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Which Offers the Best? Stent Graft or Bare Metal Stent for Endovascular Treatment of Aortoiliac Disease

World Journal of Cardiovascular Diseases 2018年第11期8卷 489-497页

作者： ozcan gur Ozkaramanli gur Demet gurkan Selami Department of Cardiovascular Surgery Namik Kemal University Medical Faculty Tekirdag Turkey Department of Cardiology Namik Kemal University Medical Faculty Tekirdag Turkey

Background: In the present study, it was aimed to compare the stent grafts and bare-metal stents in terms of post-procedural patency, clinical recovery and complications in the subjects with symptomatic aorto-iliac arterial disease. Methods: A total of 79 subjects with symptomatic aorto-iliac arterial disease treated with endovascular methods were included in the present study. Forty three subjects received self-expendable bare metal stent (ev3 Protégé stent system, Endovascular Inc., Plymouth, Minnesota, USA) and 36 subjects received PTFE-covered stent graft (Fluency Plus Stent Graft, Bard Peripheral Vascular, Tempe, Arizona). The subjects were compared after and at Months 1, 6, and 12 following the procedure in terms of Rutherford’s classification, ankle-arm index (AAI), patency rates, and complications. Results: The subjects receiving bare metal stent and stent graft for aorto-iliac arterial disease were followed for averagely 15 months. For the subjects receiving bare metal stent, primary patency rates at months 1, 6, and 12 were 98%, 81%, and 70%, respectively, while secondary patency rate at month 12 was found to be 84%. For the group of stent graft, primary patency rates were found as 97%, 97%, and 92%, respectively and secondary patency rate at month 12 was found to be 94%. Stent grafts were applied at the same time in 2 patients who had metal bare metal because the rupture occurred during the procedure. In the comparison between two groups, the group of stent graft was found to be statistically superior to the other in terms of patency, clinical and post-procedural complications. Conclusion: In conclusion, it was found that the stent grafts were superior to the bare metal stents in terms of patency and complication rates in the subjects with symptomatic aortoiliac disease.

关键词： Aortoiliac Disease Stent Graft Bare Metal Stent Patency Complication

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Surgical Results of Left Ventricular Lead Implantation for Cardiac Resynchronization Therapy

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World Journal of Cardiovascular Surgery 2013年第2期3卷 23-26页

作者： ozcan gur Selami gurkan Demet Ozkaramanli gur Habib Cakir Cayan Akkoyun Turan Ege Cardiology Department Tekirdag State Hospital Yil Tekirdag Turkey Cardiovascular Surgery Department Adana Numune Hospital Yil Tekirdag Turkey Cardiovascular Surgery Department Medical Faculty Namik Kemal University Yil Tekirdag Turkey

Objectives: Cardiac resynchronisation therapy (CRT) has proven its effectiveness in patients with symptomatic heart failure [1,2]. Although rewarding, the procedure of biventricular pacemaker implantation is challenging and subsequently fails in 8%-11% of patients. In patients whose left ventricular (LV) electrode cannot be placed transvenously, surgical implantation of an epicardial electrode can be achieved. Methods: Seventeen patients (14 male, 3 female), among whom LV electrode was failed to be placed transvenously, were included into our study. The epicardial LV electrodes were implanted through anterior mini thoracotomy. The patients were followed up for approximate six months and complications, ejection fraction (EF), New York Heart Association (NYHA) class, QRS durations as well as pacing parameters were recorded. Results: Mean age of the patients was 64.4 ± 7.01 (54-79) years. Preoperative mean EF of the patients was 26.1% ± 3.7%. The LV electrode was placed at the optimal place on the lateral LV wall through left sided mini thoracotomy. The mean duration of the operation was 26.76 ± 8.12 minutes and the mean hospital stay was 2.05 ± 0.42 days. There were no intraoperative or postoperative complications. Only 1 patient had LV electrode displaced on the 3rd postoperative month and the patient was reoperated successfully. The EF on the 6th postoperative month was 29.4% ± 3.81% and NYHA class was 2.58 ± 0.5. The etiology of heart failure had no influence on outcome. Conclusions: Surgical implantation of LV lead is associated with low complication rates and excellent follow-up results without exposure to radiation. Thus epicardial leads can be proposed as equal alternative to transvenous leads.

