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Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage:Comparative analytical study of physicochemical quality attributes

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Journal of Pharmaceutical Analysis 2020年第6期10卷 532-545页

作者： Natalia Navas Jesús Hermosilla Anabel Torrente-Lopez Jose Hernandez-Jimenez Jose Cabeza raquel Perez-Roblesa Antonio Salmeron-García Department of Analytical Chemistry Science Faculty/Biomedical Research Institute ibs.GranadaUniversity of GranadaGranadaE-18071Spain UGC Farmacia Hospitalaria Biomedical Research Institute ibs.Granada.Hospital Universitario San Cecilio de GranadaGranadaE-18012Spain

COVID-19,a disease caused by the novel coronavirus SARS-Co V-2,has produced a serious emergency for global public health,placing enormous stress on national health systems in many *** studies suggest that cytokine storms(interleukins)may play an important role in severe cases of *** key inflammatory factors in cytokine release syndrome(CRS)could therefore be of great value in reducing the mortality ***(TCZ)in its intravenous(IV)form of administration-Ro Actemra?20 mg/m L(Roche)-is indicated for treatment of severe CRS *** investigations have concluded that inhibition of IL-6 with TCZ appears to be efficacious and safe,with several ongoing clinical *** has led to a huge increase in demand for IV TCZ for treating severe COVID-19 patients in hospitals,which has resulted in drug ***,we present a comparability study assessing the main critical physicochemical attributes of TCZ solutions used for infusion,at 6 mg/m L and 4 mg/m L,prepared from Ro Actemra?20 mg/m L(IV form)and from Ro Actemra?162 mg(0.9 m L solution pre-filled syringe,subcutaneous(SC)form),to evaluate the use of the latter for preparing clinical solutions required for IV administration,so that in a situation of shortage of the IV medicine,the SC form could be used to prepare the solutions for IV delivery of *** is important to remember that during the current pandemic all the medicines are used off-label,since none of them has yet been approved for the treatment of COVID-19.

关键词： COVID-19 Tocilizumab Critical quality attributes IV and SC medicines

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Advances on the biosynthesis of pyridine rings

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Engineering Microbiology 2023年第2期3卷 1-7页

作者： Carolina E.Portero Yong Han M.raquel Marchán-Rivadeneira Department of Chemistry and Biochemistry Ohio UniversityAthensOH 45701USA Edison Biotechnology Institute Ohio UniversityAthensOH 45701USA Center for Research on Health in Latinamerica(CISeAL)-Biological Science Department Pontificia Universidad Católica del Ecuador(PUCE)Quito 170143Ecuador Translational Biomedical Sciences Graduate Program Ohio UniversityAthensOH 45701USA Department of Biological Sciences Ohio UniversityAthensOH 45701USA

Numerous studies have investigated the biosynthesis of pyridine heterocycles derived from nicotinic ***-ever,metabolic pathways generating pyridine heterocycles in nature remain ***,we summarize recent contributions conducted in the last decade on the biosynthetic pathways of non-derivate from nicotinic acid pyridine rings and discuss their implication on the study of natural products with pyridine structures.

关键词： Natural products Biosynthesis Pyridine ring

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Establishment of a Photoautotrophic Cell Suspension Culture of Arabidopsis thaliana for Photosynthetic, Metabolic, and Signaling Studies

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Molecular Plant 2012年第2期5卷 524-527页

作者： Christine Hampp Andreas Richter Sonia osorio Günther Zellnig Alok Krishna Sinha Alexandra Jammer Alisdair R. Fernie Bernhard Grimm Thomas Roitsch Julius-von-Sachs-Institut fuer Biowissenschaften UniversitaetWuerzburgJulius-von-Sachs-Platz 297082 WuerzburgGermany Institute of Biology/Plant Physiology Humboldt UniversityPhilippstr.13Building 1210115 Berlin Max-Planck Institute of Molecular Plant Physiology Am Mühlenberg 114476 Potsdam-GolmGermany Institut fuer Pflanzenwissenschaften Schubertstr.51A-8010 GrazAustria National Institute of Plant Genome Research PB No.10531Aruna Asaf Ali RoadNew Delhi–110067India

