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Experimental investigation on effective aerosol scavenging using different spray configurations with pre-injection of water mist for Fukushima Daiichi decommissioning

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Nuclear Science and Techniques 2024年第5期35卷 154-172页

作者： Rui-Cong Xu Avadhesh Kumar Sharma Erdal ozdemir Shuichiro Miwa Shunichi Suzuki Department of Nuclear Engineering and Management The University of Tokyo7‑3‑1 HongoBunkyo‑KuTokyo 113‑8656Japan Nuclear Professional School The University of Tokyo2‑2

During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater *** the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting *** the cutting process,aerosol particles are expected to be generated at the submicron *** has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying ***,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water *** this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water *** experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water *** results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant.

关键词： Fukushima Daiichi decommissioning Aerosol scavenging Multiphase flow Spray system Aerosol-mist agglomeration

An integrated spatial planning of the mountainous landscapes for ski sports in a case area at the eastern Türkiye

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Journal of Mountain Science 2024年第3期21卷 754-767页

作者： SATIR Onur TOSUN Busra COSKUN OZYOL Funda ozdemir Omer Faruk BERBEROGLU Suha Dept.of Landscape Architecture Van Yuzuncu Yil UniversityVan 65090Türkiye School of Physical Education&Sports Van Yuzuncu Yil UniversityVan 65090Türkiye Van Yuzuncu Yil University Dept.of Architecture&Urban Planning Van 65090Türkiye Dept.of Remote Sensing&GIS Cukurova UniversityAdana 01330Türkiye

Mountainous regions have disadvantages in economic development because of harsh physical and climatic ***,winter tourism activities are one of the key components for supporting economic development in the *** a ski resort area supports direct and indirect employment in a region,and it stops immigration from mountainous regions to other *** research aimed to assess the potential ski areas using a multi criteria evaluation technique in the Van region which is located in the eastern part of Tü*** this context,snow cover duration,sun effect,slope,slope length,elevation,population density,distance from main roads and lake visibility were used as input factors in the decision making *** factor was standardized using a fuzzy technique based on existing well-known ski centers in Tü*** weight of inputs was defined by applying a survey to the professional *** most important factors were detected as transportation opportunities and snow covers whereas,the least important factors were elevation and population ***,lake visibility was very important to make a difference from other existing facilities in the ***,it was included as constraints and lake visible areas were extracted at the final stage of the *** ski areas were mapped in three levels as professional,intermediate and beginner *** of the suitable areas was selected as a sample projection and for the 3D simulation of the ski investment *** costs and benefits were *** was found that a ski tourism area investment can be amortized in 3 years in the region.

关键词： Winter sports and tourism Decision making 3D simulation and modelling Landscape planning GIS

Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer ozdemir Yeliz Bahar-ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(P<0.001).The FIM scale includes both motor scores(P<0.05)and cognitive scores(P<0.001)and showed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer ozdemir Yeliz Bahar-ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

Comparison of non-cycloplegic photorefraction,cycloplegic photorefraction and cycloplegic retinoscopy in children

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 128-131页

作者： ozdemir ozdemir Zuhal Ozen Tunay Ikbal Seza Petricli Damla Ergintürk Acar Muhammet Kazim Erol Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital Department of Ophthalmology Antalya Education and Research Hospital

AIM: To compare the results of noncycloplegic photorefraction, cycloplegic photorefraction and cycloplegic refraction in preschool and non-verbal ***: One hundred and ninety-six eyes of 98children(50 females, 48 males) were included in the study. Firstly, non-cycloplegic photorefraction was achieved with Plusoptix A09; secondly, cycloplegic photorefraction was carried out with Plusoptix A09 after10 min cyclopentolate. Finally, 30 min after instillation of twice cyclopentolate, cycloplegic refraction was obtained with autorefraction and/or standard retinoscopy. Spheric equivalent, spheric power, cylindric power and cylindrical axis measurements were statistically ***: The mean age was 28.8±18.5mo(range12-72mo). The differences in spherical equivalent, spheric power and cylindrical power measured by the three methods were found statistically significant(P 0.05).CONCLUSION: For the determination of refractive errors in children, the Plusoptix A09 measurements give incorrect results after instillation of ***, the cylindrical power measured by Plusoptix A09 with or without cycloplegia is higher. However, the non-cycloplegic Plusoptix A09 measures spheric equivalent and spheric power similar to cycloplegic refraction measurements in preschool and non-verbal children.

关键词： cyclopentolate cycloplegia photorefraction photoretinoscopy Plusoptix retinoscopy refraction

A novel mutation of SGK-1 gene in central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 23-28页

作者： Mahmut Akyol Muhammet Kazιm Erol ozdemir ozdemir Deniz Turgut Coban Ahmet Burak Bilgin Esin Sogutlu Sari Elif Betul Turkoglu Department of Medical Biology and Genetics Akdeniz University Faculty of Medicine Department of Ophthalmology Antalya Education and Research Hospital Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Akdeniz University Faculty of Medicine Department of Ophthalmology Balιkesir University Faculty of Medicine

