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New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies

World Journal of Gastroenterology 2021年第48期27卷 8216-8226页

作者： BlažTrotovšek Mihajlo Djokić MajaČemažar Gregor Serša Department of Abdominal Surgery University Medical Centre LjubljanaLjubljana 1000Slovenia Medical Faculty Ljubljana University of LjubljanaLjubljana 1000Slovenia Department of Experimental Oncology Institute of OncologyLjubljana 1000Slovenia Faculty of Health Sciences University of PrimorskaIzola 6310Slovenia Faculty of Health Sciences University of LjubljanaLjubljana 1000Slovenia

Electrochemotherapy is a local ablative therapy that increases the cytotoxicity of either bleomycin or cisplatin by applying electric pulses(electroporation)to *** has already been widely used throughout Europe for the treatment of various types of human and veterinary cutaneous tumors,with an objective response rate ranging from 70%-90%,depending on the tumor ***,electrochemotherapy was introduced for the treatment of primary liver tumors,such as hepatocellular carcinoma(HCC).The complete response rate was 85%per treated lesion,with a durable ***,electrochemotherapy could become a treatment of choice for HCC,especially after achieving a transition from an open surgery approach to a percutaneous approach that uses dedicated *** elicits a local immune response and can be considered an in situ ***,among others,is a potentially immunogenic tumor;thus,electrochemotherapy could boost adjuvant immunotherapy to achieve a better and longer-lasting antitumor ***,therapeutic strategies that combine electrochemotherapy with immune checkpoint inhibitors or adjuvant treatment with cytokines are indicated for *** therapy using electroporation as a delivery system for plasmid DNA coding for interleukin-12 is a highly promising *** electroporation approach has shown efficacy in preclinical settings and veterinary oncology and is awaiting translation for the treatment of liver tumors,i.e.,HCC.

关键词： Electroporation Electrochemotherapy Gene therapy Gene electrotransfer Interleukin-12 Immune checkpoint inhibitors Hepatocellular carcinoma

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Induction of precocious intestinal maturation in T-cell deficient athymic neonatal rats

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World Journal of Gastroenterology 2017年第42期23卷 7531-7540页

作者： Ester arévalo Sureda Catherine Gidlund Bjorn Westrom Olena Prykhodko Department of Biology Faculty of ScienceLund University

AIM To investigate whether gut maturation could be induced precociously in an athymic T-cell deficient neonatal rat *** Fourteen day-old athymic(nude) rats(NIH-Foxn 1 rnu) were gavaged with either phytohaemagglutinin-a lectin from red kidney beans(PHA); trypsin-a protease(Prot); or water-vehicle(control) as a single dose on one day or once a day for 3-day. The nude rats were either nurtured by their mothers or cross-fostered by conventional foster dams of the Sprague-Dawley strain from days 3-5 after birth. At 17 d of age, 72 h after administration of the first treatment, intestinal macromolecular permeability was tested in vivo, prior to euthanasia, after which blood and gut organs were *** Provocation with both, PHA and protease, resulted in increased gut growth and maturation in nude rat pupsindependent of nursing. Foetal-type enterocytes were replaced by non-vacuolated adult-type enterocytes in the distal small intestine epithelium. Decreased intestinal macromolecular permeability(gut closure) was observed, with reduced permeability markers(BIg G and BSA, P ar absorptive capacity(BSA, P arly to in euthymic pups, thus showing an independence from thymusderived T-cells.

关键词： Gut Intestinal permeability Passive immunity Pancreas Immunoglobulin G

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Potential of RP-UHPLC-DAD-MS for the qualitative and quantitative analysis of sofosbuvir in film coated tablets and profiling degradants

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Journal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： María del Mar Contreras aránzazu Morales-Soto Antonio Segura-Carretero Javier Valverde Department of Analytical Chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food Centre (CIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

Sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis C virus(HCV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLC) coupled to diode array detection(DAD) and mass spectrometry(MS) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation armaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLC Sofosbuvir

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Cleaning method of InSb [111] B of n-InSb [111] A/B for the growth of epitaxial layers by liquid phase epitaxy

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Journal of Semiconductors 2011年第5期32卷 146-148页

作者： Gh.Sareminia F.Zahedi Sh.Eminov ar.Karamian Electronic Component Industry(ECI)-Optoelectronic Industry P.O.Box 19575-199TehranIran Institute of Physics Azerbaijan UniversityBakuAzerbaijan Department of Mathematics Razi UniversityKermanshaIran

The crystal structure of InSb [111] A/B surfaces shows that this structure is polarized. This means that the surfaces of InSb [111] A and InSb [1^-1^- 1^-] B contain two different crystallized directions and they have different physical and chemical properties. Experiments were carried out on the InSb [ 111 ] A/B surfaces, showing that tartaric acid etchant could create a very smooth surface on the InSb [1^-1^- 1^-] B without any traces of oxides and etch pit but simultaneously create etch pit on InSb [ 111 ] A surfaces. After lapping and polishing, some particles remained on the InSb [1^-1^- 1^-] B surface, they could not be removed easily by standard cleaning process and if these particles remain on the surface of the substrate, the growth layer was not uniform and some island-like regions were observed. The purpose of this work is to remove these particles on the lnSb [1^-1^- 1^-] B surface. Some morphology images of both surfaces, InSb [11 1] A/B, will be presented.