Dear Editor, Plant cell suspension cultures have been used as model systems to circumvent the problems associated with the analyses of a multi-factorial plant that is composed of multiple tissue and cell types exposed to diverse signals. A number of plant suspension cultures have proven to be valuable to study various topics including defense response, secondary metabolite formation, ion transport, gene regulation, and signal duction （Roitsch and Sinha, 2002 and references therein）. However, most cultures reported to date, including the cultures from model species such as Arabidopsis （Christie and Jenkins,

关键词： Photosynthetic Metabolic Signaling Studies

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Comparison between standard and wide-field autofluorescence in detection of retinal displacement after rhegmatogenous retinal detachment surgery

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Advances in Ophthalmology Practice and Research 2022年第3期2卷 32-37页

作者： raquel Maroto Cejudo Cristina Blanco Marchite Teresa Prieto Moran Sergio Copete Piqueras Retina Department Service of OphthalmologyAlbacete University ComplexAlbaceteSpain

Purpose To analyse the differences between 30°blue autofluorescence(BAF30),55°blue autofluorescence(BAF55)and 200°green Ultra-Wide Field autofluorescence(UWF200)imaging to detect retinal displacement(RD)after vitrectomy surgery for rhegmatogenous retinal detachment(RRD).Methods This cross-sectional study considers forty-nine consecutive patients who underwent RRD surgery in the time period 4–8 months previous to image *** exclusion criteria contemplate previous retinal pathology,under 18-year-olds and non-assessable images in any of the 3 *** images were analysed by two masked graders that assessed either the presence or absence of retinal displacement.A third observer reviewed the images that presented *** A total of forty-nine patients were analysed.7 eyes were excluded due to poor quality in either of the imaging *** final analysis included 42 eyes of forty-two patients with a mean age of 60.3±11.9 *** patients underwent a 3 port 23-gauge pars plana vitrectomy as the technique of *** grade of RD was detectable in 45.2% of *** was similar between BAF30 and UWF200(42.9% of eyes).BAF55 showed RD to a lesser extent(38.1%).Agreement index between BAF30 and BAF55 was 0.901,0.903 between BAF30 and UWF200 and 0.803 between BAF55 and *** agreement index between graders was 0.775 for BAF30,0.798 for BAF50 and 0.808 for UWF200 *** All imaging modalities were able to detect RD after vitrectomy for RRD,with no inferiority of BAF30 and BAF55 over UWF200.

关键词： Blue fundus autofluorescence Green fundus autofluorescence Rhegmatogenous retinal detachment Retinal displacement Retinal vessel printings

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Overweight and abdominal fat are associated with normal bone mineral density in patients with ulcerative colitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第4期13卷 57-66页

作者： Mirella Brasil Lopes Andre Castro Lyra raquel Rocha Fernanda Gomes Coqueiro Carla Andrade Lima Carolina Cunha de Oliveira Genoile Oliveira Santana Programa de Pós-graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110-060Brazil Departamento Ciências da Nutrição Universidade Federal da BahiaSalvador 40110-060Brazil Departamento de Nutrição Universidade Federal de SergipeLagarto 49060-110Brazil Departamento Ciências da Vida Universidade do Estado da BahiaSalvador 41.150-000Brazil

BACKGROUND Low bone mineral density(BMD)is common in patients with inflammatory bowel ***,nutritional risk factors for low BMD in the ulcerative colitis(UC)population are still poorly *** To investigate the association of anthropometric indicators and body composition with BMD in patients with *** This is a cross-sectional study on adult UC patients of both genders who were followed on an outpatient basis.A control group consisting of healthy volunteers,family members,and close people was also *** nutritional indicators evaluated were body mass index(BMI),total body mass(TBM),waist circumference(WC),body fat in kg(BFkg),body fat in percentage(BF%),trunk BF(TBF),and also lean *** composition and BMD assessments were performed by dual-energy X-ray *** The sociodemographic characteristics of patients with UC(n=68)were similar to those of healthy volunteers(n=66)(P>0.05).Most patients(97.0%)were in remission of the disease,58.8%were eutrophic,33.8%were overweight,39.0%had high WC,and 67.6%had excess BF%.However,mean BMI,WC,BFkg,and TBF of UC patients were lower when compared to those of the control group(P<0.05).Reduced BMD was present in 41.2%of patients with UC(38.2%with osteopenia and 2.9%with osteoporosis)and 3.0%in the control group(P<0.001).UC patients with low BMD had lower BMI,TBM,and BFkg values than those with normal BMD(P<0.05).Male patients were more likely to have low BMD(prevalence ratio[PR]=1.86;95%confidence interval[CI]:1.07-3.26).Those with excess weight(PR=0.43;95%CI:0.19-0.97)and high WC(PR=0.44;95%CI:0.21-0.94)were less likely to have low *** Patients with UC in remission have a high prevalence of metabolic bone *** fat appears to protect against the development of low BMD in these patients.

