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Effective approach for conformal subarray design based on maximum entropy of planar mappings

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Journal of Electronic Science and Technology 2024年第3期22卷 16-25页

作者： Xiao-Dong Zheng Sheng-Teng Shi Jun ou-yang Feng yang Qammer Abbasi Abubakar Sharif School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China School of Engineering University of GlasgowScotlandG128QQUK

In this paper,an effective algorithm for optimizing the subarray of conformal arrays is *** method first divides theconformal array into several first-level *** uses the X algorithm to solve the feasible solution of first-level subarray tiling and employs the particle swarm algorithm to optimize the conformal array subarray tiling scheme with the maximum entropy of the planar mapping as the fitness ***,convex optimization is applied to optimize the subarray amplitude *** results verify that the method can effectively find the optimal conformal array tiling scheme.

关键词： Conformal array Irregular arrays Particle swarm optimal algorithm Maximum entropy model

A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

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Nano-Micro Letters 2024年第7期16卷 31-45页

作者： Tao Zhang Cheng-Hui Li Wenbo Li Zhen Wang Zhongya Gu Jiapu Li Junru Yuan Jun ou-yang Xiaofei yang Benpeng Zhu School of Integrated Circuit Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093People’s Republic of China National Institute of Dental and Craniofacial Research(NIDCR) National Institutes of Health(NIH)35A Convent DriveBethesdaMD 20892USA Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People’s Republic of China

Compared with traditional piezoelectric ultrasonic devices,optoacoustic devices have unique advantages such as a simple preparation process,anti-electromagnetic interference,and wireless long-distance power ***,current optoacoustic devices remain limited due to a low damage threshold and energy conversion efficiency,which seriously hinder their widespread *** this study,using a self-healing polydimethylsiloxane(PDMS,Fe-Hpdca-PDMS)and carbon nanotube composite,a flexible optoacoustic patch is developed,which possesses the self-healing capability at room temperature,and can even recover from damage induced by cutting or laser ***,this patch can generate high-intensity ultrasound(>25 MPa)without the focusing *** laser damage threshold is greater than 183.44 mJ cm^(-2),and the optoacoustic energy conversion efficiency reaches a major achievement at 10.66×10^(-3),compared with other carbon-based nanomaterials and PDMS *** patch is also been successfully examined in the application of acoustic flow,thrombolysis,and wireless energy *** findings in this study provides new insight into designing and fabricating of novel ultrasound devices for biomedical applications.

关键词： Optoacoustic Self-healing PDMS Acoustic flow Thrombolytic Wireless energy harvesting

Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

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Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su Le Chang Guanzhong Jiao yang ou Mei yang Chao Xu Pengtao Liu Zejia Wang Zewen Qi Wenwen Liu Linhua Sun Guangming He Xing Wang Deng Hang He School of Advanced Agriculture Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain *** reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related *** interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in *** compartment domain(CD)boundaries,the distal interactions were more in hybrids than their *** the hybrids of CURLY LEAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower ***-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance *** addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop *** findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection

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Zoological Research 2024年第4期45卷 833-844页

作者： Ying Liu Lin yang Hong-Yong Xiang Ming Niu Jia-Cheng Deng Xue-Yuan Li Wen-Jie Hao Hong-Sheng ou-yang Tong-Yu Liu Xiao-Chun Tang Da-Xin Pang Hong-Ming Yuan State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Animal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin 130062China Chifeng Best Genetics Technology Co. Ltd.ChifengNei Mongol 024000China Chongqing Jitang Biotechnology Research Institute Co. Ltd.Chongqing 400015China

Porcine reproductive and respiratory syndrome(PRRS)is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus(PRRSV),resulting in substantial economic losses in the swine *** the CD163 SRCR5 domain,either through deletion or substitution,can eff1ectively confer resistance to PRRSV infection in ***,large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth *** the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant *** the current study,we identified a specific functional amino acid in CD163 that influences PRRSV *** infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV(HP-PRRSV)proliferation by preventing viral binding and ***,individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type(WT)pigs,confirming effective resistance to *** of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G *** findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs,providing novel insights into controlling future PRRSV outbreaks.

