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Determination of a novel ACE inhibitor in the presence of alkaline and oxidative degradation products using smart spectrophotometric and chemometric methods

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Journal of Pharmaceutical Analysis 2014年第2期4卷 132-143页

作者： Maha abdel-Monem Hegazy Maya Shaaban Eissa osama ibrahim abd el-sattar Mohamed Mohamed abd el-Kawy Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyEgyptian Russian UniversityCairoEgypt National Organization of Drug Control and Research GizaEgypt

Simple, accurate, sensitive and validated UV spectrophotometric and chemometric methods were developed for the determination of imidapril hydrochloride （IMD） in the presence of both its alkaline （AKN） and oxidative （OXI） degradation products and in its pharmaceutical formulation. Method A is the fourth derivative spectra （D4） which allows the determination of IMD in the presence of both AKN and OXD, in pure form and in tablets by measuring the peak amplitude at 243.0 nm. Methods B, C and D, manipulating ratio spectra, were also developed. Method B is the double divisor-ratio difference spectrophotometric one （DD-RD） by computing the difference between the amplitudes of IMD ratio spectra at 232 and 256.3 nm. Method C is the double divisor-first derivative of ratio spectra method （DD-DR1） at 243.2 nm, while method D is the mean centering of ratio spectra （MCR） at 288.0 nm. Methods A, B, C and D could successfully determine IMD in a concentration range of 4.0-32.0 mg/mL. Methods E and F are principal component regression （PCR） and partial least-squares （PLS）, respectively, for the simultaneous determination of IMD in the presence of both AKN and OXI, in pure form and in its tablets. The developed methods have the advantage of simultaneous determination of the cited components without any pre-treatment. The accuracy, precision and linearity ranges of the developed methods were determined. The results obtained were statistically compared with those of a reported HPLC method, and there was no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

关键词： Double divisor-ratio difference Double divisor-ratio derivative Mean centering of ratio spectra Chemometry Imidapril hydrochloride

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A Review: Manufacturing, and Properties of the D-Fructose Epimer D-Allulose (D-Psicose)

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Advances in Bioscience and Biotechnology 2024年第9期15卷 522-542页

作者： osama O. ibrahim Bioinnovation LLC Gurnee IL USA

D-allulose, also known by the name D-psicose or just allulose, is a rare keto-sugar epimer of D-fructose in the third carbon (C3), and naturally occurs in small quantity in fruits such as grapes and figs. It is low calorie sweetener produced enzymatically from D-fructose by enzymes D-ketose 3-epimerase (DKEase) family. D-allulose has a similar taste, texture and functionality as sweetener comparing to high calorie sweetener sugar table sucrose. D-allulose is poorly metabolized in the body with minimal impact on blood sugar levels making it a natural low-calorie sweetener. This property makes D-allulose an attractive sweetener for diabetes and for body weight management. Laboratory studies on D-allulose intake demonstrated its safety with no significant adverse effects. United States Food and Drug Administration (FDA) has granted D-allulose the status of Generally Recognized as Safe (GRAS). Plus, it is considered safe for human consumption by regulatory organizations in other countries except in European Union due to their request for further laboratory testing. Maximum acceptable daily intake of D-allulose is 0.9 grams per kilogram body weight. Excessive intake for more than the recommended daily intake could lead to some side effects such as gastrointestinal discomfort or laxative effects. In general, D-allulose is considered one of the preferred natural low calories sweeteners for those seeking an alternative to table sugar sucrose.

关键词： D-Allulose D-Ketose 3-Epimerase (DKEase) D-Tagatose 3-Epimerase (DTEase) D-Allulose 3-Epimerase (DAEase) D-Psicose 3-Epimerase (DPEase)

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Improved RC6 Block Cipher Based on Data Dependent Rotations

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Computers, Materials & Continua 2022年第1期70卷 1921-1934页

作者： osama S.Faragallah ibrahim F.elashry Ahmed AlGhamdi Walid el-Shafai S.el-Rabaie Fathi E.abd el-Samie Hala S.el-sayed Mohamed A.elaskily Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of electrical Communications Faculty of EngineeringKafrelsheikh UniversityKafrelsheikhEgypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of electronics and electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Kom32511Egypt Department of Informatics Electronic Research Institute(ERI)CairoEgypt

This paper introduces an Improved RC6(IRC6)cipher for data encryption based on data-dependent *** proposed scheme is designed with the potential of meeting the needs of the Advanced Encryption Standard(AES).Four parameters are used to characterize the proposed *** parameters are the size of the word(w)in bits,the number of rounds(r),the length of the secret key(b)in bytes,and the size of the block(L)in *** main feature of IRC6 is the variable number of working registers instead of just four registers as in RC6,resulting in a variable block size for plaintext and *** IRC6 cipher is designed to improve the robustness against attacks by increasing the diffusion for each round and providing greater security with fewer *** effectiveness of the proposed IRC6 scheme is verified against theoretical *** proposed IRC6 scheme depends on full diffusion and confusion mechanisms regardless of the utilized block *** proposed IRC6 scheme saves 70%of the encryption time and 64%of the decryption time of *** simulation results prove that the IRC6 achieves a better encryption/decryption time compared to the ***,the proposed IRC6 is anticipated to fulfill the market needs and system security requirements.

