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Quality of Diabetes Annual Management in the Internal Medicine Department in Yalgado Ouédraogo Teaching Hospital, Ouagadougou

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Open Journal of Internal Medicine 2020年第3期10卷 256-262页

作者： oumar guira Amsa Ouédraogo lassané zoungrana Réné Bognounou Solo Traoré Aline Tondé Joseph Y. Drabo Unité de Formation et de Recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: The periodic management of diabetes improves disease’s prognosis. We aimed to evaluate the quality of diabetes annual management and the effectiveness of its treatment in Ouagadougou. Material and Method: It was a cross-sectional and descriptive study, from retrospective records in the internal medicine department, Yalgado Ouédraogo Teaching Hospital (CHU-YO). Diabetic patient’s (15 years old and more) files that were registered between January, 2012 and December, 2016 have been analyzed. Files containing less than 80% data were excluded. Data relating to the baseline characteristics of the patients, the therapeutic education dispensation, the clinical and paraclinical assessment of the initial and annual visits at the first year of patient’s follow-up have been collected. The 2007 diabetes management standards of the French “Haute Autorité de Santé” as well as the biological standards of the same instance have been used. The quantitative variables were expressed as means and standard deviations and qualitative variables were expressed as absolute and relative frequencies. Results: 317 patients, including 218 women (68.77%) were studied. The mean age of women was 51.67 ± 12.46 years, and that of men 55.71 ± 10.63. Diabetes was type 2 in 302 (95.26%) patients. The mean duration since the diagnosis of diabetes was 2.9 years. The completeness rate of therapeutic education at the annual visit was 10.46%. That of the clinical examinations was at best 38.17% and 44.23% for the measurement of weight and blood pressure;otherwise it was less than 5%. About the paraclinical data, apart from the measurement of the fasting blood glucose which completeness rate was 71.61%, that of the others exams were less than 10%. At the annual visit, the mean value of HbA1C was 7.5%, and the target for HbA1C was achieved in 47.90% patients. Conclusion: The quality of diabetes annual management is unsatisfying.

关键词： Chronic Disease’s Management Diabetes Sub-Saharan Africa

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Spectrum of Hypertriglyceridemia at the Onset of Type 2 Diabetes in Ouagadougou

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Open Journal of Internal Medicine 2020年第1期10卷 83-89页

作者： oumar guira Réné Bognounou lassané zoungrana Aline Tonde André Nagalo Réné Traore Joseph Youssouf Drabo Unité de Formation et de Recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Laboratoire de Biochimie Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: Hypertriglyceridemia is a frequent dyslipidemia in type 2 diabetes. We aimed to determine its prevalence, its typology, and its associated factors in newly type 2 diabetes patients in Ouagadougou. Material and Method: This cross-sectional, descriptive and analytic study has been performed from May 2015 to June 2016 in the Internal medicine department in Yalgado Ouédraogo teaching hospital, Ouagadougou. An accidental sample of newly type 2 diabetes outpatients, na?ve of antidiabetics therapy was studied. A 12-hour fasting triglyceridemia was performed;hypertriglyceridemia was defined for triglyceridemia > 1.5 g/L (1.7 mmol/L). Data were analyzed with Epi info 7.***.5.0. Proportions and means were compared respectively with Khi2 or Fisher’s test and Student’s test with a significance of p Results: One hundred and three patients, i.e. 35 (34%) men and 68 (66%) women were included. The sex ratio was 0.51 and the mean age 49.3 ± 10.1 years [limits: 24 and 70]. The mean value of triglyceridemia was 1.8 ± 1.7 mmol/L [limits: 0.5 and 14.9]. Hypertriglyceridemia was reported in 32 patients (31.1%): minor (11.30 mmol/L) in one (3.1%) patients. Hypertriglyceridemia’s phenotype was commonly integrated into a mixed dyslipidemia;it was often combined with a total cholesterolemia increase and a HDL cholesterolemia decrease. In bivariate analysis, hyperglycemia was associated with severe hyperglycemia (p = 0.006) and renal failure (p = 0.03). Conclusion: Hypertriglyceridemia in type 2 diabetes is frequent and often combined with other lipids disorders. It may need an optimal care.