关键词： PRRSV CD163 Point mutation E529G Pigs

秦孝道律令化历程论考——以岳麓秦简户时复申令为中心

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古代文明（中英文） 2024年第3期18卷 88-99,158,159页

作者：欧扬湖南大学法学院湖南长沙410082

本文首先复原岳麓秦简一秦令。令文含乡里吏向上级官署移送孝悌为善者牒及惩处不孝罪,且吏在每年核验户籍时向黔首宣读此令。秦在早期颁行的律文确认家主对子女、奴婢的惩戒权,官吏不受理对家主的控告。而秦在乡里秩序稳固之后颁行此令... 详细信息

本文首先复原岳麓秦简一秦令。令文含乡里吏向上级官署移送孝悌为善者牒及惩处不孝罪,且吏在每年核验户籍时向黔首宣读此令。秦在早期颁行的律文确认家主对子女、奴婢的惩戒权,官吏不受理对家主的控告。而秦在乡里秩序稳固之后颁行此令,规定由官府惩处不孝罪,并规定如果父母不向官府控告不孝子女则予以惩罚,且惩罚家主杀伤子女、奴婢的行为。秦在以法为教框架内完成了孝道伦理的律令化,为汉朝所继承。

关键词：以法为教孝悌不孝罪岳麓秦简

Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors

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World Journal of Diabetes 2024年第1期15卷 53-71页

作者： Min Wang yang ou Xiang-Lian Yuan Xiu-Fang Zhu Ben Niu Zhuang Kang Bing Zhang Anwar Ahmed Guo-Qiang Xing Heng Su School of Chemical Science and Technology Yunnan UniversityKunming 650091Yunnan ProvinceChina Department of Endocrinology The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Clinical Laboratory Nanchong Central Hospital&The Second Clinical Medical College of North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health SciencesBethesdaMD 20814United States The Affiliated Hospital and Second Clinical Medical College North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Research and Development Lotus *** LLCGaithersburgMD 20878United States

BACKGRouND The lack of specific predictors for type-2 diabetes mellitus(T2DM)severely impacts early intervention/prevention *** branched-chain amino acids(BCAAs:Isoleucine,leucine,valine)and aromatic amino acids(AAAs:Tyrosine,tryptophan,phenylalanine)show high sensitivity and specificity in predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in clinical ***,improvement is needed to support its clinical *** To evaluate the effects of body mass index(BMI)and sex on BCAAs/AAAs in new-onset T2DM individuals with varying body *** Ninety-seven new-onset T2DM patients(ously elevated amino acids,especially BCAAs/AAAs,across new-onset T2DM patients in differing BMI categories revealed a potentially skewed prediction of T2DM *** higher BCAA/AAA levels in obese T2DM patients would support T2DM prediction in obese individuals,whereas the lower levels of BCAAs/AAAs in NW-T2DM individuals may underestimate T2DM risk in NW *** potentially skewed T2DM prediction should be considered when BCAAs/AAAs are to

关键词： Hyperaminoacidemia Branched-chain/aromatic amino acids New-onset type-2 diabetes Predictor Obesity Sex

Concomitant atypical knee gout and seronegative rheumatoid arthritis:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5245-5252页

作者： Zhou-Yi Chen Min-Hua ou-yang Shao-Wei Li Rui ou Zhi-Huang Chen Song Wei Department of Chinese Medicine General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Gout Guangdong Hydropower HospitalGuangzhou 511340Guangdong ProvinceChina

BACKGRouND Gout and seronegative rheumatoid arthritis(SNRA)are two distinct inflammatory joint diseases whose co-occurrence is relatively infrequently *** information is available regarding the clinical management and prognosis of these combined *** SUMMARY A 57-year-old woman with a 20-year history of joint swelling,tenderness,and morning stiffness who was negative for rheumatoid factor and had a normal uric acid level was diagnosed with *** initial regimen of methotrexate,leflunomide,and celecoxib alleviated her symptoms,except for those associated with the *** symptom recurrence after medication cessation,her regimen was updated to include iguratimod,methotrexate,methylprednisolone,and folic acid,but her knee issues *** invasive needle-knife scope therapy revealed proliferating pannus and needle-shaped crystals in the knee,indicating coexistent SNRA and atypical knee *** postarthroscopic surgery to remove the synovium and urate crystals,and following a tailored regimen of methotrexate,leflunomide,celecoxib,benzbromarone,and allopurinol,her knee symptoms were significantly alleviated with no recurrence observed over a period of more than one year,indicating successful management of both *** This study reports the case of a patient concurrently afflicted with atypical gout of the knee and SNRA and underscores the significance of minimally invasive joint techniques as effective diagnostic and therapeutic tools in the field of rheumatology and immunology.

