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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos m.Kanczler Stuart Lanham Andrew Rawlings marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca cidonio Richard O.c.Oreffo Faculty of medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK center for Life Nano-and Neuro-Science(cLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-Ecm)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBmScs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-Ecm(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBmScs viability upon *** composite of human bone-Ecm-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(cAm)*** inclusion of bone morphogenetic protein-2(Bmp-2)with the HBmScs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-Ecm)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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Advancements in Fixed point Theorems for α-Geraghty contractions in complete metric Space

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Journal of mathematical research with Applications 2024年第5期 697-710页

作者： V.c.BORKAR mohammed m.A.TALEB Saeed A.A.AL-SALEHI School of mathematical at Yeshwant mahavidyalaya Swami Ramanand Teerth Marathwada University School of mathematical at Science college Swami Ramanand Teerth Marathwada University Department of mathematics Hodeidah University Department of mathematics Aden University

This article improves and advances the results achieved by Vishal and Naveen, leveraging the use of Lebesgue integrable functions. Going beyond, we investigate fixed point theorems associated with a concept introduced by Ovidiu popescu. Our research not only bolsters the theoretical framework but also unveils practical applications in the domain of Lebesgue integrals as in Example 3.6. Furthermore, our contribution enhances the understanding of fixed point theorems in metric spaces and introduces novel perspectives in the study of generalized α-Geraghty contractive mappings on Lebesgue integrals.

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refractory Ventricular Fibrillation with Underlying coronary Artery Disease after cOVID-19 Vaccine-Kounis Syndrome or coincidence

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case reports in clinical medicine 2024年第8期13卷 309-314页

作者： Elaine m. c. chau cardiology centre Hong Kong Sanatorium & Hospital Hong Kong SAR China

A 63-year-old man with diabetes and asymptomatic coronary artery disease developed refractory ventricular arrhythmia at 20 hours at rest after his second cOVID-19 vaccine. Despite significant stenosis in the coronary arteries, there was no evidence of acute or old myocardial infarction, heart failure, myocarditis or structural abnormalities on post-mortem to account for the substrate for the fatal arrhythmia. The refractory and incessant nature of the ventricular fibrillation and post-mortem finding of a grossly elevated unexplained IgE level (in the absence of acute myocardial infarction) suggested the possibility of Kounis Syndrome or allergic acute coronary syndrome.

关键词： refractory Ventricular Fibrillation cOVID-19 Vaccine Kounis Syndrome

Adaptive marine predator Optimization Algorithm(AOmA)-Deep Supervised Learning classification(DSLc)based IDS framework for mANET security

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Intelligent and converged Networks 2024年第1期5卷 1-18页

作者： m.Sahaya Sheela A.Gnana Soundari Aditya mudigonda c.Kalpana K.Suresh K.Somasundaram Yousef Farhaoui Department of Electronics and communication Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600069India Department of computer Science and Engineering Saveetha School of EngineeringSIMATSChennai 602105India JNIAS School of planning and Architecture Hyderabad 500034India Department of computer Science and Engineering NPR College of Engineering and TechnologyNatham Dindigul 624401India Department of computer Science and Engineering PSNA College of Engineering and TechnologyPoolangulathupatti 620009India Department of computer Science and Engineering Sri Muthukumaran Institute of TechnologyChennai 600069India Department of computer Science Moulay Ismail UniversityMeknes 5003Morocco

Due to the dynamic nature and node mobility,assuring the security of mobile Ad-hoc Networks(mANET)is one of the difficult and challenging tasks *** mANET,the Intrusion Detection System(IDS)is crucial because it aids in the identification and detection of malicious attacks that impair the network’s regular *** machine learning and deep learning methodologies are used for this purpose in the conventional works to ensure increased security of ***,it still has significant flaws,including increased algorithmic complexity,lower system performance,and a higher rate of ***,the goal of this paper is to create an intelligent IDS framework for significantly enhancing mANET security through the use of deep learning ***,the min-max normalization model is applied to preprocess the given cyber-attack datasets for normalizing the attributes or fields,which increases the overall intrusion detection performance of ***,a novel Adaptive marine predator Optimization Algorithm(AOmA)is implemented to choose the optimal features for improving the speed and intrusion detection performance of ***,the Deep Supervise Learning classification(DSLc)mechanism is utilized to predict and categorize the type of intrusion based on proper learning and training *** evaluation,the performance and results of the proposed AOmA-DSLc based IDS methodology is validated and compared using various performance measures and benchmarking datasets.

关键词： Intrusion Detection System(IDS) Security mobile Ad-hoc Network(mANET) min-max normalization Adaptive marine predator Optimization Algorithm(AOmA) Deep Supervise Learning classification(DSLc)

A preliminary comparative Study on the centering Algorithms for cassiniISS NAc Images

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research in Astronomy and Astrophysics 2024年第10期24卷 58-65页

作者： T.Liang Q.-F.Zhang G.-m.Liu W.-H.Zhu c.-S.Wang Department of computer Science Jinan UniversityGuangzhou 510632China Sino-French Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China School of computer Science Guangdong University of EducationGuangzhou 510303China

Obtaining high precision is an important consideration for astrometric studies using images from the Narrow Angle camera(NAc)of the cassini Imaging Science Subsystem(ISS).Selecting the best centering algorithm is key to enhancing astrometric *** this study,we compared the accuracy of five centering algorithms:Gaussian fitting,the modified moments method,and three point-spread function(pSF)fitting methods(effective pSF(epSF),pSFEx,and extended pSF(x pSF)from the cassini Imaging central Laboratory for Operations(cIcLOpS)).We assessed these algorithms using 70 ISS NAc star field images taken with cL1 and cL2 filters across different stellar *** epSF method consistently demonstrated the highest accuracy,achieving precision below 0.03 pixels for stars of magnitude *** to the previously considered best,the modified moments method,the e pSF method improved overall accuracy by about 10%and 21%in the sample and line directions,***,the xpSF model provided by cIcLOpS had lower precision than the ***,the epSF exhibits an improvement in measurement precision of 23%and 17%in the sample and line directions,respectively,over the *** discrepancy might be attributed to the xpSF focusing on photometry rather than *** findings highlight the necessity of constructing pSF models specifically tailored for astrometric purposes in NAc images and provide guidance for enhancing astrometric measurements using these ISS NAc images.

