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Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori

World Journal of Gastroenterology 2003年第5期9卷 1126-1128页

作者： Mehmet Sarg■n oyauygur-bayramili Haluk Sarg■n Ekrem Orbay Dilek Yavuzer Ali Yayla Departments of Endocrinology and Diabetes GastroenterologyFamily MedicinePathology and Internal Medicine Kartal Education and Research Hospital IstanbulTurkey

AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with an age and sex matched non-diabetic ***: 40 diabetic patients (21 females, 19 males;56±7 years) and 40 non-diabetic dyspeptic patients (20females, 20 males; 54±9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy specimens were performed on each patient. Patients with positive Hp results on histopathological examination comprised the study group. Non-diabetic dyspeptic patients seen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group.A triple therapy with amoxycillin (1 g b.i.d), clarithromycin (500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given to both groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies in control upper gastrointestinal endoscopies performed 6weeks after completing the antimicrobial ***: The eradication rate was 50 % in the diabetic group versus 85 % in the non-diabetic control group (P＜0.001).CONCLUSION: Type 2 diabetic patients showed a significantly lower eradication rate than controls which may be due to changes in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains.

关键词： Helicobacter pylori Amoxicillin Anti-Ulcer Agents Case-Control Studies Clarithromycin Diabetes Mellitus, Type 2 Drug Therapy, Combination Female Helicobacter Infections Humans Male Middle Aged Omeprazole Prospective Studies

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