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侧脑室注射IL-1对IL-1RAcp基因敲除小鼠免疫功能的影响

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中国免疫学杂志 2001年第3期17卷 164-165页

作者：李康生董菁高明霞付清玲 p j neveu 汕头大学医学院微生物学与免疫学教研室汕头515031 法国INSERMU394

IL-1是介导机体免疫应答、免疫防御的重要细胞因子，在临床自身免疫病及慢性炎症的发生发展中亦具有重要作用，IL-1的合成和释放失控常引起慢性炎症而导致临床疾病，如类风湿性关节炎等。

关键词：小鼠免疫功能基因敲除侧脑室 IL-1 IL-1RAcp

甲基-苯基四氢吡啶对脑不对称小鼠纹状体内多巴胺和白介素含量的影响

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生物化学与生物物理进展 2005年第1期32卷 53-59页

作者：申延琴李康生 E.MOZE p.j.neveu 汕头大学医学院微生物学与免疫学教研室 Neurobiologie Intégrative CNRS FRE2723 Institut Francois Magendie Rue Camille Saint-Saêns 33077 Bordeaux Cedex France

为探讨甲基-苯基四氢吡啶(MpTp) 注射后脑不对称小鼠纹状体内多巴胺降低程度,及纹状体内细胞因子水平变化,C57BL/6j小鼠经过伸爪取食试验,筛选为反映脑不对称的左利鼠和右利鼠,并接受25 mg/kg MpTp腹腔注射连续5天,检测注射后的第1天,第... 详细信息

为探讨甲基-苯基四氢吡啶(MpTp) 注射后脑不对称小鼠纹状体内多巴胺降低程度,及纹状体内细胞因子水平变化,C57BL/6j小鼠经过伸爪取食试验,筛选为反映脑不对称的左利鼠和右利鼠,并接受25 mg/kg MpTp腹腔注射连续5天,检测注射后的第1天,第3天和第14天纹状体内多巴胺及代谢物含量和细胞因子IL-1茁、IL-6的动态水平. 结果表明,无论在左利鼠还是右利鼠,纹状体内多巴胺含量在MpTp注射后每个检测时间点都显著降低,纹状体内IL-1茁水平在第1天显著降低,纹状体内IL-6水平在MpTp注射后每个检测时间点也显著降低. 实验结果同时表明,左利鼠和右利鼠IL-1茁和IL-6的基础水平有显著不同. MpTp注射后,与右利小鼠相比,左利小鼠有较高的多巴胺翻转降低和较低的细胞因子表达,而且,纹状体内多巴胺水平与纹状体内IL-6水平呈正相关. 这些结果提示,MpTp诱导多巴胺丢失伴随着黑质纹状体系统内细胞因子水平的改变,而且,脑不对称有可能通过影响纹状体内细胞因子水平而进一步影响MpTp诱导的多巴胺降低的程度.

关键词：甲基-苯基四氢吡啶多巴胺纹状体白介素6(IL-6) 白介素1(IL-1) 脑不对称

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小鼠帕金森病模型中的大脑皮质细胞因子表达

第四军医大学学报 2005年第13期26卷 1160-1162页

作者：申延琴赵丽纯李康生 E.Moze p.j.neveu 汕头大学医学院微生物学与免疫学教研室广东汕头515041 法国国立卫生研究院波尔多神经生物学研究所法国波尔多33077

目的:探讨甲基苯基四氢吡啶(MpTp)是否可诱导小鼠大脑皮质内细胞因子水平变化.方法:28只C57BL/6j雄性小鼠接受MpTp25mg/kgip注射连续5d,对照组(10只)注射生理盐水,在最后一次注射的第1日(10只),第3日(8只)和第14日(10只)杀鼠,然后用酶... 详细信息

目的:探讨甲基苯基四氢吡啶(MpTp)是否可诱导小鼠大脑皮质内细胞因子水平变化.方法:28只C57BL/6j雄性小鼠接受MpTp25mg/kgip注射连续5d,对照组(10只)注射生理盐水,在最后一次注射的第1日(10只),第3日(8只)和第14日(10只)杀鼠,然后用酶联免疫吸附的方法检测大脑皮质匀浆液上清内细胞因子IL1β和IL6的水平.结果:注射MpTp对大脑皮质IL1β水平有影响(pppTp注射对大脑皮质IL6水平没有影响.结论:MpTp诱导了大脑皮质促炎症细胞因子IL1β的水平改变.