关键词： cleaning lnSb lapping polishing InSb [1^-1^- 1^-] B

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Resistant patterns of Pseudomonas aeruginosa in a Malaysian teaching hospital

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 59-62页

作者： Zaidah ar Siti SMN Zahiruddin WM Zeehaida M Department of Medical Microbiology and Parasitology School of Medical SciencesUniversiti Sains MalaysiaKelantanMalaysia Department of Community Medicine School of Medical SciencesUniversiti Sains MalaysiaKelantanMalaysia

Objective:Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of nosocomial infections. Currently a notable increase in the prevalence of multidrug-resistant *** worldwide has been reported in hospitalized patients and was associated with high morbidity and ***:A retrospective laboratory based analysis regarding the spectrum and distribution of *** from a wide range of clinical samples in Hospital Universiti Sains Malaysia since January 2003 to December 2007 was ***: Altogether,there were 2 308 clinical isolates *** main sources of *** were from swab,respiratory,urine and blood specimens which accounted for 28.2%,21.8%,13.2%and 12.8% *** showed significant reduction in percentage of resistant towards three antibiotic namely ciprofloxacin,ceftazidime and *** the percentage of pan-resistant *** increased steadily over these ***:This data is helpful to the clinician in guiding the choice of appropriate antibiotic to treat *** *** the same time,it warrants a more aggressive infection control activity to be implemented to control the spread of pan resistant strain in this centre.

关键词： Pseudomonas aeruginosa Resistant pattern Infection

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Prognostic Value of the Brain CT-Scan in Head Trauma in Yaounde Central Hospital

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Open Journal of Clinical Diagnostics 2023年第3期13卷 80-87页

作者： Freddy Mertens Bombah Ebogo Messina Figuim Bello Doulanni bouba Pierre Ongolo Zogo Department of Surgery and Specialty Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Oral and Maxillofcaila Surgery Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University of Dakar Dakar Senegal Department of Surgery and Specialities Faculty of Medicine and Biomedical Sciences University of Yaounde Yaounde Cameroon Department of Medical Imaging and Radiation Therapy Faculty of Medicine and Biomedical Sciences University of Yaounde Yaounde Cameroon

Introduction: Cranial trauma is a serious medico-surgical pathology that hinders the vital and functional prognosis. The Rotterdam computed tomography (CT) score refined features of the Marshall score. This score was designed to categorize traumatic brain injury (TBI) type and severity in adults. The aim of our research was to evaluate the association between the Rotterdam CT scores of patients after a cranial traumatism in terms of survival. Material and methods: It was a cross-sectional and analytical study from January 2018 to March 2020, using medical records of patients suffering from cranial traumatism, received and taken in charge in the Yaounde central hospital. Results: 100 patients were retained out of 115 recruited patients. The average age was 35.20 with a sex ratio of 4.55. The Rotterdam score was between 1 and 5 with a median of 2. The overall mortality at 6 months and 1 year was 32%. With an equal score compared to European studies, we recorded significantly higher mortality. We found the sequelae in 24% of the patients. GOS ranged from 1 to 5, and survival without sequelae (GOS 1) was the most represented. There was a positive correlation between the Rotterdam score and the GOS with a Pearson correlation coefficient of +0.514. Conclusion: The death rate in Rotterdam score equals is greater in our context compared to European studies.

关键词： Cranial Traumatism Cerebral CT-Scan Prognosis Rotterdam Score

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Aquatic fungal diversity in two freshwater ecosystems of Madhya Pradesh,India

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Studies in Fungi 2021年第1期6卷 116-137页

作者： Mehboob A Ganie AH Dar ar Soni KK Rani Durgawati Vishwavidyalaya Jabalpur M.P-India Departments of Botany University of KashmirKargil CampusIndia Govt Degree College Bemina J&K-India Forest Pathology Division Tropical Forest Research Institute Jabalpur M.P-India

Aquatic fungi play an important role in litter decomposition in aquatic *** in view the importance of aquatic fungi,diversity of these organisms was studied in two freshwater ecosystems of Gaur River and Khurji Nala Jabalpur Madhya Pradesh *** the present study,34 fungal species and 6 chromista species have been recorded on decomposing *** number of fungal genera were recorded in submerged litter samples of Tectona grandis followed by Dendroclamus *** maximum percentage frequencies of various fungal species which colonize litter of different tree species were also *** cluster analysis revealed that different fungal communities on various plant hosts vary significantly.

