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Concentrations and sources of an emerging pollutant, decabromodiphenylethane (DBDPE), in sewage sludge for land application

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Journal of Environmental Sciences 2012年第3期24卷 558-563页

作者： De la Torre A Concejero M A martínez M A Persistent Organic Pollutant Group Environment Department CIEMAT Avd. Complutense 22 Madrid 28040 Spain

The presence of an emerging brominated flame retardant, decabromodiphenylethane （DBDPE）, has been confirmed in Spanish sewage sludge. Thirty one samples from different urban wastewater treatment plants （WWTPs） were analyzed for this brominated flame retardant. DBDPE was positively identified and quantified in all samples at lower concentrations （47.0 ± 29.7 ng/g dry weight （dw）; mean ± SD） than those obtained for decabromodiphenyl ether （BDE-209）（290 ± 236 ng/g dw; mean ± SD） in a previous study. Influence of the WWTP characteristics in the pollutant levels was evaluated. No significant correlations were obtained between DBDPE concentrations and the population or sewage sludge production rate associated with the plants, neither wastewater treatment method. Sources of DBDPE in the sludge were also evaluated. Data indicate a common origin for DBDPE and BDE-209, which may be related to leaching processes during the use and disposal of consumer products containing these chemicals. Nevertheless, DBDPE contents are not influenced by industrial activities, which suggests that the infusion of DBDPE commercial mixture is not a source of this chemical into the environment, and indicates that the use of DBDPE in the Spanish industry is still low compared to deca-BDE.

关键词： decabromodiphenylethane polybrominated diphenyl ethers wastewater treatment plants sewage sludge

Classification of anemia for gastroenterologists

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World Journal of Gastroenterology 2009年第37期15卷 4627-4637页

作者： Jose Antonio Moreno Chulilla Maria Soledad Romero Colás martín Gutiérrez martín Department of Hematology University Hospital "Lozano Blesa" University of Zaragoza C/San Juan Bosco 15 Zaragoza 50009 Spain

Most anemia is related to the digestive system by dietary deficiency, malabsorption, or chronic bleeding. We review the World Health Organization definition of anemia, its morphological classifi cation (microcytic, macrocytic and normocytic) and pathogenic classi-fication (regenerative and hypo regenerative), and integration of these classifications. Interpretation of laboratory tests is included, from the simplest (blood count, routine biochemistry) to the more specific (iron metabolism, vitamin B12, folic acid, reticulocytes, erythropoietin, bone marrow examination and Schilling test). In the text and various algorithms, we propose a hierarchical and logical way to reach a diagnosis as quickly as possible, by properly managing the medical interview, physical examination, appropriate laboratory tests, bone marrow examination, and other comple-mentary tests. The prevalence is emphasized in all sections so that the gastroenterologist can direct the diagnosis to the most common diseases, although the tables also include rare diseases. Digestive diseases potentially causing anemia have been studied in preference, but other causes of anemia have been included in the text and tables. Primitive hematological diseases that cause anemia are only listed, but are not discussed in depth. The last section is dedicated to simplifying all items discussed above, using practical rules to guide diagnosis and medical care with the greatest economy of resources and time.

关键词： Anemia Microcytic anemia Iron Deficiency diseases Macrocytic anemia Normocytic anemia

Insights into induction of the immune response by the hepatitis B vaccine

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World Journal of Gastroenterology 2022年第31期28卷 4249-4262页

作者： Federico Alejandro Di Lello Alfredo Pedro martínez Diego martín Flichman Microbiology Universidad de Buenos Aires.Facultad de Farmacia y Bioquímica.Instituto de Investigaciones en Bacteriología y Virología MolecularBuenos Aires C1113AADArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires C1425FQBArgentina Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno“CEMIC”Buenos Aires C1431FWOArgentina Microbiology Universidad de Buenos AiresInstituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia AdquiridaBuenos Aires C1121ABGArgentina

After more than four decades of hepatitis B virus(HBV)vaccine implementation,its safety and efficacy in preventing HBV infection have been proven and several milestones have been *** countries have included HBV immunization schedules in their health policies and progress has been made regarding universalization of the first HBV vaccine dose at *** of these actions have significantly contributed to reducing both the incidence of HBV infection and its related ***,there are still many drawbacks to *** main concerns are the deficient coverage rate of the dose at birth and the large adult population that has not been reached timely by universal ***,the current most widely used second-generation vaccines do not induce protective immunity in 5%to 10%of the population,particularly in people over 40-years-old,obese(body mass index>25 kg/m2),heavy smokers,and patients undergoing dialysis or infection with human immunodeficiency *** developed and approved novel vaccine formulations using more potent adjuvants or multiple antigens have shown better performance,particularly in difficult *** advances re-launch the expectations of achieving the World Health Organization’s objective of completing hepatitis control by 2030.

