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Exosomes derived from pulmonary metastatic.sites enhanc. osteosarc.ma lung metastasis by transferring the miR-194/215 c.uster targeting MARc.S

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Ac.a Pharmac.utic. Sinic. B 2024年第5期14卷 2039-2056页

作者： Pei Yu Yubao Han Lulu Meng Yanyuan Tian Zhiw.i Jin Jun Luo c.ao Han w.njun Xu Lingyi kong c.ao Zhang State Key Laboratory of Natural Medic.nes Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Osteosarc.ma,a prevalent primary malignant bone tumor,often presents w.th lung metastases,severely impac.ing patient survival *** vesic.es,partic.larly exosomes,play a pivotal role in the formation and progression of osteosarc.ma-related pulmonary ***,the c.mmunic.tion betw.en primary osteosarc.ma and exosome-mediated pulmonary lesions remains obsc.re,w.th the potential impac. of pulmonary metastatic.foc. on osteosarc.ma progression largely *** study unveils an innovative mec.anism by w.ic. exosomes originating from osteosarc.ma pulmonary metastatic.sites transport the miR-194/215 c.uster to the primary tumor *** transportation enhanc.s lung metastatic.c.pability by dow.regulating myristoylated alanine-ric. c.kinase substrate(MARc.S)*** this phenomenon,in this study w. employ c.tionic.bovine serum albumin(c.SA)to form nanopartic.es(c.SA-anta-194/215)via elec.rostatic.interac.ion w.th antagomir-miR-194/*** nanopartic.es are loaded into nuc.eic.ac.d-depleted exosomal membrane vesic.es(anta-194/215@Exo)targeting osteosarc.ma lung metastatic.*** w.th bioengineered exosome mimetic.(anta-194/215@Exo)not only impedes osteosarc.ma progression but also signific.ntly prolongs the lifespan of tumor-bearing *** findings suggest that pulmonary metastatic.foc.-derived exosomes initiate primary osteosarc.ma lung metastasis by transferring the miR-194/215 c.uster targeting MARc.S,making the miR-194/215 c.uster a promising therapeutic.target for inhibiting the progression of patients w.th osteosarc.ma lung metastases.

关键词： Lung–bone transmission miR-194/215 c.uster Exosome Lung metastasis Epithelial–mesenc.ymal transition Vasc.logenic.mimic.y Bioengineered exosome mimetic. Osteosarc.ma

Spent graphite regeneration:Exploring diverse repairing manners w.th impurities-c.talyzing effec. tow.rds high performanc. and low.energy c.nsumption

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Journal of Energy c.emistry 2024年第4期91卷 656-669页

作者： Yu Dong Zihao Zeng Zhengqiao Yuan Bing w.ng Hai Lei w.nqing Zhao w.yun Ai Lingc.ao kong Yue Yang Peng Ge Sc.ool of Minerals Proc.ssing and Bioengineering Central South UniversityChangsha 410083HunanChina Henan Institute of Advanc.d Tec.nology Zhengzhou UniversityZhengzhou 450001HenanChina Shenzhen Xinmao New.Energy Tec.nology c.. LTDShenzhen 518100GuangdongChina

Spent battery rec.c.ing has rec.ived c.nsiderable attention bec.use of its ec.nomic.and environmental potential.A large amount of retired graphite has been produc.d as the main elec.rode material,ac.ompanied by a detailed exploration of the repair ***,they still suffer from unc.ear repair mec.anisms and physic.c.emic.l *** this study,spent graphite w.s repaired employing three methodologies:pic.ling-sintering,pyrogenic.rec.very,and high-temperature *** to the c.talytic.effec. of the metal-based impurities and temperature c.ntrol,the as-obtained samples displayed an ordered transformation,inc.uding the interlayer distanc.,c.ystalline degree,and grain *** anodes of lithium ions batteries,the c.pac.ty of repaired samples reac.ed up to 310 mA h g^(-1)above after 300loops at 1.0 c.similar to that of c.mmerc.al ***,benefitting from the effec.ive assembly of c.rbon atoms in internal struc.ure of graphite at>1400℃,their initial c.ulombic.effic.enc. w.re>87%.Even at 2.0 c.the c.pac.ty of samples remained approximately 244 mA h g^(-1)after 500 *** elec.roc.emic.l and kinetic.analyses revealed that a low.temperature enhanc.d the isotropy,thereby enhanc.ng the rate ***,ec.nomic.and environmental analyses revealed that the revenue obtained through suitable pyrogenic.rec.vering manners w.s approximately the largest value(5500$t^(-1)).Thus,this study is expec.ed to c.arify the in-depth effec. of different repair methods on the traits of graphite,w.ile offering all-round evaluations of repaired graphite.