关键词：甲基-苯基-四氢吡啶大脑皮质白细胞介素6 白细胞介素1

IL-1α、Bax、Bcl-2等基因mRNA在帕金森病小鼠模型中的表达

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汕头大学医学院学报 2003年第1期16卷 5-8,15页

作者：申延琴李康生 j.Arsaut E.Moze p.j.neveu 汕头大学医学院微生物学与免疫学教研室广东汕头515031 INSERMU394 NeurobiologieIntegrative InstitutFranoisMagendie1RueCamilleSaintSens

目的 :探讨细胞因子IL 1α和IL 10与凋亡相关基因Bcl 2家族中Bax和Bcl 2在 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶(MpTp)致C5 7BL6j小鼠帕金森病模型中黑质和纹状体内的表达意义及关系。方法 :利用RT pCR的方法检测对照组 (NS组 )C5 7BL6... 详细信息

目的 :探讨细胞因子IL 1α和IL 10与凋亡相关基因Bcl 2家族中Bax和Bcl 2在 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶(MpTp)致C5 7BL6j小鼠帕金森病模型中黑质和纹状体内的表达意义及关系。方法 :利用RT pCR的方法检测对照组 (NS组 )C5 7BL6j小鼠及皮下注射MpTp后第 6天C5 7BL6j小鼠的左右侧脑内黑质、纹状体、下丘脑内的IL 1α ,IL 10 ,Bax和Bcl 2的mRNA的表达。结果 :与对照组相比 ,IL 1αmRNA在帕金森小鼠模型纹状体内表达显著增加 ;除对照组 1只外 ,对照组和MpTp组均未检测到IL 10mRNA的表达 ;BaxmRNA和Bcl 2mRNA在黑质内的表达均显著低于对照组。结论 :黑质和纹状体在MpTp所致的小鼠帕金森病中受累 ,表现为有不同基因的消长。促进炎症发生的细胞因子IL

关键词： IL-1α Bax Bcl-2 基因mRNA 帕金森病小鼠模型表达

Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making approach

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： M.p.SALAIMANIMAGUDAM j.jAYApRAKASH Department of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have provided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex *** paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)printing,shotcrete,smart dynamic casting,material intrusion,mesh molding,injection concrete 3D printing,and thin forming *** criteria include formwork utilization,reinforcement incorporation,geometrical complexity,material enhancement,assembly complexity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subjective and objective weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorporation,build area,and geometrical complexity play a pivotal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D printing emerged as the best performer,however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication multicriteria decision-making concrete 3D printing

proteins as nanomagnets and magnetoreceptors

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Zoological Research 2024年第4期45卷 831-832页

作者： p.j.Hore Department of Chemistry University of OxfordUK

It is an appealing notion that a protein molecule could act as a nanomagnet.A genetically encodable biomolecule with a permanent magnetic moment at room temperature could have a range of applications:a magnetogenetic actuator,a magnetic tag for purifying and immobilizing enzymes,a contrast agent for magnetic resonance imaging,and a basis for a biomimetic magnetic sensing device,to name just a few.A magnetic protein could perhaps also function as the sensor in the magnetic compass that enables small songbirds to navigate the huge distances between their breeding and wintering *** though such possibilities may be,how realistic are they?

