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Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model

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World Journal of Stem Cells 2019年第2期11卷 84-99页

作者： Mariana Lizeth Orozco Morales Nagi M Marsit owen D McIntosh Andrew Hopkinson Laura E Sidney Academic Ophthalmology Division of Clinical Neuroscience University of Nottingham

BACKGROUND An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells(hCEC).AIM To investigate whether corneal-stroma derived stem cells(CSSC) seeded on an amniotic membrane(AM) construct manifests an anti-inflammatory, healing *** Treatment of hCEC with ethanol and pro-inflammatory cytokines were compared in terms of viability loss, cytotoxicity, and pro-inflammatory cytokine release, in order to generate the in vitro injury. This resulted in an optimal injury of 20%(v/v) ethanol for 30 s with 1 ng/mL interleukin-1(IL-1) beta. Co-culture experiments were performed with CSSC alone and with CSSC-AM *** effect of injury and co-culture on viability, cytotoxicity, IL-6 and IL-8 production, and IL1 B, TNF, IL6, and CXCL8 mRNA expression were *** Co-culture with CSSC inhibited loss of hCEC viability caused by injury. Enzyme linked immunosorbent assay and polymerase chain reaction showed a significant reduction in the production of IL-6 and IL-8 pro-inflammatory cytokines, and reduction in pro-inflammatory cytokine mRNA expression during co-culture with CSSC alone and with the AM construct. These results confirmed the therapeutic potential of the CSSC and the possible use of AM as a cell carrier for application to the ocular *** CSSC were shown to have a potentially therapeutic anti-inflammatory effectwhen treating injured hCEC, demonstrating an important role in corneal regeneration and wound healing, leading to an improved knowledge of their potential use for research and therapeutic purposes.

关键词： Cornea Corneal injuries Injury model Corneal epithelium Corneal stroma-derived stem cells Amnion Anti-inflammatory Cell therapy

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Changing paradigms in lower extremity reconstruction in war-related injuries

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Journal of Medical Colleges of PLA(China) 2016年第2期31卷 104-109页

作者： Margaret Connolly Zuhaib R.Ibrahim owen N.Johnson III Department of Surgery University of Maryland Medical Center 22 S Greene St Baltimore MD 21201 USA Department of Plastic and Reconstructive Surgery Johns Hopkins University School of Medicine 601 N Caroline St. Baltimore MD 21287 USA Johns Hopkins University School of Medicine 601 N Caroline St. Baltimore MD 21287 USA

Background: Ballistic high-energy trauma has substantially increased the severity of non-fatal extremity injuries incurred in modern warfare. Expedient medical care, refinement in surgical techniques, and soft tissue coverage have brought about a paradigm shift in the management of lower extremity wounds during the last decade with an increased emphasis on limb ***: A literature-based study was conducted to analyze reconstructive modalities based on the location, depth, and severity of wounds, as well as mechanism of injury, concomitant vascular injuries and open fractures, choice of flap, timing of definitive reconstruction, and ***: Extremity injuries account for over 60% of injuries in the recent conflicts in Iraq and Afghanistan, with the majority secondary to explosive devices. The severity of these injuries is profound compared with civilian registries, and conventional injury scoring systems have failed to accurately predict outcomes in combat trauma. The mainstay of treatment is serial debridement, negative pressure therapy, fracture stabilization, and treatment of concomitant injuries by the forward medical teams with subsequent definitive reconstruction after transport to an advanced military treatment facility. Autologous reconstruction with free tissue transfer and pedicled flaps remains the primary modality for soft tissue coverage in limb salvage. Adjunct innovative modalities, such as external tissue expansion, dermal substitutes, and regenerative matrices, have also been successfully utilized for limb ***: Lower extremity injuries account for the vast majority of injuries in modern warzones. Explosive devices represent the most common mechanism of injury, with blast impact leading to extensive soft tissue injuries necessitating complex reconstructive strategies. Serial debridement, negative pressure therapy, and autologous reconstruction with free tissue transfer and pedicled flaps remain the mainstay of t

关键词： Limb salvage Free flap Pedicled flap Lower extremity Blast injury Combat Battlefield Reconstruction

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胶北粉子山群石榴云母片岩的三叠纪独居石年龄及其地质意义

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岩石学报 2016年第12期32卷 3800-3816页

作者：曹汇 VERVOORT Jeff 王达李广旭 NEILL owen 中国地质调查局大陆构造与动力学创新研究中心中国地质科学院地质研究所北京100037 美国华盛顿州立大学普尔曼wa99163 中国地质大学北京100083

胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中MgO、FeO、MnO和CaO含量变化特征表明其核部到... 详细信息

胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中MgO、FeO、MnO和CaO含量变化特征表明其核部到边部温度先升高后降低,对应进变质及退变质过程。根据原位独居石Y元素成分面扫描图显示,部分独居石颗粒由核部到边部Y含量呈现逐渐降低趋势,说明测得的232.6±1.1Ma^229.5±3.7Ma的独居石U-Pb年龄,对应石榴石的进变质生长过程。结合1869±72Ma的锆石U-Pb年龄数据,可推断粉子山群石榴云母片岩至少经历了古元古代及三叠纪两期变质事件的改造。粉子山群石榴云母片岩卷入了苏鲁超高压变质带的俯冲碰撞造山事件。电子探针成分分析结果表明粉子山群石榴云母片岩中的石榴石属于铁铝榴石,反映出经受中级区域变质作用的特征。说明粉子山群石榴云母片岩虽然参与了三叠纪苏鲁超高压变质带的俯冲碰撞造山过程,但俯冲深度较浅。这可用大陆俯冲过程中上盘的俯冲剥蚀来解释,并可为陆-陆碰撞俯冲剥蚀模式提出的扬子板片在240~220Ma的深俯冲作用过程中拽动胶北地块向下俯冲又折返的运动过程提供佐证,但胶北地块是否经历了深俯冲超高压变质作用,还需要进一步验证。

关键词：粉子山群石榴石变斑晶变质作用独居石U—Pb定年

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THE UNIQUE CHINESE FLAVORS OF LABA FESTIVAL

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China News Release 2022年第1期 74-76页

作者： owen Fishwick 不详

Laba porridge is a traditional dish associated with Laba Festival—a historical Chinese festival dating back to the Northern Song Dynasty(960-1127)that celebrates the enlightenment of the *** porridge is traditionally served on the eighth day of the twelfth month of the Chinese calendar,and has warmed the bellies of Chinese people in the coldest months of the year for more than a 1,000 years.

关键词： traditionally dating Buddha

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Polymer graph neural networks for multitask property learning

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npj Computational Materials 2023年第1期9卷 1420-1429页

作者： owen Queen Gavin A.McCarver Saitheeraj Thatigotla Brendan P.Abolins Cameron L.Brown Vasileios Maroulas Konstantinos D.Vogiatzis Department of Mathematics University of TennesseeKnoxvilleTN 37996-1320USA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996-2250USA Department of Chemistry University of TennesseeKnoxvilleTN 37996-1600USA Eastman Chemical Company KingsportTN 37660USA

The prediction of a variety of polymer properties from their monomer composition has been a challenge for material informatics,and their development can lead to a more effective exploration of the material *** this work,POLYMERGNN,a multitask machine learning architecture that relies on polymeric features and graph neural networks has been developed towards this *** provides accurate estimates for polymer properties based on a database of complex and heterogeneous polyesters(linear/branched,homopolymers/copolymers)with experimentally refined *** POLYMERGNN,each polyester is represented as a set of monomer units,which are introduced as molecular graphs.A virtual screening of a large,computationally generated database with materials of variable composition was performed,a task that demonstrates the applicability of the POLYMERGNN on future studies that target the exploration of the polymer ***,a discussion on the explainability of the models is provided.

关键词： properties space polyester

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Is resource allocation and grain yield of rice altered by inoculation with arbuscular mycorrhizal fungi?

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Journal of Plant Ecology 2015年第4期8卷 436-448页

作者： Shujuan Zhang Li Wang Fang Ma Keith J.Bloomfield Jixian Yang owen K.Atkin State Key Laboratory of Urban Water Resource and Environment School of Municipal and Environmental EngineeringHarbin Institute of Technology73 Huanghe RoadNangang DistrictHarbin 150090China ARC Centre of Excellence in Plant Energy Biology Division of Plant ScienceResearch School of BiologyThe Australian National UniversityBuilding 46Sullivans Creek RoadCanberraAustralian Capital Territory 0200Australia

Aims our study quantified the combined effects of fertilization and inoculation with arbuscular mycorrhizal fungi(AMF)on grain yield and allocation of biomass and nutrients in field-grown rice(Oryza sativa l.).Methods a two-factor experiment was conducted at a field site in northeast of China(in shuangcheng,Heilongjiang Province,songhua river basin):six nitrogen-phosphorus-potassium fertilizer levels were provided(0,20,40,60,80 and 100%of the local norm of ferti-lizer supply),with or without inoculation with Glomus *** maturity,we quantified the percentage of root length colonization by AMF,grain yield,shoot:root ratios,shoot N and P contents and nutrients allocated to panicles,leaves and *** Findingsas expected,inoculation resulted in greatly increased AMF colo-nization,which in turn led to higher shoot:root ratios and greater shoot N ***:root ratios of inoculated rice increased with increasing fertilization while there was a significant interaction between fertilization and inoculation on shoot:root ***,a F inoculation increased panicle:shoot ratios,panicle N:shoot N ratios and panicle P:shoot P ratios,especially in plants grown at low fertilizer ***,inoculated rice exhibited higher grain yield,with the maximum improvement(near 62%)at the lower fertilizer *** results showed that(i)AMFinoculated plants conform to the functional equilibrium theory,albeit to a reduced extent compared to non-inoculated plants and(ii)AMF inoculation resulted in greater allocation of shoot biomass to panicles and increased grain yield by stimulating N and P redis-tribution to panicles.

