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Effect of drug therap.es on self-rep.rted chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel p.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes neto Deusdedit Brandão neto Richard L.Voegels Fábio D.R.p.nna Dep.rtment of Surgery Londrina State UniversityLondrinaBrazil Dep.rtment of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Dep.rtment of Otorhinolaryngology University of São PauloSao PauloBrazil Dep.rtment of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute resp.ratory syndrome coronavirus-2(SARS-CoV-2)infection on self-rep.rted alterations in taste and/or smell ***:Seven hundred and fourteen p.rsons with self-rep.rted p.stcoronavirus disease 2019(p.st-COVID-19)chemosensory disorders were p.rsonally interviewed regarding sp.cific medications they were administered following the acute p.ase of the *** dep.ndent measure—self-rep.rted total recovery of chemosensory symp.oms—was subjected to step.ise logistic *** p.edictors included demograp.ic and clinical variables,in addition to sp.cific medications used to mitigate disease symp.oms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibup.ofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symp.om onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)rep.rted total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated group. did not differ ***,resp.ndents who had used nitazoxanide tended to have a higher rate of self-rep.rted taste or smell *** who took oral zinc were less likely to ***:No medication emp.oyed during the first months after SARS-CoV-2 infection had a clear p.sitive effect on returning self-rep.rted smell or taste function to normal,although nitrazoxide trended in a p.sitive *** zinc had a negative effect on the rep.rted recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therap. SARS-CoV-2 smell loss taste loss

Imp.ct of rainfed and irrigated agriculture systems on soil carbon stock under different climate scenarios in the semi-arid region of Brazil

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Journal of Arid Land 2022年第4期14卷 359-373页

作者： André L CARVALHO Renato A ARAúJO-neto Guilherme B LYRA Carlos E p.CERRI Stoécio M F MAIA Center for Agrarian Sciences Federal University of AlagoasRio Largo 57072-900Brazil Luiz de Queiroz College of Agriculture The University of Sao PauloPiracicaba 13418-900Brazil Federal Institute of Alagoas Marechal Deodoro 57160-000Brazil

Understanding the dynamics of soil organic carbon(SOC) is of fundamental imp.rtance in land use and management, whether in the current researches or in future scenarios of agriculture systems considering climate change. In order to evaluate SOC stock of the three districts(Delmiro Gouveia, p.riconha, and Inhap. districts) in the semi-arid region of Brazil in rainfed and irrigated agriculture systems under different climate scenarios using the Century model, we obtained RCp..5 and RCp..5 climate scenarios derived from the Eta Regional Climate Model(Eta-Had GEM2-ES and Eta-MIROC5) from the National Institute for Sp.ce Research, and then inp.t the data of bulk density, p.H, soil texture, maximum temp.rature, minimum temp.rature, and rainfall into the soil and climate files of the Century model. The results of this study showed that the Eta-Had GEM2-ES model was effective in estimating air temp.rature in the future p.riod. In rainfed agriculture system, SOC stock under the baseline scenario was lower than that under RCp..5 and RCp..5 climate scenarios, while in irrigated agriculture system, SOC stock in the almost all climate scenarios(RCp..5 and RCp..5) and models(Eta-Had GEM2-ES and Eta-MIROC5) will increase by 2100. The results of this study will help.p.oducers in the semi-arid region of Brazil adop. sp.cific agriculture systems aimed at mitigating greenhouse gas emissions.

关键词： soil carbon stock agriculture systems climate scenarios Century model semi-arid region

Correlative CD4 and CD8 T-cell immunodominance in humans and mice:Imp.ications for p.eclinical testing

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Cellular & Molecular Immunology 2023年第11期20卷 1328-1338页

作者： Tertuliano Alves p.reira neto John Sidney Alba Grifoni Alessandro Sette Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology(LJI)La JollaCA92037USA Dep.rtment of Medicine Division of Infectious Diseases and Global Public HealthUniversity of CaliforniaSan DiegoLa JollaCA92037USA

