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Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley osman Paul Ashwood Department of Medical Microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(MIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with ASD by the age of 8 years,with ASD rates continuing to increase in prevalence in USA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

A review of feed efficiency in swine:biology and application

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Journal of Animal Science and Biotechnology 2015年第4期6卷 369-377页

作者： John F.Patience Mariana C.Rossoni-Seräo Nestor a.gutiérrez Department of Animal Science Iowa State University

Feed efficiency represents the cumulative efficiency with which the pig utilizes dietary nutrients for maintenance, lean gain and lipid accretion. It is closely linked with energy metabolism, as the oxidation of carbon-containing components in the feed drive all metabolic processes. While much is known about nutrient utilization and tissue metabolism, blending these subjects into a discussion on feed efficiency has proven to be difficult. For example, while increasing dietary energy concentration will almost certainly increase feed efficiency, the correlation between dietary energy concentration and feed efficiency is surprisingly low. This is likely due to the plethora of non-dietary factors that impact feed efficiency, such as the environment and health as well as individual variation in maintenance requirements, body composition and body weight. Nonetheless, a deeper understanding of feed efficiency is critical at many levels. To individual farms, it impacts profitability. To the pork industry, it represents its competitive position against other protein sources. To food economists, it means less demand on global feed resources. There are environmental and other societal implications as well. Interestingly, feed efficiency is not always reported simply as a ratio of body weight gain to feed consumed. This review will explain why this arithmetic calculation, as simple as it initially seems, and as universally applied as it is in science and commerce, can often be misleading due to errors inherent in recording of both weight gain and feed intake. This review discusses the importance of feed efficiency, the manner in which it can be measured and reported, its basis in biology and approaches to its improvement. It concludes with a summary of findings and recommendations for future efforts.

关键词： Caloric efficiency Energy Feed efficiency Residual feed intake Swine

Selecting SNP markers reflecting population origin for cacao(Theobroma cacao L.)germplasm identification

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Beverage Plant Research 2021年第1期1卷 133-141页

作者： osman a.gutiérrez Kathleen Martinez Dapeng Zhang Donald S.Livingstone Chris J.Turnbull Juan Carlos Motamayor USDA-ARS Subtropical Horticulture Research Station 13601 Old Cutler RoadMiamiFL 33158USA USDA-ARS Beltsville Agricultural Research CenterSPCL10300 Baltimore AvenueBldg.001Rm.223BARC-WBeltsvilleMD 20705USA Mars Wrigley Plant Science Laboratory DavisCA 95616USA School of Agriculture Policy and DevelopmentUniversity of ReadingRG66ARUK Universal GeneticSolutions LLCOrlandoFLUSA

Cacao is one of the most economically important agricultural commodities in the world,providing the principal ingredient for the global chocolate *** genotype identification is essential for effective conservation and utilization of cacao ***,we report the screening of 956 candidate SNPs,pre-selected from the 6 and 15K Theobroma cacao SNP Arrays using targeted Genotyping-by-Sequencing on 451 cacao germplasm accessions,representing ten known genetic groups from the tropical *** on call rate(No call rate0.15)and Linkage Disequilibrium(LD≤0.5),a total of 219 SNPs were *** efficacy of these SNP markers for population classification was compared with the previous SSR-based analysis in *** population assignment results of the retained 420 cacao accessions was highly comparable with the SSR *** matrix of genetic distance between SSR and SNP markers is highly correlated(r=0.718;P<0.001).These results demonstrated the consistency in using the present SNP markers for cacao germplasm *** is our pilot project for the development of SNP markers reflecting population origin for cacao germplasm *** SNP markers and the selected reference germplasm for different populations are suitable for use in cacao germplasm management and crop improvement,including genotype identification,seed gardens and nursery accreditation,and cocoa *** is being continued with the emphasis on selecting SNP markers for the detection of sub-population structures in the primary gene pool of ***.

