparable to that of the control cells (p> 0.05). Similarly, the pre-incubation of GS-depleted cells with purified tumor GS GD 2, the most abundant GS in LA-N5 cells, restored adhesion. Conclusions Endogenous tumor GS regulates neuroblastoma cell adhesion to collagen, suggesting that it may play a role in tumor cell migration, invasion and metastasis.

关键词： Gangliosides Neuroblastoma Adhesion

Viral haemorrhagic fevers and malaria co-infections among febrile patients seeking health care in Tanzania

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Infectious Diseases of poverty 2022年第2期11卷 95-95页

作者： Sima Rugarabamu Susan F.Rumisha Gaspary O.Mwanyika Calvin Sindato Hee-Young Lim Gerald Misinzo leonard E.G.Mboera SACIDS Foundation for One Health Sokoine University of AgricultureMorogoroTanzania 不详

Background:In recent years there have been reports of viral haemorrhagic fever(VHF)epidemics in sub-Saharan Africa where malaria is *** and malaria have overlapping clinical presentations making diferential diagno‑sis a *** objective of this study was to determine the prevalence of selected zoonotic VHFs and malaria co-infections among febrile patients seeking health care in ***:This facility-based cross-sectional study was carried out between June and November 2018 in Buhigwe,Kalambo,Kyela,Kilindi,Kinondoni,Kondoa,Mvomero,and Ukerewe districts in *** study involved febrile patients seeking health care from primary healthcare *** samples were collected and tested for infections due to malaria,Crimean-Congo haemorrhagic fever(CCHF),Ebola virus disease(EVD),Marburg virus disease(MVD),Rift Valley fever(RVF)and yellow fever(YF).Malaria infections were tested using rapid diagnostics tests while exposure to VHFs was determined by screening for immunoglobulin M antibodies using commercial enzyme-linked immuno‑sorbent *** Chi-square test was used to compare the ***:A total of 308 participants(mean age=35±19 years)were involved in the *** these,54(17.5%)had malaria infection and 15(4.8%)were positive for IgM antibodies against VHFs(RVF=8;CCHF=2;EBV=3;MBV=1;YF=1).Six(1.9%)individuals had both VHF(RVF=2;CCHF=1;EVD=2;MVD=1)and malaria *** highest co-infection prevalence(0.6%)was observed among individuals aged 46‒60 years(ppprevalence recorded in Buhigwe(1.2%)followed by Kinondoni(0.9%)***(100%)and muscle,bone,back and joint pains(83.3%)were the most signifcant complaints among those infected with both VHFs and malaria(p=0.001).Conclusions:Co-infections of VHF and malaria are prevalent in Tanzania and afect more the older than the younger *** the overlapping symptoms in co-inf

关键词： Malaria Viral haemorrhagic fevers Febrile illnesses Co-infection Tanzania

159例腹腔镜根治性前列腺癌切除术的疗效评估

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中华泌尿外科杂志 2005年第12期26卷 816-819页

作者：李爱华 Demetrius H.Bagley Edouard Trabulsi Deborah T.Glassman Stephen Strup Mark Chang Dolores Shupp-Byrne leonard G.Gomella 上海市杨浦区中心医院泌尿外科 200940 美国费城托马斯.杰弗逊大学医院泌尿外科

目的探讨腹腔镜根治性前列腺切除术的疗效.方法回顾性分析2000年3月至2003年8月159例腹腔镜根治性前列腺切除术患者资料.平均年龄58岁(42～74岁),同时行双侧盆腔淋巴结清扫术57例(35.9%).术前159例患者前列腺活检均确诊为前列腺癌.Glea... 详细信息

目的探讨腹腔镜根治性前列腺切除术的疗效.方法回顾性分析2000年3月至2003年8月159例腹腔镜根治性前列腺切除术患者资料.平均年龄58岁(42～74岁),同时行双侧盆腔淋巴结清扫术57例(35.9%).术前159例患者前列腺活检均确诊为前列腺癌.Gleason肿瘤分级:3+3:129例(81.1%),3+4:23例(14.5%),4+3:4例(2.5%),4+4:3例(1.9%).TNM肿瘤分期:T1c126例(79.3%),T2a 33例(20.7%).结果 159例患者平均手术时间298 min(165～660min).术中估计失血量平均293 ml(50～2500 ml),发生严重并发症15例(9.4%),其中中转开放手术6例(3.8%),无死亡病例.术后病理确诊为前列腺癌158例,1例诊断为良性前列腺增生伴急性前列腺炎.标本切缘阳性34例(21.5%).术后1年53例患者获得随访,术前31例(58.5%)有阴茎勃起功能的患者根据国际阴茎勃起功能指数(ⅡEF-5)评分分组进行术后变化评估.术后ⅡEF-5评分显著下降,各评分组间的差异无统计学意义.36例(67.9%)可通过使用Viagra等药物进行性生活,6例(11.3%)有尿失禁.结论腹腔镜根治性前列腺切除术是一种相对安全、微创、并发症低、术后康复快,同时又能达到肿瘤治疗效果的手术方法.但长期疗效尚待进一步观察.

关键词：腹腔镜根治性前列腺切除术疗效

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