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Changing paradigms in lower extremity reconstruction in war-related injuries

Journal of Medical Colleges of PLA(China) 2016年第2期31卷 104-109页

作者： Margaret Connolly Zuhaib R.Ibrahim owen N.Johnson III Department of Surgery University of Maryland Medical Center 22 S Greene St Baltimore MD 21201 USA Department of Plastic and Reconstructive Surgery Johns Hopkins University School of Medicine 601 N Caroline St. Baltimore MD 21287 USA Johns Hopkins University School of Medicine 601 N Caroline St. Baltimore MD 21287 USA

Background: Ballistic high-energy trauma has substantially increased the severity of non-fatal extremity injuries incurred in modern warfare. Expedient medical care, refinement in surgical techniques, and soft tissue coverage have brought about a paradigm shift in the management of lower extremity wounds during the last decade with an increased emphasis on limb ***: A literature-based study was conducted to analyze reconstructive modalities based on the location, depth, and severity of wounds, as well as mechanism of injury, concomitant vascular injuries and open fractures, choice of flap, timing of definitive reconstruction, and ***: Extremity injuries account for over 60% of injuries in the recent conflicts in Iraq and Afghanistan, with the majority secondary to explosive devices. The severity of these injuries is profound compared with civilian registries, and conventional injury scoring systems have failed to accurately predict outcomes in combat trauma. The mainstay of treatment is serial debridement, negative pressure therapy, fracture stabilization, and treatment of concomitant injuries by the forward medical teams with subsequent definitive reconstruction after transport to an advanced military treatment facility. Autologous reconstruction with free tissue transfer and pedicled flaps remains the primary modality for soft tissue coverage in limb salvage. Adjunct innovative modalities, such as external tissue expansion, dermal substitutes, and regenerative matrices, have also been successfully utilized for limb ***: Lower extremity injuries account for the vast majority of injuries in modern warzones. Explosive devices represent the most common mechanism of injury, with blast impact leading to extensive soft tissue injuries necessitating complex reconstructive strategies. Serial debridement, negative pressure therapy, and autologous reconstruction with free tissue transfer and pedicled flaps remain the mainstay of t

关键词： Limb salvage Free flap Pedicled flap Lower extremity Blast injury Combat Battlefield Reconstruction

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胶北粉子山群石榴云母片岩的三叠纪独居石年龄及其地质意义

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岩石学报 2016年第12期32卷 3800-3816页

作者：曹汇 VERVooRT Jeff 王达李广旭 NEILL owen 中国地质调查局大陆构造与动力学创新研究中心中国地质科学院地质研究所北京100037 美国华盛顿州立大学普尔曼wa99163 中国地质大学北京100083

胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中Mgo、Feo、Mno和Cao含量变化特征表明其核部到... 详细信息

胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中Mgo、Feo、Mno和Cao含量变化特征表明其核部到边部温度先升高后降低,对应进变质及退变质过程。根据原位独居石Y元素成分面扫描图显示,部分独居石颗粒由核部到边部Y含量呈现逐渐降低趋势,说明测得的232.6±1.1Ma^229.5±3.7Ma的独居石U-Pb年龄,对应石榴石的进变质生长过程。结合1869±72Ma的锆石U-Pb年龄数据,可推断粉子山群石榴云母片岩至少经历了古元古代及三叠纪两期变质事件的改造。粉子山群石榴云母片岩卷入了苏鲁超高压变质带的俯冲碰撞造山事件。电子探针成分分析结果表明粉子山群石榴云母片岩中的石榴石属于铁铝榴石,反映出经受中级区域变质作用的特征。说明粉子山群石榴云母片岩虽然参与了三叠纪苏鲁超高压变质带的俯冲碰撞造山过程,但俯冲深度较浅。这可用大陆俯冲过程中上盘的俯冲剥蚀来解释,并可为陆-陆碰撞俯冲剥蚀模式提出的扬子板片在240~220Ma的深俯冲作用过程中拽动胶北地块向下俯冲又折返的运动过程提供佐证,但胶北地块是否经历了深俯冲超高压变质作用,还需要进一步验证。

关键词：粉子山群石榴石变斑晶变质作用独居石U—Pb定年

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加拿大法院裁定妻子无权阻止丈夫的医疗辅助死亡

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英国医学杂志中文版 2020年第12期23卷 691-692页

作者： owen Dyer 吴焱斌(译) 王岳(译) 不详北京大学医学人文学院

加拿大新斯科舍省一名男子在该省上诉法院拒绝延长其妻子获裁的临时禁令的禁止期限后,可以在未来几天内自由寻求医疗辅助死亡。该男子的妻子辩称其丈夫夸大了自己的病情,不符合法定的医疗辅助死亡条件1。这起案件导致这对匿名夫妇在结婚... 详细信息

