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Large eddy simulations of a turbulent mixing layer periodically excited with fundamental and third harmonic frequency

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Chinese Journal of Aeronautics 2023年第5期36卷 33-40页

作者： Jörg SCHLÜter Dan ZHAO Abhishek SARKAR School of Engineering Deakin UniversityWaurn Ponds 3216Australia College of Engineering University of CanterburyChristchurch 8041New Zealand School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore

A better understanding of the mixing behavior of excited turbulent mixing layers is critical to a number of aerospace *** studies of excited turbulent mixing layers focused on single frequency excitation or the excitation with fundamental and its second harmonic *** is a lack of detailed studies on applying low and higher frequency *** this study,we have performed large-eddy simulations of periodically excited turbulent mixing *** excitation consists of a fundamental frequency and its third *** have used phase-averaging to identify the vortex structure and strength in the mixing layer,and we have studied the vortex *** different vortex paring mechanisms are observed depending on the phase shift between the two excitation *** influence of these two mechanisms on the mixing of a passive scalar is also *** is found that exciting the mixing layer with these low and high frequencies has initially an adverse influence on the mixing process;however,it improves the mixing further downstream of the splitter plate with the excitation using a phase shift ofΔφ=πshowing the best mixing *** present works shed lights on the fundamental vortex dynamics,and has great potential for aeronautical,automotive and combustion engineering applications.

关键词： Flow control Flow excitation Large eddy simulations Turbulent mixing layer Vortex dynamics

Classical Chinese Novels in Hungarian Translation

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中国比较文学 2014年第4期 110-119页

作者： peter Hajdu Institute for Literary Studies Hungarian Academy of Sciences

社会主义时期(1957-1989)的匈牙利迎来了翻译的黄金时代:不以盈利为目的的国有出版社能够赞助长期的翻译项目,并因拥有可靠的编辑人员和众多优秀的译者而生产佳作。在此期间,《金瓶梅》和中国古典小说四大名著中的三部被译为匈牙利语,不... 详细信息

社会主义时期(1957-1989)的匈牙利迎来了翻译的黄金时代:不以盈利为目的的国有出版社能够赞助长期的翻译项目,并因拥有可靠的编辑人员和众多优秀的译者而生产佳作。在此期间,《金瓶梅》和中国古典小说四大名著中的三部被译为匈牙利语,不过,其中只有《水浒传》(1961)和《西游记》(1969)是由一位杰出的汉学家直接从中文译入的,而《红楼梦》(1959)和《金瓶梅》(1964)均转译自德文删简版。然而,那些转译的作品却更受欢迎,不断再版。究其原因,也许是原作的异国因素在经过转译后,更易引起匈牙利读者的共鸣,但也可能是因为家族题材的小说与西方小说更为相类,更易为本土读者所接受。1989年之后匈牙利对中国文学的翻译急剧减少,此种状况今后或许会有改善。

关键词：直译转译中国古典小说匈牙利的翻译传统莫言

Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon péter Hauser György péter Csongor Kiss Miklós Garami István peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of pharmacology and pharmacotherapy Semmelweis UniversityBudapestHungary Department of pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support pediatric tumors precision oncology Tumor board

Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review

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World Journal of Gastroenterology 2020年第40期26卷 6270-6278页

作者： Márk Félix Juhász Klementina Ocskay Szabolcs Kiss péter Hegyi Andrea párniczky Institute for Translational Medicine University of PécsMedical SchoolPécs 7624Hungary Doctoral School of Clinical Medicine University of SzegedSzeged 6720Hungary Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of pediatrics Heim Pál National Institute for PediatricsBudapest 1089Hungary

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection, mostly causing respiratory symptoms, is also known to affect the gastrointestinal tract. Several case reports hypothesize that SARS-CoV-2 could be an etiological factor in acute pancreatitis(Ap).AIM To assess all the available evidence in the literature relating to coronavirus disease 2019(COVID-19) and *** We performed a systematic review of the available literature on the topic. The systematic search was conducted on 15 May 2020 on MEDLINE, EMBASE, CENTRAL, Web of Science and Scopus with a search key using the terms "amylase," "lipase," "pancr*," "COVID-19" and synonyms. Due to the low quality and poor comparability of the studies, a meta-analysis was not *** Six case reports and two retrospective cohorts were included, containing data on eleven COVID-19 patients with Ap. Five patients had Ap according to the Atlanta classification. Other publications did not provide sufficient information on the diagnostic criteria. Most cases were considered SARS-CoV-2-induced, while several established etiological factors were not investigated. We were able to identify other possible causes in most of *** We strongly highlight the need for adherence to the guidelines during a diagnostic and etiological workup, which could alter therapy.

关键词： pancreas COVID-19 pancreatic involvement pancreatitis Amylase Lipase

Restoration of energy level in the early phase of acute pediatric pancreatitis

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World Journal of Gastroenterology 2017年第6期23卷 957-963页

作者： Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus péter Varjú péter Hegyi Andrea párniczky First Department of pediatrics Semmelweis University Institute for Translational Medicine University of Pécs Institute for Bioanalyses University of Pécs Department of Gastroenterology First Department of MedicineUniversity of Pécs Department of Translational Medicine First Department of MedicineUniversity of Pécs First Department of Surgery Semmelweis University Hungarian Academy of Sciences-University of Szeged Momentum Gastroenterology Multidisciplinary Research Group Heim pál Children’s Hospital

Acute pancreatitis (Ap) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of Ap. Moreover, it has been revealed that restoration of intracellular ATp level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric Ap. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(pRISMA-p) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: p: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe Ap, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, p = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. prospective studies and better pres

关键词： pediatric pancreatitis enteral nutrition nil per os diet ATp restoration length of hospitalization

Challenging the term symbiosis in plant-microbe associations to create an understanding across sciences

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Journal of Integrative plant Biology 2024年第1期66卷 7-11页

作者： Anna Neubauer Daniela Aros‐Mualin Vicente Mariscal péter Szövényi Department of Systematic and Evolutionary Botany University of ZurichZurich 8008Switzerland Zurich‐Basel plant Science Center Zurich 8092Switzerland Instituto de Bioquímica Vegetal y Fotosíntesis CSIC y Universidad de SevillaSevilla 41092Spain

THE IMpORTANCE OF WELL DEFINED terMINOLOGY,Effective communication across fields and disciplines relies on well defined *** use of accurate definitions has been advocated by scientists across various disciplines(pySek... 详细信息

关键词： terminology definition fields

Hyperactive learning for data-driven interatomic potentials

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npj Computational Materials 2023年第1期9卷 599-612页

作者： Cas van der Oord Matthias Sachs Dávid péter Kovács Christoph Ortner Gábor Csányi University of Cambridge Cambridge CB21PZUK University of Birmingham Birmingham B152TTUK University of British Columbia VancouverBC V6T 1Z2Canada

Data-driven interatomic potentials have emerged as a powerful tool for approximating ab initio potential energy *** most time-consuming step in creating these interatomic potentials is typically the generation of a suitable training *** aid this process hyperactive learning(HAL),an accelerated active learning scheme,is presented as a method for rapid automated training database *** adds a biasing term to a physically motivated sampler(*** dynamics)driving atomic structures towards uncertainty in turn generating unseen or valuable training *** proposed HAL framework is used to develop atomic cluster expansion(ACE)interatomic potentials for the AlSi10 alloy and polyethylene glycol(pEG)polymer starting from roughly a dozen initial *** HAL generated ACE potentials are shown to be able to determine macroscopic properties,such as melting temperature and density,with close to experimental accuracy.

关键词： starting generating consuming

Smooth free-cycle dynamic soaring in unspecified shear wind via quadratic programming

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Chinese Journal of Aeronautics 2022年第7期35卷 19-29页

作者： Haichao HONG Benedikt GRüter patrick pIpREK Florian HOLZApFEL Institute of Flight System Dynamics Technical University of MunichGarching D-85748Germany

Harvesting wind energy is promising for extending long-endurance flights,which can be greatly facilitated by a flight technique called dynamic *** presented study is concerned with generating model-based trajectories with smooth control histories for dynamic soaring maneuvers exploiting wind *** desired smoothness is achieved by introducing a trigonometric series parameterization for the controls,which are formulated with respect to the normalized ***,the periodicity of the trigonometric functions is leveraged to facilitate the connection of cycles and streamline the problem *** relying on a specified wind profile,a freefinal-time quadratic programming-based control strategy is developed for the online correction of the flight trajectory,which requires only the instant wind *** and online numerical studies show the trade-off to achieve the smoothness and demonstrate the effectiveness of the proposed method in a varying wind field.

关键词： Dynamic soaring Optimal control Quadratic programming Trajectory generation Trigonometric series

Bioelectrochemistry for flexible control of biological processes

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Environmental Science and Ecotechnology 2020年第1期1卷 83-84页

作者： Annemiek ter Heijne Environmental Technology Wageningen University&ResearchBornse Weilanden 96708 WGWageningenthe Netherlands

Societal awareness and worries about the future of the earth are rapidly *** does not want to contribute to a sustainable future,in which the earth’s resources will still be available for future generations?In my view,a sustainable world is a world in which we live in close collaboration with *** nature,microorganisms are a key player in the global carbon,nitrogen and phosphorous cycle.

关键词： earth sustainable collaboration