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Prenatal diagnosed caudal regression syndrome

Open Journal of Obstetrics and Gynecology 2013年第2期3卷 227-231页

作者： osman temizkan Faruk Abike Habibe Ayvaci Ali Yilmaz Ersan Demirag Ilhan Sanverdi Department of Obstetrics and Gynecology Sisli Etfal Education and Research HospitalIstanbulTurkey Department of Obstetrics and Gynecology Florence Nightingale Kadikoy HospitalIstanbulTurkey Department of Obstetrics and Gynecology Zeynep Kamil HospitalIstanbulTurkey Department of Obstetrics and Gynecology Haydarpasa GATA HospitalIstanbulTurkey

Background: Caudal regression syndrome (CRS) is a rare complex congenital anomaly which is characterized by agenesis of the sacral and lumbar spine. Pelvis, lower extremity, genitourinary, cardiac anomalies and lower extremity neurological and motor development deficits may be accompanied. The exact etiology is unclear but the maternal insulindependent diabetes mellitus (hyperglycaemia during embryogenesis seems to act as a teratogen), genetic factors, vascular hypoperfusion may play a role in the etiology. Case: A 41-year-old gravida 4, para 2, live 1, abortus 1 patient with 35 weeks of gestation. The patient had 12-year history of type 1 diabetes mellitus. In ultrasonographic examination we found the length of the bones (all the upper and lower bones) 8 weeks underdeveloped and didn’t observe the lumbar, sacral vertebrae and iliac bones. Lower extremities were crossed in froglike position, there wasn’t lower extremity movements. Due to sacral agenesia the head of the femurs were closer. Also pes equinovarum deformity, single umbilical artery, kidneys in contact at the midline were present. All of these findings indicated the diagnosis of caudal regression syndrome. Conclusion: Diabetes is increased fetal anomalities in pregnancy. Diabetic pregnancy should be more evaluated than pregnancies with no risk. Antenatal care should be done more carefully. Especially, prenatal maternal blood glucose levels and HbA1cis most important for prevention of fetal anomalities.

关键词： Caudal Regression Syndrome Prenatal Diagnosis Diabetes Sacral Agenesis

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SYNTHESIS AND CHARACTERIZATION OF A NEW DYESTUFF POLYMER SOLUBLE IN ALKALINE AQUEOUS MEDIA

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Chinese Journal of Polymer Science 2013年第12期31卷 1632-1646页

作者： Ismet Kaya Aysel Ayd n Kevser temizkan Canakkale Onsekiz Mart University Faculty of Sciences and ArtsDepartment of ChemistryPolymer Synthesis and Analysis Laboratory

Novel dyestuff polymers were successfully obtained through oxidative polymerization technique. The synthesized Schiff base and its polymer were soluble in alkaline＇aqueous medium and they have various colors in different solutions. Also, it can be said that the synthesized compounds are suitable as coloring agent （dyestuff） for textile applications. Fluorescence properties of the compounds were determined in DMF with different concentrations （mg/L）. Poly-tris（4- aminophenyl）methanol （P-TAPM） has quite high emission and excitation intensity values. Optical and electrochemical band gaps of the polymers were lower than those of the monomers indicating the more conjugated structure of the polymers. The oxidized states of the novel dyestuff compounds were examined by cyclic voltammetry （CV） technique. The solid state conductivity measurements showed that the synthesized polymers were semiconductors when exposed to the iodine vapour their conductivities could be increased. P-TAPM had the highest undoped conductivity. Thermal characterizations of the synthesized compounds were carried out by TG-DTA and DSC methods.

关键词： Dyestuff polymers Thermal properties Fluorescence Oxidative polymerization.

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影响原发性甲状旁腺功能亢进症患者99Tcm-甲氧基异丁基异腈显像结果的生化和病理因素

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中华核医学与分子影像杂志 2018年第9期38卷 646-648页

作者：李雪娜(译) 中国医科大学附属第一医院核医学科沈阳110001

目的99Tcm-甲氧基异丁基异腈（99Tcm-MIBI）显像是检测原发性甲状旁腺功能亢进症（PHPT）患者病变腺体最常用的显像方式。该研究旨在确定影响MIBI灵敏度的潜在生物因素。方法回顾性分析147例经手术证实的甲状旁腺腺瘤患者。检索并记录... 详细信息

目的99Tcm-甲氧基异丁基异腈（99Tcm-MIBI）显像是检测原发性甲状旁腺功能亢进症（PHPT）患者病变腺体最常用的显像方式。该研究旨在确定影响MIBI灵敏度的潜在生物因素。方法回顾性分析147例经手术证实的甲状旁腺腺瘤患者。检索并记录相关数据，包括病史、生化和激素测定、颈部超声、99Tcm-MIBI显像和病理报告。结果99Tcm-MIBI显像示，147例中分别有77例阳性、39例阴性和31例可疑甲状旁腺腺瘤患者。MIBI阳性和阴性患者的血清Ca分别为（11.5±0.9）与（11.3±0.9） mg/dl（P＝0.42），甲状旁腺激素（PTH）分别为216（146～347）与194（140～317） pg/ml（P＝0.45），25（OH）D水平分别为8.4（5.7～18.2）与10.0（4.7～23.3） ng/ml（P＝0.64）。2组中P糖蛋白（P-gp）染色均为阴性。此外，组织病理学检查示MIBI阳性和阴性组的腺瘤体积、囊性腺瘤发生率、细胞类型（嗜酸细胞）、脂肪百分比和细胞增殖核抗原Ki-67比值无差异。MIBI阳性组和阴性组玻璃样变率分别为13%和28%，差异具有统计学意义（P＝0.04）。结论甲状旁腺腺瘤中的玻璃样变与MIBI显像结果呈负相关。

关键词： 99Tcm-MIBI 甲状旁腺瘤 P糖蛋白 Ki-67比值

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