关键词： Ulcerative colitis Bone mineral density Body composition Fat body Abdominal fat

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Ascorbic acid and prunasin,two candidate biomarkers for endodormancy release in almond flower buds identified by a nontargeted metabolomic study

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Horticulture Research 2020年第1期7卷 117-129页

作者： Jesús Guillamón Guillamón Ángela Sánchez Prudencio JoséEnrique Yuste Federico Dicenta raquel Sánchez-Pérez Department of Plant Breeding.CEBAS-CSIC Campus Universitario de Espinardo30100 EspinardoSpain Metabolomics Platform of CEBAS-CSIC Campus Universitario de Espinardo30100 EspinardoSpain

Temperate fruit trees belonging to Prunus species have the ability to suspend(induce dormancy)and resume growth periodically in response to environmental and seasonal *** release requires the long-term accumulation of *** accumulation of cultivar-specific chill requirements,plants enter the state of ecodormancy,which means the ability to grow has been restored,depending on the fulfilment of heat *** many different metabolic pathways are implicated in endodormancy release,we have performed a metabolomic analysis,using the ultra-high-performance liquid chromatography–quadrupole time-of-flying(UPLC–QToF)*** assayed flower buds in different stages of endodormancy in four almond cultivars with different flowering times:the extra-early Desmayo Largueta,the late Antoñeta,the extra-late Penta,and the ultra-late *** orthogonal projection to latent-structure discriminant-analysis model was created to observe differences between endodormant and ecodormant flower *** metabolites showing the most significant variation were searched against the Metlin,HMDB,and KEGG libraries,which allowed us to identify 87 *** metabolites were subsequently assigned to specific pathways,such as abscisic acid biosynthesis,phenylpropanoid biosynthesis,and D-sorbitol metabolism,among *** two metabolites that exhibited the most significant variations in all the cultivars studied with fold changes of up to 6.49 were ascorbic acid and *** the first time,these two metabolites have been proposed as potential biomarkers for endodormancy release in *** the high synteny present between the Rosaceae species,these results could be extrapolated to other important crops like peach,plum,cherry,or apricot,among others.

关键词： metabolism release crops

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Interpolating Socioeconomic Data for the Analysis of Deforestation:A Comparison of Methods

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Journal of Geographic Information System 2012年第4期4卷 358-365页

作者： Michelle Farfán Jean Francois Mas Laura osorio Centro de Investigaciones en Geografía Ambiental Universidad Nacional Autonoma de MexicoMoreliaMexico

This study compares local-level socioeconomic variables interpolated with three different methods: 1) Thiessen polygons, 2) Inverse distance weighting, and 3) Areas of influence based on cost of distance. The main objective was to determine the interpolation technique capable of generating the most efficient variable to explain the distribution of deforestation through two statistical approaches: generalized linear models and hierarchical partition. The study was conducted in two regions of western Mexico: Coyuquilla River watershed, and the Sierra de Manantlan Biosphere Reserve (SMBR). For SMBR it was found that the Thiessen polygons and areas of influence were the techniques that interpolated variables with greatest explanatory power for the deforestation process, in Coyuquilla it was inverse distance weighting. These differences are related to the distribution and the spatial correlation of the values of the variables.

