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Glyoxylate Reductase Isoform 1 is Localized in the Cytosol and Not Peroxisomes in Plant Cells

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Journal of Integrative Plant Biology 2012年第3期54卷 152-168页

作者： Steven L. K. Ching Satinder K. Gidda Amanda Rochon owen R. van Cauwenberghe Barry J. Shelp Robert T. Mullen Department of Molecular and Cellular Biology University of Guelph Guelph Ontario N1G 2W1 Canada Department of Plant Agriculture University of Guelph Guelph Ontario N1G 2W1 Canada

Glyoxylate reductase （GLYR） is a key enzyme in plant metabolism which catalyzes the detoxification of both photorespiratory glyoxylate and succinic semialdehdye, an intermediate of the γ-aminobutyrate （GABA） pathway. Two isoforms of GLYR exist in plants, GLYR1 and GLYR2, and while GLYR2 is known to be localized in plastids, GLYR1 has been reported to be localized in either peroxisomes or the cytosol. Here, we reappraised the intracellular localization of GLYR1 in Arabidopsis thaliana L. Heynh （ecotype Lansberg erecta） using both transiently-transformed suspension cells and stably-transformed plants, in combination with fluorescence microscopy. The results indicate that GLYR1 is localized exclusively to the cytosol regardless of the species, tissue and/or cell type, or exposure of plants to environmental stresses that would increase flux through the GABA pathway. Moreover, the C-terminal tripeptide sequence of GLYR1, -SRE, despite its resemblance to a type 1 peroxisomal targeting signal, is not sufficient for targeting to peroxisomes. Collectively, these results define the cytosol as the intracellular location of GLYR1 and provide not only important insight to the metabolic roles of GLYR1 and the compartmentation of the GABA and photorespiratory pathways in plant cells, but also serve as a useful reference for future studies of proteins proposed to be localized to peroxisomes and/or the cytosol.

关键词： Arabidopsis GABA GLYR1 cytosol photobleaching peroxisome PTS stress tobacco BY-2.

A New Occurrence of （Gold-Bearing） Graphite in the Assosa Region, BenishanguI-Gumuz State, W Ethiopia

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Journal of Earth Science and Engineering 2015年第7期5卷 417-435页

作者： Liam A. Bullock owen J. Morgan School of Geoscienees University of Aberdeen Aberdeen AB24 3UE United Kingdom Tactical Environmental Response Yorkshire LS29 9BZ United Kingdom

The Assosa region of western Ethiopia hosts newly discovered and potentially highly economic graphite-bearing schist units. Due to its unique physical and chemical properties, graphite is quickly becoming an increasingly important economic resource. Graphite occurs over much of the area, and is hosted predominantly by quartz-graphitic schist, quartz-feldspar-mica schist and quartzite. The quartz-graphitic schist covers an area of 37 km2, forming steep valleys and ridges across a 190 km long belt. Graphite is texturally-variable within and across units. Crystal habit varies from highly crystalline to irregular flakes. Flake sizes range from amorphous and crystalline small flake to coarse large flake （〉 150 p.m）, with beneficiation of- 70% and yield potential of 〉 95% （froth flotation methods）. The license area is already a well-known gold-hosting area, and potentially economic gold deposits occur within the graphite-bearing units. Overall, the site shows excellent geochemical indicators, field observations and historical accounts of high gold content. It is suggested that textural variations may be the product of （1） early in-situ formation during （early- to late-Proterozoic） prograde metamorphism and （2） later vein-type mineralization during retrograde metamorphism. The discovery of graphite in western Ethiopia is the first documented and preliminary studies suggest a high economic potential for the deposits.

关键词： Graphite gold metamorphism X-ray fluorescence X-ray diffraction.