关键词： Cryptography block cipher RC6,IRC6,AES

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Numerical damage evaluation of perforated steel columns subjected to blast loading

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Defence Technology（防务技术） 2022年第5期18卷 735-746页

作者： Mahmoud T.Nawar ibrahim T.Arafa osama M.elhosseiny Structural Engineering Department Zagazig UniversityZagazig44519Egypt

The structural performance of perforated steel columns(PSCs)is significantly more complex than the one of solid web I-shaped elements under the diversity of blast loading *** damage criterion of PSCs is not only related to initial deformation response during the blast but also the residual axial load capacity and it can be considered as a reliable index after the blast ***,the PSCs damages will be studied in two stages;direct and post blast *** the present study,the dynamic response of PSCs was numerically evaluated under different levels of blast threats using LS-DYNA *** explicit finite element(FE)analyses are carried out to investigate the effect of various parameters,such as web opening shapes,boundary conditions and strengthening details on the damage index and toughness of the PSCs compared to the parent steel *** results of the comparative study show that the damage and toughness decrease when the support condition changes from pinned to fixed ends through the two stages of *** give high toughness compared to its parent sections during blast shock stage while,a remarkable decrease in toughness is observed during the application of axial gravity after blast ***,the web opening shapes have slight effects on the global dynamic behavior of PSCs,particularly in terms of residual *** the contrary,the retrofitting strategy using both closed holes at end and vertical stiffeners have an effective enhancement to get higher toughness in case of the extreme blasts.

关键词： Perforated steel columns Blast load Damage criterion Numerical modeling Explicit finite element analysis Web-opening shapes

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Portraying Diabetic Foot Ulcers: Comparative Evaluation of Diabetic Foot Infections versus Diabetic Foot Ulcers

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Advances in Infectious Diseases 2024年第2期14卷 297-309页

作者： Jamal Wadi Al Ramahi Leen Sharqawi Sarah AL-Najafi Eman Awwad Haya M. Al-Obaidi abdel Hafez Mohammad Sara Nofal Dina Riyadh Al-Janabi ibrahim Zuhair Hamza Jamal Al-Masaeid Mohammed Al-Ithawi Dina Rasheed Bellal O. Al-Far osama Al-Izi Qutaiba Al-Bustanji School of Medicine The University of Jordan Amman Jordan Department of the Internal Medicine The Specialty Hospital Amman Jordan Department of Pharmacy The Specialty Hospital Amman Jordan Department of the Medical Al Khalidi Hospital Amman Jordan Department of Pharmacy Jordan Hospital Amman Jordan Department of Internal Medicine Jordan Hospital Amman Jordan Department of General Surgery Jordan Hospital Amman Jordan

Background: Confusion often arises in caring for diabetic foot infections and ulcers, especially with antimicrobials;we aim to shed light on this entity and alert healthcare workers to its stewardship. Methods: Records were reviewed between February 2016 and September 2023. Data for patients diagnosed with diabetes and foot ulcers, infected or not, were examined following ICD 9 search terms. Records for patients were included if they were prediabetic/diabetic adults with foot ulcers, more than 18 years old, and on antidiabetic treatment. Patients were excluded if they insulin resistant, with normal HgbA1c levels, wheel-chair dependent, bed-bound, non-diabetic patients, diabetic patients who had vascular lower limb surgery earlier to ulcers, diabetic patients who had aortocoronary bypass, deep venous thrombosis within six months, malignancy, and severe clinical depression. A modified IWGDF/IDSA guidelines definitions for DFI and DFU was considered. Statistical analysis was done using R programming. Statistical methods were employed as appropriate, and a significant P-value was considered for P Results: Most characteristics were well balanced between DFI and DFU, on imaging osteomyelitis and tissue swelling were significantly more in DFI. Endovascular radiological procedures showed angiograms to be considerably more in DFI, while angioplasty was more in DFU, in addition to smoking. Bacteremia was uncommon, and swab cultures were mostly polymicrobial in both ulcers;no clear association with blood bacteria was detected with the polymicrobial growth, though few were concordant. Antimicrobials prescribed for both ulcers were not statistically different except for carbapenems, which were more in DFI (P Conclusion: Attention should be paid to best practices while caring for diabetic ulcers. These include swab culture interpretations, the use of antimicrobials, and plan management according to DFI or DFU to utilize either local care or combination with antimicrobials.