关键词： Hypertriglyceridemia Type 2 Diabetes Burkina Faso

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Trends of Kalemia at Diagnosis of Acidosis versus Non-Acidosis Diabetic Ketosis Décompensations in Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2016年第1期6卷 1-5页

作者： oumar guira Hervé Tiéno Abraham Bagbila Yempabou Sagna Gérard Coulibaly lassané zoungrana Joseph Y. Drabo Unité de Formation et de Recherche en Sciences de la Santé Université de Ouagadougou Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Service de Néphrologie et d’Hémodialyse Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: Electrolyte’s profile in non-acidosis diabetic ketosis is poorly specified. We aimed to determine the nature of diabetic ketosis decompensations as well as the profile of kalemia and factors associated with its disorders at diagnosis of acidosis compared to non-acidosis diabetic ketosis. Methods: The study was retrospective from 1 January 2010 to 31 December 2011 in Yalgado Ouédraogo teaching hospital. Diabetic in-patients suffering from simple ketosis, keto-acidosis or mixed decompensation, who achieved blood electrolytes assessment before intensive insulin therapy were included. Results: Sixty two patients were studied. The sex ratio was 0.7 and the mean age was 41.7 years. Keto-acidosis, simple ketosis and mixed decompensation were diagnosed respectively in 18 (29%), 32 (51.6%) and 12 (19.4%) patients. Kalemia was normal in 42 (67.7%), while hypokalemia and hyperkalemia were reported respectively in 11 (17.8%) and 9 (14.5%) patients. Kalemia was often normal in all types of ketosis decompensation and disorders of kalemia occurred more in patients with keto-acidosis (50%) than those with simple ketosis (21.9%);p = 0.04. Renal failure was diagnosed in 10 patients (50%) with and 2 (4.8%) without kalemia’s disorders;p = 0.0001. Seven patients (35%) with and 4 (9.5%) without kalemia’s disorders suffered from unconsciousness;p = 0.02. It happens more in hyperkalemia (44.4%) than in normal kalemia condition (9.5%);p = 0.02. Conclusion: If kalemia is often normal in all types of diabetic ketosis emergencies, hypokalemia is the most initial frequent potassium disorder.

关键词： Diabetic Ketosis Kalemia Disorders Burkina Faso

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Performance of the Finnish Diabetes Risk Score (FINDRISC) in the Identification of Dysglycemia in an Urban Population in Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第2期11卷 39-54页

作者： Solo Traoré Boyo Constant Paré Désiré Lucien Dabourou oumar guira Yempabou Sagna Julie Patricia Kamouni lassané zoungrana Réné Bognounou Hervé Tiéno Youssoufou Joseph Drabo Training and Research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Institute for Research in Health Sciences/National Center for Scientific and Technical Research Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/Nazi BONI University Bobo Dioulasso Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Diabetes mellitus is a real public health problem worldwide and is growing in developing countries. Our aim was to determine the prevalence of undiagnosed type 2 diabetes mellitus (T2DM) and to evaluate the performance of the Finnish Diabetes Risk Score (FINDRISC) questionnaire to identify type 2 diabetics in the urban population of Ouagadougou, Burkina Faso. Methodology: This was a cross-sectional study among volunteers aged 18 years and older recruited systematically from November 11 to 16, 2019, in the city of Ouagadougou, Burkina Faso, FINDRISC score was used. Analysis of the Receiver Operating Characteristic (ROC) curve was used to study the diagnostic performance of FINDRISC for the identification of type 2 diabetics. The optimal threshold was determined by the sum of the highest sensitivity and specificity. Multivariate logistic regression was used to analyze the association of each variable used in the calculation of the FINDRISC score. Results: A total of 1276 individuals were included in the analyses, of which 667 (52.27%) were women. The average age was 34.16 years (SD: ±12.42). The prevalence of T2DM was 10.74%. The mean FINDRISC score was 5.85 (SD: ±4.31). The majority (58.54%) of individuals had a low risk of diabetes according to the FINDRISC score 0 - 7, while 3.61% had a score ≥ 15. The FINDRISC score showed good performance (AUC = 0.70) in identifying undiagnosed type 2 diabetics. However, the variables in the score that best predicted the likelihood of being diabetic were age (p Conclusion: The Finnish Risk Score (FINDRISC) is a good predictor of the risk of dysglycemia in Burkina Faso. It is a score to be promoted in daily clinical practice because it is

关键词： Identification Diabetes Type 2 FINDRISC Performance Burkina Faso

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Hypothyroidism in Hospitals (Burkina Faso)

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Open Journal of Internal Medicine 2021年第2期11卷 55-67页

