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Combinatory effect of hesperetin and mesenchymal stem cells on the deteriorated lipid profile,heart and kidney functions and antioxidant activity in STZ-induced diabetic rats

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BIOCELL 2020年第1期44卷 27-39页

作者： osama m.ahmed mohamed A.HASSAN Ablaa S.SALEH Experimental Obesity and Diabetes Research Lab(EODRL) Physiology DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityPO 62521Beni-SuefEgypt Biochemistry Department Faculty of ScienceBeni-Suef UniversityPO 62521Beni-SuefEgypt

This study aimed to assess the effect of hesperetin and/or bone marrow-derived mesenchymal stem cells(Bm-mSCs)on disturbed lipid profile,heart and kidney functions,oxidative stress and antioxidant defense system in streptozotocin(STZ)-induced diabetic *** 1 diabetes mellitus(T1Dm)was induced in male Wistar rats by injecting 40 mg/kg body weight(b.w.)STZ dissolved in citrate buffer(pH 4.5).The diabetic rats were treated with hesperetin orally administered at dose 20 mg/kg b.w.,Bm-mSCs intravenously injected at a dose of 1 x 106 cells/rat/week and their combination for 6 *** diabetic rats exhibited lipid abnormalities manifested by elevated serum levels of total cholesterol,triglycerides,LDL-cholesterol and VLDL-cholesterol and lowered HDL-cholesterol as well as elevated liver cholesterol and triglycerides content in association with the resultant fasting and postprandial hyperglycemia and insulin *** heart function biomarkers including CK-mB,AST and LDH activities as well as levels of kidney function parameters,creatinine,and urea,were significantly raised in the serum of diabetic *** changes were concomitant with abnormal redox balance represented by elevated lipid peroxidation,decreased glutathione content,and suppressed antioxidant enzyme activities in both heart and kidney of diabetic *** previous deleterious alterations were significantly ameliorated after the treatment of diabetic rats with hesperetin and Bm-mSCs singly or in combination;the treatment with hesperetin together with Bm-mSCs was the most *** on these findings,it can be concluded that the use of hesperetin with Bm-mSCs may have more additive therapeutic value than their uses singly in *** addition,the ameliorative effects of hesperetin and Bm-mSCs on lipid profile and heart and kidney functions in diabetic rats may be mediated,at least in part,via their suppressive effects on oxidative stress and ameliorative effects on the antioxidant defense system

关键词： Bm-mSCs Hesperetin Streptozotocin-induced diabetes

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Thyme oil and thymol abrogate doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats via repression of oxidative stress and enhancement of antioxidant defense mechanisms

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BIOCELL 2020年第1期44卷 41-53页

作者： osama m.ahmed Sanaa R.GALALY mai RASLAN mennah-Allah m.A.mOSTAFA Physiology Division Zoology DepartmentFaculty of ScienceBeni-Suef UniversityP.O.Box 62521Beni-SuefEgypt Cell Biology Histology and Genetics DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityP.O.Box 62521Beni-SuefEgypt Biotechnology and Life Sciences Department Faculty of Postgraduate Studies for Advanced SciencesBeni-Suef UniversityBeni-SuefB.O.Box 62511Egypt

