检索结果-南通市图书馆

High percentage of bone marrow CD8^(+)tissue-resident-like memory T cells predicts inferior survival in patients with acute myeloid leukemia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Blood Science 2024年第3期6卷 23-32页

作者： Letong Cai Wenpu Lai Danlin Yao Yinfeng Gu Chaofeng Liang Lian Liu Jing Lai Zhi Yu Xianfeng Zha Xibao Yu Xiuli Wu Shaohua Chen oscar junhong luo Yangqiu Li Chunyan Wang Pengfei Qin Xin Huang Ling Xu Key Laboratory for Regenerative Medicine of Ministry of Education Institute of HematologySchool of MedicineDepartment of HematologyThe First Affiliated Hospital Jinan UniversityGuangzhou 510632China b Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China Department of Clinical Laboratory First Affiliated HospitalJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China Department of Hematology First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Hematology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina

Tissue-resident memory T(TRM)cells infiltrating solid tumors could influence tumor progression and the response to immune ***,the proportion and prognostic value of TRM cells in the bone marrow(BM)of patients with acute myeloid leukemia(AML)are *** this study,we used flow cytometry to assay the phenotype of 49 BM samples from patients newly diagnosed with AML(ND-AML).We found that the BM CD8^(+)effector memory(TEM)cells highly expressed CD69(CD8^(+)TRM-like T cells),and their percentage was significantly increased in patients with ND-AML compared with that in healthy individuals(HI).The high percentage of CD8^(+)TRM-like subset was associated with poor overall survival in our ND-AML *** Kaplan–Meier Plotter database verified a significantly reduced survival rate among patients with high expression of CD8^(+)TRM-like T cell characteristic genes(CD8A,CD69,and TOX),especially the M4 and M5 *** analysis revealed that the BM CD8^(+)TRM-like subpopulation exhibited exhausted T cell characteristics,but its high expression of CD27 and CD28 and low expression of CD57 suggested its high proliferative *** single-cell proteogenomic dataset confirmed the existence of TRM-like CD8^(+)T cells in the BM of patients with AML and verified the high expression of immune checkpoints and costimulatory *** conclusion,we found that the accumulation of BM CD8^(+)TRM-like cells could be an immune-related survival prediction marker for patients with AML.

关键词： Acute myeloid leukemia Bone marrow CD69 Tissue-resident-like memory T cells

Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 663-666页

作者： Biao Di Hongling Jia oscar junhong luo Fangqin Lin Kuibiao Li Yuanliang Zhang Huadong Wang Huiying Liang Jun Fan Zhicong Yang Guangzhou Center for Disease Control and Prevention 510440 GuangzhouGuangdongChina Department of Medical Biochemistry and Molecular Biology School of MedicineJinan University510632 GuangzhouGuangdongChina Department of Systems Biomedical Sciences School of MedicineJinan University510632 GuangzhouGuangdongChina GMU-GIBH Joint School of Life Sciences Guangzhou Medical University511436 GuangzhouGuangdongChina BGI-Shenzhen.Beishan Industrial Zone 11th buildingYantian District518055 ShenzhenGuangdongChina Department of Pathophysiology Key Laboratory of National Administration of Traditional Chinese Medicine of the People’s Republic of ChinaSchool of MedicineJinan University510632 GuangzhouGuangdongChina Clinical Data Center Guangdong General Hospital/Guangdong Academy of Medical Sciences510080 GuangzhouGuangdongChina

Dear Editor,Recent study showed that around 80%of coronavirus disease-19(COVID-19)patients are moderate cases who will recover with or without conventional treatment,while the remaining 20%developed severe disease requiring intensive care.1 Early and accurate screening of new COVID-19 patients to identify those who will develop severe disease will facilitate decision-making on appropriate treatment regimens and reasonable allocation of limited healthcare ***,novel predictive factors for disease progress from moderate to severe are urgently needed.

关键词： treatment COV severe

Room-temperature hydrogen adsorption in Pd nanoparticle decorated UiO-66-NH2 via spillover

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第10期93卷 309-315页

作者： Jingchuan Wang junhong luo Yong Yao Jiangfeng Song Yan Shi Institute of Materials China Academy of Engineering PhysicsJiangyou621908China

To improve room-temperature hydrogen storage, palladium (Pd) nanoparticles were innovatively decorated by carbon bridge onto the amino-group functioned Zr-terephthalate metal-organic framework (MOF) UiO-66 to reduce the diffusion energy barrier and then improve the hydrogen spillover effect. Powder X-ray diffraction shows broad Pd peak and retained UiO-66-NH_(2) integrity after Pd decoration. The hydrogen uptake capacity show that UiO-66-NH_(2)-Pd exhibits best hydrogen storage performance than UiO-66-NH_(2) and pristine UiO-66. The hydrogen up taken in Pd decorated UiO-66 (UiO-66-NH_(2)-1Pd) was close to 4 wt% under 20 MPa at room temperature. Density functional theory (DFT) calculations show that hydrogen adsorption energy of UiO-66-NH_(2)-Pd was −0.5897 eV, which was much lower than that of UiO-66-NH_(2) (−0.3716 eV) and UiO-66 (−0.2975 eV). Ultimately, Pd decorated NH_(2) group functioned UiO-66 enable improve storage capacities through hydrogen spillover under ambient conditions which could satisfy the demand for sustainable energy, especially for the long-term storage energy media.