加拿大新斯科舍省一名男子在该省上诉法院拒绝延长其妻子获裁的临时禁令的禁止期限后,可以在未来几天内自由寻求医疗辅助死亡。该男子的妻子辩称其丈夫夸大了自己的病情,不符合法定的医疗辅助死亡条件1。这起案件导致这对匿名夫妇在结婚近50年后开始分居,而加拿大的医疗辅助死亡法正处于不断变化之中。加拿大最高法院就辅助死亡的现行法律过于严格一事对外发布意见,认为该法律过于严格的理由在于要求由两名医生证明患者面临"合理可预见"的死亡,且无法忍受的痛苦。当局政府对此已承诺通过立法来取消面临可预见死亡的要求,但目前还未落实承诺。

关键词：上诉法院加拿大最高法院可预见现行法律新斯科舍省临时禁令裁定医疗

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Spatiotemporal dynamics in butterfly hybrid zones

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Insect Science 2024年第2期31卷 328-353页

作者： Ananda R.Pereira Martins Natalie B.Warren W.owen McMillan Rowan D.H.Barrett Redpath Museum McGill University859 Sherbrooke Street WestMontrealQuebecCanada Smithsonian Tropical ResearchInstitute GamboaPanama CityPanama

Evaluating whether hybrid zones are stable or mobile can provide novelinsights for evolution and conservation biology. Butterflies exhibit high sensitivity to envi-ronmental changes and represent an important model system for the study of hybrid zoneorigins and maintenance. Here, we review the literature exploring butterfly hybrid zones,with a special focus on their spatiotemporal dynamics and the potential mechanisms thatcould lead to their movement or stability. We then compare different lines of evidenceused to investigate hybrid zone dynamics and discuss the strengths and weaknesses ofeach approach. our goal with this review is to reveal general conditions associated withthe stability or mobility of butterfly hybrid zones by synthesizing evidence obtained us-ing different types of data sampled across multiple regions and spatial scales. Finally, wediscuss spatiotemporal dynamics in the context of a speciation/divergence continuum, therelevance of hybrid zones for conservation biology, and recommend key topics for futureinvestigation.

关键词： butterflies human impacts hybrid zones movement spatiotemporaldynamics stability

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THE UNIQUE CHINESE FLAVoRS oF LABA FESTIVAL

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China News Release 2022年第1期 74-76页

作者： owen Fishwick 不详

Laba porridge is a traditional dish associated with Laba Festival—a historical Chinese festival dating back to the Northern Song Dynasty(960-1127)that celebrates the enlightenment of the *** porridge is traditionally served on the eighth day of the twelfth month of the Chinese calendar,and has warmed the bellies of Chinese people in the coldest months of the year for more than a 1,000 years.

关键词： traditionally dating Buddha

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Polymer graph neural networks for multitask property learning

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npj Computational Materials 2023年第1期9卷 1420-1429页

作者： owen Queen Gavin A.McCarver Saitheeraj Thatigotla Brendan P.Abolins Cameron L.Brown Vasileios Maroulas Konstantinos D.Vogiatzis Department of Mathematics University of TennesseeKnoxvilleTN 37996-1320USA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996-2250USA Department of Chemistry University of TennesseeKnoxvilleTN 37996-1600USA Eastman Chemical Company KingsportTN 37660USA

The prediction of a variety of polymer properties from their monomer composition has been a challenge for material informatics,and their development can lead to a more effective exploration of the material *** this work,PoLYMERGNN,a multitask machine learning architecture that relies on polymeric features and graph neural networks has been developed towards this *** provides accurate estimates for polymer properties based on a database of complex and heterogeneous polyesters(linear/branched,homopolymers/copolymers)with experimentally refined *** PoLYMERGNN,each polyester is represented as a set of monomer units,which are introduced as molecular graphs.A virtual screening of a large,computationally generated database with materials of variable composition was performed,a task that demonstrates the applicability of the PoLYMERGNN on future studies that target the exploration of the polymer ***,a discussion on the explainability of the models is provided.

关键词： properties space polyester

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Is resource allocation and grain yield of rice altered by inoculation with arbuscular mycorrhizal fungi?