This study aimed to assess the preventive effects of thyme oil and thymol on doxorubicin(DOX)-induced renotoxicity,cardiotoxicity,and oxidative stress in Wistar *** oil was subjected to GC-mS analysis,which indicated that thymol was the major constituent representing 33.896%.Rats intraperitoneally injected with DOX at a dose of 2 mg/kg b.w./one per week for 7 weeks were co-treated with thyme oil and its major constituent,thymol,at doses 250 and 100 mg/kg b.w./every other day,respectively,by oral gavage for the same *** oil and thymol markedly ameliorated the raised levels of serum urea,uric acid,and creatinine in DOX-administered *** also reduced the elevated activities of serum CK-mB and *** oil was more effective than thymol in decreasing the elevated serum creatinine level and serum CK-mB activity in DOX-administered rats,thereby reflecting its more potent effect on kidney and heart *** peroxidation significantly decreased while GSH level and GST and GPx activities significantly increased in kidney and heart of DOX-administered rats treated with thyme oil and *** DOX-induced perturbed kidney histological changes including congestion of glomerulus tuft,inflammatory cells infiltration,protein cast in lumina of the renal tubule,and thickening of the parietal layer of Bowman’s capsule were remarkably ameliorated as a result of treatment with thyme oil and thymol;thyme oil was more *** addition,DOX-induced deleterious heart histological alterations,including intramuscular infiltration of inflammatory cells,focal necrosis of cardiac myocytes,and edema,were remarkably reduced by treatment with thyme oil and ***,it can be concluded that DOX could induce marked toxicity in kidney and heart,and the treatment with thyme oil or thymol produced potential improvement of kidney and heart function and histological integrity via repression of oxidative stress and enhancement of antioxidant defense mechanisms.

关键词： Doxorubicin Nephrotoxicity Cardiotoxicity Oxidative stress Thyme oil Thymol

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Anti-proliferative and apoptotic efficacy of diallyl disulfide onEhrlich ascites carcinoma

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Hepatoma Research 2015年第1期1卷 67-74页

作者： osama m.ahmed Rasha R.ahmed Physiology Division Zoology DepartmentFaculty of ScienceBeni-Suef UniversityBeni-Suef 62514Egypt Faculty of Oral and Dental medicine Nahda UniversityBeni-Suef 11787Egypt Cell Biology Histology and Genetics DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityBeni-Suef 62514Egypt

Aim:This study was conducted to assess the in vivo and in vitro anti-tumor effects of diallyl disulfi de(DADS)against Ehrlich ascites carcinoma(EAC)and to suggest its probable mechanism of ***:EAC was induced in female mice by intraperitoneal injection of EAC-cells from stock ***-bearing mice were orally treated with 100 mg/kg body weight for 2 weeks beginning from the 1st day of EAC intraperitoneal *** effects of DADS against EAC-cells in vitro were investigated at different concentrations(0,6.25,12.5,25,50,and 100μg/mL)of DADS using trypan blue exclusion ***:Data from this study exhibited a signifi cant decrease in EAC-aliquot volume as well as total and alive EAC-cell number and a marked increase in dead EAC-cell number and percent in EAC-bearing mice treated with DADS as compared with EAC-bearing *** changes were consistent with increased number of cells which exhibited phenotypic apoptotic signs marked by a decrease in the expression of anti-apoptotic protein Bcl-2,an increase of pro-apoptotic and cell cycle arrest mediator p53 and an elevation of DNA fragmenting indicator terminal deoxynucleotidyl transferase in EAC-bearing mice treated with *** addition,the tumor marker sialic acid level was markedly decreased in plasma and Ehrlich ascites in EAC-bearing mice treated with *** vitro,DADS also produced anti-proliferative and anti-tumor cytotoxic potentials against ***:DADS may have anti-cancer effects which may be mediated via modulation of apoptosis and cell cycle arrest.

关键词： Anti-proliferative effects apoptosis diallyl disulfi de Ehrlich ascites carcinoma imaging semi-quantitative analysis

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Perspective on early lens extraction for primary angle-closure glaucoma

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Eye Science 2017年第1期32卷 9-11页

作者： osama m.ahmed Lisa A.Hark michael Waisbourd Glaucoma Research Center Wills Eye HospitalPhiladelphiaPAUSA Department of Ophthalmology Tel-Aviv Medical CenterAffiliated to the Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

Primary angle-closure glaucoma(PACG)is a subtype of glaucoma that affects 16 million people worldwide,of whom4 million are bilaterally *** prevalence of PACG is expected to increase to 21 million cases by 2020,and it ... 详细信息

关键词： PACG IOP Perspective on early lens extraction for primary angle-closure glaucoma LPI

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Assessment of clay stiffness and strength parameters using index properties

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Journal of Rock mechanics and Geotechnical Engineering 2018年第3期10卷 579-593页

