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Mapping global research trends: Nutrition associations with nonalcoholic fatty liver disease - a Scopus bibliometric analysis

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World Journal of Gastroenterology 2024年第24期30卷 3106-3119页

作者： Muna Shakhshir Sa'ed H Zyoud Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Public Health College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Center An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Several bibliometric analyses have been carried out to identify research hotspots and trends in nonalcoholic fatty liver disease(NAFLD)***,there are still significant knowledge gaps that must be filled to advance our understanding of and ability to treat *** To evaluate,through bibliometric and visual analysis,the current status of related research,related research frontiers,and the developmental trends in the field of diet and *** We retrieved publications about diet and NAFLD published between 1987 and 2022 from ***,we used VOSviewer 1.6.20 to perform bibliometric analysis and *** We found a total of 1905 studies,including 1637(85.93%)original articles and 195(10.24%)reviews,focused on the examination of NAFLD and its correlation with diet that were published between 1987 and *** the remai.ing five types of documents,38 were letters,notes,editorials,meeting minutes,or brief surveys,representing 1.99%of the total *** countries with the most publications on this topic were China(n=539;28.29%),followed by the United States(n=379;19.90%),Japan(n=133;6.98%),and South Korea(n=127;6.6%).According to the citation analysis,the retrieved papers were cited an average of 32.3 times and had an h-index of 106,with 61014 total *** two mai. clusters on the map included those related to:(1)Inflammation and oxidative stress;and(2)Dietary interventions for *** This was the first study to use data taken from Scopus to visualize network mapping in a novel bibliometric analysis of studies focused on diet and *** 2017,the two domai.s that received the most attention were“dietary interventions for NAFL”’and“‘inflammation and oxidative stress implicated in NAFLD and its correlation with diet.”We believe that this study provides important information for academics,dietitians,and doctors,and that additional research on dietary interventions and NAFLD is warranted.

关键词： Dietary Nutrition Bibliometric Nonalcoholic fatty liver Scopus VOSviewer

Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brai.

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Neural Regeneration Research 2024年第5期19卷 969-970页

作者： Anne-Eva van der Wijk ed VanBavel Amsterdam UMC location University of Amsterdam Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands Amsterdam Neuroscience Neurovascular Disorders ProgramAmsterdamThe Netherlands Amsterdam Cardiovascular Sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of therapeutics for brai. diseases has remai.ed challenging,in particular due to the difficulty of passing the blood-brai. *** a result,the current arsenal of therapeutics targeting the brai. is limited to small,lipid-soluble drugs and there is a lack of options for treating neuroblastomas,Alzheimer’s disease,and many other devastating *** the advances in strategies for crossing the blood-brai. barrier such as the use of nanoparticles(Hersh et al.,2022;Duan et al.,2023),such delivery systems have not yet reached clinical ***,novel platforms for the transport of therapeutics across the blood-brai. barrier remai. highly *** specifically holds for large molecules such as monoclonal antibodies and recombinant proteins,as well as nucleotide-based therapeutics and cell *** efforts in this field are increasing exponentially,with thousands of publications in the last few years.

关键词： therapeutics holds spite

Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang ai.ai.Gao Cheng Zhu Tao He James G Herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detai.ed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ed)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chai. reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ed and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both Ped between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

An Abstract Reachability Approach by Combining HOL Induction and Multiway Decision Graphs

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Journal of Computer Science & Technology 2009年第1期24卷 76-95页

作者： Sa'ed Abed otmane ai. moha.ed Ghiath Al-Sammane ECE Department Concordia UniversityMontrealCanada

In this paper, we provide a necessary infrastructure to define an abstract state exploration in the HOL theorem prover. Our infrastructure is based on a deep embedding of the Multiway Decision Graphs （MDGs） theory in HOL. MDGs generalize Reduced Ordered Binary Decision Diagrams （ROBDDs） to represent and manipulate a subset of first-order logic formulae. The MDGs embedding is based on the logical formulation of an MDG as Directed Formulae （DF）. Then, the MDGs operations are defined and the correctness proof of each operation is provided. The MDG teachability algorithm is then defined as a conversion that uses our MDG theory within HOL. Finally, a set of experimentations over benchmark circuits has been conducted to ensure the applicability and to measure the performance of our approach.

关键词： HOL theorem prover multiway decision graphs correctness reachability analysis

NuMDG:A New Tool for Multiway Decision Graphs Construction

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Journal of Computer Science & Technology 2011年第1期26卷 139-152页

作者： Sa'ed Abed Yassine Mokhtari otmane ai.-moha.ed Sofiene Tahar Department of Computer Engineering Hashemite UniversityZarqaJordan Department of Electrical and Computer Engineering Concordia UniversityMontrealCanada

Multiway Decision Graphs （MDGs） are a canonical representation of a subset of many-sorted first-order logic. This subset generalizes the logic of equality with abstract types and uninterpreted function symbols. The distinction between abstract and concrete sorts mirrors the hardware distinction between data path and control. Here we consider ways to improve MDGs construction. Efficiency is achieved through the use of the Generalized-If-Then-Else （GITE） commonly operator in Binary Decision Diagram packages. Consequently, we review the mai. algorithms used for MDGs verification techniques. In particular, Relational Product and Pruning by Subsumption are algorithms defined uniformly through this single CITE operator which will lead to a more efficient implementation. Moreover, we provide their correctness proof. This work can be viewed as a way to accommodate the ROBBD algorithms to the realm of abstract sorts and uninterpreted functions. The new tool, called NuMDG, accepts an extended SMV language, supporting abstract data sorts. Finally, we present experimental results demonstrating the efficiency of the NuMDG tool and evaluating its performance using a set of benchmarks from the SMV package.