关键词： arbuscular mycorrhizal fungi resource allocation rice grain yield fertilizer

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整级透平中转静轮缘封严问题研究PartⅠ:封严与入侵

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工程热物理学报 2014年第5期35卷 873-877页

作者：吴康任静蒋洪德 J Michael owen 清华大学热能工程系北京100084 University of Bath UK BA2 7AY

本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结... 详细信息

本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结果表明:静叶尾缘的压力分布是造成燃气入侵的主要原因,即在主流的压力大于密封腔室内压力的区域会出现燃气侵入腔室,造成局部温度过高;主流压力小于腔室内部的压力区域,密封气体能够较好的封严转静间隙。入侵气体和封严气体的掺混主要发生在腔内高半径处并在高速旋转的动盘引发的夹带作用下深入腔室内部低半径处。因此在轮缘密封的结构设计中需要全面的考虑这些因素的影响。

关键词：整级透平转静轮缘封严与入侵动盘夹带效应

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A Green Approach to Producing Polymer Microparticles for Local Sustained Release of Flavopiridol

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Chemical Research in Chinese Universities 2021年第5期37卷 1116-1124页

作者： Matthew J.owen Jasper H.N.YIK Congwang YE Brianca NETTO Dominik R.HAUDENSCHILD Gang-yu LIU Department of Chemistry University of CaliforniaOne Shields AvenueDavisCalifornia95616USA Department of Orthopedic Surgery University of California-Davis School of Medicine4635 Second Ave.SacramentoCalifornia95817USA Materials Engineering Division Lawrence Livermore National LaboratoryLivermoreCalifornia94550USA

Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug *** synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organic phase *** to the health and environmental toxicity of DCM and its slow degradation,this work replaces DCM with a greener solvent,dimethyl carbonate(DMC).

关键词： Release replace emulsion

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Elephants Can Mimic1 Traffic and Other Noises

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大学英语 2005年第5期 21-23页

作者： James owen 刘嘉

It isn't only children playing with toy cars who make engine noises. Elephants produce a similar roar2, though in their case it's the rumble3 of trucks on an African highway that the animals imitate4, scientists *** experts behind the discovery say elephants are capable of vocal6 imitation, joining a select group of animals that includes parrots7, songbirds8, dolphins9, and humans.

关键词：大学英语注释读物科普文阅读

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The Specimen Data Refinery:A Canonical Workflow Framework and FAIR Digital Object Approach to Speeding up Digital Mobilisation of Natural History Collections

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Data Intelligence 2022年第2期4卷 320-341页

作者： Alex Hardisty Paul Brack Carole Goble Laurence Livermore Ben Scott Quentin Groom Stuart owen Stian Soiland-Reyes School of Computer Science and Informatics Cardiff UniversityCardiff CF243AAUK The Department of Computer Science The University of ManchesterManchester M139PLUK The Natural History Museum London SW75BDUK Meise Botanic Garden 1860 MeiseBelgium Informatics Institute Faculty of ScienceUniversity of Amsterdam1090 GH AmsterdamThe Netherlands

A key limiting factor in organising and using information from physical specimens curated in natural science collections is making that information computable,with institutional digitization tending to focus more on imaging the specimens themselves than on efficiently capturing computable data about *** data are traditionally manually transcribed today with high cost and low throughput,rendering such a task constrained for many collection-holding institutions at current funding *** show how computer vision,optical character recognition,handwriting recognition,named entity recognition and language translation technologies can be implemented into canonical workflow component libraries with findable,accessible,interoperable,and reusable(FAIR)*** libraries are being developed in a cloudbased workflow plaform-the Specimen Data Refinery'(SDR)-founded on Galaxy workflow engine,Common Workflow Language,Research Object Crates(RO-Crate)and WorkflowHub *** SDR can be applied to specimens'labels and other artefacts,offering the prospect of greatly accelerated and more accurate data capture in computable *** kinds of FAIR Digital Objects(FDO)are created by packaging outputs of SDR workflows and workflow components as digital objects with metadata,a persistent identifier,and a specific type *** first kind of FDO are computable Digital Specimen(DS)objects that can be consumed/produced by workflows,and other applications.A single DS is the input data structure submitted to a workflow that is modified by each workflow component in turn to produce a refined DS at the *** Specimen Data Refinery provides a library of such components that can be used individually,or in *** cofunction,each library component describes the fields it requires from the DS and the fields it will in turn populate or *** second kind of FDO,RO-Crates gather and archive the diverse set of digital and real-world resources,configurations,a

关键词： Digital Specimen Workflow FAIR Digital Object RO-Crate

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