Training in video capsule endoscopy: Current status and unmet needs

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World Journal of Gastrointestinal Endoscopy 2019年第6期11卷 395-402页

作者： Apostolos Koffas Faidon-Marios Laskaratos owen Epstein Gastroenterology Department University Hospital of LarisaMezourloLarisa 41110Greece Centre for Gastroenterology Royal Free HospitalPond StLondon NW3 2QGUnited Kingdom

Since its introduction to clinical practice nearly 20 years ago, wireless capsule endoscopy has revolutionized the landscape in the diagnosis and management of small bowel diseases. Over the past 10 years, capsule endoscopy has evolved beyond the small intestine and a range of capsules are now available to examine the esophagus, stomach and colon. Because of its ease of use, tolerability, paucity of complications and ability to visualize the entire gastrointestinal tract, capsule endoscopy has entered the mainstream of clinical practice. This review of the literature summarizes the current state of capsule training and highlights the limited data available to assess reader competence and standards expected of an independent practitioner. There are neither standardized teaching strategies nor national or international metrics for accreditation of physicians and nonphysicians interested in mastering this examination. Summating the few publications, there appears to be consensus that diagnostic expertise improves with experience, and that trainees should be fully supervised for at least 20 full case studies. Formative and summative assessment is advisable and the number of taught cases should not be the sole determinant of competence. The review also highlights differences in recommendations from major national gastroenterology societies. Finally, the authors discuss areas of unmet needs in teaching and learning for capsule endoscopy.

关键词： Small bowel capsule endoscopy Colon capsule endoscopy Training

A Prey- Predator Model for Venture Capital Investment

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Journal of Mathematics and System Science 2017年第11期7卷 297-307页

作者： Letetia Mary Addison Balswaroop Bhatt David owen Department of Mathematics and Statistics Faculty of Science and Technology The University of the West lndies St. Augustine Campus Trinidad and Tobag

The Rosenzweig-Macarthur Model is used to partially explain Venture Capital investment cycles. Investment opportunities and the experience of the investors, represent the prey and predator respectively. Stability analysis with respect to the interior equilibrium point is performed and dynamics of the system are investigated using numerical simulations and results are presented. The model shows that parameter variation affects the stability of the system and it experiences bifurcations. The results show that stability analysis is useful to provide a Venture Capitalist with the stability ranges of parameters in the system, to improve the quality of the investment process.

关键词： prey- predator stability Hopf bifurcations Venture Capital

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橡树里的世界

Innovative two closed loop Control Techniques for realization prebias feature in isolated brick application

丛书名：大猫英语分级阅读,外研社英语分级阅读

2015年

作者： (英)Anna owen

《大猫英语分级阅读二级3》包含《橡树里的世界》、《早餐吃什么？》、《河流之旅》、《小老鼠与大狮子》、《找风的小鼹鼠》、《海盗寻宝记》、《你爱吃什么？》和《最棒的鸟儿》8个英文故事，一本配套的家庭阅读指导手册，以及一张MP... 详细信息

ISBN: (纸本)9787513556071

《大猫英语分级阅读二级3》包含《橡树里的世界》、《早餐吃什么？》、《河流之旅》、《小老鼠与大狮子》、《找风的小鼹鼠》、《海盗寻宝记》、《你爱吃什么？》和《最棒的鸟儿》8个英文故事，一本配套的家庭阅读指导手册，以及一张MP3光盘。故事主题丰富，画风多样，并配有点读功能，适合小学二、三年级学生阅读欣赏。本册为橡树里的世界。

关键词：英语

来源：畅想之星图书光盘版（南... 评论

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Innovative two closed loop Control Techniques for realizatio...

染色体DNA指纹图谱——一种鉴定病原体种属和菌株的新方法

The 10th PCIM Asia Conference

作者： owen Jiang Mark Ng Texas Instruments Semiconductor Technologies （Shanghai） Co. Ltd.

Designing a power converter with the output rising monotonically, without undershoot or overshoot is difficult to achieve in isolated designs. Most often, asmooth, controlled rise is required so that load circuits can start correctly. This problem is compounded when Isolated designs are subjected to a pre-biased voltage at the output. This paper proposes a dual closed loop control scheme which can be used to implement pre-bias startup in half bridge control solutions. Basic principles and concepts are presented. This paper also compares two other approaches. Finally experimental results based on a Texas Instruments 75W board is presented to show the pre-bias performance .