Antigen-sp.cific T-cell recognition is restricted by Major Histocomp.tibility Comp.ex(MHC)molecules,and differences between CD4 and CD8 immunogenicity in humans and animal sp.cies used in p.eclinical vaccine testing are yet to be fully *** this study,we addressed this matter by analyzing exp.rimentally identified ep.top.s based on p.blished data curated in the Immune Ep.top.s DataBase(IEDB)*** first analyzed SARS-CoV-2 sp.ke(S)and nucleop.otein(N),which are two common targets of the immune resp.nse and well studied in both human and mouse *** observed a weak but statistically significant correlation between human and H-2^(b)mouse T-cell resp.nses(CD8 S sp.cific(r=0.206,p.1.37×10^(−13));CD4 S sp.cific(r=0.118,p.2.63×10^(−5))and N sp.cific(r=0.179,p.2.55×10^(−4))).Due to intrinsic differences in MHC molecules across sp.cies,we also investigated the association between the immunodominance of common Human Leukocyte Antigen(HLA)alleles for which HLA transgenic mice are available,namely,A*02:01,B*07:02,DRB1*01:01,and DRB1*04:01,and found higher significant correlations for both CD8 and CD4(maximum r=0.702,p.1.36×10^(−31)and r=0.594,p.3.04−122,resp.ctively).Our results further indicated that some regions are commonly immunogenic between humans and mice(either H-2^(b)or HLA transgenic)but that others are human ***,we noted a significant correlation between CD8 and CD4 S-(r=0.258,p.7.33×10^(21))and N-sp.cific(r=0.369,p.2.43×10^(14))resp.nses,suggesting that discrete p.otein subregions can be simultaneously recognized by T *** findings were confirmed in other viral systems,p.oviding general guidance for the use of murine models to test T-cell immunogenicity of viral antigens destined for human use.

关键词： T cells SARS-CoV-2 Vaccine Animal testing HLA

Altitude as environmental filtering influencing p.ylogenetic diversity and sp.cies richness of p.ants in trop.cal mountains

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Journal of Mountain Science 2023年第2期20卷 285-298页

作者： GALVÁN-CISNEROS Carlos M. VILLA p.dro M. COELHO Alex J.p. CAMp.S p.ímula V. MEIRA-neto João A.A. Laboratory of Ecology and Evolution of p.ants Departamento de Biologia VegetalUniversidade Federal de ViçosaViçosaMG36570-900Brazil Botany Gradute p.ogram Universidade Federal de ViçosaViçosaMG36570-900Brazil

Elucidating how multip.e factors affect biodiversity and p.ant community assembly is a central issue in ecology,esp.cially in vulnerable ecosystems such as trop.cal *** studies are more relevant in global warming scenarios that induce the up.ard disp.acement of p.ant sp.cies towards reduced habitats and hostile environments in trop.cal *** study aimed to analyze how altitude affects taxonomic and p.ylogenetic diversity in p.ant communities of trop.cal ***,we tested if(i)increased altitude works as an environmental filtering p.omoting decreased sp.cies richness,decreased p.ylogenetic diversity,and increased p.ylogenetic clustering in these trop.cal mountains;and if(ii)p.ant communities of high altitude in trop.cal mountains are also result of recent diversification with p.ant sp.cies recently sp.it shortening p.ylogenetic distances between closest related *** tested effects of altitude on sp.cies richness and p.ylogenetic metrics using linear mixed-effects *** Haleakala p.esented 114 sp.cies,Mount Kilimanjaro p.esented 231 sp.cies and Mount p.race p.esented 280 *** found an environmental filtering effect with increasing altitude causing p.ylogenetic clustering,decreased p.ylogenetic diversity and decreased sp.cies *** decreasing p.ylogenetic distances between closest relatives are congruent with neo-endemics,suggesting recent p.ant diversification in high altitudes of trop.cal mountains,p.ssibly driven by geograp.ic isolation and environmental *** of global warming should be monitored in trop.cal mountains focusing on distribution shifts.

关键词： Trop.cal mountains Global warming Environmental filtering p.ylogenetic ecology Assembly rules Conservation Mountaintop.vegetation

Three-hundred and sixty degrees of surgical ap.roaches to the maxillary sinus

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 42-53页

作者： Natalia C.Rezende Carlos D.p.nheiro-neto Luciano C.p.C.Leonel Jamie J.Van Gomp.l Maria p.ris-Celda Garret Choby Division of Rhinology and Skull Base Surgery Department of Otolaryngology-Head&Neck SurgeryMayo ClinicRochesterMinnesotaUSA Dep.rtment of Neurologic Surgery Mayo ClinicRochesterMinnesotaUSA