关键词： Interpolation Socioeconomic Variables Deforestation Hierarchical Partition

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Game Theory Applications in a Water Distribution Problem

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Journal of Water Resource and Protection 2013年第1期5卷 91-96页

作者： Ardeshir Ahmadi raquel Salazar Moreno IHU University Tehran Iran Autonomous University of Chapingo Texcoco México

A water distribution problem in the Mexican Valley is modeled first as a three-person noncooperative game. Each player has a five-dimensional strategy vector, the strategy sets are defined by 15 linear constraints, and the three payoff functions are also linear. A nonlinear optimization problem is first formulated to obtain the Nash equilibrium based on the Kuhn-Tucker conditions, and then, duality theorem is used to develop a computational procedure. The problem can also be considered as a conflict between the three players. The non-symmetric Nash bargaining solution is suggested to find the solution. Multiobjective programming is an alternative solution concept, when the water supply of the three players are the objectives, and the water authority is considered to be the decision maker. The optimal water distribution strategies are determined by using these solution concepts and methods.

关键词： Nash Equilibrium Conflict Resolution Multiobjective Optimization Water Distribution

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Social Construction of Dependence in Elderly Men in Chile

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Health 2014年第10期6卷 998-1003页

作者： Paulina osorio-Parraguez Andrés G. Seguel Department of Anthropology University of Chile Santiago Chile Department of Social Psychology Universitat Autónoma de Barcelona Barcelona Spain

Based on a qualitative research restricted to aging processes in Chile, the paper presents the experience and significance of dependence in elderly men and how it is related with the social construction of old age. It is important to know how the identity of aging is configured when facing such a significant biographical and social landmark as the loss of functionality in later life. When analyzing the social construction of dependence in elderly men, three aspects of that configuration stand out: first, the way in which they understand and signify their situations of illness, physical problems, disability, and evaluation of their health;second, the characteristics of the social significant contexts in which disability or physical problems become evident;and third, the actions, roles or activities that they perform in those contexts, which are valued differently according to the experiences of dependence or autonomy. Dependence in elderly men does not appear as a static condition, but rather as a passage from physical-biological conditioners to the social context in which their everyday actions take place. So the agency of the dependence, its construction, experience and significance is the understanding of the social phenomenon of old age.

关键词： Dependence Health Aging Elderly Men Chile

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Tree growth is more limited by drought in rear-edge forests most of the times

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Forest Ecosystems 2021年第2期8卷 330-344页

作者： J.Julio Camarero Antonio Gazol Gabriel Sangüesa-Barreda Marta Vergarechea raquel Alfaro-Sánchez Nicolás Cattaneo Sergio M.Vicente-Serrano Instituto Pirenaico de Ecología(IPE-CSIC) Avda.Montañana 1005E-50192 ZaragozaSpain Ei FAB-iu FOR University of ValladolidCampus Duques de SoriaE-42004 SoriaSpain NIBIO Norwegian Institute of Bioeconomy ResearchPostboks 155NO-1431ÅsNorway Department of Biology Wilfrid Laurier UniversityN2L 3C575 Univ.Avenue WWaterlooOntarioCanada

Background:Equatorward,rear-edge tree populations are natural monitors to estimate species vulnerability to climate *** to biogeographical theory,exposition to drought events increases with increasing aridity towards the equator and the growth of southern tree populations will be more vulnerable to drought than in central ***,the ecological and biogeographical margins can mismatch due to the impact of ecological factors(topography,soils)or tree-species acclimation that can blur large-scale geographical imprints in trees responses to drought making northern populations more drought ***:We tested these ideas in six tree species,three angiosperms(Fagus sylvatica,Quercus robur,Quercus petraea)and three gymnosperms(Abies alba,Pinus sylvestris and Pinus uncinata)by comparing rear-edge tree populations subjected to different degrees of *** used dendrochronology to compare the radial-growth patterns of these species in northern,intermediate,and southern tree populations at the continental rear *** and conclusions:We found marked variations in growth variability between species with coherent patterns of stronger drought signals in the tree-ring series of the southern populations of ***,***,and *** was also observed in species from cool-wet sites(*** and ***),despite their limited responsiveness to ***,in the case of *** the intermediate population showed the strongest relationship to *** drought-sensitive species as *** and ***,southern populations presented more variable growth which was enhanced by cool-wet conditions from late spring to *** found a trend of enhanced vulnerability to drought in these two *** response of tree growth to drought has a marked biogeographical component characterized by increased drought sensitivity in southern populations even within the species distribution rear ***,the relationship

关键词： Climate change Dendroecology Latitudinal gradient Mediterranean forests Standardized evapotranspiration precipitation index(SPEI)

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