关键词： Hepatitis B virus Vaccine Immune response Antibodies Neutralizing

A new player in the beneficial effects of exercise on the aged brain

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Signal Transduction and Targeted Therapy 2020年第1期5卷 901-902页

作者： M.Llorens-martín Department of Molecular Neuropathology Centro de Biología Molecular“Severo Ochoa”CBMSOCSIC-UAMMadridSpain Center for Networked Biomedical Research on Neurodegenerative Diseases(CIBERNED) MadridSpain Department of Molecular Biology Faculty of SciencesUniversidad Autónoma de MadridMadridSpain

In a recent article in Science,Horowitz et *** glycosylphosphatidylinositol(GPI)-degrading enzyme Gpld1 as the most critical player in the blood that can transfer the effects of exercise on adult neurogenesis and cognition to sedentary aged *** also demonstrate the importance of this liver-to-brain axis in ameliorating age-related regenerative and cognitive impairments.

关键词： tar player critical

Changes in niche differentiation and environmental filtering over a hydric stress gradient

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Journal of Plant Ecology 2020年第2期13卷 185-194页

作者： Alejandra martínez-Blancas Carlos martorell Departamento de Ecología y Recursos Naturales Facultad de CienciasUniversidad Nacional Autónoma de MéxicoCoyoacán04510 Ciudad de MéxicoMexico Posgrado en Ciencias Biológicas Universidad Nacional Autónoma de MéxicoAv.Ciudad Universitaria 3000C.P.04510CoyoacánCiudad de MéxicoMexico

Aims Diversity in communities is determined by species’ability to coexist with each other and to overcome environmental stress that may act as an environmental *** differentiation(ND)results in stronger intra-than interspecific competition and promotes *** stress affects interactions,the strength of ND may change along stress gradients.A greater diversity of plant growth forms has been observed in stressful habitats,such as deserts and alpine regions,suggesting greater ND when stress is *** tested the hypothesis that niche differences and environmental filters become stronger with *** In a semiarid grassland in southern Mexico,we sowed six annual species in the field along a hydric stress *** were grown alone(without interactions),with conspecific neighbors(intraspecific interactions)or with heterospecific neighbors(interspecific interactions).We analyzed how the ratio of intra-to interspecific competition changed along the gradient to assess how water availability determines the strength of *** also determined if hydric stress represented an environmental *** Findings We observed stronger intra-than interspecific competition,especially where hydric stress was ***,we found ND in at least some portion of the gradient for all but one *** species were hindered by stress,but others were favored by it perhaps because it eliminates soil *** strong ND was slightly more frequent with stress,our species sample was small and there were exceptions to the general pattern,so further research is needed to establish if this is a widespread phenomenon in nature.

关键词： hydrological niche species interactions environmental constraints species coexistence stabilizing mechanisms equalizing mechanisms

Main factors affecting lacertid lizard thermal ecology

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Integrative Zoology 2019年第3期14卷 293-305页

作者： Zaida ORTEGA Francisco Javier martÍN-VALLEJO Postgraduate Program in Ecology and Conservation Federal University of Mato Grosso do SulCampo GrandeMato Grosso do SulBrazil Department of Statistics University of SalamancaSpain

The thermal ecology of ectotherms has been studied for almost 2 centuries,but additional attention is currently being paid to it,to understand how organisms deal with the environment in a climate change context.A consensus is still far away due to the large number of factors involved and their complex *** this context,3 analyses in lacertid lizards were carried out:(i)a meta-analysis,to test for differences between body and air temperatures from 71 populations;(ii)a meta-analysis concerning correlations between body and air temperatures from 60 populations;and(iii)a multimodel inference of thermoregulation effectiveness indices from 45 *** importance of different factors,including body size,habitat,insularity,altitude,climate and season,was evaluated in all analyses to model the response variables.A strong seasonality effect was observed,with a consistent pattern of less effective thermoregulation in summer compared to other *** was the second most important factor,with a consistent higher thermoregulation effort in populations occurring at high elevations(>1000 m above sea level).Other factors,such as insularity or body size,can also be important,but did not exhibit a clear ***,thermoregulation was less affected by climate and habitat type.