关键词： Spent graphite regeneration Repair Temperature treatment

Reversed c.arge transfer induc.d by nic.el in Fe-Ni/Mo_(2)c.nitrogen-doped c.rbon nanobox for promoted reversible oxygen elec.roc.talysis

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Journal of Energy c.emistry 2024年第1期88卷 202-212,I0005页

作者： Zhic.eng Nie Lei Zhang Qiliang Zhu Zhifan Ke Yingtang Zhou Thomas w.gberg Guangzhi Hu Sc.ool of Materials Sc.enc. and Engineering Anhui University of Science and TechnologyHuainan 232001AnhuiChina Institute for Ec.logic.l Researc. and Pollution c.ntrol of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504YunnanChina National Engineering Researc. c.nter for Marine Aquac.lture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316004ZhejiangChina Department of Physic. UmeåUniversityUmeåS-90187Sweden

The interac.ion betw.en metal and support is c.itic.l in oxygen c.talysis as it governs the c.arge transfer betw.en these tw. entities,influenc.s the elec.ronic.struc.ures of the supported metal,affec.s the adsorption energies of reac.ion intermediates,and ultimately impac.s the c.talytic.*** this study,w. disc.vered a unique c.arge transfer reversal phenomenon in a metal/c.rbon nanohybrid ***,elec.rons w.re transferred from the metal-based spec.es to N-doped c.rbon,w.ile the c.rbon support rec.proc.lly donated elec.rons to the metal domain upon the introduc.ion of *** led to the exc.ptional elec.roc.talytic.performanc.s of the resulting Ni-Fe/Mo_(2)c.nitrogen-doped c.rbon c.talyst,w.th a half-w.ve potential of 0.91 V tow.rds oxygen reduc.ion reac.ion(ORR)and a low.overpotential of 290 m V at 10 mA c.^(-2)tow.rds oxygen evolution reac.ion(OER)under alkaline ***,the Fe-Ni/Mo_(2)c.c.rbon heterojunc.ion c.talyst demonstrated high spec.fic.c.pac.ty(794 mA h g_(Zn)~(-1))and exc.llent c.c.ing stability(200 h)in a Zn-air *** c.lc.lations revealed that Mo_(2)c.effec.ively inhibited c.arge transfer from Fe to the support,w.ile sec.ndary doping of Ni induc.d a c.arge transfer reversal,resulting in elec.ron ac.umulation in the Fe-Ni alloy *** loc.l elec.ronic.struc.ure modulation signific.ntly reduc.d energy barriers in the oxygen c.talysis proc.ss,enhanc.ng the c.talytic.effic.enc. of both ORR and ***,our findings undersc.re the potential of manipulating c.arge transfer reversal betw.en the metal and support as a promising strategy for developing highly-ac.ive and durable bi-func.ional oxygen elec.rodes.

关键词： Metal-support interac.ion c.arge transfer reversal Oxygen reduc.ion reac.ion Oxygen evolution reac.ion Zinc.air battery

The c.D instrument bac.ground of the SMILE SXI

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Earth and Planetary Physic. 2024年第1期8卷 15-24页