作者： Sayed m.ahmed Structural Engineering Department Ain Shams University

A new approach is developed to determine the shear wave velocity in saturated soft to firm clays using measurements of the liquid limit, plastic limit, and natural water content with depth. The shear wave velocity is assessed using the site-specific variation of the natural water content with the effective mean stress. Subsequently, an iterative process is envisaged to obtain the clay stiffness and strength *** at-rest earth pressure coefficient, as well as bearing capacity factor and rigidity index related to the cone penetration test, is also acquired from the analyses. Comparisons are presented between the measured clay parameters and the results of corresponding analyses in five different case studies. It is demonstrated that the presented approach can provide acceptable estimates of saturated clay stiffness and strength parameters. One of the main privileges of the presented methodology is the site-specific procedure developed based on the relationships between clay strength and stiffness parameters, rather than adopting direct correlations. Despite of the utilized iterative processes, the presented approach can be easily implemented using a simple spreadsheet, benefiting both geotechnical researchers and practitioners.

关键词： Soft to firm clays Atterberg limits Shear wave velocity Small-strain shear modulus Constrained modulus Undrained shear strength Effective friction angle Cone penetration test

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On null Controllability of fractional stochastic differential system with fractional Brownian motion

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Journal of Control and Decision 2021年第1期8卷 50-63页

作者： Hamdy m.ahmed Higher Institute of Engineering El-Shorouk AcademyEl-Shorouk CityCairoEgypt

In this paper,we are dealing with the null controllability of fractional stochastic differential system with fractional Brownian *** null controllability for Sobolev-type Hilfer fractional stochastic differential system with fractional Brownian motion of Clarke’s subdifferential type is *** sufficient conditions for null controllability of fractional stochastic differential system with fractional Brownian motion and control on the boundary are ***,an example is given to illustrate the obtained results.

关键词： Fractional Brownian motion Clarke subdifferential fractional stochastic differential system null controllability

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Hilfer fractional neutral stochastic partial differential equations with delay driven by Rosenblatt process

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Journal of Control and Decision 2022年第2期9卷 226-243页

作者： Hamdy m.ahmed Higher Institute of Engineering El-Shorouk AcademyEI-Shorouk CityCairoEgypt

This manuscript is mainly focusing on the approximate controllability and the null controllability for fractional neutral stochastic partial differential equations with delay driven by Rosenblatt *** discuss the sufficient conditions for approximate controllability and null controllability for Hilfer fractional neutral stochastic partial differential equations driven by Rosenblatt ***,we provide two examples to verify the obtained results.

关键词： Hilfer fractional neutral stochastic integro-differential systems approximate controllability null controllability Rosenblatt process

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Standard precaution measurements during ophthalmology practice in the pandemic stage of COVID-19

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1017-1022页

作者： ahmed mohamed Reda Wael m.ahmed Department of ophthalmology Faculty of MedicineAin Sham UniversityCairo 11566Egypt Dar Eloyoun Eye Laser Centers Muscat 118Oman

AIm:To take specific precautions and keep a safe practice during providing ophthalmology health services without compromising the patient’s safety as well as the team workers and the community in the pandemic stage of corona virus disease 2019(COVID-19).mETHODS:Applying patient circulation scheme implemented in our ophthalmology centers with the guidance of ministry of health infection control guidelines star ted from the moment that we receive a call or Whats App message or Facebook inquiry from patients until 21 d after patients first visit if *** directions were ***,community awareness of the disease and the ophthalmology related advices in how eye can transfers the infection and how to protect our eyes not to be infected through videos interviews of our consultants and distribution in social media like Instagram,Facebook,Whats App pages radio and TV interviews as well as leaflet health awareness for distribution for ***,scheduling of patients’appointments to prevent overcrowdings and cross ***,protective measurements tools in the center to detect and prevent any exposure of the patients to patients and to protect medical staff,COVID-19 scoring system was set up to identify patients with fever,respiratory symptoms,acute conjunctivitis or recent travel to outbreak areas and to encourage these individuals to postpone their appointments for at least 21 *** use of personal protective equipment was *** all the elective surgeries keeping only the emergency types advised by fourth:how to deal with our patients if they need an urgent ophthalmological intervention and how to deal with suspected cases of corona if any cases ***:Our measures helped our colleagues to try to keep providing ophthalmology health services without increasing the incidence of infection for COVID-19 until this pandemic is ***:In our practice,ophthalmologists should work with new aura of social media to facilitate the

