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Phytochemical composition and toxicity assessment of Ammi majus L.

Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 165-175页

作者： otman el-guourrami Najoua Salhi Fatima Zahra Benkhouili Gokhan Zengin Mustafa Abdullah Yilmaz Mouna Ameggouz Ahmed Zahidi Lamiaa Rouas Abdelhakim Bouyahya Khang Wen Goh Toong Hai Sam Long Chiau Ming Anass Doukkali Hanane Benzeid Laboratory of Analytical Chemistry Faculty of Medicine and PharmacyMohammed Ⅴ UniversityRabatMorocco Laboratory of Pharmacology and Toxicology Faculty of Medicine and Pharmacy Mohammed Ⅴ UniversityRabatMorocco Laboratory of Medicinal Chemistry Faculty of Medicine and PharmacyMohammed Ⅴ UniversityRabatMorocco Department of Biology Faculty of ScienceSelcuk UniversityCampus/KonyaTurkey Dicle University Science and Technology Research and Application Center 21280DiyarbakirTurkey Dicle University Faculty of PharmacyDepartment of Analytical Chemistry21280DiyarbakirTurkey Center Hospitalo-Universitaire Ibn Sina Laboratory of AnatomopathologyRabatMorocco Laboratory of Human Pathologies Biology Department of BiologyFaculty of SciencesGenomic Center of Human PathologiesMohammed Ⅴ University in RabatMorocco Faculty of Data Science and Information Technology INTI International UniversityNilai 71800Malaysia Faculty of Business and Communications INTI International UniversityNilai 71800Malaysia School of Medical and Life Sciences Sunway UniversitySunway City 47500Malaysia

Objective:To assess the acute and subacute toxicity as well as the phytochemical composition of two extracts and three fractions of Ammi majus ***:The aqueous extracts were prepared separately by maceration for 48 h and by infusion for 1 h,while the fractions were prepared by the Soxhlet extractor,successively employing cyclohexane,ethyl acetate,and *** acute toxicity study was carried out in accordance with the OECD N°423 guideline at a single dose(2000 mg/kg)in mice for 14 *** subacute toxicity study was performed by a daily oral administration of 250 mg/kg 2 for 10 d and 100 mg/kg doses for 28 *** screening was performed using staining and precipitation reactions,while the chemical characterization of some analytes was detected by HPLC-MS/MS ***:In the acute toxicity study,no signs of toxicity such as convulsion,salivation,diarrhea,sleep and coma were observed during 30 minutes and 14 days,so the lethal dose was higher than 2000 mg/kg for each extract and *** subacute toxicity results showed that at a dose of 250 mg/kg,61.10%of the animals died and the rest developed *** the other hand,at a dose of 100 mg/kg,all the animals were still alive after 28 days,with no morbidity and the biochemical parameters were normal with no abnormalities in the liver,kidneys and *** screening indicated the presence of flavonoids,tannins,coumarins,and free quinones and the absence of alkaloids and ***:The extracts and fractions of Ammi majus *** not toxic in the short and long term with a varied chemical *** tests on animals other than rodents and in the long term(more than 28 days)are needed to further confirm the safety of Ammi majus extracts.

关键词： Ammi majus L. Phytochemical composition Acute toxicity Subacute toxicity Flavonoids

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