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Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley osman Paul Ashwood Department of medical microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(mIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with ASD by the age of 8 years,with ASD rates continuing to increase in prevalence in USA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(mAA),a form of mIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Synthesis and evaluation of some novel additives as antioxidants and corrosion inhibitors for petroleum fractions

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Petroleum Science 2014年第1期11卷 161-173页

作者： Ahmed El-mekabaty osman m. o. Habib Department of Chemistry Faculty of Science Mansoura University

Benzoxazinone 2 was prepared and reacted with formamide,acetamide,some primary aromatic amines and heterocyclic amines giving the corresponding quinazolone derivatives 3-15 *** reaction of benzoxazinone 2 with hydrazine hydrate and phenyl hydrazine was also *** compounds of the synthesized products were evaluated as antioxidants and corrosion inhibitors for gasoline engine lubricating *** highest antioxidant activities were obtained with compounds *** optimum concentration recommended for these new additives was found to be *** for 1L ofoil for compounds *** addition,some of the highly effective antioxidant additives,namely 10-15,were thermally analyzed by using thermogravimetric analysis （TGA） and differential thermal gravimetric analysis （DTGA） techniques and the results indicated that compounds are thermally stable and could be used under thermal ***,a comparison of the oxidation stability between the tested oil containing the prepared products and lubricating oil containing commercial additives was also studied.

关键词： Benzoxazinone quinazolinone thermal stability antioxidant additives anticorrosive additives

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Analysis of strong refractive effect within 11Li projectile structure

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Chinese Physics C 2021年第2期45卷 414-425页

作者： Kassem o.Behairy m.El-Azab Farid Awad A.Ibraheem ola ramadan m.Anwar Physics Department Aswan UniversityAswan 81528Egypt Physics Department Assiut UniversityAssiut 71516Egypt Physics Department King Khalid UniversityAbhaSaudi Arabia Physics Department Al-Azhar UniversityAssiut 71524Egypt

In the context of the double folding optical model,the strong refractive effect for elastic scattering of 11Li+12C and 11Li+28Si systems at incident energies of 29,50,and 60 meV/n is *** folded potentials are generated based on a variety of nucleon-nucleon interactions with the suggested density distributions for the halo structure of 11Li *** rearrangement term(RT)of the extended realistic density dependent CDm3Y6 effective interaction is *** imaginary potential was taken in the traditional standard Woods-Saxon *** results for the calculated potentials are obtained,with a slight effect of the RT in CDm3Y6 *** reproduction with a normalization factor close to one for the observed angular distributions of the elastic scattering differential cross section has been achieved using the derived *** obtained reaction cross-section is studied as a guide by extrapolating our calculations and previous results.

关键词： optical model elastic and inelastic scattering halo nuclei folding model refraction effect

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for molecular and Cell Biology(IBmC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

URBAN PLANNING:A TooL FoR URBAN PoVERTY ALLEVIATIoN IN SUDAN

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Chinese Geographical Science 2004年第2期14卷 110-116页

作者： Elnazir ramadan Department of Urban and Resources Sciences Nangjing University Nanjing 210093. P. R. China Department of Geography University of Juba 321/1 Khartoum Sudann the past few dacades urbanization and urban growth have been increasing rapidly in many of the developing countries. It is expected that over 50% of the world population will live in cities in 2005. The growing trend indicates that as many as one fifth of all households still remain with housing tenure problems which they try to solve through very expensive rentals insecurity socially and environmentally-hazardous squatting or unhealthy overcrowding sometimes ending up with none at all. And hence propcr planning is necessary in urban development policies to improve human settlement managements in a sustainable way. This article has tried to handle urban poverty in the Sudan to a reasonable level of detail. It dealt with selected areas with regard to promotion of sustainable human settlement. The study managed to identity some recent progress in Sudanese human settlements that is however still accompanied by numerous serious instances of decline in the urban environment especially that of the greater Khartoum. Such instances of environmental deterioration are profiled and analyzed by the study with respect to all human settlement aspects of management land-use infrastructure energy and transport. The paper's conclusion emphasized that improving all these aspects is of high priority.