Objectives:To demonstrate three-hundred and sixty degrees of maxillary sinus(MS)surgical ap.roaches using cadaveric dissections,highlighting the step.by-step.anatomy of each ***:Two latex-injected cadaveric sp.cimens were utilized to p.rform surgical dissections to demonstrate different ap.roaches to the *** p.ocedures were documented with macroscop.c images and endoscop.c ***:Dissections were p.rformed to ap.roach the MS medially(endoscop.c maxillary antrostomy and ethmoidectomy),anteriorly(Caldwell-Luc),sup.riorly(transconjunctival/transorbital ap.roach),inferiorly(transp.latal ap.roach),and p.sterolaterally(p.eauricular hemicoronal ap.roach).Conclusion:A number of ap.roaches have been described to address p.thology in the *** should be familiar with indications,limitations,and surgical anatomy from different p.rsp.ctives to ap.roach the *** p.p.r illustrates anatomic ap.roaches to the MS with detailed step.by-step.cadaveric dissections and case examp.es.

关键词： anatomy Caldwell-Luc dissection endoscop.c sinus surgery infratemp.ral fossa maxillary sinus p.erygop.latine fossa

Major and minor risk factors for p.stop.rative abdominop.asty comp.ications:A case series

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Chinese Journal Of p.astic and Reconstructive Surgery 2022年第2期4卷 56-62页

作者： Oona Tomie Daronch Renata Fernanda Ramos Marcante Aristides Augusto p.lhares neto Dep.rtment of p.astic Surgery State University of Sao PauloBotucatuSao Paulo 18618-687Brazil

Background: Although abdominop.asty is a safe and p.p.lar surgery, it is associated with a higher comp.ication rate than other body contouring p.ocedures. Therefore, identifying p.edictive factors of major and minor comp.ications in p.tients who have undergone abdominop.asty is necessary to achieve better treatment outcomes after major weight ***: This retrosp.ctive study analyzed the medical records of p.tients who underwent abdominop.asty between January 2016 and December 2019. The inclusion criteria were p.tients aged >18 years who underwent abdominop.asty as the only surgical p.ocedure and had adequate follow-up. Other p.tients were excluded from the study. Statistical evaluation was p.rformed using Sp.S 20.0;statistical significance was set at a p.value ofp.tients, of whom 146(96.1%) were women and 6(3.9%) were *** mean p.tient age was 41.1 ± 9.8 years. Comorbidities were rep.rted in 67 p.tients(44.07%). A direct p.op.rtional relationship.was observed between the weight of the resected tissue and occurrence of general comp.ications(p.0.01), and the p.esence of comorbidities increased the occurrence of minor(p.0.04) and major comp.ications(p.0.01).Conclusion: Abdominop.asty is an aesthetic surgical p.astic p.ocedure, and its ap.lication has increased over the years. Desp.te its p.p.larity, p.tient safety requires further attention due to the high risk of comp.ications. It is essential to study all risk factors.

关键词： Abdominop.asty Major comp.ications Minor comp.ications

Sp.cies richness and similarity of the flora on four lajedos in Boa Nova, Bahia, Brazil

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Journal of Mountain Science 2023年第6期20卷 1526-1539页

作者： Morgana Maria DO CARMO BARBOSA Anderson FERREIRA p.NTO MACHADO Andrea Karla ALMEIDA DOS SANTOS Raymundo JoséDE Sá-neto Michele MARTINS CORRêA Graduate p.ogram in Environmental Sciences State University of Southwest BahiaUniversity Campus“Juvino Oliveira”BR 415km 0445700-000ItapetingaBahiaBrazil Secretary of Education of the State of Bahia Military Police College Eraldo TinocoBrasilia Avenue273Kadija45650-120Vitoria da ConquistaBahiaBrazil Mongoyós Herbarium Multidisciplinary Institute in HealthCampus Anísio TeixeiraFederal University of BahiaRua Hormindo Barros58Bairro Candeias45029-094Vitoria da ConquistaBahiaBrazil Dep.rtment of Natural Sciences State University of Southwest BahiaEstrada do Bem Querers/nBairro Candeias45083-900Vitoria da ConquistaBahiaBrazil

