Turkey is an important country which has pistachio trees in the world. The Southeastern Anatolia Project (GAP) region located in southeastern of Anatolia has all of pistachio trees. In other words, pistachio trees h...
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Turkey is an important country which has pistachio trees in the world. The Southeastern Anatolia Project (GAP) region located in southeastern of Anatolia has all of pistachio trees. In other words, pistachio trees have grown only in GAP region. Provinces of ~anliurfa, Gaziantep and Adiyaman are in the GAP region. In this study, we have investigated problems of pistachio farmers in these cities. So, we applied survey to pistachio farmers. Then we analyzed data which we had from the surveys with SPSS. As a result, the farmers have mainly got input problems, marketing problems, processing problems, keeping problems, financial problems, labor problems and managerial problems. As a solution, pistachio farmers must set up cooperatives which help finding inputs, markets, loan, labor, manager them and come up with their problems. Government has to support pistachio farmers and price of pistachio yield, pistachio farmers must have training programs about theirs works. Finally, pistachio nuts of stock market must be surely founded.
The nature of the binding site(s) involved in the insulin secretory activity of imidazoline compo- unds remains unclear. An imidazoline I2 binding site (I2BS) has been neglected since the classic I2 ligand, idazoxan, ...
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The nature of the binding site(s) involved in the insulin secretory activity of imidazoline compo- unds remains unclear. An imidazoline I2 binding site (I2BS) has been neglected since the classic I2 ligand, idazoxan, does not release insulin. Using the rabbit as an appropriate model for the study of this type of binding sites, we have tried to re-evaluate the effects of idazoxan, the selective I2 compound BU 224, and efaroxan on insulin secretion. Mimicking efaroxan, idazoxan and BU 224 potentiated insulin release from perifused islets in the presence of 8 mM glucose. In static incubation, insulin secretion induced by idazoxan and BU 224 exhibited both dose and glucose dependencies. ATP-sensitive K+ (KATP) channel blockade, though at a different site from the SUR1 receptor, with subsequent Ca2+ entry, mediates the insulin releasing effect of the three ligands. However, additional MAO independent intracellular steps in stimulus- secretion coupling linked to PKA and PKC activation are only involved in the effect of BU 224. Therefore, both an I2 related binding site at the channel level shared by the three ligands and a putative I3-intracellularly located binding site stimulated by BU 224 would be mediating insulin release by these compounds. In vivo experiments reassess the abilities of idazoxan and BU 224 to enhance glucose-induced insulin secretion and to elicit a modest blood glucose lowering response.
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