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四川建材 2011年第3期37卷 86-88页

作者： paul M.Santi Christopher p.Russell Jerry D.higgins Jessica I.Spriet 李楚根中铁二院工程集团有限责任公司四川成都610031

（接上期）1.3.8不连续面：裂隙数目改良的RHRS系统加上了不连续面裂隙数目这一参数,用来反映破裂岩体中发生的渗透,冻楔作用以及化学风化的重要性（Senior,1999;Maerz et al.,2005;Romana,

关键词：评估系统统计分析危岩落石科罗拉多不连续面破裂岩体化学风化裂隙

科罗拉多危岩落石评估系统的修正和统计分析(一)

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四川建材 2011年第2期37卷 78-81,83页

作者： paul M. Santi Christopher p. Russell Jerry D. higgins Jessica I. Spriet 李楚根（译）不详中铁二院工程集团有限责任公司四川成都610031

修正的科罗拉多危岩落石评估系统是通过加入一些新近的有助于危岩产生的地质和气象因素开发的。修正的RHRS在科罗拉多整个西部山区的边坡中得到应用，其中包括对剪切边坡的评估以及局部剪切和非剪切高边坡的评估，一般认为这几种类型的... 详细信息

修正的科罗拉多危岩落石评估系统是通过加入一些新近的有助于危岩产生的地质和气象因素开发的。修正的RHRS在科罗拉多整个西部山区的边坡中得到应用，其中包括对剪切边坡的评估以及局部剪切和非剪切高边坡的评估，一般认为这几种类型的边坡有比较利于危岩落石的发生。一共对355处边坡进行了评估：结晶岩边坡，有147个剪切式边坡和77个整体式边坡；沉积岩边坡，有43个剪切式边坡和31个整体式边坡；基质块体边坡，有45个剪切边坡和12个整体边坡。利用最小二乘回归分析，得到对总危险评分在统计学上有重要影响的参数。然后使用顺序逻辑回归对这些子集进行分析，再把这些参数划分等级，以确定哪个参数对总危险评分影响最大。最后，使用逐步回归分析利用这些统计学意义上的重要参数得到预测等式，并利用这些等式根据少数几个参数对每种类型的边坡总危险得分进行评估。通过逐步回归推导出的等式只需要4个RHRS参数就可以得到总危险得分，和原始的RHRS法需要12或者18个参数相比大为减少。这些参数的选取主要取决于边坡的类型，R^2值在68—82％之间。对一些情况，还可以使用更多参数的等式以及相应的更高的R2数值。通过分析等式能够区分出每种边坡类型中最重要和最不重要的参数。对所有边坡类型来说，发生特征和倾斜面很重要，而倾角、每年冻结／解冻等级、边坡水特征，以及不连续面的摩擦并不重要。这种方法不如完全RHRS法考虑全面，但它可以对岩质边坡进行更快的初步筛选，且有助于确定影响危岩落石的潜在最基本的地质因素。

关键词：落石风险边坡分级

WONCA研究论文摘要汇编——全科医生同理心与健康结局:贫困与富裕地区问诊的前瞻性观察研究

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中国全科医学 2016年第14期19卷 1695-1695页

作者：本刊编辑部 Mercer SW higgins M Bikker AM

目的比较贫困与富裕地区问诊患者的期待、问诊特点和结局,探讨两种经济情况下相同因素能否预测出更佳结局。方法苏格兰贫困与富裕地区的47位全科医生负责的659例患者参与研究。在问诊之前评估患者对于决策参与的期待,并在问诊结束后立... 详细信息

目的比较贫困与富裕地区问诊患者的期待、问诊特点和结局,探讨两种经济情况下相同因素能否预测出更佳结局。方法苏格兰贫困与富裕地区的47位全科医生负责的659例患者参与研究。在问诊之前评估患者对于决策参与的期待,并在问诊结束后立即评估患者对全科医生同理心的感知。对问诊进行录像,并对医生的语言与非语言行为进行分析。对基线与1个月后症状严重性与相关健康状况进行评估。利用反向选择法,找到1个月后预测更佳结局的因素。结果贫困地区患者对共同决策的意愿更低(pp=0.01)。贫困地区的患者认为全科医生的同理心更少(p=0.02),语言与非语言行为中体现的以患者为中心的程度更低。贫困与富裕地区相比,1个月后结局更差(回应率70%;p<0.001)。医生同理心的感知在两组中均预测更佳结局。结论贫困与富裕地区相比,患者期待、全科医生在问诊中的行为、健康结局的差异较大。在两种情况下,患者对医生同理心的感知能够预测健康结局。本研究在不平等性和逆向照顾法则的情况下得到此发现。

关键词：同理心 WONCA 非语言行为选择法前瞻性观察不平等性

Gene Copy number variation and associated polymorphisms of complement component C4 in human SLE

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Gene Copy number variation and associated polymorphisms of c...