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Journal of Plant Ecology 2015年第4期8卷 436-448页

作者： Shujuan Zhang Li Wang Fang Ma Keith J.Bloomfield Jixian Yang owen K.Atkin State Key Laboratory of Urban Water Resource and Environment School of Municipal and Environmental EngineeringHarbin Institute of Technology73 Huanghe RoadNangang DistrictHarbin 150090China ARC Centre of Excellence in Plant Energy Biology Division of Plant ScienceResearch School of BiologyThe Australian National UniversityBuilding 46Sullivans Creek RoadCanberraAustralian Capital Territory 0200Australia

Aims our study quantified the combined effects of fertilization and inoculation with arbuscular mycorrhizal fungi(AMF)on grain yield and allocation of biomass and nutrients in field-grown rice(oryza sativa l.).Methods a two-factor experiment was conducted at a field site in northeast of China(in shuangcheng,Heilongjiang Province,songhua river basin):six nitrogen-phosphorus-potassium fertilizer levels were provided(0,20,40,60,80 and 100%of the local norm of ferti-lizer supply),with or without inoculation with Glomus *** maturity,we quantified the percentage of root length colonization by AMF,grain yield,shoot:root ratios,shoot N and P contents and nutrients allocated to panicles,leaves and *** Findingsas expected,inoculation resulted in greatly increased AMF colo-nization,which in turn led to higher shoot:root ratios and greater shoot N ***:root ratios of inoculated rice increased with increasing fertilization while there was a significant interaction between fertilization and inoculation on shoot:root ***,a F inoculation increased panicle:shoot ratios,panicle N:shoot N ratios and panicle P:shoot P ratios,especially in plants grown at low fertilizer ***,inoculated rice exhibited higher grain yield,with the maximum improvement(near 62%)at the lower fertilizer *** results showed that(i)AMFinoculated plants conform to the functional equilibrium theory,albeit to a reduced extent compared to non-inoculated plants and(ii)AMF inoculation resulted in greater allocation of shoot biomass to panicles and increased grain yield by stimulating N and P redis-tribution to panicles.

关键词： arbuscular mycorrhizal fungi resource allocation rice grain yield fertilizer

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整级透平中转静轮缘封严问题研究PartⅠ:封严与入侵

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工程热物理学报 2014年第5期35卷 873-877页

作者：吴康任静蒋洪德 J Michael owen 清华大学热能工程系北京100084 University of Bath UK BA2 7AY

本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结... 详细信息

本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结果表明:静叶尾缘的压力分布是造成燃气入侵的主要原因,即在主流的压力大于密封腔室内压力的区域会出现燃气侵入腔室,造成局部温度过高;主流压力小于腔室内部的压力区域,密封气体能够较好的封严转静间隙。入侵气体和封严气体的掺混主要发生在腔内高半径处并在高速旋转的动盘引发的夹带作用下深入腔室内部低半径处。因此在轮缘密封的结构设计中需要全面的考虑这些因素的影响。

关键词：整级透平转静轮缘封严与入侵动盘夹带效应

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A Green Approach to Producing Polymer Microparticles for Local Sustained Release of Flavopiridol

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Chemical Research in Chinese Universities 2021年第5期37卷 1116-1124页

作者： Matthew J.owen Jasper H.N.YIK Congwang YE Brianca NETTo Dominik R.HAUDENSCHILD Gang-yu LIU Department of Chemistry University of CaliforniaOne Shields AvenueDavisCalifornia95616USA Department of orthopedic Surgery University of California-Davis School of Medicine4635 Second Ave.SacramentoCalifornia95817USA Materials Engineering Division Lawrence Livermore National LaboratoryLivermoreCalifornia94550USA

Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug *** synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organic phase *** to the health and environmental toxicity of DCM and its slow degradation,this work replaces DCM with a greener solvent,dimethyl carbonate(DMC).

关键词： Release replace emulsion

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Molecular basis of inherited calcium channelopathies:role of mutations in pore-forming subunits

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Acta Pharmacologica Sinica 2006年第7期27卷 799-812页

作者： Lynn MCKEoWN Philip RoBIN owen T JoNES Faculty of Life Sciences the University of ManchesterManchesterUK

The pore-forming alpha subunits of voltage-gated calcium channels contain theessential biophysical machinery that underlies calcium influx in response to *** combination with requisite auxiliary subunits,these pore sub-units form calcium channel complexes that are pivotal to the physiology andpharmacology of diverse cells ranging from sperm to *** surprisingly,mutations in the pore subunits generate diverse pathologies,termedchannelopathies,that range from failures in excitation-contraction coupling tonight *** the last decade,major insights into the mechanisms ofpathogenesis have been derived from animals showing spontaneous or *** parallel,there has been considerable growth in our understandingof the workings of voltage-gated ion channels from a structure-function,regula-tion and cell biology *** we document our current understandingof the mutations underlying channelopathies involving the voltage-gated calciumchannel alpha subunits in humans and other species.

关键词： calcium channels channelopathies mutation

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