关键词： Arthroscopic debridement Minimally invasive diagnostic techniques Seronegative rheumatoid arthritis Atypical knee gout Case report

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关注矮身材儿童心理健康

中国当代儿科杂志 2024年第4期26卷 331-336页

作者：欧阳力雪杨凡四川大学华西第二医院儿科/出生缺陷与相关妇儿疾病教育部重点实验室四川成都610041

在矮身材儿童的临床诊断和治疗难点中,心理健康问题值得特别关注。目前普遍认为矮身材儿童的心理健康水平低于正常身高儿童。因此,在矮身材的诊治及护理过程中,应积极关注患儿的心理健康状态,及时发现潜在的心理行为问题并予以纠正,对... 详细信息

在矮身材儿童的临床诊断和治疗难点中,心理健康问题值得特别关注。目前普遍认为矮身材儿童的心理健康水平低于正常身高儿童。因此,在矮身材的诊治及护理过程中,应积极关注患儿的心理健康状态,及时发现潜在的心理行为问题并予以纠正,对于改善患儿生活质量、促进身心健康发展具有积极作用。该文对矮身材儿童的心理状态评估与心理行为干预现状进行分析与阐述,以期为改善矮身材儿童心理健康提供参考。

关键词：矮身材心理健康儿童

局部受热锈蚀预应力混凝土梁力学性能试验研究

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铁道科学与工程学报 2024年第2期21卷 681-696页

作者：杨鸥刘智宇葛鹏吕博文风工程与桥梁工程湖南省重点实验室(湖南大学) 湖南长沙410082 湖南大学土木工程学院湖南长沙410082

随着我国基础建设的发展,大量混凝土桥梁在恶劣环境影响下发生腐蚀和老化,腐蚀桥梁结构的灾害破坏机理研究对桥梁结构的运营安全具有重要意义。为研究已经锈蚀受损的桥梁在局部受热状态下的高温力学性能,设计10根预应力混凝土梁试件。... 详细信息

随着我国基础建设的发展,大量混凝土桥梁在恶劣环境影响下发生腐蚀和老化,腐蚀桥梁结构的灾害破坏机理研究对桥梁结构的运营安全具有重要意义。为研究已经锈蚀受损的桥梁在局部受热状态下的高温力学性能,设计10根预应力混凝土梁试件。其中对照组的2根试件在常温下加载,试验变量为预应力筋初始应力,试验组的8根试件在高温下加载,试验变量分别为钢筋锈蚀、预应力筋初始应力、初始荷载。首先,基于电化学原理对4根预应力混凝土梁进行钢筋加速锈蚀处理,然后利用复合高温试验炉对8根预应力混凝土梁(4根锈蚀、4根未锈蚀)在跨中进行三面受火试验。最后,采用数值方法对局部受热预应力混凝土梁进行了仿真分析。研究结果表明:局部受热条件下,预应力混凝土梁的承载能力会发生明显降低,下降幅度约为11.3%~14.9%;钢筋锈蚀导致的混凝土开裂会对预应力混凝土梁的抗火性能产生不利影响,主要表现为2个方面,1)相同试验条件下,锈蚀后的试件预应力增量更大;2)锈蚀试件在局部受热条件下承载能力下降幅度更大,约为19.4%~21.9%;增大预应力筋的初始应力可以减小预应力混凝土梁在局部受热时的高温蠕变变形;局部高温作用下预应力混凝土梁对初始荷载较为敏感,当试件初始荷载值提升20%时,三分点位移量约增大60%。研究成果可以为实际锈蚀桥梁的防火设计和灾后应急提供理论依据。

关键词：预应力混凝土梁局部受热钢筋锈蚀火灾试验温度场