关键词： Cardiac Resynchronization Therapy Surgical Epicardial Lead Implantation

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The Role of Chlamydia pneumoniae in the Atherosclerotic Process of Patients under 50 Years of Age Who Underwent Coronary Artery Bypass Graft Surgery

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World Journal of Cardiovascular Surgery 2013年第5期3卷 146-151页

作者： Selami gurkan Suat Canbaz ozcan gur Serhat Huseyin Turan Ege Enver Duran Department of Cardiovascular Surgery Namik Kemal University HospitalTekirdagTurkey Department of Cardiovascular Surgery Trakya University HospitalEdirneTurkey

Background: To evaluate the presence of C. pneumoniae DNA in the tissues and C. pneumoniae DNA antibodies in the blood samples of patients who underwent CABG surgery. Material and Methods: Fifty-one patients aorta. C. pneumoniae DNA was evaluated in the tissues collected from the atrium, left internal thoracic artery and ascending aorta of patients. Results: Although, C. pneumoniae DNA was negative in the atrial and left internal thoracic artery tissues of all patients, it was positive in the tissues obtained from the ascending aortas of twelve patients. C. pneumoniae DNA positivity was significantly higher in patients with increased aortic intimal thickness compared to those without increased aortic thickness. Conclusion: The question whether C. pneumoniae is triggering atherosclerosis or is involved as a super-infection could not be clarified.

关键词： Bypass Surgery Chlamydia pneumoniae Atherosclerosis

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Levosimendan usage in patients with left ventricle dysfunction in coronary artery bypass graft surgery

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World Journal of Cardiovascular Diseases 2012年第4期2卷 291-294页

作者： Habib Cakir Funda Tor Hasan Uncu ozcan gur Mehmet Acipayam Ozsoyler Ibrahim Cardiovascular Surgery Adana Numune Education and Training Hospital Adana Turkey Cardiovascular Surgery Katip Celebi University Ataturk Education and Training Hospital Izmir Turkey Cardiovascular Surgery Mustafa Kemal University Medicine Faculty Hatay Turkey Cardiovascular Surgery Namik Kemal University Medicine Faculty Tekirdag Turkey

Introduction: In this study we explicated early results of patients (the patients in whom levosimendan was used) who underwent coronary artery bypass graft surgery with ejection fraction 35% or less. We compared this group with the patients in whom levo-simendan was not used. Material and Methods: 97 patients who have 35% ejection fraction or less taken to isolated coronary artery bypass surgery between January 2009 and December 2011 in our clinic are chosen for this study retrospectively. We compared the patients in whom levosimendan was used with the patients in whom levosimendan was not used. Levo- simendan (Simdax, Abbott) has been used according to surgeon’s decision in patients. Results: The mean age of group 1 was 62.3 ± 7.6, and the mean age of group 2 was 59.3 ± 10.5 (p > 0.05). It was detected that the average ejection fraction was less in group 1 (p 0.05). It was found that need for blood transfusion were less in group 1 than group 2 (p 0.05). Conclusion: We consider levosimendan reduces need for blood transfusion in coronary artery bypass graft surgery. This results may change with increasing number of patients so we consider that multicenter larger study is needed.

关键词： Levosimendan Mortality Coronary Artery Bypass Surgery

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Is coronary artery bypass surgery riskier in female?

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World Journal of Cardiovascular Diseases 2013年第1期3卷 46-48页

作者： Habib Cakir Hasan Uncu ozcan gur Mehmet Acipayam Ismail Yurekli Ozsoyler Ibrahim Cardiovascular Surgeon Cardiovascular SurgeryKatip Celebi University Ataturk Education and Training HospitalIzmirTurkey Cardiovascular Surgeon Cardiovascular SurgeryAdana Numune Education and Training HospitalAdanaTurkey Cardiovascular Surgeon Cardiovascular SurgeryNamik Kemal University Medicine FacultyTekirdagTurkey Cardiovascular Surgeon Cardiovascular SurgeryMustafa Kemal University Medicine FacultyAntakya andİskenderunTurkey

