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Predictive Factors of Renal Failure in COVID-19 Patients at the Anti-COVID Center in Lome, Togo

Open Journal of Nephrology 2024年第2期14卷 125-135页

作者： Kossi Akomola Sabi Yoan Makafui Amekoudi Awéréou Kotosso Laune Odilon Blatome Badomta Dolaama Ayodélé Jonathan Sabi oscar Gnirimi Gbahbang Loutou Ahoub-Laye Affo Béfa Noto-Kadou-Kaza Nephrology-Hemodialysis Department of CHU Sylvanus Olympio University of Lom Lom Togo Faculty of Health Sciences University of Lom Lom Togo Nephrology Department of the CHU Kara University of Kara Kara Togo Centre Hospitalier Universitaire Pointe--Pitre Pointe--Pitre Guadeloup

Background: Angiotensin-converting enzyme 2 has been identified as the receptor that allows the entry of SarsCov2 into the human cell. Its expression in the kidney is 100 times higher than in the lung;thus, making the kidney an excellent target for SarsCov2 infection manifesting as renal failure (RF). The objective of this study was to determine the predictive factors of RF during COVID-19 in the Togolese context. Patients and Methods: This was a retrospective descriptive and analytical study conducted at the Lomé Anti-COVID Center including the records of patients hospitalized for COVID-19, of age ≥ 18 years and having performed a creatinemia. RF was defined by a GFR 2 calculated according to the MDRD formula. Patients were randomized into 2 groups according to GFRResults: 482 patients were selected for this study with a mean age of 58.02 years. Sixty-five percent of the patients were men, i.e., a sex ratio of 1.88. Fifty-two patients had RF, i.e., a frequency of 10.8%.There were 65% men (315 cases), for a sex ratio (M/F) of 1.88. Risk factors for renal failure in COVID-19 were age ≥ 65 years (ORa 2.42;CIa95% [1.17 - 4.95];p = 0.016), anemia (ORa 2.49;CIa95% [1.21 - 5.26];p = 0.015), moderate (ORa 13;CIa95% [2.30 - 2.44];p = 0.017), severe (ORa 26.2;CIa95% [4.85 - 4.93];p = 0.002) and critical (ORa 108;CIa95% [16.5 - 21.76];p Conclusion: Renal failure would therefore be related to the severity of COVID-19 and is the most formidable factor, conditioning the course of the disease and the patient’s vital prognosis.

关键词： COVID-19 Renal Failure Risk Factors Togo

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Contribution of Genomic Surveillance in the Detection and Monitoring of SARS-CoV-2 Variants during the 6 Pandemic Waves in the Central African Republic from 2020 to 2023

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Journal of Tuberculosis Research 2024年第3期12卷 151-164页

作者： Clotaire Donatien Rafaï Ernest Lango-Yaya Marie Roseline Darnicka Belizaire Ouoko Fa-Ti-Gbia Maurel Annicet Adonis Marcel Mbeko Simaleko Jean-Baptiste Roungou oscar Senzongo Karl G. Njuwa Fai Boniface Koffi National Laboratory of Clinical Biology and Public Health of Bangui Bangui Republic Central African University of Bangui Bangui Central African Republic World Health Organization Geneva Switzerland Ministry of Health and Population Bangui Central African Republic Africa CDC Addis-Abeba Ethiopia Homegrown Solutions for Health Yaounde Cameroon

Objective: The COVID-19 pandemic has highlighted the need to strengthen diagnosis and genomic surveillance capacities. In 2021, Central African managed five waves of COVID-19 by integrating genomic surveillance into their health monitoring system. This study sought to report surveillance data from the National Laboratory of Clinical Biology and Public Health and describe the circulation of SARS-CoV-2 variants. Materials and Methods: This retrospective, descriptive observational study spans three years, from April 2020 to November 2023. It was conducted on a population of consenting volunteers from across the Central African Republic, who were tested using RT-PCR on nasopharyngeal samples. Data with sufficient information were obtained from the National Laboratory of Clinical Biology and Public Health (LNBCSP) databases. Sequencing was largely carried out at the National Institute of Biomedical Research (INRB) in Kinshasa until May 2023, and subsequently at the LNBCSP. Results and Discussion: Out of 97,864 RT-PCR tests performed, 9,764 were positive, resulting in a prevalence of 9.98%. The average age of the patients was 39.97 years ± 13.76, and the male-to-female sex ratio was 2.12. RT-PCR test positivity was significantly associated with age (p = 0.001), sex (p = 0.013) and clinical manifestations. Ten variants circulated during the five recorded waves, with Omicron (B.1.1.529), Delta (B.1.617.2) variants being predominant. Notably, the B.1.620 and B.640 variants were prominent during the second wave. Conclusion: This retrospective study provides key insights into the COVID-19 pandemic in the CAR. It identifies risk factors and details the circulation of various SARS-CoV-2 variants. Enhancing national genomic surveillance capacities would enable the country to better respond to future pandemic challenges.

关键词： SARS-CoV-2 Variants Central African Republic RT-PCR

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Lessons from International Students’ Reaction to the 2011 Great East Japan Earthquake:The Case of the School of Engineering at Tohoku University

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International Journal of Disaster Risk Science 2013年第3期4卷 137-149页

作者： oscar A.Gómez Graduate School of Global Studies Doshisha UniversityKyoto 602-0898Japan

The objective of this study is to document the reaction of international students to the 11 March 2011 emergency in order to inform and improve disaster management strategies, both public and institutional. The study is based mainly on a questionnaire survey carried out in August 2011 and follow-up interviews with students and other stakeholders. It describes the background of Tohoku University’s School of Engineering and covers six different stages in the evolution of the emergency:(1) immediate response;(2) taking shelter in Sendai;(3) life in the city during the aftermath;(4) sheltering outside Sendai;(5) coming back;plus(6) an overview of the experience. Major findings include: the process of evacuation and safety confirmation was successful, yet the subsequent phases(2 and 3) went on mostly unmanaged;students relied mostly on secondary sources of information to make decisions, mainly family and friends of the same nationality, most of whom probably were not better informed than the students themselves. Based on the findings, suggestions for future disaster planning are advanced, as well as a discussion on the challenges of information provision during crisis.

关键词： disaster mostly Great

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Polygeneration Study of Low-to-Medium Enthalpy Geothermal Reservoirs in Mexico

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Journal of Thermal Science 2021年第3期30卷 1077-1087页

作者： CHÁVEZ oscar GODÍNEZ Francisco Tecnológico Nacional de México/I.T.Chihuahua.Av.Tecnológico 2909 C.P.31310ChihuahuaChihuahuaMéxico Instituto de Ingeniería Universidad Nacional Autónoma de MéxicoUNAMC.U.Ciudad de MéxicoC.P.04510México Polo Universitario de Tecnología Avanzada Universidad Nacional Autónoma de MéxicoVía de la Innovación No.410Autopista Monterrey-Aeropuertokm.10 PIITC.P.66629Apodaca Nuevo LeónMéxico

This study combines the thermodynamic analysis of a polygeneration system along with the numerical modelling of the thermal behavior of geothermal reservoirs in Mexico to exploit their *** reservoir was modeled as a porous medium assuming a five-spot well configuration and local thermal *** heat conduction-convection along with the Laplace equations were solved to compute temperature distributions,the useful life and the optimum distance between injection-extraction *** predicted temperature and pressure of the geothermal fluid at the outlet of the reservoir were exploited in the polygeneration system consisting of:(1)a Rankine cycle,(2)an absorption refrigeration cycle,and(3)a heat *** developed approach allows calculating both the optimal distance between injection-extraction wells and the global(utilization)efficiency of six arrangements(each composed by a reservoir connected to a polygeneration system)by assuming that reservoirs have a lifespan of 30 *** also show that:(a)due to the low efficiency of the Rankine cycle,very little thermal energy is converted into electrical one;(b)not only the temperature and the size are important when evaluating the power production performance of reservoirs,but also the permeability plays a fundamental role;(c)the first law efficiency of the polygeneration system ranges from 41.9%to 43.7%;(d)the utilization efficiency of the six arrangements lies in the range between 25.8%and 31%.

关键词： polygeneration system geothermal reservoir local thermal equilibrium low-to-medium enthalpy

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Bile-acid-induced cell injury and protection

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World Journal of Gastroenterology 2009年第14期15卷 1677-1689页

作者： Maria J Perez oscar Briz Research Unit University Hospital of Salamanca Laboratory of Experimental Hepatology and Drug Targeting CIBERehd University of Salamanca E.D. 129 37007 Salamanca Spain

Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids （BAs） in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involving oxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyI-N- methylglycine or pharmacological properties. cholylsarcosine, interest owing have also aroused to their protective

关键词： Apoptosis Cholestasis Liver Necrosis Oxidative stress Ursodeoxycholic acid

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TWO NOVEL GRADIENT METHODS WITH OPTIMAL STEP SIZES

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Journal of Computational Mathematics 2021年第3期39卷 375-391页

作者： Harry Oviedo oscar Dalmau Rafael Herrera Centro de Investigacion en Matematicas CIMAT A.C.GuanajuatoGto.Mexico

In this work we introduce two new Barzilai and Borwein-like steps sizes for the classical gradient method for strictly convex quadratic optimization *** proposed step sizes employ second-order information in order to obtain faster gradient-type *** step sizes are derived from two unconstrained optimization models that involve approximate information of the Hessian of the objective function.A convergence analysis of the proposed algorithm is *** numerical experiments are performed in order to compare the efficiency and effectiveness of the proposed methods with similar methods in the ***,it is observed that our proposals accelerate the gradient method at nearly no extra computational cost,which makes our proposal a good alternative to solve large-scale problems.

关键词： Gradient methods Convex quadratic optimization Hessian spectral properties Steplength selection

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Oviposition behavior of the mirid Macrolophus pygmaeus under risk of intraguild predation and cannibalism

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Insect Science 2021年第1期28卷 224-230页

作者： Frangois Dumont Eric Lucas oscar Alomar Departement des Sciences Biologiques Universite du Quebec a MontrealCentre VilleMontrealQCCanada Sustainable Plant Protection Programme Institute of Agri food Research and Technology(IRTA)CabrilsCataloniaSpain

Zoophytophagous mirid species,that feed and develop either on prey or plant resources,are often found simultaneously on the same ***,these species can engage in both intraguild predation and cannibalism,which can pose a threat to mirid *** females may respond to such risks of predation on their eggs by reducing the number of eggs laid or selecting safer oviposition *** tested the oviposition behavior of Macrolophus pygmaeus(Rambur)(Hemiptera:Miridae)females under the risk of cannibalism by *** males and intraguild predation by Nesidiocoris tenuis(Reuter)males(Hemiptera:Miridae)under laboratory *** predators and cannibals were introduced during or after the oviposition *** number of eggs laid(using counts of newly hatched nymphs)and their proportion on each part of a tomato plant were both *** results reveal that only cannibalism by *** males after the period of oviposition significantly decreased the number of hatched *** thus represents a greater risk to mirid eggs than intraguild *** *** female responded to the presence of potential intraguild predators(or competitors)by decreasing the nu mber of eggs laid in the upper *** results suggest that *** females avoid competition by ***,by laying fewer eggs on upper *** could regulate zoophytophagous predator populations under prey scarcity conditions and minimize the risk of crop damage associated with those biological control agents.

关键词： antipredator behavior cannibalism intraguild predation Macrolophus pygmaeus',Nesidiocoris tenuis zoophytophagy

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Processing of ingredients and diets and effects on nutritional value for pigs

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Journal of Animal Science and Biotechnology 2017年第4期8卷 751-763页

作者： oscar Javier Rojas Hans Henrik Stein Devenish Nutrition Fairmont MN 56031 USA Department of Animal Sciences University of Illinois Urbana IL 61801 USA.

A conventional diet based on corn and soybean meal fed to pigs is usually provided in a mash form and in most cases, processing other than grinding and mixing is not used. However, due to the high cost of energy in pig diets,use of high fiber ingredients such as soybean hulls, distillers dried grains with solubles, and wheat middlings has increased. High fiber concentrations in the diet usually results in reduced energy and nutrient digestibility due to the low capacity of pigs to digest fiber, which negatively impacts growth performance and carcass composition of the pigs. Feed processing technologies such as changes in grinding procedures, expansion, extrusion, pelleting, use of enzymes or chemical treatments may, however, be used to solubilize some of the cel ulose and hemicel ulose fractions that form the cel wal of plants in the ingredients, and therefore, increase nutrient availability. This may have a positive effect on energy digestibility, and therefore, also on pig growth performance and carcass composition, but effects of different feed technologies on the nutritional value of feed ingredients and diets fed to pigs are not fully understood. It has however, been demonstrated that reduced particle size of cereal grains usually results in increased digestibility of energy, primarily due to increased digestibility of starch. Extrusion or expansion of ingredients or diets may also increase energy digestibility and it appears that the increase is greater in high fiber diets than in diets with lower concentrations of fiber. Chemical treatments have not consistently improved energy or nutrient digestibility, but a number of different enzymes may be used to increase the digestibility of phosphorus, calcium, or energy. Thus, there are several opportunities for using feed technology to improve the nutritional value of diets fed to pigs.

关键词： Chemical treatments Enzymes Particle size Pig Processing Starch

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Weighted Weak-type Estimates for Multilinear Commutators of Fractional Integrals on Spaces of Homogeneous Type

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Acta Mathematica Sinica,English Series 2007年第10期23卷 1813-1826页

作者： Osvaldo GOROSITO Gladis PRADOLINI oscar SALINAS Department of Mathematics Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina

We obtain weighted distributional inequalities for multilinear commutators of the fractional integral on spaces of homogeneous type, The techniques developed in this work involve the behavior of some fractional maximal functions. In relation to these operators, as a main tool, we prove a weighted weak type boundedness result, which is interesting in itself.

关键词： commutators fractional integral operator multilinear operators

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The complete short stories

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作者： by oscar Wilde edited with an introduction and notes by John Sloan.

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