关键词： Diabetic Foot Ulcers Diabetic Limb Amputation Antimicrobials Stewardship Broad-Spectrum Antimicrobials in Diabetic Foot Ulcers

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Analytic Beta-Wavelet Transform-Based Digital Image Watermarking for Secure Transmission

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Computers, Materials & Continua 2022年第3期70卷 4657-4673页

作者： Hesham Alhumyani ibrahim Alrube Sameer Alsharif Ashraf Afifi Chokri Ben Amar Hala S.el-Sayed osama S.Faragallah Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityP.O.11099Taif21944Saudi Arabia Department of electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Kom32511Egypt Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.11099Taif21944Saudi Arabia

The rapid development in the information technology field has introduced digital watermark technologies as a solution to prevent unauthorized copying and redistribution of *** article introduces a self-embedded image verification and integrity *** images are firstly split into dedicated segments of the same block ***,different Analytic Beta-Wavelet(ABW)orthogonal filters are utilized for embedding a self-segment watermark for image segment using a predefined *** orthogonal filter coefficients are estimated to improve image reconstruction under different block *** conduct a comparative study comparing the watermarked images using three kinds of ABW filters for block sizes 64×64,128×128,and 256×*** embed the watermark using the ABW-based image watermarking method in the 2-level middle frequency sub-bands of the ABW digital image *** imperceptibility and robustness of the ABW-based image watermarking method image is evaluated based on the Peak Signal to Noise Ratio(PSNR)and Correlation coefficient *** the implementation results,we came to know that this ABW-based image watermarking method can withstand many image manipulations compared to other existing methods.

关键词： Watermarking ABW median filtering JPEG compression PSNR

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Numerical Investigation of Rotating Stall in Centrifugal Compressor with Vaned and Vaneless Diffuser

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Journal of Thermal Science 2015年第4期24卷 323-333页

作者： Taher Halawa Mohamed Alqaradawi Mohamed S.Gadala ibrahim Shahin osama Badr Mechanical Engineering Department UBC-University of British ColumbiaVancouverB.C.Canada Mechanical Engineering Department Cairo University Mechanical & Industrial Engineering Department Qatar University Mechanical Engineering Department Abu Dhabi University Mechanical and Industrial Engineering Department Qatar UniversityDohaQatar Mechanical Engineering Department Benha University Mechanical Engineering Department British University

This study presents a numerical simulation of the stall and surge in a centrifugal compressor and presents a description of the stall development in two different *** first case is for a compressor with vaneless diffuser and the second is for a compressor with vaned diffuser of the vane island *** main aim of this study is to compare the flow characteristics and behavior for the two compressors near the surge operating condition and provide further understanding of the diffuser role when back flow occurs at *** showed that for a location near the diffuser entrance,the amplitude of the static pressure fluctuations for the vaneless diffuser case is higher than that for the vaned diffuser case near surge *** pressure fluctuations in the case of the vaneless diffuser appear with a gradual decrease of the mean pressure value as a part of the surge *** for the case of the vaned diffuser,the pressure drop during surge occurs faster than the case of the vaneless ***,results indicated that during surge in the case of vaneless diffuser,there is a region with low velocity and back flow that appears as a layer connecting all impeller passages near shroud surface and this layer develops in size with *** the other hand,for the case of vaned diffuser during surge,the low velocity regions appear in random locations in some passages and these regions expand with time towards the shroud *** showed that during stall,the impeller passages are exposed to identical impact from stall cells in the case of vaneless diffuser while the stall effect varies from passage to another in the case of the vaned diffuser.

关键词： centrifugal compressors rotating stall surge vaneless diffuser vaned diffuser

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Opto-Video Encryption Based on Logistic Adjusted Sine map in FrFT

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Computers, Materials & Continua 2022年第8期72卷 3651-3663页

作者： osama S.Faragallah Ashraf Afifi ibrahim F.elashry Ensherah A.Naeem Heba M.el-Hoseny Ahmed I.Sallam Hala S.el-sayed Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of electrical Engineering Kafrelsheikh UniversityKafrelsheikh 61519Egypt electrical Department Faculty of Industrial EducationSuez UniversitySuez 43527Egypt Department of electronics and electrical Communication Engineering Al-Obour High Institute for Engineering and Technology 3036Egypt Department of Computer Science and Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf 32952Egypt Department of electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Kom 32511Egypt