Introduction: In this study we examined the early results of coronary artery bypass surgery in our female patients and compared them with those of our male patients. Material and Methods: One thousand and ninety four patients who underwent coronary artery bypass surgery between January 2009 and December 2011 inour clinic were included into this study. Three hundred and thirteen female patients (group 1) were compared to 781 male patients (group 2). Results: The mean age of group 1 was 61.4 ± 9.6, and the mean age of group 2 was 58.1 ± 9.6 (p 0.05). It was found that the amount of drainage was higher in group 1 than group 2 (p < 0.001). There was no significant difference between two groups when compared in terms of mortality, re-operation (because of bleeding), postoperative atrial fibrillation, need for intraaortic balloon pump, usage of levosimendan, cerebrovascular accident, chronic renal failure, discharging intervals and period in intensive care unit. It was found that sternal wound infection was higher in group 1 than group 2 (p < 0.05). Conclusion: We consider that female gender does not put an additional risk to increase mortality and morbidity in coronary artery bypass surgery.

关键词： Female Mortality Coronary Artery Bypass Graft Surgery

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Artificial Intelligence ChatGPT’s Perspective on Implementation of Augmented Intelligence within Orthopaedic Practice—A Comparative Narrative Synthesis?

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Intelligent Information Management 2024年第1期16卷 10-20页

作者： Neil Capes Hiran Patel Islam Sarhan gur-Aziz S. Sidhu Neil Ashwood Andrew Dekker Department of Trauma & Orthopaedics University Hospitals Derby and Burton Derby United Kingdom Department of Trauma & Orthopaedics University Hospital Lewisham London United Kingdom Research Institute University of Wolverhampton Wolverhampton United Kingdom

ChatGPT has obvious benefits in the way it can interrogate vast amounts of reference information and utilise metadata generation to answer questions posed to it and is freely available having been developed through human feedback. Already there are ethical and practical implications on its impact on learning and research. Artificial Intelligence (AI) has been seen as a way of improving healthcare provision by delivering more robust outcomes but measuring these and implementing AI within this setting is at present limited and disjointed. Methods: ChatGPT was interrogated to see what it felt were the barriers to its implementation within healthcare and in particular orthopaedic practice. The evidence for this determination was then examined for validity and applicability for a practical roll out at a Trust, Regional or National level. Results: AI can synthesise a vast amount of information to help it answer specific questions. The context and structure of any question will determine the usefulness of the answer which can then be used to develop practical solutions based on experience and resource limitations. Conclusions: AI has a role in service development and can quickly focus a working group to areas to consider when practically implementing change.

关键词： Artificial Intelligence ChatGPT

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Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptorubiquitylation

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Cell Research 2005年第1期15卷 66-71页

作者： Chanan RUBIN,Gal gur,Yosef YARDEN Department of Biological Regulation The Weizmann Institute of Science Rehovot 76100 Israel Department of Biological Regulation The Weizmann Institute of Science Rehovot 76100 Israel Department of Biological Regulation The Weizmann Institute of Science Rehovot 76100 Israel

Intracellular signals mediated by the family of receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis. Precise control of signal amplitude and duration is critical for the fidelity and robustness of these processes. Activation of receptor tyrosine kinases by their cognate growth factors not only leads to propagation of the signal through various biochemical cascades, but also sets in motion multiple attenuation mechanisms that ulti- mately terminate the active state. Early attenuators pre-exist prior to receptor activation and they act to limit signal propagation. Subsequently, late attenuators, such as Lrig and Sprouty, are transcriptionally induced and further act to dampen the signal. Central to the process of signaling attenuation is the role of the E3 ubiquitin ligase c-Cbl. While Cbl- mediated processes of receptor ubiquitylation and endocytosis are relatively well understood, the links of Cbl to other negative regulators are just now beginning to be appreciated. Here we review some emerging interfaces between Cbl and the transcriptionally induced negative regulators Lrig and Sprouty.

关键词： endocytosis growth factor oncogene signal transduction ubiquitin tyrosine kinase.