关键词： infinite state model checking multiway decision graphs uninterpreted functions

A Multilayer Perceptron Artificial Neural Network Study of Fatal Road Traffic Crashes

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Journal of Data Analysis and Information Processing 2024年第3期12卷 419-431页

作者： ed Pearson III Aschalew Kassu Louisa Tembo Oluwatodimu Adegoke Department of Electrical Engineering & Computer Science Alabama A&M University Normal AL USA Department of Mechanical Civil Engineering & Construction Management Alabama A&M University Normal AL USA Department of Mathematics and Computer Science Alabama State University Montgomery AL USA

This paper examines the relationship between fatal road traffic accidents and potential predictors using multilayer perceptron artificial neural network (MLANN) models. The initial analysis employed twelve potential predictors, including traffic volume, prevai.ing weather conditions, roadway characteristics and features, drivers’ age and gender, and number of lanes. Based on the output of the model and the variables’ importance factors, seven significant variables are identified and used for further analysis to improve the performance of models. The model is optimized by systematically changing the parameters, including the number of hidden layers and the activation function of both the hidden and output layers. The performances of the MLANN models are evaluated using the percentage of the achieved accuracy, R-squared, and Sum of Square Error (SSE) functions.

关键词： Artificial Neural Network Multilayer Perceptron Fatal Crash Traffic Safety

Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance:A visualization and bibliometric study

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World Journal of Hepatology 2024年第6期16卷 951-965页

作者： Sa'ed H Zyoud Omar E Hegazi Samer O Alalalmeh Muna Shakhshir Faris Abushamma Shadi Khilfeh Samah W Al-Jabi Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Center An-Najah National University HospitalNablus 44839Palestine College of Pharmacy and Health Sciences Ajman UniversityAjman 346United Arab Emirates Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Urology An-Najah National University HospitalNablus 44839Palestine Department of Gastroenterology Hepatology and EndoscopyAn-Najah National University HospitalNablus 44839Palestine

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a liver condition that is prevalent worldwide and associated with significant health risks and economic *** it has been linked to insulin resistance(IR),this study ai.ed to perform a bibliometric analysis and visually represent the scientific literature on IR and *** To map the research landscape to underscore critical areas of focus,influential studies,and future directions of NAFLD and *** This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to *** search strategy used terms from the literature and medical subject headings,focusing on terms related to IR and *** software was used to visualize research trends,collaborations,and key thematic *** analysis examined publication type,annual research output,contributing countries and institutions,funding agencies,journal impact factors,citation patterns,and highly cited *** This analysis identified 23124 documents on NAFLD,revealing a significant increase in the number of publications between 1999 and *** search retrieved 715 papers on IR and NAFLD,including 573(80.14%)articles and 88(12.31%)*** most productive countries were China(n=134;18.74%),the United States(n=122;17.06%),Italy(n=97;13.57%),and Japan(n=41;5.73%).The leading institutions included the Universitàdegli Studi di Torino,Italy(n=29;4.06%),and the Consiglio Nazionale delle Ricerche,Italy(n=19;2.66%).The top funding agencies were the National Institute of Diabetes and Digestive and Kidney Diseases in the United States(n=48;6.71%),and the National Natural Science Foundation of China(n=37;5.17%).The most active journals in this field were Hepatology(27 publications),the Journal of Hepatology(17 publications),and the Journal of Clinical Endocrinology and Metabolism(13 publications).The mai. research hotspots were“therapeutic approaches for IR and NAFLD”and“inflamma

关键词： Nonalcoholic fatty liver disease Insulin resistance Bibliometric Visualization

Fritz Ackermann:a true and unequalled friend

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Geo-Spatial Information Science 2023年第2期26卷 151-152页

作者： ed Mikhai. Professor Emeritus&Former Head Geomatics Engineering Purdue UniversityWest LafayetteINUSA

I am certai. that several other contributors to this memorial volume have expounded on the many attributes,both professional and personal,of Professor Fritz *** is unquestionable that he was a giant in our field,on whose shoulders current and future practitioners shall stand in order to keep the wheels of progress and advancement moving forward.

关键词： moving Fritz Ackermann

A Circular Economy Approach to Sustai. the Souss River, Morocco, Ecosystem Services

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Journal of Environmental Science and Engineering(A) 2015年第12期4卷 628-640页

作者： moha Haddouch Regional Department for Agricultural Circular Economy Project Management Unit Agadir POB 13/S 84000 Morocco

This article discusses the role of the Souss river in disaster risk reduction, climate change adaptation and sustai.able development through mai.streaming natural capital into macro-economic policies. The river course, rising from several headstreams in the high Atlas mountai. and flowing westward for 180 km to the atlantic ocean is the beating heart of the Argan biosphere reserve. Its alluvial basin ensures the vital link between biodiversity and the population＇s utility functions for more than three million inhabitants. It is one of Morocco＇s most fertile regions where citrus fruits, vegetables, olives are grown beside an argan natural grove, and many of them are for export. Recent growing concern of local authorities tackles natural disasters and subsequent social issues associated to climate change, resource scarcities and flooding damages, especially after the 2014 flood events. This situation paved the way for local NGO incentives to embrace an ecological civilization approach for reconciliation with the Souss river. The local option adopted is to reverse the trend of intensive modem agriculture through a counterbalancing circular economy approach towards an agro-ecological producing pattern in order to sustai. the river water balance.

关键词： Souss river ecosystem services disaster risk reduction environment engineering