关键词： germplasm origin continued

c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases

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Neural Regeneration Research 2023年第2期18卷 237-243页

作者： Daniela a.gutiérrez América Chandía-Cristi María JoséYáñez Silvana Zanlungo Alejandra R.Alvarez Cell Signaling Laboratory Department of Cellular and Molecular BiologyCenter for Aging and Regeneration(CARE)Millennium Institute on Immunology and ImmunotherapyBiological Sciences FacultyPontificia Universidad Católica de ChileSantiagoChile School of Medical Technology Health Sciences FacultyUniversidad San SebastianSede Los LeonesSantiagoChile Department of Gastroenterology Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile

Our ability to learn and remember depends on the active formation,remodeling,and elimination of ***,the development and growth of synapses as well as their weakening and elimination are essential for neuronal *** structural reorganization of synaptic complexes,changes in actin cytos keleton and organelle dynamics,as well as modulation of gene expression,determine synaptic *** has been proposed that dys regulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative *** is known about downstream signaling of activated N-methyl-D-aspartate andα-amino-3-hydroxy-5-methyl-4-isoazolepro pionate receptors;howeve r,other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and *** non-receptor tyrosine kinase c-Abl(ABL1)is a key signal transducer of intra and extracellular signals,and it shuttles between the cyto plasm and the *** review focuses on c-Abl and its synaptic and neuronal ***,we discuss the evidence showing that the activation of c-Abl can be detrimental to neurons,promoting the development of neurodegenerative ***,c-Abl activity seems to be in a pivotal balance between healthy synaptic plasticity,regulating dendritic spines remodeling and gene expression after cognitive training,and synaptic dysfunction and loss in neurodegenerative ***,c-Abl genetic ablation not only improves learning and memory and modulates the brain genetic program of trained mice,but its absence provides dendritic spines resiliency against *** re,the present review has been designed to elu cidate the common links between c-Abl regulation of structural changes that involve the actin cytos keleton and organelles dynamics,and the transc riptional program activated during synaptic *** summarizing the recent discove ries on c-Abl functions,we aim to provide an overview of how

关键词： actin cytoskeleton activity-dependent plasticity Alzheimer's disease c-Abl dendritic spines learning synapse synaptic plasticity transcription tyrosine kinase

Hepatoprotective properties of oleanolic and ursolic acids in anti-tubercular drug-induced liver damage

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 625-632页

作者： Gabriel a.gutiérrez-Rebolledo Georgina A.Siordia-Reyes Mariana Meckes-Fischer Adelina Jiménez-Arellanes Unidad de Investigación Médica en Farmacología (UIMF) UMAE Hospital de EspecialidadesCentro Médico Nacional-Siglo XXI (CMN-SXXI)Instituto Mexicano del Seguro Social (IMSS) Servicio de Patología UMAE Hospital de PediatríaCMN-SXXIIMSS Centro de Diagnóstico en Metabolismo Energético y Medicina Mitocondrial A.C.

Objective:To estimate to what extent the mixture of ursolic acid and oleanolic acid,in addition to the antitubercular standard regime,affects the hepatotoxicity ***:Liver injury was induced in male BALB/c mice by administering,per os and daily for 11 weeks,a combination of anti-Tubercular(anti-TB) agents Rifampicin(10 mg/kg),Isoniazid(10 mg/kg),and Pyrazinamide(30 mg/kg).The ursolic acid and oleanolic acid mixture at doses of 100 or 200 μg/mouse/day was subcutaneously injected throughout the entire study period(11 weeks).Biochemical and hematological analysis was supplemented by liver histological ***:Animals treated with the mixture of triterpenic acids exhibited significantly decreased aspartate transaminase and alanine aminotransferase levels and amelioration of the histopathological alterations produced by the anti-TB ***:The triterpene mixture is able to prevent the steatosis induced by the anti-TB drugs.