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国外医学（流行病学．传染病学分册） 1990年第3期17卷 114-118页

作者： owen RJ 倪浩林

本文对染色体DNA指纹图谱在临床和公共卫生微生物学方面的应用以及鉴定有关细菌种系和菌株的方法学作了详细介给,并讨论了染色体指纹图谱对细菌分型的可能性。

关键词：染色体 DNA指纹图谱病原体鉴定

Developmental staging of male murine embryonic gonad by SAGE analysis

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Journal of Genetics and Genomics 2009年第4期36卷 215-227页

作者： Tin-Lap Lee Yunmin Li Diana Alba Queenie R Vong Shao-Ming Wu Vanessa Baxendale owen M. Rennert Yun-Fai Chris Lau Wai-Yee Chan Section on Developmental Genomics Laboratory of Clinical Genomics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD 20892 USA Department of Medicine VA Medical Center University of California San Francisco CA 94121 USA Department of Pediatrics Biochemistry Molecular & Cellular Biology Georgetown University Washington DC 20007 USA

Despite the identification of key genes such as Sry integral to embryonic gonadal development, the genomic classification and identification of chromosomal activation of this process is still poorly understood. To better understand the genetic regulation of gonadal development, we performed Serial Analysis of Gene Expression （SAGE） to profile the genes and novel transcripts, and an average of 152,000 tags from male embryonic gonads at E10.5 （embryonic day 10.5）, E11.5, E12.5, E13.5, E15.5 and E17.5 were analyzed. A total of 275,583 non-singleton tags that do not map to any annotated sequence were identified in the six gonad libraries, and 47,255 tags were mapped to 24,975 annotated sequences, among which 987 sequences were uncharacterized. Utilizing an unsupervised pattern identification technique, we established molecular staging of male gonadal development. Rather than providing a static descriptive analysis, we developed algorithms to cluster the SAGE data and assign SAGE tags to a corresponding chromosomal position; these data are displayed in chromosome graphic format. A prominent increase in global genomic activity from E10.5 to E17.5 was observed. Important chromosomal regions related to the developmental processes were identified and validated based on established mouse models with developmental disorders. These regions may represent markers for early diagnosis for disorders of male gonad development as well as potential treatment targets.

关键词： SAGE transcriptome male gonads gene tag novel transcripts cluster analysis chromosome transcription hotspot

Battery state-of-charge estimation using machine learning analysis of ultrasonic signatures

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能源与人工智能(英文) 2022年第4期10卷 60-72页

作者： Elias Galiounas Tom G.Tranter Rhodri E.owen James B.Robinson Paul R.Shearing Dan J.L.Brett Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondonWC1E 7JEUK The Faraday Institution Quad OneBecquerel AvenueHarwell CampusDidcotOX11 The Alan Turing Institute British Library96 Euston RoadLondon NW12DB

The potential of acoustic signatures to be used for State-of-Charge(SoC)estimation is demonstrated using artificial neural network regression *** approach represents a streamlined method of processing the entire acoustic waveform instead of performing manual,and often arbitrary,waveform peak *** applications where computational economy is prioritised,simple metrics of statistical significance are used to formally identify the most informative waveform *** alone can be exploited for SoC *** is further shown that signal portions representing both early and late interfacial reflections can correlate highly with the SoC and be of predictive value,challenging the more common peak selection methods which focus on the *** later echoes represent greater through-thickness coverage,and are intuitively more information-rich,their presence is not *** waveform treatment offers a more robust approach to correlating acoustic signatures to electrochemical *** is further demonstrated that transformation into the frequency domain can reduce the dimensionality of the problem significantly,while also improving the estimation *** importantly,it is shown that acoustic signatures can be used as sole model inputs to produce highly accurate SoC estimates,without any complementary voltage *** makes the method suitable for applications where redundancy and diversification of SoC estimation approaches is *** is obtained experimentally from a 210 mAh LiCoO2/graphite pouch *** estimation errors as low as 0.75%are achieved on a SoC scale of 0-100%.

关键词： Battery diagnostics Ultrasonic battery monitoring Acoustic battery inspection Mechanical-electrochemical correlation Machine learning Artificial neural networks