AIM: To investigate the association of serum glucocorticoid kinase gene-1(SGK-1) DNA variants with chronic central serous chorioretinopathy(CSC).METHODS: We enrolled 32 eyes of 32 patients who were diagnosed with chronic CSC and composed 32 normal eyes as a control group. Peripheral blood was used for DNA extraction and polymerase chain reaction amplification. SGK1 gene was sequenced by using Big Dye Terminator v3.1 cycle sequencing Kit(Applied Biosystems, Foster City, CA, USA). The SGK-1 gene and its variants were investigated in CSC patient group and control ***: We identified a new polymorphism M32 V in two person in the patient group [Minor allele frequency(MAF) =0.009] on the region of 1-60 amino acids. The rs1057293 was located in the encoder region of the SGK- 1 gene but not associated with CSC(P =0.68). An intrinsic rs1743966 is also not associated(P =0.28).CONCLUSION: The new polymorphism M32 V is located on the region of 1-60 amino acids which is necessary for localization to the mitochondria in CSC patient. This mutation is probably important for the energy metabolism and plays an important role in the cellular response to hyperosmotic stress and other stress stimuli. Both rs1057293 and rs1743966 are not associated with CSC.

关键词： central serous chorioretinopathy mutation polymerase chain reaction serum glucocorticoid kinase gene-1

Inflammation: Complexity and significance of cellular and molecular responses

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Journal of Acute Disease 2024年第1期13卷 3-7页

作者： Serdar ozdemir University of Health Science Umraniye Training and Research HospitalIstanbulTurkey

Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological *** as a protective defense mechanism,the inflammatory response involves clinical signs like redness,swelling,pain,and increased body *** cells,notably neutrophils and macrophages,play key roles in orchestrating this *** delicate balance between proinflammatory and anti-inflammatory mediators,including cytokines and chemokines,regulates the inflammatory *** acute inflammation is crucial for tissue repair,chronic inflammation may indicate an imbalance,contributing to conditions like autoimmune *** these mechanisms is vital for developing therapeutic strategies and managing chronic diseases.

关键词： Inflammation C-reactive protein Platelets SCUBE1 Adrenomedullin Calprotectin Pentraxin-3 Immune response Acute phase response Vascular function

Performance comparison of training algorithms for the estimation of B?hme abrasion resistance using neural networks

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Journal of Mountain Science 2023年第12期20卷 3732-3742页

作者： Ali Can ozdemir Esma KAHRAMAN Department of Mining Engineering Çukurova UniversityAdana 01250Türkiye

Natural stones used as floor and wall coverings are exposed to many different abrasive forces,so it is essential to choose suitable materials for wear resistance in terms of the life of the *** abrasion resistance of natural stones can be determined in the laboratory by applying the B?hme abrasion resistance(BAR)***,the direct analysis of BAR in the laboratory has disadvantages such as wasting time and energy,experimental errors,and health *** eliminate these disadvantages,the estimation of BAR using artificial neural networks(ANN)was *** natural stone samples were collected from Türkiye,and uniaxial compressive strength(UCS),flexural strength(FS),water absorption rate(WA),unit volume weight(UW),effective porosity(n),and BAR tests were carried *** outputs of these tests were gathered and a data set,consisting of a total of 105 data,was randomly divided into two groups:testing and *** the current study,the success of three different training algorithms of Levenberg-Marquardt(LM),Bayesian regularization(BR),and scaled conjugate gradient(SCG)were compared for BAR prediction of natural *** criteria such as coefficient of determination(R~2),mean square error(MSE),mean square error(RMSE),and mean absolute percentage error(MAPE),which are widely used and adopted in the literature,were used to determine predictive *** findings of the study indicated that ANN is a valid method for estimating the BAR ***,the LM algorithm(R~2=0.9999,MSE=0.0001,RMSE=0.0110,and MAPE=0.0487)in training and the BR algorithm(R~2=0.9896,MSE=0.0589,RMSE=0.2427,and MAPE=1.2327)in testing showed the best prediction *** has been observed that the proposed method is quite practical to *** the artificial neural networks method will provide an advantage in similar laborintensive experimental studies.

关键词： Böhme abrasion resistance Neural networks Levenberg-Marquardt Bayesian regularization Scaled conjugate gradient

Traveling wave structures of some fourth-order nonlinear partial differential equations

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Journal of Ocean Engineering and Science 2023年第2期8卷 124-132页

作者： Handenur Esen Neslihan ozdemir Aydin Secer Mustafa Bayram Department of Mathematical Engineering Yildiz Technical UniversityIstanbul34220Turkey Department of Software Engineering Istanbul Gelisim UniversityIstanbulTurkey Department of Computer Engineering Biruni UniversityIstanbulTurkey

This study presents a large family of the traveling wave solutions to the two fourth-order nonlinear partial differential equations utilizing the Riccati-Bernoulli sub-ODE *** this method,utilizing a traveling wave transformation with the aid of the Riccati-Bernoulli equation,the fourth-order equation can be transformed into a set of algebraic *** the set of algebraic equations,we acquire the novel exact solutions of the integrable fourth-order equations presented in this research *** physical interpretation of the nonlinear models are also detailed through the exact solutions,which demonstrate the effectiveness of the presented *** Bäcklund transformation can produce an infinite sequence of solutions of the given two fourth-order nonlinear partial differential ***,3D graphs of some derived solutions in this paper are depicted through suitable parameter values.

关键词： Fourth-order equations Riccati-Bernoulli sub-ODE method Traveling wave solution Bäcklund transformation