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FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer’s Disease

Advances in Molecular Imaging 2014年第2期4卷 15-26页

作者： John Murray wai H. Tsui Yi Li Pauline McHugh Schantel williams Megan cummings Elizabeth Pirraglia Lilja Solnes Ricardo Osorio Lidia Glodzik Shankar Vallabhajosula Alexander Drzezga Satoshi Minoshima Mony J. de Leon Lisa Mosconi New York University School of Medicine New York USA University of Cologne Cologne Germany University of washington Seattle USA weill Cornell Medical College New York USA

Having a parent affected by late-onset Alzheimer’s disease (AD) is a major risk factor for cognitively normal (NL) individuals. This study explores the potential of PET with 18F-FDG and the amyloid-β (Aβ) tracer 11C-Pittsburgh Compound B (PiB) for detection of individual risk in NL adults with AD-parents. Methods: FDG- and PiB-PET was performed in 119 young to late-middle aged NL individuals including 80 NL with positive family history of AD (FH+) and 39 NL with negative family history of any dementia (FH-). The FH+ group included 50 subjects with maternal (FHm) and 30 with paternal family history (FHp). Individual FDG and PiB scans were Z scored on a voxel-wise basis relative to modality-specific reference databases using automated procedures and rated as positive or negative (+/-) for AD-typical abnormalities using predefined criteria. To determine the effect of age, the cohort was separated into younger (49 ± 9 y) and older (68 ± 5 y) groups relative to the median age (60 y). Results: Among individuals of age >60 y, as compared to controls, NL FH+ showed a higher frequency of FDG+ scans vs. FH- (53% vs. 6% p was observed for both FHm and FHp groups. Among individuals of age ≤60 y, NL FHm showed a higher frequency of FDG+ scans (29%) compared to FH- (5%, p = 0.04) and a trend compared to FHp (11%) (p = 0.07), while the distribution of PiB+ scans was not different between groups. In both age cohorts, FDG+ scans were more frequent than PiB+ scans among NL FH+, especially FHm (p was a significant predictor of FH+ status. Classification according to PiB status was significantly less successful. Conclusions: Automated analysis of FDG- and PiB-PET demonstrates higher rates of abnormalities in at-risk FH+ vs FH-subjects, indicating potentially ongoing early AD-pathology in this population. The frequency of metabolic abnormalities was higher than that of Aβ pathology in the younger c

关键词： Alzheimer’s Disease Early Detection Positron Emission Tomography Amyloid Imaging Glucose Metabolism Normal Aging

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美金刚对接受多奈哌齐治疗阿尔茨海默病患者的行为效应

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 12-13页

作者： cummings J.L. Schneider E. Tariot P.N. Graham S.M. 郭俊 Dr.Reed Neurological Research Center UCLABox 951769710 Westwood PlazaLos AngelesCA90095-1769United States

OBJECTIVE:To investigate the behavioral effects of memantine in moderate to severe Alzheimer disease(AD).METHODS:The authors conducted a hypothesis-generating,exploratory analysis of a 24-week,double-blind,placebo-controlled trial comparing memantine(20 mg/day)with placebo in subjects with moderate to severe AD on stable donepezil *** employed the Neuropsychiatric Inventory(NPI;12-item),administered at baseline,week 12,and week 24,to assess the effects of memantine on ***,cognitive,and functional measures were collected and relationships between these assessments and changes in behavior were *** intent-to-treat population was examined using last-observation-carried-forward and observed-cases ***:Patients treated with memantine had significantly lower NPI total scores than patients treated with *** of the 12 NPI domains revealed significant effects in favor of memantine on agitation/aggression,eating/appetite,and irritability/*** patients who exhibited agitation/aggression at baseline,those treated with memantine showed significant reduction of symptoms compared with placebo-treated ***-treated patients without agitation/aggression at baseline evidenced significantly less emergence of this symptom compared with similar patients receiving *** of patients receiving memantine registered significantly less agitation-related *** were significant relationships between the NPI and the global rating scale and performance of activities of daily living,but not between changes in the NPI and ***:Treatment with memantine reduced agitation/aggression,irritability,and appetite/eating *** reduced agitation/aggression in patients who were agitated at baseline and delayed its emergence in those who were free of agitation at baseline.

关键词：多奈哌齐攻击行为侵犯行为阿尔茨海默病美金刚患者行为效应

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结核病的诊断与实验方法

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1958年

作者：（美）威理斯（H.S.willis）（美）卡敏斯（M.M.cummings）陈广田等译

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我将你的心带在身上

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健康世界 2016年第10期24卷 52-53页

作者：爱德华·埃斯特林·肯明斯

在2015年的美国心脏病学会年会上，一名医生朗诵了美国著名诗人***的诗歌《我将你的心带在身上》。他认为，这里的“心”有双重含义——不仅要治疗患者的心脏疾病，同时要走进患者的内心,医生也要从心出发，去关爱患者。

关键词：美国心脏病学会心脏疾病患者医生

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临床语言学入门(节译)

