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Pentamidine in Pneumocystis jirovecii prophylaxis in heart transplant recipients

World Journal of Transplantation 2016年第1期6卷 193-198页

作者： Adem Ilkay diken ozlem er?en diken Onur Hanedan Seyhan Y?lmaz Ata Niyazi Ecevit Emir erol Adnan Yal??nkaya Department of Cardiovascular Surgery Hitit University Faculty of Medicine Department of Chest Diseases Hitit University Faculty of Medicine Department of Cardiovascular Surgery Turkiye Yuksek Ihtisas Hospital

Despite advances in transplantation techniques and the quality of post-transplantation care, opportunistic infections remain an important cause of complications. Pneumocystis jirovecii(P. jirovecii) is an opportunistic organism, represents an important cause of infections in heart transplantation patients. Almost 2% to 10% of patients undergoing cardiac transplantation have Pneumocystis pneumonia. Prophylaxis is essential after surgery. Various prophylaxis regimes had been defined in past and have different advantages. Trimethoprim/sulfamethoxazole(TMP/SMX) has a key role in prophylaxis against P. jirovecii. Generally, although TMP/SMX is well tolerated, serious side effects have also been reported during its use. Pentamidine is an alternative prophylaxis agent when TMP/SMX cannot be tolerated by the patient. Structurally, pentamidine is an aromatic diamidine compound with antiprotozoal activity. Since it is not effectively absorbed from the gastrointestinal tract, it is frequently administered via the intravenous route. Pentamidine can alternatively be administered through inhalation at a monthly dose in heart transplant recipients. Although, the efficiency and safety of this drug is well studied in other types of solid organ transplantations, there are only few data about pentamidine usage in heart transplantation. We sought to evaluate evidence-based assessment of the use of pentamidine against P. jirovecii after heart transplantation.

关键词： Pentamidine Prophylaxis Trimethoprim Heart transplantation Pneumocystis pneumonia Pneumocystis jirovecii Pneumocystis carinii

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Role of serological rapid antibody test in the management of possible COVID-19 cases

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World Journal of Experimental Medicine 2021年第4期11卷 44-54页

作者： Fatma Yıldırım Pinar Yildiz Gulhan ozlem ercen diken Aylin Capraz Meltem Simsek Berna Botan Yildirim Muhammet Ridvan Taysi Sakine Yilmaz Ozturk Nurcan Demirtas Julide ergil Adem Dirican Tugce Uzar Irem Karaman Sevket Ozkaya Department of Pulmonary and Critical Care Medicine University of Health Sciences Diskapi Yildirim Beyazit Research and Education HospitalAnkara 06110Turkey Department of Pulmonary Medicine Düzce UniversityFaculty of MedicineDüzce 81100Turkey Department of Chest Diseases Adana Research and Education HospitalUniversity of Health SciencesAdana 01230Turkey Department of Pulmonary Medicine Amasya University Sabuncuoglu Serefeddin Research and Education HospitalAmasya 05200Turkey Medical Intensive Care Unit University of Health Sciences Diskapi Yildirim Beyazit Research and Education HospitalAnkara 06110Turkey Department of Pulmonology Research and Education Hospital of Baskent UniversityKonya 42030Turkey Department of Infectious and Clinical Microbiology University of Health Sciences Diskapi Yildirim Beyazit Research and Education HospitalAnkara 06110Turkey Department of Pulmonary Medicine Vezirkopru State HospitalSamsun 55090Turkey Department of Pulmonary Medicine Kumluca State HospitalAntalya 07070Turkey Department of Anaesthesiology and Reanimation Diskapi Yildirim Beyazit Research and Education HospitalUniversity of Health SciencesAnkara 06110Turkey Department of Pulmonary Medicine Samsun Medicalpark HospitalSamsun 55090Turkey Irem Karaman Medical Student/InternBahcesehir University Faculty of MedicineIstanbul 34734Turkey Department of Pulmonary Medicine Bahcesehir UniversityFaculty of MedicineIstanbul 34734Turkey

Although the detection of viral particles by reverse transcription polymerase chain reaction(RT-PCR)is the gold standard diagnostic test for coronavirus disease 2019(COVID-19),the false-negative results constitute a big *** To examine a group of patients diagnosed and treated as possible COVID-19 pneumonia whose multiple nasopharyngeal swab samples were negative for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by RT-PCR but then serological immunoglobulin M/immunoglobulin G(IgM/IgG)antibody against SARS-CoV-2 were detected by rapid antibody *** Eighty possible COVID-19 patients who had at least two negative consecutive COVID-19 RT-PCR test and were subjected to serological rapid antibody test were evaluated in this *** The specific serological total IgM/IgG antibody against SARS-CoV-2 was detected in twenty-two *** mean age of this patient group was 63.2±13.1-yearsold with a male/female ratio of 11/*** was the most common symptom(90.9%).The most common presenting chest computed tomography findings were bilateral ground glass opacities(77.2%)and alveolar consolidations(50.1%).The mean duration of time from appearance of first symptoms to hospital admission,to hospital admission,to treatment duration and to serological positivity were 8.6 d,11.2 d,7.9 d,and 24 d,*** with reference laboratory values,serologically positive patients have shown increased levels of acute phase reactants,such as C-reactive protein,ferritin,and procalcitonin and higher inflammatory markers,such as erythrocyte sedimentation rate,lactate dehydrogenase enzyme,and fibrin end-products,such as D-dimer.A left shift on white blood cell differential was observed with increased neutrophil counts and decreased *** Our study demonstrated the feasibility of a COVID-19 diagnosis based on rapid antibody test in the cases of patients whose RT-PCR samples were *** of antibodies against SARS-CoV-2 with

关键词： COVID-19 Rapid antibody test Reverse transcription polymerase chain reaction High resolution computed tomography Serology Pneumonia

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