作者： lassane zoungrana Hervé Tiéno Seydou Yaméogo Solo Traoré oumar guira Constance Tiendrebéogo Réné Bognounou Aline Tondé Jospeh Y. Drabo Health Sciences Training and Research Unit Joseph Ki ZERBO University Ouagadougou Burkina Faso Internal Medicine Department Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Internal Medicine Service Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: The epidemiology of hypothyroidism has been characterized by an increase in its frequency, especially in females and the elderly. Our aim was to study hypothyroidism in hospitals in Ouagadougou. Material and Method: This was a cross-sectional descriptive study with retrospective data collection covering a period of four (04) years between January 1, 2015 and December 31, 2018. It included patients followed in the internal medicine departments of three (03) teaching hospitals in the city of Ouagadougou. Yalgado OUEDRAOGO, Bogodogo and Tengandogo Teaching Hospitals, were the study setting. Results: 120 cases of hypothyroidism were enrolled. The mean age of the patients was 45.7 years with a sex ratio of 0.26. The signs frequently reported were weight gain (28.3%), asthenia (15.8%), and myalgia (15%). TSHus was elevated in 99.2% of patients in our series. The T3L assay level was lowered in 40.9%, with an average of 2.2 ± 1.5 pg/ml. T4L was lowered in 68.2% with an average of 6.6 ± 4 pg/ml. Primary hypothyroidism accounted for 99.2% of the cases, of which iatrogenic hypothyroidism was the most frequent with 77.5% followed by Hashimoto’s thyroiditis with 9.2% of the cases. Hormonal balance was achieved in the majority of patients (59.2%) who received hormonal supplementation with levothyroxine at an average dose of 84.5 μg/day. Conclusion: Hypothyroidism is common in women in their forties. Iatrogenic hypothyroidism was the predominant etiology reported in Ouagadougou.

关键词： Hypothyroidism Hospital Ouagadougou

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Factors Associated with Prolonged Poor Glycemic Control in Type 2 Diabetes Mellitus (T2DM) Patients Followed in the Department of Internal Medicine at the Yalgado Ouedraogo Teaching Hospital, Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第1期11卷 1-26页

作者： Solo Traoré oumar guira.lassané zoungrana Yempabou Sagna Réné Bognounou Constant B. Paré Désiré L. Dabourou Lassina Séré Daniel Zemba Laurette S. Dembélé Patricia D. Somé Patrice P. C. Savadogo Aline Tondé Tiéno Hervé Joseph Y. Drabo Training and Research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/Nazi Boni University Bobo Dioulasso Burkina Faso Institute for Research in Health Sciences/National Center for Scientific and Technical Research Ouagadougou Burkina Faso Department of Internal Medicine Tengandogo Teaching Hospital Ouagadougou Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Achieving and maintaining glycemic targets are a challenge for health practitioners around the world. We aimed to study the factors associated with prolonged poor diabetes control in the cohort of T2DM patients monitored and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital in Ouagadougou in order to optimize therapeutic education in these patients. Methodology: This was a descriptive and analytical cross-sectional study combining retrospective data collection from the last year of patient follow-up and prospective collection of some information. The study included all diabetic patients, aged at least 18 years old, followed and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital between January 1, 2010 and December 31, 2018 following a systematic random sampling with a sampling step of 10. The variables collected were sociodemographic, anthropometric, lifestyle, cardiovascular risk factors and diabetes-related characteristics. To determine the risk factors associated with prolonged poor glycemic control, we performed modeling using logistic regression. All variables associated with prolonged poor glycemic control, in bivariate logistic regression with a p-value less than 0.20 were included in the full model. Later, we used a stepwise descending method to obtain the final model, which was then tested by a receiver operating characteristic (ROC) curve. The significance threshold was set at 5%. Raw and fitted Odds-Ratio (OR) and 95% confidence interval were presented. Results: 270 patients were included. Prolonged poor control of diabetes mellitus was observed in 73.70%. The mean age was 55.97 years (SD: ±11.52) and the sex ratio was 0.6 in favor of female. The mean time since diabetes mellitus diagnoses was 5.85 years (SD: ±5.15). A monthly ga

关键词： Type 2 Diabetes Mellitus Prolonged Poor Control Prevalence Associated Factors Burkina Faso

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Protein Profiles of Pod Borer Maruca Resistant Transgenic Cowpea

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American Journal of Plant Sciences 2023年第12期14卷 1453-1463页

作者： Mounyratou Rabo Teyioue Benoit Joseph Batieno Assita Traoré-Barro Salimata Traoré Orokia Coulibaly Aboubacar Toguyeni Chantal Kaboré-zoungrana oumar Traoré Laboratoire National de Biosécurité Agence Nationale de Biosécurité (ANB) Ouagadougou Burkina Faso Institut de l’Environnement et Recherches Agricoles Département Productions Végétales Ouagadougou Burkina Faso Laboratoire d’Etudes et de Recherches sur les Ressources Naturelles et les Sciences de l’Environnement (LERNSE) Université Nazi BONI Bobo-Dioulasso Burkina Faso Laboratoire de Génétique et amélioration des plantes (LAGAMEP) Institut de l’Environnement et Recherches Agricoles Ouagadougou Burkina Faso Laboratoire de protection et défense des cultures (LAPRODEC) Institut de l’Environnement et Recherches Agricoles Ouagadougou Burkina Faso