关键词： lizards meta-analysis seasonality temperature thermoregulation

Parametrization of the Teichmüller Space of Bordered Surface NEC Groups

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Acta Mathematica Sinica,English Series 2008年第6期24卷 1039-1056页

作者： B.ESTRADA E.martíNEZ Departamento de Matemdticas Fundamentales UNEDPaseo Senda del Rey 928040 MadridSpain

A non-Euclidean crystallographic group F （NEC group, for short） is a discrete subgroup of isometries of the hyperbolic plane H, with compact quotient space H/Г. These groups uniformize Klein surfaces, surfaces endowed with dianalytic structure. These surfaces can be seen as a generalization of Riemann surfaces. Fundamental polygons play an important role in the study of parametrizations of the Teichmuller space of NEC groups. In this work we construct a class of right-angled polygons which are fundamental regions of bordered surface NEC groups. The free parameters used in the construction of the polygons give a parametrization of the Teichmuller space. From the parameters we obtain explicit matrices of the generators of the groups. Finally, we give examples to exhibit how different relations between the parameters reflect the existence of automorphisms on the quotient surfaces.

关键词： non-Euclidean crystallographic groups hyperbolic polygons Klein surfaces automorphisms of surfaces Teichmfiller space

Neuroprotective therapy for retinal neurodegenerative diseases by stem cell secretome

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Neural Regeneration Research 2021年第1期16卷 117-118页

作者： Ricardo Usategui-martín Ivan Fernandez-Bueno Instituto Universitario de Oftalmobiología Aplicada(IOBA) Retina GroupUniversidad de ValladolidValladolidSpain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León Red Temática de Investigación Cooperativa en SaludOftaredInstituto de Salud Carlos IIIValladolidSpain

Retinal neurodegenerative diseases like agerelated macular degeneration,glaucoma,diabetic retinopathy or retinitis pigmentosa are the most frequent causes of incurable low vision and blindness *** had been estimated that the prevalence of these diseases varies between 1/750 and 1/5000 depending on the region,the level of consanguinity or ethnicity(Na et al.,2017).The functional and structural complexity of the retina makes it susceptible to multiple types of pathogenic damage.

关键词： diseases protective degenerative

Real-World Evidence in Localized Pancreatic: Coping with Uncertainty in Unselected Populations

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Journal of Cancer Therapy 2024年第4期15卷 164-178页

作者： María I. Pamies Ramón Diana Ibarra Anguita Paula Rodríguez Payá Alvaro Muñoz Abad David Sánchez García María Valero Revert Beatriz Grau Mirete Mariano martínez Marín Alicia Calero Amaro Lorena Rodríguez Cazalla Javier Gallego Plazas Medical Oncology Department Elche University Hospital Elche (Alicante) Spain General Surgery Department Elche University Hospital Elche (Alicante) Spain General Surgery Department Vega Baja Hospital Orihuela (Alicante) Spain

Background: Localized pancreatic cancer, including resectable (R), borderline resectable (BR) and locally advanced unresectable disease (LAU), is considered in clinical guidelines for diverse treatment options based on clinical trials in selected populations. Hence, exploring with real world evidence (RWE) clinicians’ preferences for treatment options and their results seems pertinent. Methods: In a set of consecutive patients with localized pancreatic cancer assisted in a third level hospital from January 2013 to December 2022, medical records, symptoms, diagnostic process, distribution between subtypes, and treatment plans, with safety and efficacy results, were assessed. Results: A total of 152 patients with localized disease were included (43.4% R, 21.0% BR, 33.6% LAU). The population characteristics exemplified differences between daily practice and clinical trials. Tumor location and symptoms were as expected. Treatment plan was conditioned by PS or comorbidities in 23.0% of patients. In patients with R disease, surgery followed by different adjuvant chemotherapy (CT) regimes was the antineoplastic treatment of choice (64.8%) with efficacy results (OS 37.5 months;95% CI 18.4 - 56.7), in the range of contemporary standards. The common use of neoadjuvant CT for BR disease (94.4%), with surgery in 50% of them, and its results (OS 30.8 months;95% CI 10.5 - 51.2) reflected current controversies of treatment recommendations and evolution in this scenario. Paliative CT with or without radiotherapy was the standard specific treatment in LAU disease (95.1%) with survival results (PFS: 10.8 months;95% CI 8.8 - 12.7. OS: 20.3 months;95% CI 13.5 - 27.2) that justify the distinct character and the specific study of this entity. Conclusion: RWE for localized pancreatic cancer aroused from the analysis of this population confirms the distinct nature of patients assisted in daily practice, as well as mirrors the complexity of decision making in clinical assumptions in which a

关键词： Real-World Evidence Localized Pancreatic Cancer