In the last few years,videos became the most common form of information transmitted over the internet,and a lot of the traffic is confidential and must be protected and delivered safely to its intended *** introduces the challenges of presenting encryption systems that can encode videos securely and efficiently at the same *** paper presents an efficient opto-video encryption system using Logistic Adjusted Sine map(LASM)in the Fractional Fourier Transform(FrFT).In the presented opto-video LASM-based FrFT scheme,the encoded video is split into distinct frames and transformed into optical signals utilizing an optical *** of the developed optical video frames is ciphered by utilizing the LASM in optical FrFT system using two-phase modulation forms on the video frame,the first in the time-domain and the second in the FrFT *** the end,the ciphervideo frame is spotted utilizing a CCD digital camera and transformed into a digital structure that can be managed using a *** test the proposed opto-video LASM-based FrFT scheme using various security *** outcomes demonstrate that the presented scheme can effectively encrypt and decrypt video *** addition,it encrypts videos with a high level of encryption qualitywithout sacrificing its resistance to noise ***,the test outcomes demonstrate that the presented scheme is immune to known attacks.

关键词： Optical encryption FrFT logistic-adjusted sine map

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Development of Mobile App to Support the Mobility of Visually Impaired People

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Computers, Materials & Continua 2022年第11期73卷 3473-3495页

作者： R.Meenakshi R.Ponnusamy Saleh Alghamdi osama ibrahim Khalaf Youseef Alotaibi Center for Artificial Intelligence&Research Chennai Institute of TechnologyKundrathur600069India Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaifSaudi Arabia Al-Nahrain Nano-Renewable Energy Research Center Al-Nahrain UniversityBaghdadIraq Department of Computer Science College of Computer and Information SystemsUmm Al-Qura UniversityMakkahSaudi Arabia

In 2017,it was estimated that the number of persons of all ages visually affected would be two hundred and eighty-five million,of which thirty-nine million are *** are several innovative technical solutions available to facilitate the movement of these *** next big challenge for technical people is to give cost-effective *** of the challenges for people with visual impairments is navigating safely,recognizing obstacles,and moving freely between locations in unfamiliar environments.A new mobile application solution is developed,and the application can be installed in android *** application will visualize the environment with portable cameras and persons with visual impairment directly to the *** designed system mainly uses the YOLO3 program to identify and locate the distance between the objects and the ***,it determines the direction of the ***,the system will give the voice command to teach/inform the visually impaired people to navigate the *** is a novel work at the global *** proposed approach is cost-effective and affordable to all strata of society.

关键词： Visual Impairment cost-effective YOLO(“You Only Look Once”) computer vision object recognition CNN(Convolution Neural Networks) virtual mapping navigate voice command

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Application of microalgal-ZnO-NPs for reusing polyester/cotton blended fabric wastes after modification by cellulases enzymes

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Waste Disposal and Sustainable Energy 2023年第4期5卷 471-482页

作者： osama M.Darwesh Naser G.Al-Balakocy Ahmed Ghanem ibrahim A.Matter Agricultural Microbiology Department National Research Centre33 EL-Buhouth St.DokkiCairo12622Egypt Protenic and Manmade Fibers Department National Research CentreDokkiCairo12622Egypt Packaging Materials Department National Research CentreCairo12622Egypt

Polyester/cotton(PET/C)blended fabric wastes are produced daily in huge amounts,which constitutes an economic loss and an environmental threat if it is not reused *** textile waste recycling technologies put much effort into developing fabric materials with unique properties,such as bioactivity or new optical goods based on modern technologies,especially *** this study,zinc oxide nanoparticles(ZnO-NPs)were biosynthesized using the aqueous extract of Dunaliella *** immobilized on PET/C waste fabrics after enzymatically activated with *** produced Dunaliella-ZnO-NPs(10–20 nm with a spherical shape)were characterized by High-resolution transmission electron microscopy(HRTEM),Fourier-transform infrared spectroscopy(FTIR),X-Ray diffraction analysis(XRD),and Scanning electron microscopy-energy dispersive X-ray analyzer(SEM-EDAX),and some functional groups,such as CH,CO,NH,and CN(due to the presence of carboxyl,proteins and hydroxyl groups),were detected,revealing the biosynthesis of *** analysis showed that the resulting ZnO-NPS had potent antimicrobial effects,Ultraviolet(UV)protection capabilities,and no cytotoxic effects on the normal human fibroblast cell line(BJ1).On the other hand,enzymatic treatments of PET/C fabric waste with cellulases enhanced the immobilization of biosynthetic nanoparticles on their *** PET/C fabrics loaded with Dunaliella-ZnO-NPs showed antibacterial and UV protection capabilities making them an eco-friendly and cost-effective candidate for numerous *** applications can include the manufacture of active packaging devices,wastewater treatment units,and many other environmental applications.

关键词： Wastewater remediation Polyester/cotton wastes Cytotoxicity Microalgal-ZnO-NPs Dunaliella sp. Microbial nanotechnology

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