The Effectiveness of the Squared Error and higgins-Tsokos Loss Functions on the Bayesian Reliability Analysis of Software Failure Times under the power Law process

The 8th International Congress on SLE

作者： Erwin K Chung Yee Ling Wu Stephanie Savelli Haikady N Nagaraja Maddie Hebert Karla Jones Kathryn Kitzmiller Carol A Blanchong NatalieJacobsen-Longman Kim McBride Gloria C higgins Robert M Rennebohm Robert R Rice Kevin V Hackshaw Robert A Roubey Jennifer M Grossman Betty p Tsao Daniel J Birmingham Brad H Rovin Lee A Hebert C Yung Yu Columbus Children’s Research Institute College of Medicine and Public HealthThe Ohio State UniversityColumbusOhioUSA Division of Rheumatology Allergy and ImmunologyThe University of North Carolina at Chapel HillChapel Hill.NC.USA Department of Internal Medicine University of California.Los AngelesCaliforniaUSA

＜正＞purpose:To determine the inter-individual gene copy number variation（GCNV）of complement C4 and its associated polymorphisms in gene size（long and short）and protein isotypes（C4A and C4B）in human SLE. Method...

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Engineering（科研） 2019年第5期11卷 272-299页

作者： Freeh N. Alenezi Christ p. Tsokos University of South Florida Tampa FL USA Majmaah University Al-Zulfi Saudi Arabia

Reliability analysis is the key to evaluate software’s quality. Since the early 1970s, the power Law process, among others, has been used to assess the rate of change of software reliability as time-varying function by using its intensity function. The Bayesian analysis applicability to the power Law process is justified using real software failure times. The choice of a loss function is an important entity of the Bayesian settings. The analytical estimate of likelihood-based Bayesian reliability estimates of the power Law process under the squared error and higgins-Tsokos loss functions were obtained for different prior knowledge of its key parameter. As a result of a simulation analysis and using real data, the Bayesian reliability estimate under the higgins-Tsokos loss function not only is robust as the Bayesian reliability estimate under the squared error loss function but also performed better, where both are superior to the maximum likelihood reliability estimate. A sensitivity analysis resulted in the Bayesian estimate of the reliability function being sensitive to the prior, whether parametric or non-parametric, and to the loss function. An interactive user interface application was additionally developed using Wolfram language to compute and visualize the Bayesian and maximum likelihood estimates of the intensity and reliability functions of the power Law process for a given data.

关键词： power Law process Bayesian Reliability Intensity Function Kernel Density Loss Function Robustness

Diagnostic Ultrasonography of Fascitis to plant. presentation of a Case

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International Journal of Clinical Medicine 2014年第11期5卷 630-633页

作者： Dayneri León Valladares Alexis Matheu pérez Emilio Villanueva Cagiga Alex pérez León Institute of Medicine of the Sport Havana Cuba Universidad Bernardo O’higgins Santiago Chile

The use of Ultrasonography is very important in the diagnosis of several conditions of the body, particularly the muscular skeletal system, and it is grateful as a very valuable method of exploration complementary of image. The fascitis to plant is frequent in the corridors. The use of the Ultrasonography is with the objective of visualizing the presence and the magnitude of the fascitis plant in a fond corridor and to know the sensibility of the Ultrasonography of High Resolution in the diagnosis of this lesion. This study in a fond corridor, symptomatic of affection to plant fascitis, in this case severe increase of low ecogenicidad of the insert was verified in the calcaneus of the fascia to plant of the tweeted right with bony proliferation sketch at that level, in contrast with the one against-lateral. The Ultrasonography demonstrated its sensibility in the diagnosis of the fascitis to plant that it is recognized as the most frequent affection that is presented in corridors related with the occasional incursion of career or to its systematic practice associated with factors external they predispose.

关键词： Sportsmen A Fond Corridor Ultrasonography Lesions Fascitis Sport

One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第28期29卷 4466-4480页

作者： Mahmoud Obeidat Brigitta Teutsch Anett Rancz Edina Tari Katalin Márta Dániel Sándor Veres Nóra Hosszúfalusi Emese Mihály péter Hegyi Bálint Erőss Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7623Hungary Department of Internal Medicine and Hematology Semmelweis UniversityFaculty of MedicineBudapest 1085Hungary Institute of pancreatic Diseases Semmelweis UniversityBudapest 1083Hungary Department of Biophysics and Radiation Biology Semmelweis UniversityBudapest 1085Hungary

BACKGROUND Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal ***,there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal *** To determine the pooled event rates in the available literature and specify them based on the bleeding *** The protocol was registered on pROSpERO in advance(CRD42021283258).A systematic search was performed in three databases(pubMed,EMBASE,and CENTRAL)on 14^(th) October *** proportions with 95%CI were calculated with a random-effects model.A subgroup analysis was carried out based on the time of assessment(on admission or during hospital stay).Heterogeneity was assessed by higgins and Thompson’s I^(2) *** Joanna Briggs Institute prevalence Critical Appraisal Tool was used for the risk of bias *** Reference Citation Analysis(https://***/)tool was applied to obtain the latest highlight *** We identified 11589 records,of which 220 studies were eligible for data *** overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25(95%CI:0.17-0.36,I^(2)=100%).In non-variceal bleeding,the proportion was 0.22(95%CI:0.14-0.31,I^(2)=100%),whereas it was 0.25(95%CI:0.19-0.32,I^(2)=100%)in variceal *** proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12(95%CI:0.06-0.22,I^(2)=90%).The risk of bias was low,and heterogeneity was high in all *** One in five,one in four,and one in eight patients develops shock or hemodynamic instability on admission or during hospitalization in the case of non-variceal,variceal,and colonic diverticular bleeding,respectively.