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Significant exercise limitations after recovery from MIS-C related myocarditis

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World Journal of Pediatrics 2023年第12期19卷 1149-1154页

作者： gur Mainzer Merav Zucker-Toledano Moneera Hanna Ronen Bar-Yoseph Einat Kodesh Pediatric Heart Institute Edmond and Lily Safra Children’s HospitalSheba Medical Center52621 Tel HashomerIsrael Pediatric Cardiology Department Hadassah Medical CenterJerusalemIsrael Pediatric Cardiology Unit Padeh Medical CenterPoriyaIsrael Pediatric Cardiology Institute Ruth Children’s HospitalRambam Health Care CampusHaifaIsrael Pediatric Pulmonary Institute Ruth Children’s HospitalRambam Health Care CampusHaifaIsrael The Technion Faculty of Medicine HaifaIsrael Department of Physical Therapy Faculty of Social Welfare and Health ScienceUniversity of HaifaHaifaIsrael

Background Myocarditis is one of the presentations of multisystemic infammatory syndrome in children(MIS-C)following coronavirus disease 2019(COVID-19).Although the reported short-term prognosis is good,data regarding medium-term functional capacity and limitations are *** study aimed to evaluate exercise capacity as well as possible cardiac and respiratory limitations in children recovered from MIS-C related *** Fourteen patients who recovered from MIS-C related myocarditis underwent spirometry and cardiopulmonary exercise testing(CPET),and their results were compared with an age-,sex-,weight-and activity level-matched healthy control group(n=14).Results All participants completed the CPET with peak oxygen uptake(peak.V O2),and the results were within the normal range(MIS-C 89.3%±8.9%and Control 87.9%±13.7%predicted.V O2).Five post-MIS-C patients(35%)had exerciserelated cardio-respiratory abnormalities,including oxygen desaturation and oxygen-pulse fattening,compared to none in the control *** MIS-C group also had lower peak exercise saturation(95.6±3.5 vs.97.6±1.1)and lower breathing reserve(17.4%±7.5%vs.27.4%±14.0%of MVV).Conclusions Patients who recovered from MIS-C related myocarditis may present exercise *** assessment(e.g.,CPET)should be included in routine examinations before allowing a return to physical activity in post-MIS-C ***,longer term studies assessing functional capacity and focusing on physiological mechanisms are needed.

关键词： Cardiopulmonary exercise testing COVID 19 Hypoxemia Myocarditis

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Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure

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World Journal of Gastroenterology 2005年第45期11卷 7183-7187页

作者： Selim Aydemir Binnaz Handan Ozdemir gurden gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu Department of Gastroenterology Department of Pathology

AIM： To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure （CRF）. METHODS： Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori （H pylori） and CRF status. Groups were labeled as follows： la： normal renal function, H pylori negative （n = 12）, lb： normal renal function, H pylori positive （n = 11）, 2a： CRF, H pylori negative （n = 10）, 2b： CRF, H pylori positive （n = 11）. Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation, antral biopsy specimens were taken from each patient. In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen （PCNA） labeling indexes （LI） were assessed with immunohistochemical staining method. RESULTS： For groups la, lb, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5, 60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22, respectively. When the one-way ANOVA test was applied, statistically significant differences were detected between the groups for both Bax LI （P = 0.004 〈0.01） and PCNA LI （P = 0.009 〈0.01）. When groups were compared further in terms of Bax LI and PCNA LI with Tukey＇s HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups la and 2b （P = 0.006 〈0.01）.CONCLUSION： In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells.

关键词： Helicobacter pylori Chronic renal failure Bax Proliferating cell nuclear antigen

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Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded,multicenter study

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World Journal of Pediatrics 2017年第1期13卷 27-33页

作者： Herman Avner Cohen Moshe Hoshen Shmuel gur Arie Bahir Yoseph Laks Hannah Blau Pediatric Ambulatory Community Clinic Petah—TikvaIsrael Sackler Faculty of Medicine Tel.Aviv UniversityTel—AvivIsrael Clalit Research Institute Chief Physician's OfficeClalit Health ServicesTel AvivIsrael Pediatric Ambulatory Community Clinic Kefar SabaIsrael Pediatric Ambulatory Community Clinic Bat YamIsrael Pediatric Ambulatory Community Clinic Ramat Aviv.Israel Pulmonary Institute Schneider Children Medical Center ofIsrael.Petah Tikva.Israel.

Background:Available pediatric treatments for acute cough are limited by lack of demonstrated *** objective of this trial is to compare the effects of a poIysaccharide—resin-honey based cough syrup,and carbocysteine ... 详细信息

关键词： cough children upper respiratory tract infection

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