关键词： Hydrogen storage UiO-66-NH_(2) Pd decorated Spillover

Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenomics 2023年第4期3卷 360-374页

作者： Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen oscar junhong luo Yifang Gao Zhinan Yin Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Institute of Translational Medicine Zhuhai People’s Hospital Affiliated With Jinan UniversityJinan UniversityZhuhai 519000GuangdongChina The Biomedical Translational Research Institute Health Science Center(School of Medicine)Jinan UniversityGuangzhou 510632GuangdongChina Guangzhou Purui Biotechnology Co. Ltd.Guangzhou 510660GuangdongChina Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632GuangdongChina Guangzhou Geriatric Hospital Guangzhou 510550GuangdongChina Organ Transplantation Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080GuangdongChina Emergency Department The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou 510632GuangdongChina NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic DiseasesChu Hsien-I Memorial HospitalTianjin Medical UniversityTianjin 300134China Tianjin Institute of Endocrinology Tianjin Medical UniversityTianjin 300134China Zhongke Regenerative Medicine Technology Co. LtdDongguan 523808GuangdongChina Wuhan Purui Medical Laboratory Co. LtdWuhan 430223HubeiChina Department of Clinical Laboratory Department of Laboratory MedicineThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina

Ageing is often accompanied with a decline in immune system function,resulting in immune *** studies have focussed on the changes in different lymphocyte subsets in diseases and *** change in immune phenotype is a key indication of the diseased or healthy ***,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively ***,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known ***-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year *** data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network *** initial analysis and machine modelling prediction showed that *** T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T *** is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and *** age of a person's immune system might be different from their chronological *** immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing *** research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice.

关键词： Immunosenescence Phenotype T cell subset Natural killer cell subsets Immune-ageing modelling

双块式无砟轨道轨枕与道床板界面脱空损伤识别

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

振动．测试与诊断 2024年第1期44卷 81-87,198,199页

作者：许雪山杜威任娟娟杜俊宏罗磊西南交通大学高速铁路线路工程教育部重点实验室成都610031 西南交通大学土木工程学院成都610031

为准确识别双块式无砟轨道轨枕与道床板连接面脱空损伤,建立了双块式无砟轨道冲击回波有限元模型,分析界面损伤对弹性波传播规律的影响。在室内浇筑含有不同损伤位置和不同损伤程度的混凝土复合试件,采用冲击回波法进行损伤识别。研究... 详细信息

为准确识别双块式无砟轨道轨枕与道床板连接面脱空损伤,建立了双块式无砟轨道冲击回波有限元模型,分析界面损伤对弹性波传播规律的影响。在室内浇筑含有不同损伤位置和不同损伤程度的混凝土复合试件,采用冲击回波法进行损伤识别。研究结果表明:脱空损伤会显著影响弹性波在界面处的传播,基于回波信号分析可识别损伤;弹性波频率主要受激振锤大小的影响,应结合结构易损位置和理论计算选取合适的激振锤;混凝土复合试件的试验厚度值与理论厚度值相差仅为1 cm,测试结果合理,可用于判断脱空损伤程度,但不能确定损伤区域;利用平面成像技术可准确识别轨枕与道床板界面脱空范围,为双块式无砟轨道结构养护维修提供一定参考,试验结果验证了冲击回波法用于双块式轨道层间脱空识别的可行性和合理性。

关键词：双块式无砟轨道脱空识别冲击回波法模型试验平面成像

亚热带森林植物的叶片和根系功能性状部分耦合但具有不同的群落性状分布格局

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2024年第1期17卷 94-110页

作者： Wenqi luo oscar J Valverde-Barrantes Monique Weemstra James F Cahill Jr Zi Wang Dong He Yongfa Chen Chengjin Chu Youshi Wang State Key Laboratory of Biocontrol School of Life Sciences/School of EcologySun Yat-sen UniversityGuangzhou 510275China International Center for Tropical Botany Department of Biological SciencesFlorida International UniversityMiamiFL 33199USA Department of Biological Sciences University of AlbertaEdmontonABT6G 2E9Canada School of Ecology and the Environment Xinjiang UniversityUrumqi 830046China