关键词： Gastrointestinal bleeding Hemodynamic instability Shock Meta-analysis Statistics Review

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慢性化脓性汗腺炎基础上发生女阴鳞状细胞癌

世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 38-38页

作者： Short K.A Kalu G Mortimer p.S higgins E.M 冯义国 Department of Dermatology King's College Hospital London SE5 9RS United Kingdom

We report a case of vulval squamous cell carcinoma (SCC)arising in chronic hidradenitis suppurativa (HS). The patient had a complex medical history including a 2 5-year-history of Crohns disease. In addition she had recently received immunosuppressive therapy for nephrotic syndrome secondary to membranous glomerulonephritis. A painful nodule was noted on the vulva that was clinically very suspicious of SCC. An excision biopsy confirmed the diagnosis. There are few publications in the English literature citing association between HS and the development of SCC. The first report in the English literature of vulval SCC arising in chronic HS was published in 1999. We wish to draw attention to the possibility that patients with HS may develop SCC in lesional skin. A painful lump or ulcer could easily be mistaken for an inflammatory lesion and a low threshold for biopsy is warranted. We suggest constant vigilance with regard to malignant change in ano-genital HS as the diagnosis can be difficult.

关键词：化脓性汗腺炎女阴鳞状细胞癌切除活检病变皮肤膜性肾小球肾炎痛性结节肾病综合征疼痛性英语文献

GRADE指南：Ⅶ.证据质量评价--不一致性

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中国循证医学杂志 2011年第12期11卷 1444-1451页

作者： Gordon H.Guyatt Andrew D.Oxman Regina Kunz James Woodcock Jan Brozek Mark Helfand pablo Alonso-Coello paul Glasziou Roman Jaeschke Elie A.Akl Susan Norris Gunn Vist philipp Dahm Vijay K.Shukla Julian higgins Yngve Falck-Ytter Holger J.Schünemann 代表GRADE小组李幼平杨晓妍王莉蔡羽嘉陈群飞机构不详

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质... 详细信息

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质性检验和I2。系统评价作者应提出并检验少数几个与患者、干预措施、结局指标以及方法学相关的先验假设以探寻异质性来源。当不一致性很大且无法解释时,因不一致性而降低质量级别是恰当的,特别当某些研究显示有显著益处而其他显示无益甚至有害时(而非仅是疗效大与疗效小的比较)。明显的亚组效应可能不可靠。如果亚组效应满足以下条件,其可信度将会增加:基于少数几个有具体方向的先验假设、亚组比较来自研究内而非研究间、交互检验的p值小、结果有生物学意义。

关键词： GRADE 不一致性异质性变异性亚组分析交互作用

一个轻型智力发育迟缓家族中异常ATp依赖的Lon蛋白酶基因突变

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 33-33页

作者： higgins J.J. pucilowska J. Lombardi R.Q. Rooney J.p. 李一明 Ctr. for Hum. Genet./Child Neurol. Mid-Hudson Family Health Institute 279 Main St . New Paltz NY 12561 United States Dr.

Background: Identifying the genetic factors that contribute to memory and lea rning is limited by the complexity of brain development and the lack of suitable human models for mild disorders of cognition. Methods: previously, a disease lo cus was mapped for a mild type of nonsyndromic mental retardation (IQ between 50 and 70) to a 4.2-MB interval on chromosome 3p25-pter in a large kindred. Th e genes and transcripts within the candidate region were systematically analyzed for mutations by single-strand polymorphism analysis and DNA sequencing. Resu lts: A nonsense mutation causing a premature stop codon in a novel gene (cereblo n; CRBN) was identified that encodes for an ATp-dependent Lon protease. The pr edicted protein sequence is highly conserved across species, and it belongs to a family of proteins that selectively degrade short-lived polypeptides and regu late mitochondrial replication and transcription. One member of the Lon-contai ning protein family is regionally expressed in the human hippocampus, an importa nt neuroanatomic region that is involved in long-term potentiation and learnin g. The mutation in the CRBN gene described interrupts an N-myristoylation site and eliminates a casein kinase II phosphorylation site at the C terminus. Concl usions: A gene on chromosome 3p that is associated with mild mental retardation in a large kindred is reported. This finding implicates a role for the ATp-dep endent degradation of proteins in memory and learning.

关键词：智力发育迟缓 ATp Lon 基因突变认知障碍线粒体复制蛋白谱无义突变终止密码子长时程增强