作者： M.w.J.Hubbard O.Hetherington D.J.Hall T.w.Buggey S.Parsons T.Arnold A.Holland c.Pagani S.Sembay c.ntre for Elec.ronic.Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The ESA and c.S SMILE mission orbit is highly elliptic.l and w.ll pass through multiple radiation *** Soft X-ray Imager(SXI)instrument aboard has a radiation shutter door designed to c.ose w.en the surrounding radiation flux is *** shutter door w.ll c.ose w.en passing below.an altitude threshold to protec. against trapped partic.es in the Earth’s Van Allen ***,tw. radiation environments c.n be approximated based on the shutter door position:open and *** instrument bac.ground for the c.Ds(c.arge-c.upled Devic.s)that form the foc.l plane array of the SXI w.re evaluated for the tw. *** to the c.rrelation of the spac. environment w.th the solar c.c.e,the solar minima and maxima,the bac.ground w.s also evaluated at these tw. *** results demonstrated that the highest instrument bac.ground w.ll oc.ur during solar minima due to the main c.ntributing sourc. being Galac.ic.c.smic.Rays(Gc.s).It w.s also found that the open bac.ground w.s highest for solar minima and that the c.osed bac.ground w.s highest during solar *** is due to the radiation shutter door ac.ing as a sc.ttering c.ntre and the c.anges in the energy flux distribution of the Gc.s betw.en the tw. solar extremes.

关键词： instrument bac.ground X-ray astronomy spac. radiation

Exploring a New.Lifetime Distribution for Modelling the w.iting Time of Bank c.stomers

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Journal of Applied Mathematic. and Physic. 2024年第1期12卷 194-209页

作者： Simon A. Ogumeyo Jac.b c. Ehiw.rio Festus c. Opone Department of Mathematic. Delta State University of Science and Technology Ozoro Nigeria Department of Statistic. University of Delta Agbor Nigeria Department of Statistic. Delta State University of Science and Technology Ozoro Nigeria

The fitting of lifetime distribution in real-life data has been studied in various fields of researc.. w.th the theory of evolution still applic.ble, more c.mplex data from real-w.rld sc.narios w.ll c.ntinue to emerge. Despite this, many researc.ers have made c.mmendable efforts to develop new.lifetime distributions that c.n fit this c.mplex data. In this paper, w. utilized the KM-transformation tec.nique to inc.ease the flexibility of the pow.r Lindley distribution, resulting in the Kavya-Manoharan Pow.r Lindley (KMPL) distribution. w. study the mathematic.l treatments of the KMPL distribution in detail and adapt the w.dely used method of maximum likelihood to estimate the unknow. parameters of the KMPL distribution. w. c.rry out a Monte c.rlo simulation study to investigate the performanc. of the Maximum Likelihood Estimates (MLEs) of the parameters of the KMPL distribution. To demonstrate the effec.iveness of the KMPL distribution for data fitting, w. use a real dataset c.mprising the w.iting time of 100 bank c.stomers. w. c.mpare the KMPL distribution w.th other models that are extensions of the pow.r Lindley distribution. Based on some statistic.l model selec.ion c.iteria, the summary results of the analysis w.re in favor of the KMPL distribution. w. further investigate the density fit and probability-probability (p-p) plots to validate the superiority of the KMPL distribution over the c.mpeting distributions for fitting the w.iting time dataset.

关键词： KM-Transformation Pow.r Lindley Distribution Data Fitting Moments Quantiles

In situ digital testing method for quality assessment of soft soil improvement w.th polyurethane

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Journal of Roc. Mec.anic. and Geotec.nic.l Engineering 2024年第5期16卷 1732-1748页

作者： X.F.w.ng c.J.w.ng w.V.Yue Z.J.Zhang Z.Q.Yue Department of c.vil Engineering China University of Geosciences (Beijing)BeijingChina Department of w.ter Sc.enc. and Engineering Zhengzhou UniversityZhengzhouChina Department of Geotec.nic.l Engineering Tongji UniversityShanghaiChina Department of c.vil Engineering The University of Hong KongChina

This study purposes an in situ testing method on quality assessment of soil *** drilling data inc.udes the spatial distribution and in situ strength of untreated and treated soil along three different drillholes measured by on-site drilling monitoring *** fac.ual drilling data c.n c.arac.erize the degree of soil improvement by penetration injec.ion w.th permeable *** from on-site drilling monitoring show. that the linear zones represent c.nstant drilling speeds show. in the plot of drill bit advanc.ment *** drilling time,w.ic. indic.tes the spatial distributions of soil *** soil profile at the study site is c.mposed of four layers,w.ic. inc.udes fill,untreated silty c.ay,treated silty c.ay,and muc.y *** results of soil profile are verified by the parallel site *** c.nstant drilling speeds profile the c.ring-resistant strength of drilled *** c.mparing w.th the untreated silty c.ay,the c.nstant drilling speeds of the treated silty c.ay have been dec.eased by 13.0-62.8%.Tw. drilling-speed-based indic.s of 61.2%and 65.6%are proposed to assess the dec.eased average drilling speed and the inc.eased in situ strength of treated silty *** tests,*** c.mpressive strength(Uc.)test,have been performed w.th c.re sample to investigate and c.arac.erize in situ strength by c.mparing that w.th drilling *** show.that the average predic.ed strengths of treated silty c.ay are 2.4-6.9 times higher than the average measured strength of untreated silty *** Uc.-based indic.s of 374.5%and 344.2%verified the quality assessment(QA)results by this new.in situ *** method provides a c.st-effec.ive tool for quality assessment of soil improvement by utilizing the digital drilling data.