The grain legume cowpea Vigna unguiculata (L.) Walp. is a major protein source used for food and feed in Sub-Saharan Africa. The crop is affected by the pod borer Maruca vitrata against which transgenic lines were developed as part of the genetic control approach. This study aimed to assess the protein profiles in seeds and leaves of transgenic cowpea lines and their non-transgenic near-isogenic counterparts. Crude protein content was determined by the Kjeldahl method, and soluble proteins were quantified using Bradford dye binding assay. The average crude protein content ranged between 21.61% and 26.58% in the seeds and between 10.86% and 17.90% in the leaves. Total solubility varied between 13.03% and 20.64%. Osborne’s protein fractions contents in the seeds were 52.41% - 69.52% (albumin), 4.62% - 7.19% (globulin), 7.95% - 11.40% (glutelin) and 3% - 4% (prolamin). In any case, protein content differed significantly between cowpea genotypes but not between pairs of transgenic/non-transgenic lines. Insecticidal Cry1Ab protein expressed by transgenic lines was only detected in the albumin and globulin fractions. Altogether, these findings enhance our understanding of the effects of genetic modification on cowpea protein content and composition, with potential implications for nutritional and safety assessments.

关键词： Cowpea Protein Cry1Ab Protein Fractions

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Reactions of Maruca Resistant Transgenic Cowpea to Cowpea Aphid-Borne Mosaic Virus

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Agricultural Sciences 2024年第7期15卷 742-753页

作者： Mounyratou Rabo Moustapha Ouédraogo Orokia Coulibaly Assita Traoré-Barro Salimata Traoré Teyioue Benoit Joseph Batieno Chantal Kaboré-zoungrana Aboubacar Toguyeni oumar Traoré Laboratoire National de Bioscurit Agence Nationale de Bioscurit (ANB) Ouagadougou Burkina Faso Institut de lEnvironnement et Recherches Agricoles Dpartement Productions Vgtales Ouagadougou Burkina Faso Laboratoire dEtudes et de Recherches sur les Ressources Naturelles et les Sciences de lEnvironnement (LERNSE) Universit Nazi BONI Bobo-Dioulasso Burkina Faso Laboratoire De Gntique et Amlioration Des Plantes (LAGAMEP) Institut de lEnvironnement et Recherches Agricoles Ouagadougou Burkina Faso Laboratoire De Protection et Dfense Des Cultures (LAPRODEC) Institut de lEnvironnement et Recherches Agricoles Ouagadougou Burkina Faso

Cowpea (Vigna unguiculata L. [Walp.]) in one of the main grain legumes contributing to food security and poverty alleviation in Sub-Saharan Africa. To control the highly damaging legume pod borer Maruca vitrata F., transgenic cowpea lines expressing the insecticidal Cry1Ab Bt protein were developed. In this study, we evaluated the impact of Cry1Ab transgene expression on the susceptibility of four cowpea lines (named IT97K-T, IT98K-T, Gourgou-T and Nafi-T) and their respective non-transgenic near isogenic lines (IT97K, IT98K, Gourgou and Nafi) to Cowpea aphid-borne mosaic virus (CABMV) in greenhouse conditions. In a preliminary quality control test by enzyme-linked immunosorbent assay, the presence of Cry1Ab protein in transgenic seed lots ranged from 59% to 72%, with no significant differences among the lines (χ2 = 3.26;p = 0.35). Upon virus inoculation, all cowpea lines exhibited mosaic symptoms with similar severity between 7- and 11-day post-inoculation. No significant differences were observed in symptom severity. Significant differences were found between cowpea lines for time of symptom onset, virus accumulation in plants and days to 50% flowering. However, while comparing pairs of transgenic lines and corresponding non-transgenic lines, virus accumulation showed not significant differences whatever the pair. Time of symptom onset and days to 50% flowering did not also differ significantly between pairs of cowpea lines except Nafi/Nafi-T in which transgenic Nafi-T showed earlier symptoms (7.4 ± 0.7 vs. 8.9 ± 0.8 days post-inoculation) and shorter flowering time (37.3 ± 0.6 vs. 42 ± 1.7 days after sowing). Overall, these findings improve our understanding of the effects of Cry1Ab gene mediated genetic modification on cowpea infection by Cowpea aphid-borne mosaic virus, with potential implications for environmental safety assessment.

关键词： Cowpea Cry1Ab Cowpea Aphid-Borne Mosaic Virus Environmental Safety

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