In the past few dacades, urbanization and urban growth have been increasing rapidly in many of the developing countries. It is expected that over 50% of the world population will live in cities in 2005. The growing trend indicates that as many as one fifth of all households still remain with housing tenure problems, which they try to solve through very expensive rentals, insecurity, socially and environmentally-hazardous squatting or unhealthy overcrowding, sometimes ending up with none at all. And hence, proper planning is necessary in urban development policies to improve human settlement managements in a sustainable way. This article has tried to handle urban poverty in the Sudan to a reasonable level of detail. It dealt with selected areas with regard to promotion of sustainable human settlement. The study managed to identity some recent progress in Sudanese human settlements, that is, however, still accompanied by numerous serious instances of decline in the urban environment, especially that of the greater *** instances of environmental deterioration are profiled and analyzed by the study with respect to all human settlement aspects of management, land-use, infrastructure, energy and transport. The paper's conclusion emphasized that improving all these aspects is of high priority.

关键词：城市规划贫困经济发展苏丹

Synthesis and evaluation of some new oxazolones and imidazolones as antioxidant additives for Egyptian lubricating oils

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Petroleum Science 2012年第3期9卷 389-399页

作者： Ahmed El-mekabaty osman m.o.Habib Hussein m.Hassan Evelin B.moawad Department of Chemistry Faculty of ScienceMansoura University

oxazolone derivative 2 was utilized as a key intermediate for synthesis of some new oxazolone and imidazolone derivatives. Reaction of oxazolone derivative 2 with diamines under different conditions afforded the corresponding imidazolone derivatives 3-8, respectively. moreover, oxazolone 2 reacted with some heterocyclic amines in glacial acetic acid giving the corresponding imidazolone derivatives 9-14, respectively. Cyclocondensation of thiosemicarbazide with compound 2 in dry pyridine afforded compound 15. Addition of secondary amines to olefin double bond of compound 2 gave the corresponding addition products 16-19, respectively. michael addition of compound 2 with some active methylene compounds afforded oxazolone derivatives 20-23, respectively. These prepared products were evaluated as antioxidant and corrosion inhibitors for gasoline lubricating oil and compounds 6a-e, 10 and 15 exhibited the highest antioxidant and anticorrosive activities. The effect of concentration of additives was studied to recommend the optimum concentration to be used. The results showed, for additive 15, 0.1 g for 1 L oil was the more effective concentration. measurements for thermal analysis and of surface tension of oil after oxidation were also carried out.

关键词： oxazolone imidazolone benzoimidazole surface tension thermal stability antioxidant additives.

Inelastic displacement ratio of low-to mid-rise BRBFs designed under variable levels of seismicity

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 763-775页

作者： Hamdy Abou-Elfath mostafa ramadan Faculty of Engineering Alexandria UniversityAlexandria 21544Egypt

Buckling-restrained braces(BRBs)have shown their capability to provide building structures with stiffness,strength,and *** the seismic drifts of buckling-restrained braced frames(BRBFs)is an important design step to control structural and non-structural *** current practice of seismic design,the estimation of seismic drifts of BRBFs is performed by using empirical calculations that are independent upon either the type of the structural system or the design level of *** these empirical calculations,the seismic drifts are estimated by amplifying the reduced elastic drifts obtained under design lateral loading with a displacement amplification factor(DAF).The value of DAF is considered equal to the product of the response modification factor R and the inelastic displacement ratioρ.The goal of the current research is to assess the value ofρfor low-to mid-rise BRBFs designed under low and high levels of *** goal has been achieved by conducting a series of elastic and inelastic time-history analyses pertaining to an ensemble of earthquake records on 3-,6-and 9-story *** results indicate that theρ-ratio increases with an increase in design seismic intensity and an increase in experienced *** range ofρfor low seismicity designs ranges from 0.63 to 0.9,while for high seismicity designs this range stretches from 0.83 to *** has been found that the consideration of a generalρ-ratio of 1.0 is a reasonable estimation for the design of the BRBFs considered in this study.

关键词： displacement amplification factor inelastic displacement ratio seismicity buckling-restrained brace seismic drift seismic design