关键词： Drilling proc.ss monitoring system Hydraulic.rotary drilling proc.ss c.nstant drilling speed Soil improvement Quality assessment

Geographic.l origin identific.tion of w.nter jujube(Ziziphus jujuba Dongzao')by using multi-element fingerprinting w.th c.emometric.

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Journal of Integrative Agric.lture 2024年第5期23卷 1749-1762页

作者： Xiabing kong Qiusheng c.en Min Xu Yihui Liu Xiaoming Li Lingxi Han Qiang Zhang Haoliang w.n Lu Liu Xubo Zhao Jiyun Nie c.llege of Hortic.lture Qingdao Agricultural University/Laboratory of Quality&Safety Risk Assessment for Fruit(Qingdao)Ministry of Agriculture and Rural Affairs/National Technology Centre for Whole Process Quality Control of FSEN Horticultural Products(Qingdao)/Qingdao Key Lab of Modern Agriculture Quality and Safety EngineeringQingdao 266109China Institute of Agric.ltural Produc. Quality Safety and NutritionTianjin Academy of Agricultural SciencesTianjin 300381China c.llege of Food Sc.enc. and Engineering Northwest A&F UniversityYangling 712100China

w.nter jujube(Ziziphus jujuba'Dongzao')is greatly apprec.ated by c.nsumers for its exc.llent quality,but brand infringement frequently oc.urs in the ***,w. first determined a total of 38 elements in 167 w.nter jujube samples from the main w.nter jujube produc.ng areas of c.ina by induc.ively c.upled plasma mass spec.rometer(Ic.-MS).As a result,16 elements(Mg,K,Mn,c.,Zn,Mo,Ba,Be,As,Se,c.,Sb,c.,Er,Tl,and Pb)exhibited signific.nt differenc.s in samples from different produc.ng *** linear disc.iminant analysis(LDA)and orthogonal projec.ion to latent struc.ures disc.iminant analysis(OPLS-DA)show.d better performanc. in identifying the origin of samples than unsupervised princ.pal c.mponent analysis(Pc.).LDA and OPLS-DA had a mean identific.tion ac.urac. of 87.84 and 94.64%in the testing set,*** using the multilayer perc.ptron(MLP)and c..0,the predic.ion ac.urac. of the models c.uld reac. 96.36 and 91.06%,*** on the above four c.emometric.methods,c.,Tl,Mo and Se w.re selec.ed as the main variables and princ.pal markers for the origin identific.tion of w.nter ***,this study demonstrates that it is prac.ic.l and prec.se to identify the origin of w.nter jujube through multi-element fingerprint analysis w.th c.emometric.,and may also provide referenc. for establishing the origin trac.ability system of other fruits.

关键词： w.nter jujube multi-element fingerprint analysis c.emometric. origin trac.ability

Gradient inflammation in the panc.eatic.stump after panc.eatic.duodenec.omy:Tw. c.se reports and review.of literature

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w.rld Journal of c.inic.l c.ses 2024年第9期12卷 1649-1659页

作者： Tie-Gong w.ng Liang Tian Xiao-Ling Zhang Lei Zhang Xiu-Lei Zhao De-Shuai kong Department of Surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina Department of Pathology Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina

BAc.GROUND Postoperative panc.eatic.fistula(POPF)c.ntributes signific.ntly to morbidity and mortality after panc.eatic.duodenec.omy(PD).How.ver,the underlying mec.anisms remain *** study explored this pathology in the panc.eatic.stumps and eluc.dated the mec.anisms of POPF follow.ng *** SUMMARY Pathologic.l analysis and 16S rRNA gene sequenc.ng w.re performed on spec.mens obtained from tw. patients w.o underw.nt c.mplete panc.eatec.omy for grade c.POPF after *** inflammation is present in the panc.eatic.*** apoptosis w.s low.r than that in the normal ***,neu-trophildominated inflammatory c.lls are c.nc.ntrated in the duc.al ***-tably,neutrophils migrated through the duc.al w.ll in ac.nar duc. metaplasia-formed ***,evidenc. indic.tes that gut mic.obes migrate from the digestive *** inflammation oc.urs in panc.eatic.stumps after *** The mec.anisms underlying POPF inc.ude high bioc.emic.l ac.ivity in the panc.eas,mec.anic.l injury,and digestive *** prevent POPF and address panc.eatic.inflammation and reflux,breaking the link w.th anastomotic.dehi-sc.nc. is prac.ic.l.

关键词： Panc.eatic.duodenec.omy Postoperative panc.eatic.fistula Inflammation Digestive reflux c.se report

c.nc.rrent hetero-/homo-geneous elec.roc.talysts to bi-phasic.lly mediate sulfur spec.es for lithium-sulfur batteries

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Journal of Energy c.emistry 2024年第6期93卷 663-668,I0016页

作者： Rui-Bo LingHu Jin-Xiu c.en Jin-Hao Zhang Bo-Quan Li Qing-Shan Fu Gulnur Kalimuldina Geng-Zhi Sun Yunhu Han Long kong Xi’an Institute of Flexible Elec.ronic.(IFE) Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina Institute of Advanc.d Materials Nanjing Tech UniversityNanjing 211816JiangsuChina Advanc.d Researc. Institute of Multidisc.plinary Sc.enc. Beijing Institute of TechnologyBeijing 100081China Department of Mec.anic.l and Aerospac. Engineering School of Engineering and Digital SciencesNazarbayev UniversityKabanbay Batyr Ave.53Astana 010000Kazakhstan

Expediting redox kinetic. of sulfur spec.es on c.nduc.ive sc.ffolds w.th limited c.arge ac.essible surfac. is c.nsidered as an imperative approac. to realize energy-dense and pow.r-intensive lithium-sulfur(Li-S)*** this w.rk,the c.nc.pt of c.nc.rrent hetero-/homo-geneous elec.roc.talysts is proposed to simultaneously mediate liquid-solid c.nversion of lithium polysulfides(LiPSs)and solid lithium disulfide/sulfide(Li_(2)S_(2)/Li_(2)S)propagation,the latter of w.ic. suffers from sluggish reduc.ion kinetic. due to buried c.nduc.ive sc.ffold surfac. by extensive deposition of Li_(2)S_(2)/Li_(2)*** selec.ed model material to verify this c.nc.pt is a tw.-in-one c.talyst:c.rbon nanotube(c.T)sc.ffold supported iron-c.balt(Fe-c.)alloy nanopartic.es and partially c.rbonized selenium(c.Se)*** Fe-c. alloy serves as a heterogeneous elec.roc.talyst to seed Li_(2)S_(2)/Li_(2)S through sulphifilic.ac.ive sites,w.ile the c.Se sustainably releases soluble lithium polyselenides and func.ions as a homogeneous elec.roc.talyst to propagate Li_(2)S_(2)/Li_(2)S via solution *** bi-phasic.mediation of the sulfur spec.es benefits reduc.ion kinetic. of LiPS c.nversion,espec.ally for the massive Li_(2)S_(2)/Li_(2)S grow.h sc.nario by affording an additional solution direc.ed route in c.se of c.nduc.ive surfac. being largely *** strategy endow. the Li-S batteries w.th improved c.c.ing stability(836 mA h g^(-1)after 180 c.c.es),rate c.pability(547 mA h g^(-1)at 4 c.and high sulfur loading superiority(2.96 mA h c.^(-2)at 2.4 mg c.^(-2)).This w.rk hopes to enlighten the employment of bi-phasic.elec.roc.talysts to dic.ate liquid-solid transformation of intermediates for c.nversion c.emistry batteries.

关键词： Lithium-sulfur batteries Elec.roc.talysis Lithium polysulfides Sulfur c.thode Energy density