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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 7-7页

作者： otley c.c. cherikh W.S. Salasche S.J. 焦婷 Division of Dermatologic Surgery Mayo Clinic 200 First St SW Rochester MN 55905 United StatesDr.

Background: Solid organ transplant recipients are at increased risk for posttransplant neoplasms. Objective: Our purpose was to determine whether various diseases causing end- organ failure are associated with different degrees of risk of skin cancer development after transplantation. Methods: The Organ Procurement and Transplantation Network/United Network for Organ Sharing Transplant Tumor Registry was searched for the incidence of skin cancer among kidney, liver, and heart transplant recipients in the United States between 1996 and 2001. Multivariate analysis was used to determine the association between disease diagnosis and posttransplant skin cancer. Results: Transplant recipients with specific pretransplant diseases, such as polycystic kidney disease and cholestatic liver disease, were at increased risk for skin cancer. Patients with diabetesmellitus had a lower incidence of skin cancer after kidney transplantation. Limitations: The study had only a brief follow- up period, indirect assessment of photodamage, and possible underreporting. conclusion: Transplant recipients with a history of certain diseases warrant intensive skin cancer surveillance and strict sun- protective practices.

关键词：皮肤肿瘤移植受者疾病诊断移植肿瘤间接评估防护措施多囊肾多变量分析前有

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Assessing disease activity using the pediatric.c.ohn’s disease activity index:can we use subjective or objective parameters alone?

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World Journal of Gastroenterology 2021年第30期27卷 5100-5111页

作者： Amy Grant Trudy Lerer Anne M Griffiths JS Hyams Anthony otley Division of Pediatrics IWK HealthHalifaxNS B3K6R8Canada Division of Research Connecticut Children's Medical CenterHartfordCT 06106United States Division of Gastroenterology Hepatology and Nutrition The Hospital for Sick ChildrenTorontoON M5G1X8Canada Division of Gastroenterology Connecticut Children's Medical CenterHartfordCT 06106United States Division of Pediatrics Dalhousie UniversityHalifaxNS B3H4C3Canada

BAcKGROUND The pediatric.c.ohn’s disease activity index(PcDAI)is used as a standard tool to assess disease activity in clinical trials for pediatric.c.ohn’s *** To examine which items on the PcDAI drive assessment of disease activity,and how subgroups of subjective and objective items reflect change in disease state over *** Selective raw data from three prospectively collected datasets were combined,including 703 children with full PcDAI data at baseline,at 3-mo(Q1,n=670),and 1-year(Q4,n=474).change in individual PcDAI scores from baseline to Q1 and to Q4 were examined using the non-weighted *** Abdominal pain,well-being,weight,and stooling had the highest change scores over *** indicators including albumin,abdominal exam,and height velocity *** scores for well-being and abdominal exam did not explain significant variance at Q1 but were significant predictors at Q4(Pctive and objective subgroups of items predicted less variance(18%and 22%)on total PcDAI scores at Q1 and Q4 compared to the full PcDAI,or a composite scale(both 32%)containing significant *** Although subjective items on the PcDAI change the most over time,the full PcDAI or a smaller composite of items including a combination of subjective and objective components classifies disease activity better than a subgroup of either subjective or objective items *** on subjective or objective items as stand-alone proxies for disease activity measurement could result in misclassification of disease state.

关键词： crohn’s disease Pediatric.c.ohn’s disease activity index Patient reported outcome measurement Disease activity clinical trials Pediatric

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