关键词： Colonization decomposing substrate fruits litter mixed twigs

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Supercritical carbon dioxide extraction of Triognella foenum graecum Linn seeds:Determination of bioactive compounds and pharmacological analysis

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1085-1091页

作者： Ola Basa’ar Samreen Fatema Ali Alrabie Mohammed Mohsin Mazahar Farooqui Department of Chemistry Hodeidah University Post Graduate & Research Center Maulana Azad College Dr.Rafiq Zakaria College for women

Objective: To investigate the effect of temperature and pressure on supercritical CO_2 extraction of Triognella foenum graecum Linn seeds, to determine the optimal condition which leads to highest percentage of the accumulative yield and revealing the chemical composition of supercritical CO_2 ***: Temperatures in the range of 40–60C and pressures in the range of 10–25 MPa were used. FTIR and GC–MS analysis were used to detect the bioactive compounds present in the extract. The broth dilution method and slope method were used to evaluate the anti-microbial and anti-tuberculosis activities and the in vitro anti-malarial assay was carried out according to the micro assay protocol of Rieckmann and his ***: The temperature was more affected than the pressure on the extraction performance and the highest yield of the extract(3.111%) was attained at 60C and 10 *** and GC–MS showed that the chemical composition of the extract included conjugated linoleic acid methyl ester as the major active principle(with concentration of72.28%), followed by saturated fatty acid methyl esters(16.03%), steroids(8.09%) and organic siloxane compound(3.61%). The extract showed moderate anti-bacterial activity with MIC values 100, 250, 125 mg/m L towards Escherichia coli, Staphylococcus aureus and Streptococcus pyogenus respectively. It exhibited high inhibition effect towards the fungi Candida albican with MFC value(250 mg/m L). The extract had low antituberculosis activity with MIC value(100 mg/m L) and comparable MIC value(0.29 mg/m L) towards Plasmodium ***: Supercritical CO_2 extraction as alternate and green technology is performed successfully to extract the bioactive compounds from the seeds of T. foenum graecum Linn and it is concluded that this extract can be used as an alternate source of synthetic anti-biotic drugs.

关键词： Anti-bacterial Anti-fungal Anti-malarial Anti-tuberculosis Sc–CO2 extraction Triognella foenum graecum Linn

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中美互换摘要

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中华高血压杂志（中英文） 2024年第2期32卷 200-200页

作者： Heckel ar arcidiacono DM Coonan KA Glasgow AC DeBlois JP Gump BB Kim JY Heffernan KS 刘青练桂丽

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour am... 详细信息

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour ambulatory blood pressure monitoring,ABPM)测量的中心血压对评估心血管疾病(cardiovascular disease,CVD)风险更有预测价值。本研究采用ABPM测量24 h中心血流动力学负荷,评估曾患与未患COVID-19成年人的CVD风险。

关键词：肱动脉血压新型冠状病毒心血管疾病 ABPM 点测量危险因素

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A Crystallization Study of Nanocrystalline PZT 53/47 Granular arrays Using a Sol-Gel Based Precursor

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Journal of Materials Science & Technology 2011年第6期27卷 489-496页

作者： A.Surez-Gómez J.M.Saniger-Blesa F.Calderón-Pinar CCADET-Universidad Nacional Autónoma de México Cd.UniversitariaCirc.Exterior s/nA.P.70-186Coyoacn 04510México D.F.México Laboratorio de Ingeniería Electroquímica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaCoyoacn 04510México D.F.México Facultad de Física/IMRE San Lzaro y LUniversidad de la Habana

In this work,we intend to perform a detailed study on the crystallization process of PZT 53/47 nanostructured powders by starting out with an amorphous precursor synthesized by a sol-gel based *** interests also lie in the feasibility for controlling the average grain size of the final structure in the submicron range on an ab initio ***,Fourier transform infrared spectroscopy（FT-IR）,Raman（Stokes and Anti-Stokes）,X-ray diffraction（XRD） and scanning electron microscopy（SEM） are used to examine the microstructural characteristics based on previously reported differential thermal analysis/thermal gravimetric analysis（DTA/TGA） *** results show a crystallization temperature of 800℃ to attain pure perovskite phase with excellent morphological quality,average grain size 〈DG〉〈 300 nm and with average crystallite size 〈DC〉〈15 nm.

关键词： Powders-chemical preparation PZT synthesis Sol-gel precursors Microstructure- final Vibrational spectroscopies X-ray diffraction

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