Waardenburg syndrome(WS) is a genetically heterogeneous disorder characterized by manifests with sensorineural deafness and pigmentation defects of the hair,skin,and *** syndrome is classified into four types dependin...
Waardenburg syndrome(WS) is a genetically heterogeneous disorder characterized by manifests with sensorineural deafness and pigmentation defects of the hair,skin,and *** syndrome is classified into four types depending on the presence or absence of additional symptoms. Waardenburg syndrome type 1 WS,type 2 WS,Type 3 WS and Type 4 *** and 3 are due to mutations in the pAX3 ***2 are associated with mutations of MITF,SNAI2,and SOX10,in addition,there are two loci,1p21-p13.3 and ***4 can result from mutations in the endothelin-B receptor gene(EDNRB),and in the gene for its ligand,endothelin-3(EDN3).WSl and 2 are distinguished by the presence or absence of dystopia canthorum,***3 is distinguished by the presence of limb ***4,referred to as shah-Waardenburg syndrome or Waardenburg-Hirschsprung disease is characterized by the presence of an aganglionic ***1, 2 and 3 are autosomal dominant disorder,whereas WS4 is autosomal recessive disorder.
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