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变... 详细信息

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变异,是否表现出类似的CTD,其CTD和群落加权平均性状值(CWM)是否沿环境梯度表现出类似的响应。研究结果表明,叶片和根系性状变异的第一轴均呈显出由资源获取向资源保守变异的经济学谱,但叶片变异的第二轴主要由叶片碳含量表征,而根系变异的第二轴主要由反映菌根协作程度的根系粗细表征。类比的叶片和根系化学性状整体正相关,但形态性状的耦合程度较低。在群落水平上,叶片和根系性状第一轴的CWM均随海拔升高而变得更保守,而第二轴的变化则不一致。随土壤磷含量的降低或钾含量的升高,根系变得更细和在养分性状上更保守,而叶片性状无显著变化。当整合多维性状轴时,叶片性状呈发散格局,且随海拔、土壤磷和钾含量的增加呈收敛趋势;而根系性状呈收敛格局,但沿上述环境梯度呈发散趋势。该研究强调,叶片和根系性状与环境互作的差异可能导致不同的性状分布格局;植物可通过多样的地上和地下功能设计应对环境异质性。

关键词：性状维度群落构建叶片性状根系性状植物经济谱群落性状结构亚热带森林

烟草黄酮醇合酶基因(NtFLS)的生物信息学及表达模式分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

烟草科技 2024年第7期57卷 33-47页

作者：和顺苏欢李冰雨刘俊宏徐馨罗朝鹏杨军王中中国烟草总公司郑州烟草研究院郑州450001

为探究烟草黄酮醇合酶(Flavonol synthase,FLS)基因的生物学功能,从普通烟草K326中鉴定了NtFLS基因家族成员,并进行了基因结构、系统进化、蛋白结构等生物信息学分析,分析了NtFLS所有成员在烟草不同组织中的表达模式,以及NtFLS1和NtFLS... 详细信息

为探究烟草黄酮醇合酶(Flavonol synthase,FLS)基因的生物学功能,从普通烟草K326中鉴定了NtFLS基因家族成员,并进行了基因结构、系统进化、蛋白结构等生物信息学分析,分析了NtFLS所有成员在烟草不同组织中的表达模式,以及NtFLS1和NtFLS2基因在不同激素和非生物胁迫条件下的表达水平。结果表明:①普通烟草基因组中含有9个NtFLS基因,其编码蛋白均含有2OG-FeII_Oxy和DIOX_N保守结构域,属于双加氧酶(2-oxoglutarate dependent dioxygenase,2-ODD)超家族。其中,NtFLS1和NtFLS2蛋白含有FLS家族的特异性序列,且分别与绒毛状烟草NtomFLS和林烟草NsylFLS亲缘关系较近。②在烟草盛花期不同组织中,NtFLS1和NtFLS2基因的表达水平均明显高于其他7个NtFLS基因,且在花蕾、雄蕊和雌蕊中表达水平较高,表明NtFLS1和NtFLS2具有较高的转录活性,可能在烟草雄蕊和雌蕊发育过程中发挥重要的调控作用。③NtFLS基因启动子中含有多个激素和非生物胁迫响应元件,且NtFLS1和NtFLS2基因的表达受多种激素和非生物胁迫的显著调控,表明NtFLS1和NtFLS2蛋白可能参与调控烟草对激素与非生物胁迫的响应。

关键词：烟草黄酮醇合酶基因(NtFLS) 生物信息学表达模式激素非生物胁迫

500 MW级冲击式水轮机配水环管加工工艺研究

在线全文

学校读者我要写书评

暂无评论

科学技术创新 2024年第19期 55-58页

作者：霍金平杨思晋雒军红哈尔滨电机厂有限责任公司黑龙江哈尔滨

介绍了500 MW级冲击式水轮机配水环管的加工工艺以及厂内装配工艺研究。配水环管是冲击式水轮机的重要过流部件,配水环管设计为多节,每节配水环管厂内加工、整体预装完成后分节运输到电站进行装配焊接,各节配水环管的加工尺寸和管口角... 详细信息

介绍了500 MW级冲击式水轮机配水环管的加工工艺以及厂内装配工艺研究。配水环管是冲击式水轮机的重要过流部件,配水环管设计为多节,每节配水环管厂内加工、整体预装完成后分节运输到电站进行装配焊接,各节配水环管的加工尺寸和管口角度对现场安装起决定性的影响,对后期机组的稳定运行有重大影响。通过对配水环管各节加工工艺研究,确定了配水环管制造加工工艺流程,保证了配水环管加工精度和质量,配水环管整体厂内装配,经过高精准测量,保证了配水环管装配后尺寸满足设计和安装要求。

关键词： 500 MW级冲击式水轮机配水环管加工工艺研究

在线全文

学校读者我要写书评

暂无评论

Biomarkers of aging

Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu oscar junhong luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock