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Plastic and Aesthetic Research 2023年第1期10卷 322-338页

作者： Priscila C.Cevallos Daniel Najafali Thomas M.johnstone Mimi R.Borrelli oscar j.manrique Gordon K.Lee Rahim S.Nazerali Division of Plastic&Reconstructive Surgery Department of SurgeryStanford University School of MedicinePalo AltoCA 94304USA Division of Plastic&Reconstructive Surgery Department of SurgeryThe Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA Carle Illinois College of Medicine University of Illinois Urbana-ChampaignUrbanaIL 61801USA Geisel School of Medicine Dartmouth UniversityHanoverNH 03755USA Division of Plastic&Reconstructive Surgery Department of SurgeryStrong Memorial HospitalUniversity of Rochester Medical CenterRochesterNY 14642USA

Breast reconstructive surgery utilizing free tissue transfer has revolutionized the restoration of aesthetic and functional outcomes for *** for the most routine free flap procedures,substantial hospital resources and costs are *** effectiveness of free flap surgery,along with any reconstructive procedure,hinges upon meticulous patient selection,thorough pre-operative planning,well-informed peri-operative decision-making,and diligent post-operative monitoring and care for the *** article presents a review of standard clinical care monitoring techniques during the post-operative period,as well as the diverse strategies currently employed for post-operative flap monitoring.

关键词： Flap monitoring flap salvage peri-operative monitoring post-operative monitoring

Octogenarian liver grafts:Is their use for transplant currently justified?

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World journal of Gastroenterology 2017年第17期23卷 3099-3110页

作者： Carlos jiménez-Romero Felix Cambra oscar Caso Alejandro manrique jorge Calvo Alejandro Marcacuzco Paula Rioja David Lora Iago justo HPB Surgery and Abdominal Organ Transplantation Unit University Hospital“Doce de Octubre” Department of Surgery Facultad de Medicina

AIMTo analyse the impact of octogenarian donors in liver *** present a retrospective single-center study, performed between November 1996 and March 2015, that comprises a sample of 153 liver transplants. Recipients were divided into two groups according to liver donor age: recipients of donors ≤ 65 years (group A; n = 102), and recipients of donors ≥ 80 years (group B; n = 51). A comparative analysis between the groups was performed. Quantitative variables were expressed as mean values and SD, and qualitative variables as percentages. Differences in properties between qualitative variables were assessed by χ2 test. Comparison of quantitative variables was made by t-test. Graft and patient survivals were estimated using the Kaplan-Meier ***, 3 and 5-year overall patient survival was 87.3%, 84% and 75.2%, respectively, in recipients of younger grafts vs 88.2%, 84.1% and 66.4%, respectively, in recipients of octogenarian grafts (P = 0.748). One, 3 and 5-year overall graft survival was 84.3%, 83.1% and 74.2%, respectively, in recipients of younger grafts vs 84.3%, 79.4% and 64.2%, respectively, in recipients of octogenarian grafts (P = 0.524). After excluding the patients with hepatitis C virus cirrhosis (16 in group A and 10 in group B), the 1, 3 and 5-year patient (P = 0.657) and graft (P = 0.419) survivals were practically the same in both groups. Multivariate Cox regression analysis demonstrated that overall patient survival was adversely affected by cerebrovascular donor death, hepatocarcinoma, and recipient preoperative bilirubin, and overall graft survival was adversely influenced by cerebrovascular donor death, and recipient preoperative *** standard criteria for utilization of octogenarian liver grafts are: normal gross appearance and consistency, normal or almost normal liver tests, hemodynamic stability with use of < 10 μg/kg per minute of vasopressors before procurement, intensive care unit s

关键词： Older liver Donor age Marginal liver Liver transplant Aging liver

Effect of heat treatment on the mechanical and biocorrosion behaviour of two Mg-Zn-Ca alloys

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journal of Magnesium and Alloys 2022年第2期10卷 581-595页

作者： N.Pulido-González P.Hidalgo-manrique S.García-Rodríguez B.Torres j.Rams Departamento de Matemática Aplicada Ciencia e Ingeniería de Materiales y Tecnología ElectrónicaESCETUniversidad Rey Juan CarlosC/Tulipán s/nMóstolesMadrid28933Spain

The effect of heat treatment on the mechanical and biocorrosion behaviour of the Mg-1 wt.%Zn-1 wt.%Ca(ZX11)and Mg-3 wt.%Zn-0.4 wt.%Ca(ZX30)alloys was *** this purpose,three-point bending tests as well as electrochemical and immersion tests in Hank’s solution were performed on both alloys in four different thermal conditions:as-cast,solution-treated,peak-aged and *** examinations revealed that the as-cast ZX11 and ZX30 alloys exhibit a microstructure composed ofα-Mg grains separated by large Mg_(2)Ca and Ca_(2)Mg_(6)Zn_(3) particles and by large Ca_(2)Mg_(6)Zn_(3) particles,*** solution treatment,the Ca_(2)Mg_(6)Zn_(3) precipitates at the grain boundaries(GBs)are fully dissolved in the ZX11 alloy,but mainly redistributed to form a more connected configuration in the ZX30 alloy,showing a poor age-hardening ***,after solution-treatment,galvanic corrosion and corrosion rate decreases in the former,but increases in the *** peak-aged condition displays the highest corrosion rate for both alloys,maybe due to an excessive number density of fine Ca_(2)Mg_(6)Zn_(3) particles acting as cathodic ***,the over-aged condition shows the lowest corrosion rate for the ZX11 alloy and a very similar one to that of the as-cast sample for the ZX30 *** ZX11 alloy shows generally better biocorrosion behaviour than the ZX30 alloy to its lower content in the Ca_(2)Mg_(6)Zn_(3) phase and thus reduced galvanic *** Mg_(2)Ca phase present in the studied ZX11 alloy has been proved to exhibit an increased corrosion potential,which has been related to an observed enrichment with Zn.

关键词： Magnesium alloys Biodegradable implants Heat treatment Microstructure Mechanical properties Corrosion

High-throughput metabarcoding of SAR11 assemblages from the southwest Atlantic shelf and arid Patagonia:richness and associated rank abundance distributions

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Quantitative Biology 2023年第3期11卷 332-342页

作者： Leandro R.jones julieta M.manrique Laboratorio de Virología y Genética Molecular Universidad Nacional dela Patagonia San Juan BoscoTrelew CP 9100Argentina

Background:Massively parallel sequencing of environmental DNA allows microbiological studies to be performed in greater detail than was possible with first-generation *** example,it facilitates the use of approaches hitherto largely applied to flora and fauna,such as rank abundance distribution(RAD)***:Here,we set out to advance the knowledge on ***(SAR11)communities from southern South America using environmental sequences from the open ocean in the Argentine sea,the uncharted Engaño Bay,as well as a river and an oligohaline shallow lake from the Patagonian Steppe *** structures of the SAR11 assemblages present in these ecosystems were dissected by direct and rarefaction-based estimates of species richness,and evaluations of the corresponding abundance distributions(ADs),which was addressed by RAD ***:Microbial community composition analyses revealed that the studied SAR11 assemblages coexist with 27 bacterial ***11 richness was in general very high,but ADs turned out to be highly *** results were compatible with prior knowledge,and similar to that derived from point estimates of ***,our comprehensive dissection allowed for more detailed quantitative comparisons to be made between the environments surveyed,and revealed differences regarding both richness and the underlying ***:Despite SAR11 assemblages being extremely rich,their ADs are very *** and ADs can vary,not only between fresh and salt water,but also between oceanic and coastal marine *** obtained results provide insights on general topics such as adaptation and the contrast between marine and freshwater radiations.

关键词： SAR11 richness species abundance distribution rank abundance distribution Patagonia Argentina

Improving colorectal cancer screening programs

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World journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： oscar j Cordero Lucia Mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and Molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain Centre for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-based screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-related biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compared to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests based on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： Mortality rates Colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble sCD26 Colonoscopy Immunoscores

Using old liver grafts for liver transplantation: Where are the limits?

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World journal of Gastroenterology 2014年第31期20卷 10691-10702页

作者： Carlos jiménez-Romero oscar Caso Maestro Félix Cambra Molero Iago justo Alonso Cristina Alegre Torrado Alejandro manrique Municio jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González Service of General and Digestive Surgery and Abdominal Organ Transplantation "Doce de Octubre" University Hospital

The scarcity of ideal liver grafts for orthotopic liver transplantation (OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts.

关键词： Old liver donors Liver transplantation Aging liver Liver graft Liver disease Aging Donor management Septuagenarian donors Octogenarian donors

Simulation Model to the Zika Virus Considering Asymptomatic Population

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Open journal of Modelling and Simulation 2018年第1期6卷 1-12页

作者： juan Carlos jamboos Dalia Marcela Munoz Anibal Munoz oscar Andres manrique Steven Raigosa Grupo de Modelacion Matematica en Epidemiologia(GMME) Facultad de EducacionUniversidad del QuindioArmeniaColombia

A simulation model based on nonlinear ordinary differential equations to interpret the transmission dynamics of Zika Virus (ZIKV), is formulated and analyzed, integrating the asymptomatic human population and coupled to the Aedes aegypti dynamics, the epidemic threshold Basic Reproduction Number R0 is determined, as the spectral radius of Next-Generation Matrix and the system is simulated with MAPLE computing program taking the parameter values from literature.

关键词： Simulation Models Zika Virus(ZIKV) Basic Reproductive Number R_(0) Spectral Radius Asymptomatic Next-Generation Matrix

Incidence, risk factors and outcome of de novo tumors in liver transplant recipients focusing on alcoholic cirrhosis

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World journal of Hepatology 2015年第7期7卷 942-953页

作者： Carlos jiménez-Romero Iago justo-Alonso Félix Cambra-Molero jorge Calvo-Pulido álvaro García-Sesma Manuel Abradelo-Usera oscar Caso-Maestro Alejandro manrique-Municio Service of General and Digestive Surgery Abdominal Organ Transplantation "Doce de Octubre" University Hospital Universidad Complutense de Madrid

Orthotopic liver transplantation(OLT) is an established life-saving procedure for alcoholic cirrhotic(AC) patients, but the incidence of de novo tumors ranges between 2.6% and 15.7% and is significantly increased in comparison with patients who undergo OLT for other etiologies. Tobacco, a known carcinogen, has been reported to be between 52% and 83.3% in AC patients before OLT. Other risk factors that contribute to the development of malignancies are dose-dependent immunosuppression, advanced age, viral infections, sun exposure, and premalignant lesions(inflammatory bowel disease, Barrett's esophagus). A significantly more frequent incidence of upper aerodigestive(UAD) tract, lung, skin, and kidney-bladder tumors has been found in OLT recipients for AC in comparison with other etiologies. Liver transplant recipients who develop de novo non-skin tumors have a decreased long-term survival rate compared with controls. This significantly lower survival rate is more evident in AC recipients who develop UAD tract or lung tumors after OLT mainly because the diagnosis is usually performed at an advanced stage. All transplant candidates, especially AC patients, should be encouraged to cease smoking and alcohol consumption in the pre- and postOLT periods, use skin protection, avoid sun exposure and over-immunosuppression, and have a yearly otopharyngolaryngeal exploration and chest computed tomography scan in order to prevent or reduce the incidence of de novo malignancies. Although still under investigation, substitution of calcineurin inhibitors for sirolimus or everolimus may reduce the incidence of de novo tumors after OLT.

关键词： De novo malignancies De novo tumorstobacco consumption Alcoholic cirrhosis De novocancer Liver transplant

Influence of the Accumulative Roll Bonding Process Severity on the Microstructure and Superplastic Behaviour of 7075 Al Alloy

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journal of Materials Science & Technology 2016年第8期32卷 774-782页

作者： R Hidalgo-manrique A.Orozco-Caballero C.M.Cepeda-jimenez O.A.Ruano, F.Carreno Department of Physical Metallurgy CENIM CSIC Av. Gregorio del Amo 8 28040 Madrid Spain School of Materials The University of ManchesterManchester M1 7SH UK. IMDEA Materials Institute. C/Eric Kandel 2 28906 Getafe MadridSpain

The 7075 Al alloy was processed by accumulative roll bonding （ARB） at 350 ℃ using 2：1, 3：1 and 4：1 thickness reductions per pass （Rp） up to 8, 6 and 3 passes, respectively. Microstructural examinations of the processed samples revealed that ARB leads to a microstructure composed of equiaxed crystallites with a mean size generally lower than 500 nm. It was found that, due to both the stored energy through- out the processing and the particle pinning effect, the alloy is affected by discontinuous recrystallisation during the inter-pass heating stages, the precise microstructural evolution being dependent on Rp. Me- chanical testing of the ARBed samples revealed that the main active deformation mechanism in the ARBed samples in the temperature range from 250 to 350 ℃ at intermediate and high strain rates is grain bound- ary sliding, the superplastic properties being determined by both the microstructure after ARB and its thermal stability.

关键词： Accumulative roll bonding (ARB) Al-Zn-Mg-Cn alloys Grain refining Precipitate coarsening Recrystallisation Superplastic deformation

Simultaneous determination of kolliphor HS15 and miglyol 812 in microemulsion formulation by ultra-high performance liquid chromatography coupled with nano quantity analyte detector

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journal of Pharmaceutical Analysis 2016年第1期6卷 11-17页

作者： Honggen Zhang ZhenyuWang oscar Liu Merck Research Laboratories Merck & Co. Inc. Rahway NJ 07065 USA

A novel method for simultaneous determination of kolliphor HS15 and miglyol 812 in microemulsion formulation was developed using ultra-high performance liquid chromatography coupled with a nano quantitation analytical detector （UHPLC-NQAD）. All components in kolliphor HS15 and miglyo1812 were well separated on an Acquity BEH C18 column. Mobile phase A was 0.1% trifluoroacetic acid （TFA） in water and mobile phase B was acetonitrile. A gradient elution sequence was programed initially with 60% organic solvent, slowly increased to 100% within 8 min. The flow rate was 0.7 mL/min. Good linearity （r 〉 0.95） was obtained in the range of 27.6-1381.1 μg/mL for polyoxyl 15 hydroxystearate in kolliphor HS15, 0.8-202.0 μg/mL for caprylic acid triglyceride and 2.7-221.9μg/mL for capric acid triglyceride in miglyol 812. The relative standard deviations （RSD） ranged from 0.6% to 1.7% for intra-day precision and from 0.4% to 2.7% for inter-day precision. The overall recoveries （accuracy） were 99.7%-101.4% for polyoxyl 15 hydroxystearate in kolliphor HS15, 96.7%-99.6% for caprylic acid triglyceride, and 94.1%- 103.3% for capric acid triglyceride in miglyol 812. Quantification limits （QL） were determined as 27.6 μg/ mL for polyoxy115 hydroxystearate in kolliphor HS15, 0.8 μg/mL for caprylic acid triglyceride, and 2.7 μg/ mL for capric acid triglyceride in miglyol 812. No interferences were observed in the retention time ranges of kolliphor HSI5 and miglyol 812. The method was validated in terms of specificity, linearity, precision, accuracy, QL, and robustness. The proposed method has been applied to microemulsion for- mulation analyses with good recoveries （82.2%-103.4%）.

关键词： Kolliphor HS15 Miglyol 812 Ultra-high performance liquid chromato-graphy (UHPLC) Nano quantitation analytical detector(NQAD)