关键词： methods:analytical techniques:image processing stars:imaging astrometry

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Investigating Stability properties for Transition metal carbonate precursors Using Universal cluster Expansion Technique(UNcLE)as cathodes for Li-Ion Batteries

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材料科学与工程（中英文A版） 2024年第1期14卷 26-33页

作者： mogahabo Tebogo morukuladi N.L.Lethole m.c.masedi N.N.Ngoepe p.E.Ngoepe materials modelling centre University of LimpopoPrivate Bag x1106Sovenga 0727South Africa Department of physics University of Fort HareAlice 5700South Africa

The universal cluster expansion technique was used in this study to determine the binary phase diagrams for the transition metal carbonate precursors mcO3(m:mn,Ni,co).The use of mixed cathode materials in lithium-ion batteries such as Nmc(Ni,mn and co)formulations,is a strategic approach to optimize performance,enhance safety and address cost and environmental considerations in the rapidly evolving field of energy *** study focuses on the cost issue related to lithium ion batteries by investigating the manganese rich Nmc since manganese is more abundant and *** doped mncO3 with nickel and doped mncO3 with cobalt then ran cluster expansion calculations to generate binary *** binary phase diagrams generated indicated that doping mncO3 with nickel favours the mn-rich side,while doping mncO3 with cobalt favours 50%mn-rich and 50%*** further extracted the most stable structures from both binary diagrams and determined their electronic,mechanical and vibrational stabilities using DFT(density functional theory)calculations within the LDA(local gradient approximation)with Hubbard parameter(U).The electronic properties revealed that both materials are semiconductors due to their narrow energy band gap obtained while the mechanical properties showed that structures are mechanically stable since their necessary conditions for trigonal and triclinic systems were satisfied.

关键词： Binary phase diagrams mechanical properties electronic conductivity phonon dispersion curves.

mid-term survival of the Optimys short stem: A prospective case series of 500 patients

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World Journal of Orthopedics 2024年第3期15卷 257-265页

作者： Bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker Esther R c Janssen Inger N Sierevelt Gino m m J Kerkhoffs Daniël Haverkamp Department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther R c Janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands centre for Orthopaedic research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery and Sports medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BAcKGROUND In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in comparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in different *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(mathys Ltd,Bettlach,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(pROms).Kaplan-meier analysis was used to calculate the 5-year survival ***-minus-log transformation was performed to calculate the 95%confidence interval(95%cI).mixed model analyses were performed to assess the course of the pROms during the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in pROms during both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile range:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%cI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%cI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival revision pROms

Ground-based and additional science support for SmILE

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Earth and planetary physics 2024年第1期8卷 275-298页

作者： J.A.carter m.Dunlop c.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.milan T.Sergienko R.c.Fear D.G.Sibeck m.connors T.Yeoman X.Tan m.G.G.T.Taylor K.mcWilliams J.Gjerloev R.Barnes D.D.Billet G.chisham A.Dimmock m.p.Freeman D.-S.Han m.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu m.K.James L.Juusola K.Kauristie E.A.Kronberg m.Lester J.manuel J.matzka I.mccrea Y.miyoshi J.Rae L.ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun m.-T.Walach B.Walsh c.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment monitoring and Information processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and climate physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space physics KirunaSweden West Highfield campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEc European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied physics Laboratory LaurelMarylandUSA Swedish Institude of Space physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China center for Space plasma physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA polar research Institute of china Shanghai 200136China Finnish meteorological Institute(FmI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany canadian Space Agency MontrealCanada GFZ German research centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and chinese Academy of Sciences Solar wind magnetosphere Ionosphere Link Explorer(SmILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SmILE ***,we describe current community efforts to prepare for SmILE,and the benefits and context various experiments that have explicitly expressed support for SmILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SmILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SmILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SmILE conjunctions missions

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Language Assessment Feedback Towards pedagogical conversational Agent

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Sino-US English Teaching 2024年第5期21卷 201-216页

作者： Bhagya prabhashini c m.Latha Jazan University JazanK.S.A. K.L.E.F. Andhra PradeshIndia

continuous development of technology provides an opportunity to incorporate feedback in online *** mode of online instruction during the pandemic was the most significant survival *** enabled every teacher and student to enter a virtual classroom to make sense of *** is part of language instruction and is a powerful key to improving students’learning *** plays an influential and crucial role in teaching and *** is an invaluable,ultimate learning tool for learners that aids them in not committing the same error again and creates ***,knowing about formative exam feedback is students’right because quality feedback allures *** students’eagerness,providing feedback is considered a good practice to be followed by all the teaching *** of online feedback,the present study attempts to study how pedagogical agents provide online feedback in language *** study also considers the characteristics of pedagogical conversational agents that are suitable for providing feedback in online language *** put,the study encapsulates that screen agents play an essential role in students’motivation and acceptability of learning through feedback.

关键词： feedback learning performance online language assessment pedagogical conversational agents