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Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia

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World Journal of Gastroenterology 2014年第12期20卷 3312-3319页

作者： Janne S Suominen Hanna Lampela pivi heikkil Jouko Lohi Hannu Jalanko Mikko p pakarinen Department of pediatric Surgery Pediatric Liver and Gut Research GroupChildren’s HospitalUniversity of Helsinki Department of pathology HUSLABHelsinki University Central Hospital Department of paediatrics Children’s HospitalHelsinki University Central Hospital

AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(pE)***:Liver specimens were obtained at pE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and *** biopsies from 35 organ donors were used as *** patterns were related to clinical data including age at pE,serum total and conjugated bilirubin concentration at the time of pE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological ***:Collagen 1(16.4%vs 4.5%,ppp=0.017)were markedly overexpressed in BA patients compared with *** who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,p=0.024),α-SMA(20.4%vs 15.4%,p=0.009)and CD34(5.9%vs 4.0%,p=0.029)at pE compared with native liver ***34-positive microvessels were identified in the centrizonal region close to central vein in every BA *** majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic *** controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the *** difference between BA patients and controls was significant(ppatients who developed esophageal varices by two years had significantly higher expression of CD34 at pE compared with patients without varices(5.6%vs 4.0%,p=0.019).Expression ofα-SMA(r=0.758,pp=0.016),and the amount of CD34-positive microvessels(r=0.356,p=0.047)were related to patient age at ***:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasin

关键词： Biliary atresia Liver fibrosis Neovascularization

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