关键词： magnetic magnets enable

脑不对称Balb/c小鼠血浆IL-1β、IL-6及皮质酮水平变化

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中国免疫学杂志 2000年第1期16卷 19-21,27页

作者：高明霞李康生董菁 p.j.neveu 汕头大学医学院微生物学及免疫学教研室汕头515031

目的：研究脑不对称性对细胞因子和ＨＰＡ轴的影响。方法：用伸爪取食法将小鼠区分为左利、右利、双利动物，ＬＰＳ分别刺激２、４ｈ后取血浆用ＥＬＩＳＡ法检测ＩＬ－１β、ＩＬ－６、放免法测定血浆皮质酮含量。结果：左利组血浆ＩＬ... 详细信息

目的：研究脑不对称性对细胞因子和ＨＰＡ轴的影响。方法：用伸爪取食法将小鼠区分为左利、右利、双利动物，ＬＰＳ分别刺激２、４ｈ后取血浆用ＥＬＩＳＡ法检测ＩＬ－１β、ＩＬ－６、放免法测定血浆皮质酮含量。结果：左利组血浆ＩＬ－１β高于右利组，左利、右利组ＩＬ－１β均低于双利组。左利、右利组血浆皮质酮水平低于双利组。ＬＰＳ刺激后左利组ＩＬ－１β高于右利组，双利组亦高于右利组；左利、右利组血浆ＩＬ－６水平则均低于双利组。结论：脑不对称性对神经免疫内分泌网络有影响，左利者免疫紊乱发生率高可能与此有关。

关键词：脑不对称性神经免疫内分泌细胞因子小鼠

Wettability,reactivity,and interface structure in Mg/Ni system

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journal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： S.Terlicka N.Sobczak Ł.Maj p.Darłak j.j.Sobczak Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta Str.KrakowPoland Faculty of Foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop method was applied to the experimental investigation of the wetting and spreading behaviors of liquid Mg drops on pure Ni *** comparison,the experiments were performed in two variants:(1)using the Capillary purification(Cp)procedure,which allows the non-contact heating and squeezing of a pure oxide-free Mg drop;(2)by classical Contact Heating(CH)*** high-temperature tests were performed under isothermal conditions(Cp:760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) *** the sessile drop tests,images of the Mg/Ni couples were recorded by CCD cameras(57 fps),which were then applied to calculate the contact angles of metal/substrate *** and transmission electron microscopy analyses,both coupled with energy-dispersive X-ray spectroscopy,were used for detailed structural characterization of the solidified *** was found that an oxide-free Mg drop obtained by the Cp procedure showed a wetting phenomenon on the Ni substrate(an average contact angleθpreading and good wetting over the Ni substrate(θ_((Cp))~20°in 5 s)to form a final contact angle ofθ_(f(Cp))~18°.In contrast,a different wetting behavior was observed for the CH procedure,where the unavoidable primary oxide film on the Mg surface blocked the spreading of liquid Mg showing apparently non-wetting behavior after 300 s contact at the test ***,in both cases,the deep craters formed in the Ni substrates under the Mg drops and significant change in the structure of initially pure Mg drops to Mg-Ni alloys suggest a strong dissolution of Ni in liquid Mg and apparent values of the final contact angles measured for the Mg/Ni system.

关键词： Magnesium-based alloys Sessile drop tests Capillary purification procedure Wettability Reactivity Contact angle

On the analytical solution of transient friction in channel flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： F.j.GARCíA-GARCíA p.FARINAS-ALVARINO Department of Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient friction in channel mean flows is the sum of two contributions,i.e.,the underlying laminar flow(ULF)and the purely turbulent component(pTC),and the contributions are analyzed separately by theoretical *** is found that,the transient friction may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time constant for plane-parallel laminar flows is reported,and the role of the time constant in a turbulent mean flow is *** is shown that the time constant is related to the turbulence's frozen ***,a study of the logarithmic layer during the transient flow is accomplished,which shows that the logarithmic layer is destroyed.

关键词： transient friction transient flow unsteady channel flow