关键词： Ursolic acid Oleanolic acid Hepatoprotector effect Antitubercular drugs Triterpenes

Indentation Load Effect on Young＇s Modulus and Hardness of Porous Sialon Ceramic by Depth Sensing Indentation Tests

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Chinese Physics Letters 2007年第11期24卷 3206-3209页

作者： osman SAHIN Department of Physics Art and Science Faculty Silleyman Demirel University Isparta Turkey

Depth sensing indentation （DSI） tests at the range of 200-1800mN are performed on porous sialon ceramic to determine the indentation load on Young＇s modulus and hardness values. The Young modulus and hardness （Dynamic and Martens） values are deduced by analysing the unloading segments of the DSI test load-displacement curves using the Oliver-Pharr method. It is found that Young＇s modulus ET, the dynamic hardness HD and the Martens hardness HM exhibit significant indentation load dependences. The values of Young＇s modulus and hardness decrease with the increasing indentation load, as a result of indentation load effect. The experimental hf /hm ratios lower than the critical value 0.7, with hm being the maximum penetration depth during loading and hf the final unloading depth, indicate that our sample shows the work hardening behaviour.

关键词： coated conductor buffer layer self-epitaxy CeO2

The Tauride Ophiolites of Anatolia(Turkey):A Review

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Journal of Earth Science 2016年第6期27卷 901-934页

作者： osman Parlak Cukurova On Universitesi Jeoloji Muhendisligi Bolumu Balcah Adana 01380 Turkey

The Tauride ophiolites lie on the northern and southern flanks of an E-W-trending Tanride carbonate platform. They mainly consist of three tectonic units namely in ascending order, ophiolitic melange, sub-ophiolitic metamorphic sole and oceanic lithospheric remnants. They were generated above intra-oceanic subduction zones and emplaced over the Tauride carbonate platform from different Neotethyan oceanic basins in the Late Cretaceous. Tauride ophiolites from west to east are described and reviewed. All are underlain by well-preserved dynamothermal metamorphic soles of varied structural thicknesses up to 500 m that have a constant structural position between ophiolitic melange below and harzburgitic mantle tectonites above and display typical inverted metamorphic sequences from amphibolite facies above to greenschist facies below. The metamorphic soles are shown to have evolved during the initiation of subduction and emplacement processes. In the PozantlKarsantl area the contact between the metamorphic sole and the overlying serpentinized harzburgites is characterized by a 1.5-2-m-thick zone of sheared serpentinized harzburgitic mantle intercalated with amphibolites and cut by thick mafic dykes （7-8 m） which postdate intraoceanic metamorphism and high-temperature ductile deformation. This contact is interpreted as an intra-oceanic decoupling surface along which volcanics from the upper levels of the down-going plate were metamorphosed to amphibolite facies and accreted to the base of the hanging wall plate. The metamorphic soles and overlying ophiolitic rocks were intruded by numerous isolated post-metamorphic diabase dykes filled by island arc tholeiitic magma. Subduction initiation and roll-back processes best explain the structural and petrological relationships of Late Cretaceous ophiolite genesis, metamorphic sole formation and subsequent dyke emplacement of the Tauride ophiolites.

关键词： ophiolite metamorphic sole dyke emplacement roll-back subduction initiation.

Relaxation theory of spin-3/2 Ising system near phase transition temperatures

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Chinese Physics B 2010年第8期19卷 257-269页

作者： osman Canko Mustafa Keskin Department of Physics Erciyes University

Dynamics of a spin-3/2 Ising system Hamiltonian with bilinear and biquadratic nearest-neighbour exchange interactions is studied by a simple method in which the statistical equilibrium theory is combined with the Onsager＇s theory of irreversible thermodynamics. First, the equilibrium behaviour of the model in the molecular-field approximation is given briefly in order to obtain the phase transition temperatures, i.e. the first- and second-order and the tricritical points. Then, the Onsager theory is applied to the model and the kinetic or rate equations are obtained. By solving these equations three relaxation times are calculated and their behaviours are examined for temperatures near the phase transition points. Moreover, the z dynamic critical exponent is calculated and compared with the z values obtained for different systems experimentally and theoretically, and they are found to be in good agrement.

关键词： spin-3/2 Ising system 0nsager theory