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语言战略研究 2021年第6期6卷 67-78页

作者： [英]露易丝·卡明斯周德宇梁丹丹(译) 方小兵(校) 特伦特大学英国诺丁汉NG14FQ 同济大学老龄语言与看护研究中心/外国语学院上海200092 南京师范大学文学院江苏南京210097 南京晓庄学院外国语学院江苏南京211171 南京大学中国语言战略研究中心江苏南京210023

作为语言研究的重要领域,临床语言学虽然发展势头强劲,但与句法学、语义学等分支学科相比,受到的关注尚显不足。本文主张进一步整合临床语言学与普通语言学,因为很多知识和方法是临床语言学家与语言学其他领域的学者共享的。我们首先审... 详细信息

作为语言研究的重要领域,临床语言学虽然发展势头强劲,但与句法学、语义学等分支学科相比,受到的关注尚显不足。本文主张进一步整合临床语言学与普通语言学,因为很多知识和方法是临床语言学家与语言学其他领域的学者共享的。我们首先审视了临床语言学的狭义和广义定义,然后考察了人际交流循环中的关键阶段。该循环展现了话语表达和理解所涉及的认知和语言加工,而语言和交流障碍是该循环中出现的某些故障。在分析语言障碍时,语音学、音系学、形态学、句法学、语义学、语用学和语篇学等语言学分支学科都有所贡献,一系列来自临床受试者(包括儿童和成人)的语料也说明了这些障碍的语言特征。最后总结了本文的讨论要点,并介绍了即将发表在《国际语言研究期刊》上的一篇配套文章。

关键词：临床语言学语言障碍言语障碍言语和语言治疗人际交流循环

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Hydrogeology of Pumice-Hosted Fens in the winema-Fremont National Forest, Oregon, USA

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Journal of water Resource and Protection（水资源与保护） 2014年第19期 1762-1780页

作者： Michael L. cummings Jonathan M. weatherford Leslie A. Mowbray

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Caspase-9和Runx3基因多态性与炎症性肠病的相关性

Caspase-9和Runx3基因多态性与炎症性肠病的相关性

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中华医学会第七次全国消化病学术会议

作者：郭长存 JR Fraser cummings Alessandra Geremia John Beckly Rachel Cooney Laura Hancock Saad Patham Derek P Jewell 第四军医大学西京医院消化内科 wellcome Trust Centre for Human Genetics University of OxfordOxford OX3 7BN UK

背景以往的 Cho 等人的两项连锁研究显示染色体 lp36与 IBD 密切连锁,该基因作为命名为 IBD7, 目前为止 IBD7 位点的 IBD 相关基因尚未见报道。RUNX3和 CASP9基因座位均位于 IBD7位点。RUNX3 基因敲除小鼠模型具有溃疡性结肠炎表型,而 C...

背景以往的 Cho 等人的两项连锁研究显示染色体 lp36与 IBD 密切连锁,该基因作为命名为 IBD7, 目前为止 IBD7 位点的 IBD 相关基因尚未见报道。RUNX3和 CASP9基因座位均位于 IBD7位点。RUNX3 基因敲除小鼠模型具有溃疡性结肠炎表型,而 CASP9在 IBD 患者肠黏膜中表达显著下调。目的研究 CASP9和 RUNX3基因多态性是否与 IBD 相关,是否是 IBD7位点的易感基因。方法研究对象为高加索人群,包括555例克隆恩患者、651例溃疡性结肠炎患者和964例健康对照。采用 MALDI-TOF MS 分析

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Perioperative care and cancer recurrence: Is there a connection?

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world Journal of Anesthesiology 2014年第1期3卷 31-45页

作者： Ashish K Khanna Efrain Riveros Perez Krzysztof Laudanski Amanda Moraska Kenneth C cummings III Cleveland Clinic Foundation Cleveland OH 44195 United States Department of Anesthesiology and Critical Care University of Pennsylvania Philadelphia PA 19104United States Anesthesiology Institute Cleveland Clinic FoundationClevelandOH 44195United States

Cancer is the second most common cause of death in the United States. Metastatic disease is a more important cause of cancer-related death relative to primary tumor progression. Surgical excision is the primary treatment for most malignant tumors. However, surgery itself can inhibit important host defenses and promote the development of metastases. An altered balance between the metastatic potential of the tumor and the anti-metastatic host defenses, including cellmediated immunity and natural killer cell function, is a plausible mechanism of increased cancer metastasis. This article reviews the increasingly recognized concept of anesthetic technique along with perioperative factors and their potential to affect long-term outcome after cancer surgery. The potential effect of intravenous anesthetics, volatile agents, local anesthetic drugs, opiates, and non-steroidal anti-inflammatory drugs are reviewed along with recent literature and ongoing clinical trials in this area. Regional anesthesia is increasingly emerging as a safer option with less cancer recurrence potential as compared to general anesthesia. Blood transfusion, pain, stress, use of beta-blockers, and hypothermia are other potentially important perioperative factors to consider.

关键词： Cancer Recurrence Survival Anesthesia Perioperative Factors

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