关键词： corona virus COVID-19 Instagram Facebook WhatsApp personal protective equipment

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Disturbance Evaluation in Power System Based on machine Learning

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Computers, materials & Continua 2022年第4期71卷 231-254页

作者： Emad m.ahmed mohamed A.ahmed Ziad m.Ali Imran Khan Department of Electrical Engineering College of EngineeringJouf UniversitySakaka72388Al-JoufSaudi Arabia Department of Electrical Engineering College of EngineeringPrince Sattam bin Abdulaziz UniversityWadi Addawaser11991Saudi Arabia Department of Electrical Engineering Aswan Faculty of EngineeringAswan UniversityAswan81542Egypt Department of Electrical Engineering University of Engineering and Technology PeshawarPakistan

The operation complexity of the distribution system increases as a large number of distributed generators(DG)and electric vehicles were introduced,resulting in higher demands for fast online reactive power *** a power system,the characteristic selection criteria for power quality disturbance classification are not *** classification effect and efficiency needs to be improved,as does the generalization *** order to categorize the quality in the power signal disturbance,this paper proposes a multi-layer severe learning computer auto-encoder to optimize the input weights and extract the characteristics of electric power quality ***,a multi-label classification algorithm based on rating is proposed to understand the relationship between the labels and identify the various power quality *** two algorithms are combined to construct a multi-label classification model based on a multi-level extreme learning machine,and the optimal network structure of the multi-level extreme learning machine as well as the optimal multi-label classification threshold are *** proposed method can be used to classify the single and compound power quality disturbances with improved classification effect,reliability,robustness,and anti-noise performance,according to the experimental *** hamming loss obtained by the proposed algorithm is about 0.17 whereas mL-RBF,SVm and mL-KNN schemes have 0.28,0.23 and 0.22 respectively at a noise intensity of 20 *** average precision obtained by the proposed algorithm 0.85 whereas the mL-RBF,SVm and mL-KNN schemes indicates 0.7,0.77 and 0.78 respectively.

关键词： Optimal power flow optimization algorithm deep learning power systems

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Complementary parametric probit regression and nonparametric classi?cation tree modeling approaches to analyze factors affecting severity of work zone weather-related crashes

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Journal of modern Transportation 2019年第2期27卷 129-140页

作者： Ali Ghasemzadeh mohamed m.ahmed Department of Civil and Architectural Engineering University of Wyoming

Identifying risk factors for road traffic injuries can be considered one of the main priorities of transportation agencies. more than 12,000 fatal work zone crashes were reported between 2000 and 2013. Despite recent efforts to improve work zone safety, the frequency and severity of work zone crashes are still a big concern for transportation agencies. Although many studies have been conducted on different work zone safety-related issues, there is a lack of studies that investigate the effect of adverse weather conditions on work zone crash severity. This paper utilizes probit–classification tree, a relatively recent and promising combination of machine learning technique and conventional parametric model, to identify factors affecting work zone crash severity in adverse weather conditions using 8 years of work zone weatherrelated crashes (2006–2013) in Washington State. The key strength of this technique lies in its capability to alleviate the shortcomings of both parametric and nonparametric models. The results showed that both presence of traffic control device and lighting conditions are significant interacting variables in the developed complementary crash severity model for work zone weather-related crashes. Therefore, transportation agencies and contractors need to invest more in lighting equipment and better traffic control strategies at work zones, specifically during adverse weather conditions.

关键词： Adverse weather Work zone Safety Crash characteristics Probit model Decision tree

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