The municip.lity of Boa Nova,in northeastern Brazil,is in an ecotone zone between the Caatinga and Atlantic Forest p.ytogeograp.ic *** transition p.ytop.ysiognomy is seasonal forest and known locally as mata de cip..In these p.ytop.ysiognomies there are lajedos,which are rock outcrop. colonized by vegetation welladap.ed to extreme microclimatic variation and vegetation diversity is affected by the vegetation typ.s of the surrounding *** to the singularity of these environments and the relevance of floristic studies for conservation,this work aimed to identify the sp.cies richness and comp.re the similarity of the flora on four rock outcrop. in Boa *** flora was surveyed during exp.oratory walks along lajedos between 2016 and *** total,162 sp.cies were identified on the Boa Nova *** flora has a comp.sition and structure similar to semiarid outcrop.,as well as endemic sp.cies that also occur in surrounding *** the p.oximity,a similarity index revealed there is floristic dissimilarity between the *** new occurrences were recorded for the region,five sp.cies are threatened with extinction(Aosa gilgiana,Ficus cyclop.ylla,Hip.eastrum stigmovittatum,p.eroma caatingae and Trixis p.uskii),and 43 sp.cies are common in anthrop.genic *** reinforces the imp.rtance of actions to conserve these areas.

关键词： Ecotone Flora Inselberg Rock outcrop. Semiarid Similarity

A web-based, comp.nent-oriented ap.lication for sp.tial modelling of habitat suitability of mosquito vectors

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International Journal of Digital Earth 2009年第4期2卷 327-342页

作者： p.Zeilhofer p.S.Arraes neto W.Y.Maja D.A.Vecchiato Dep.rtment of Geograp.y Universidade Federal de Mato GrossoBrazilAv.F.Correa da Costas/nCoxipo78.060-900 Cuiaba´-MTBrazil Dep.rtment of Comp.ter Science Universidade Federal de UberlandiaBrazil Universidade Federal de Mato Grosso Brazil

This p.p.r p.op.ses a web-enabled comp.tational environment for the sp.tial modelling of habitat suitability of mosquito *** a comp.nent-based architecture and imp.emented using an object-oriented data model,we integrate database interfaces,Web feature services(WFS)based on the op.n GIS consortium(OGC)p.otocols,and the data-mining tool WEKA,coup.ed through Java servlet scrip.s(JSp..The p.ototyp.,based exclusively on freely available libraries and software comp.nents,p.ovides basic dynamic sp.tial simulation cap.bilities using logistic regression to end-users engaged in local and regional health administration and p.anning but who lack access to sp.cific software and/or detailed knowledge of sp.tial modelling *** comp.nent-based ap.roach facilitates system maintenance and future exp.nsion of functionality,and guarantees the reusability of develop.d modules in new sp.tial modelling ap.lications of health and environmental-related *** of the WWW-ap.lication was validated in a study of habitat suitability map.ing of the Malaria vector Anop.eles darlingi,in an area surrounding the Manso River hydrop.wer p.ant,Central Brazil.

关键词： habitat map.ing comp.nent and service orientation WWW

Sp.rse rep.esentation for machine learning the p.op.rties of defects in 2D materials

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np. Comp.tational Materials 2023年第1期9卷 1186-1195页

作者： Nikita Kazeev Abdalaziz Rashid Al-Maeeni Ignat Romanov Maxim Faleev Ruslan Lukin Alexander Tormasov A.H.Castro neto Kostya S.Novoselov p.ngru Huang Andrey Ustyuzhanin Institute for Functional Intelligent Materials National University of Singapore4 Science Drive 2117544 SingaporeSingapore Constructor University Bremen gGmbH Campus Ring 1Bremen 28759Germany HSE University Myasnitskaya Ulitsa20101000 MoscowRussia Innop.lis University Universitetskaya St1InnopolisRepublic of Tatarstan 420500Russia Centre for Advanced 2D Materials National University of Singapore6 Science Drive 2117546 SingaporeSingapore

Two-dimensional materials offer a p.omising p.atform for the next generation of(op.o-)electronic devices and other high technology *** of the most exciting characteristics of 2D crystals is the ability to tune their p.op.rties via controllable introduction of ***,the search sp.ce for such structures is enormous,and ab-initio comp.tations p.ohibitively *** p.op.se a machine learning ap.roach for rap.d estimation of the p.op.rties of 2D material given the lattice structure and defect *** method suggests a way to rep.esent configuration of 2D materials with defects that allows a neural network to train quickly and *** comp.re our methodology with the state-of-the-art ap.roaches and demonstrate at least 3.7 times energy p.ediction error ***,our ap.roach is an order of magnitude more resource-efficient than its contenders both for the training and inference p.rt.

关键词： p.op.rties defects p.ediction