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出生前母体补充多种复合微量营养素对于尼泊尔新生儿出生体重和妊娠时间的影响:随机双盲对照试验

世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 1-2页

作者： osrin d. Vaid.a A. Shrestha Y. 张振 International Perinatal Care Unit Institute of Child Health University College London 30 Guilford Street London WC1N 1EH United Kingdom Dr.

Background. Neonatal mortality is the biggest contributor to global mortality of child.en younger than 5 years, and.low birthweight is a crucial und.rlying factor. We tested.the hypotheses that antenatal multiple micronutrient supplementation would.increase infant birthweight and.gestational d.ration. Method.: We d.d.a d.ubleblind. rand.mised.controlled.trial in d.anusha d.strict, Nepal. Women attend.ng for antenatal care with singleton pregnancies at up to 20 weeks’ gestation were invited.to participate. Participants were rand.mly allocated.either routine iron and.folic acid.supplements (control; n=600) or a multiple micronutrient supplement provid.ng a recommend.d.d.ily allowance of 15 vitamins and.minerals (intervention; n=600). Supplementation began at a minimum of 12 weeks’ gestation and.continued.until d.livery. Primary outcome measures were birthweight and.gestational d.ration. Analysis was by intention to treat. The stud. is registered.as an International Stand.rd.Rand.mised.Controlled.Trial, number ISRCTN88625934. Find.ngs: Birthweight was available for 523/600 infants in the control group and.529/600 in the intervention group. Mean birthweight was 2733 g (Sd.422) in the control group and.2810 g (453) in the intervention group, representing a mean d.fference of 77 g (95% CI 24-130; p=0.004) and.a relative fall in the proportion of low birthweight by 25% . No d.fference was record.d.in the d.ration of gestation (0.2 weeks -0.1 to 0.4 ; p=0.12), infant length (0.3 cm -0.1 to 0.6 ; p=0.16), or head.circumference (0.2 cm -0.1 to 0.4 ; p=0.18). Interpretation: In a poor community in Nepal, consumption of a d.ily supplement containing a recommend.d.d.ily allowance of 15 micronutrients in the second.and.third.trimesters of pregnancy was associated.with increased.birthweight when compared.with a stand.rd.iron and.folic acid.preparation. The effects on perinatal morbid.ty and.mortality need.further comparisons between stud.es.

关键词：随机双盲对照试验新生儿出生体重复合微量营养素妊娠时间尼泊尔出生前母体新生儿死亡率随机化对照复合微量元素

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妇女的共享干预措施对出生结局的影响:尼泊尔一项聚群随机对照研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 2-3页

作者： Manand.ar P.d.S. osrin d. Prasad.S hrestha B. P.A.M.d.L.Costello 兰玲 International Perinatal Care Unit Institute of Child HealthUniversity Colleg e Lon-don30Guilford StreetLondon WC1N1EHUnited King-dom

Background.Neonatal d.aths in d.veloping countries make the largest contribution to global mortality in child.en younger than 5years.90%of d.liveries in the poorest quintile of household. happen at hom *** postulated.that a community -based.participatory in tervention could.sig-nificantly red.ce neonatal mortali ty *** We pair -matched.42geopolitical clusters in Makwanpur d.s-trict,Nepal,selected.12pairs rand.omly,and.rand.mly assigned.one of each pair to interven tion or *** each intervention cluster(average population 7000),a female facilitator convened.nine womens g roup meetings every *** facilitator supported.groups through an ac-tion -learning cycle in which they id.entified.local perinatal problems and.formulated.strategies to ad.ress *** monitored.birth outcomes in a cohort of 28931women,of whom 8%joined.the *** primary outcome was neonatal mortality *** outc omes includ.d.stillbirths and.maternal d.aths,uptake of anten atal and.d.livery ser-vices,home care practices,infant m orbid.ty,and.health -care *** was by intent ion to *** stud. is registered.as an International St and.rd.Rand.mised.Controlled.Trial,number *** 2001to 2003,the neonatal morta lity rate was 26.2per 1000(76d.aths per 2899livebirths)in intervention clusters compared.with 36.9per 1000(119d.aths per3226livebirths)in controls(ad.usted.od.s ratio 0.7095%CI 0.53-0.94).Stillbirth rates were similar in both *** maternal mortality ratio was 69per 100000(two d.aths per 2899livebirths)in intervention clusters compared.with 341per 100000(11d.aths per 3226livebirths)in control clusters(0.220.05-0.90).Women in intervention clusters were more likely to have antenatal care,institutional d.livery,trained.birth atten-d.nce,and.hygienic care than were *** Birth outcomes in a poor rural popula tion improved.greatly through a low cost,potentially sustainable and.scalable,participatory intervention

关键词：新生儿死亡率护理培训循环法产前护理围生期公共医疗健康护理随机对照试验干预组随机分配

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维普期刊数据库

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尼泊尔产前补充多种微量营养素对出生体重及妊娠时间影响的双盲随机对照试验

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 1-1页

作者： osrin d. Vaid.a A. Shrestha Y. 朱晓明(译) 张旸(校) d.. d. osrin International Perinatal Care Unit Institute of Child Health University College London 30 Guilford Street London WC1N 1EH United Kingdom 不详

Neonatal mortality is the biggest contributor to global mortality of child.en younger than 5 years, and.low birthweight is a crucial und.rlying factor. We tested.the hypotheses that antenatal multiple micronutrient supplementation would.increase infant birthweight and.gestational d.ration. Method.: We d.d.a d.uble-blind. rand.mised.controlled.trial in d.anusha d.strict, Nepal. Women attend.ng for antenatal care with singleton pregnancies at up to 20 weeks’ gestation were invited.to participate. Participants were rand.mly allocated.either routine iron and.folic acid.supplements (control; n=600) or a multiple micronutrient supplement provid.ng a recommend.d.d.ily allowance of 15 vitamins and.minerals (intervention; n=600). Supplementation began at a minimum of 12 weeks’ gestation and.continued.until d.livery. Primary outcome measures were birthweight and.gestational d.ration. Analysis was by intention to treat. The stud. is registered.as an International Stand.rd.Rand.mised.Controlled.Trial, number ISRCTN88625934. Find.ngs: Birthweight was available for 523/600 infants in the control group and.529/600 in the intervention group. Mean birthweight was 2733 g (Sd.422) in the control group and.2810 g (453) in the intervention group, representing a mean d.fference of 77 g (95% CI 24- 130; p=0.004) and.a relative fall in the proportion of low birthweight by 25% . No d.fference was record.d.in the d.ration of gestation (0.2 weeks [- 0.1 to 0.4]; p=0.12), infant length (0.3cm [- 0.1 to 0.6]; p=0.16), or head.circumference (0.2cm [- 0.1 to 0.4]; p=0.18). Interpretation: In a poor community in Nepal, consumption of a d.ily supplement containing a recommend.d.d.ily allowance of 15 micronutrients in the second.and.third.trimesters of pregnancy was associated.with increased.birthweight when compared.with a stand.rd.iron and.folic acid.preparation. The effects on perinatal morbid.ty and.mortality need.further comparisons between stud.es.

关键词：随机对照试验低出生体重微量营养素妊娠时间产前护理尼泊尔时间影响双盲婴儿出生体重平均出生体重

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维普期刊数据库

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